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| 1 | 热应激和低营养摄入对猪肠道完整性和功能的影响显示文摘热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激(通过减少采食量)对生长猪肠道通透性的影响。选用体重(43±4)kg的杂交后备母猪(n=48),分别安置在以下控制环境中:热中性(TN)环境(20℃,湿度35%~50%,自由采食)、热应激(HS)环境(35℃,湿度20%~35%,自由采食)、热中性环境配对饲喂(PFTN,以消除不同采食量的交互影响)。第1、3、7天使猪只安乐死,采集的空肠样品被安装到尤式灌流室,测定跨膜电阻抗值(TER)和异硫氰基荧光标记的脂多糖(LPS)渗透性(APP,表示为表观渗透系数)。此外,评估肠道完整性以及应激基因和蛋白标志物。结果表明,不考虑热应激天数,HS组与TN组猪相比,血浆内毒素水平增加45%(P〈0.05),空肠TER降低30%(P〈0.05),LPS渗透率增加2倍(P〈0.01)。此外,与PFTN组相比,HS组第7天的猪LPS渗透性有增加的趋势(P=0.06)。整个试验阶段HS组溶菌酶和碱性磷酸酶活性下降,分别下降46%和59%(P〈0.05);然而,3 d和7 d空肠免疫细胞标记物——髓过氧化物酶活性增加(P〈0.05)。由此可见,热应激和减少采食量都会降低肠道完整性,并增加内毒素渗透性。推测这可能会导致炎症加重,在炎热的夏季可能是导致猪生长性能降低的原因。 | Pearce S C Mani V Weber T E Rhoads R P Patience J F Baumgard L H Gabler N K | 2016 | 中国饲料2016，，3： | 3 |
| 2 | Should antibiotics be administered before arthroscopic knee surgery? A systematic review of the literature显示文摘AIM To explore the current evidence surrounding the administration of prophylactic antibiotics for arthroscopic knee surgery. METHODS Databases were searched from inception through May of 2018 for studies examining prophylactic antibiotic use and efficacy in knee arthroscopy. Studies with patient data were further assessed for types of arthroscopic procedures performed,number of patients in the study,use of antibiotics,and outcomes with the intention of performing a pooled analysis. Data pertaining to 'deep tissue infection' or 'septic arthritis' were included in our analysis. Reported data on superficial infection were not included in our data analysis. For the pooled analysis,a relative risk ratio was calculated and χ~2 tests were used to assess for statistical significance between rates of infection amongst the various patient groups. Post hoc power analyses were performed to compute the statistical power obtained from our sample sizes. Number needed to treat analyses were performed for statistically significant differences by dividing 1 by the difference between the infection rates of the antibiotic and no antibiotic groups. An alpha value of 0.05 was used for our analysis. Study heterogeneity was assessed by Cochrane's Q test as well as calculation of the I^2 value.RESULTS A total of 49682 patients who underwent knee ar-throscopy for a diverse set of procedures across 19 studies met inclusion critera for pooled analysis. For those not undergoing graft procedures,there were 27 cases of post-operative septic arthritis in 34487 patients(0.08%) who received prophylactic antibiotics and 16 cases in 10911(0.15%) who received none [risk ratio(RR) = 0.53,95% confidence interval(CI): 0.29-0.99,P = 0.05]. A sub-group analysis in which bony procedures were excluded was performed which found no significant difference in infection rates between patients that received prophylactic antibiotics and patients that did not(P > 0.05). All anterior cruciate ligament reconstruction studies used prophylactic antibiotics,but two studies investigating the effect of soaking the graft in vancomycin in addition to standard intravenous(IV) prophylaxis were combined for analysis. There were 19 cases in 1095 patients(1.74%) who received IV antibioitics alone and no infections in 2034 patients who received IV antibiotics and had a vancomycin soaked graft(RR = 0.01,95%CI: 0.001-0.229,P < 0.01).CONCLUSION Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. In procedures involving graft implantation,graft soaking reduces the rate of infection. | John Carney Nathanael Heckmann Erik N Mayer Ram K Alluri Carleton Thomas Vangsness George F Hatch Ⅲ Alexander E Weber | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 3 | Feasibility and efficacy of routine PCR screening of blood donations for hepatitis virus and HIV-1 in a blood bank setting 显示文摘 | Roth WK Weber M Seifried E | 1999 | Lancet1999，353，9150： | 2 |
| 4 | 24h动态中心动脉收缩压和左心室质量的关系:一项前瞻性多中心研究显示文摘研究者在7个欧洲中心中调查左心室质量与肱动脉诊室血压以及肱动脉压和中心动脉动态收缩压之间的关系。使用校准的示波装置测量,经平均压/舒张压校准和转换函数计算中心动脉收缩压。由不知道血压值的单个操作者通过M型超声心动图测定左心室质量。研究者调查了未使用抗高血压药物的受试者289人(女性137人,平均年龄50.8岁)。 | 黄洁 叶鹏 Weber T Wassertheurer S Schmidt-Trucks?ss A Rodilla E Ablasser C Jankowski P Lorenza Muiesan M Giannattasio C Mang C Wilkinson I Kellermair J Hametner B Pascual JM Zweiker R Czarnecka D Paini A Salvetti M Maloberti A McEniery C | 2017 | 中华高血压杂志2017，25，11： | 2 |
| 5 | Correlation of mean velocity measurements downstream of a swept backward-facing step显示文摘 | Weber J Danberg E | 1992 | AIAA Journal1992，30，11： | 1 |
| 6 | Identification of molecular markers linked to Rdrl,a gene conferring resistance to blackspot in roses显示文摘 | Von Malek B Weber W E Debener T | 2000 | Theor Appl Genet2000，101，： | 1 |
| 7 | Inhibitors of protein tyrosine kinase suppress TNF-stimulated induction of endothelial cell adhesion molecules 显示文摘 | WEBER C NEGRESCU E ERL W | 1995 | The Journal of Immunology1995，155，1： | 1 |
| 8 | Improved acid neutralisation capacity assessment of iron carbonates by titration and theoretical calculation显示文摘 | Weber P A Thomas J E Skinner W M | 2004 | Applied Geochemistry2004，19，： | 1 |
| 9 | Enhanced plasmid maintenance in a CSRT upon square-wave oscillations in the dilution rate显示文摘 | Weber A E San K Y | 1988 | Biotechnology Letters1988，10，8： | 1 |
| 10 | ICAM - 1 gene expression by glial cells: differential mechanisms of inhibition by interleukin- 10 and interleukin - 6 显示文摘 | Shrikant P Weber E Jilling T | 1995 | J Immunol1995，155，： | 1 |
| 11 | Ocean Surface Currents Mapped by Radar显示文摘 | Barrick D E Evans M W Weber B L | 1977 | Science1977，198，： | 1 |
| 12 | Adaptive isletspecific regulatory CD4^+-T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo显示文摘 | WEBER S E HARBERTSON J GODEBU E | 2006 | J Immunol2006，176，8： | 1 |
| 13 | Peptides and polypeptides as modulators of the immune response:Thymopentin-An example with unknown mode of action 显示文摘 | Gonser S Weber E Folkers G | 1999 | Pharm Acta Helv1999，73，： | 1 |
| 14 | Zeigerwerte Von Pflanzen in Mitteleuropa显示文摘 | EUenberg H Weber H E Dull R | 1991 | Scripta Geobotanica1991，18，： | 1 |
| 15 | Effect of dietary distillers dried grains with solubles on indicators of oxidative stress and immune function in growing pigs显示文摘 | WEBER T E KERR B J | 2011 | Livestock Science2011，142，1： | 1 |
| 16 | Efficacy of stent angioplasty for symptomatic stenoses of the proximal vertebral artery显示文摘 | Weber W Mayer T E Henkes H | 2005 | Eur J Radiol2005，56，2： | 1 |
| 17 | Lung perfusion analysis with dual energy CT in patients with suspec- ted pulmonary embolism - influence of window set- tings on the diagnosis of underlying pathologies of perfusion defects 显示文摘 | Bauer RW Kerl JM Weber E | 2011 | Eur J Radiol2011，80，3： | 1 |
| 18 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 19 | Bevacizumab combined with chemotherapy for platinum- resistant recurrent ovarian cancer: The AURELIA open-label randomized phase Ill trial 显示文摘 | PUJADE-LAURAINE E HILPERT F WEBER B | 2014 | J Clin Oneol2014，32，13： | 1 |
| 20 | Epidemic cholera in Ecuador: Multi-drug resistance and transmission by water and seafood 显示文摘 | WEBER J T MINTZ E D CANIZARES R | 1994 | Epidemiology and infection1994，112，： | 1 |
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