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| 1 | Update in management of mesenteric ischemia显示文摘肠系膜局部缺血混乱被剥夺一或几个腹的机关遇见新陈代谢的要求足够的呼吸的一个发行量不足事件猛抛。尽管 mes 伤寒局部缺血不经常发生,死亡率从 60% ~ 100% ,依靠阻塞的消息提供者。成功的结果依赖于怀疑和迅速的管理的一个高索引。我们简短考察病理生理学和演讲各种各样是化学家实体并且在诊断和治疗考察当前的现状。尽管有在诊断和治疗的进展,迅速的诊断和支持的照顾为成功的结果仍然保持批评。新成像技术,血管内治疗和新兴的研究可以改进我们的途径到这个致命的条件。 | Robert W Chang John B Chang Walter E Longo | 2006 | World Journal of Gastroenterology2006，12，20： | 38 |
| 2 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 3 | Role of gastroesophageal reflux disease in lung transplantation显示文摘Lung transplantation is one of the highest risk solid organ transplant modalities. Recent studies have demonstrated a relationship between gastroesophageal reflux disease(GERD) and lung transplant outcomes, including acute and chronic rejection. The aim of this review is to discuss the pathophysiology, evaluation, and management of GERD in lung transplantation, as informed by the most recent publications in the field. The pathophysiology of reflux-induced lung injury includes the effects of aspiration and local immunomodulation in the development of pulmonary decline and histologic rejection, as reflective of allograft injury. Modalities of reflux and esophageal assessment, including ambulatory p H testing, impedance, and esophageal manometry, are discussed, as well as timing of these evaluations relative to transplantation. Finally, antireflux treatments are reviewed, including medical acid suppression and surgical fundoplication, as well as the safety, efficacy, and timing of such treatments relative to transplantation. Our review of the data supports an association between GERD and allograft injury, encouraging a strategy of early diagnosis and aggressive reflux management in lung transplant recipients to improve transplant outcomes. Further studies are needed to explore additional objective measures of reflux and aspiration, better compare medical and surgical antireflux treatment options, extend followup times to capture longer-term clinical outcomes, and investigate newer interventions including minimally invasive surgery and advanced endoscopic techniques. | Kelly E Hathorn Walter W Chan Wai-Kit Lo | 2017 | World Journal of Transplantation2017，7，2： | 8 |
| 4 | Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Karen L. Furie Scott E. Kasner Robert J. Adams Gregory W. Albers Ruth L. Bush Susan C. Fagan Jonathan L. Halperin S. Claiborne Johnston Irene Katzan Walter N. Kernan Pamela H. Mitchell Bruce Ovbiagele Yuko Y. Palesch Ralph L. Sacco Lee H. Schwamm Sylvia W | 2011 | Stroke2011，，1： | 8 |
| 5 | Transjugular intrahepatic portosystemic shunt in liver transplant recipients显示文摘AIM:To evaluate the efficacy of transjugular intrahepatic portosystemic shunts (TIPSs) after liver transplantation (LT). METHODS: Between November 1996 and December 2005, 10 patients with severe recurrent hepatitis C virus infection (n=4), ductopenic rejection (n=5) or portal vein thrombosis (n=1) were included in this analysis. Eleven TIPSs (one patient underwent two TIPS procedures) were placed for management of therapy-refractory ascites (n=7), hydrothorax (n=2) or bleeding from colonic varices (n=1). The median time interval between LT and TIPS placement was 15 (4-158) mo. RESULTS: TIPS placement was successful in all patients. The mean portosystemic pressure gradient was reduced from 12.5 to 8.7 mmHg. Complete and partial remission could be achieved in 43% and 29% of patients with ascites. Both patients with hydrothorax did not respond to TIPS. No recurrent bleeding was seen in the patient with colonic varices. Nine of 10 patients died during the study period. Only one of two patients, who underwent retransplantation after the TIPS procedure, survived. The median survival period after TIPS placement was 3.3 (range 0.4-20) mo. The majority of patients died from sepsis with multiorgan failure.CONCLUSION: Indications for TIPS and technical performance in LT patients correspond to those in non-transplanted patients. At least partial control of therapy-refractory ascites and variceal bleeding could be achieved in most patients. Nevertheless, survival rates were disappointing, most probably because of the advanced stages of liver disease at the time of TIPS placement and the high risk of sepsis as a consequence of immunosuppression. | Armin Finkenstedt Ivo W Graziadei Karin Nachbaur Werner Jaschke Walter Mark Raimund Margreiter Wolfgang Vogel | 2009 | World Journal of Gastroenterology2009，15，16： | 8 |
| 6 | Recent development of process simulation for industrial application显示文摘 | Walters J Wu W T Arvind A | 2000 | Journal of Materials Processing Technology2000，98，： | 2 |
| 7 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 8 | Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Karen L. Furie Scott E. Kasner Robert J. Adams Gregory W. Albers Ruth L. Bush Susan C. Fagan Jonathan L. Halperin S. Claiborne Johnston Irene Katzan Walter N. Kernan Pamela H. Mitchell Bruce Ovbiagele Yuko Y. Palesch Ralph L. Sacco Lee H. Schwamm Sylvia W | 2011 | Stroke2011，，1： | 2 |
| 9 | Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett’s oesophagus显示文摘 | Florine Kastelein Katharina Biermann Ewout W Steyerberg Joanne Verheij Marit Kalisvaart Leendert H J Looijenga Hans A Stoop Laurens Walter Ernst J Kuipers Manon C W Spaander Marco J Bruno | 2013 | Gut2013，，12： | 2 |
| 10 | Stripe wear and squeaking in ceramic total hip bearings显示文摘 | WALTER W L | 2006 | Semin Arthroplasty2006，17，3： | 1 |
| 11 | Genomic imprinting:parental influence on the ge-nome显示文摘 | Reik W Walter J | 2001 | Nat Rev Genet2001，2，1： | 1 |
| 12 | Relationship between instrumental and sensory parameters of cooked sweet potato texture显示文摘 | TRUONG V D WALTER W M HAMANN D D | | 0，，02： | 1 |
| 13 | Crea- tive performance under pressure an integrative concep- tual framework显示文摘 | Gutnick D Walter F De Dreu C K W | 2012 | Organizational Psychology Review2012，2，3： | 1 |
| 14 | Structure, properties, and phase transitions of melt-spun poly(vinylidene fluoride) fibers显示文摘 | Steinmann W Walter S Seide G Gries T Roth G Schubnell M | 2011 | Journal of Applied Polymer Science2011，120，1： | 1 |
| 15 | Delphi research:issues raised by a pilot study显示文摘 | Clibbens N Walters S Baird W | 2012 | Nurse Researcher2012，19，2： | 1 |
| 16 | A simplified insitu hybrization protcol using non-radioactivity labeled probes to detect abundant and rare mRNA on tissue section 显示文摘 | Oliver B Walter W | 1998 | Biochemical1998，20，1： | 1 |
| 17 | Hazardous Waste Site Remediation in the United States:Information Sources and Selection Trends for Innovative Technologies显示文摘 | Kovalick Walter W Kingscott | 1993 | Industry and Environment1993，16，3： | 1 |
| 18 | A Review of Impendance Plot Methods Used for Corrosion Performance Analysis of Painted Metals显示文摘 | WALTER G W | 1986 | Corrosion Science(S0010-938X)1986，26，9： | 1 |
| 19 | A clinical and polysomnographic comparison of neuroleptic-induced akathisia and the idiopathic restless legs syndrome显示文摘 | Walters AS Hening W Rubinstein M | 1991 | Sleep1991，14，4： | 1 |
| 20 | Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin-induced cytotoxicity显示文摘 | Walter R B Raden B W Kamikura D M | 2005 | Blood2005，105，3： | 1 |
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