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| 1 | 利用常间回文重复序列丛集介导的基因编辑评估Tet2和甲基转移酶3a在克隆性造血和心血管病中的作用显示文摘克隆性血细胞生成与死亡率、心血管病发生率增加有关。这种情况可能是由于造血干/祖细胞(hematopoietic stem/progenitor cells,HSPC)内的前白血病驱动基因的体细胞突变引起的。大约有40个候选驱动基因已被确定出来,但有研究证明在这些基因中,仅一个基因[10-11易位-2(TET2)]的突变在大鼠模型中可导致心血管病。 | Sano S Ohshima K Wang Y Katanasaka Y Sano M Walsh K 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，7： | 11 |
| 2 | Continuous wound infusion of local anaesthetic agents following colorectal surgery:Systematic review and meta-analysis显示文摘AIM:To provide a specifi c review and meta-analysis of the available evidence for continuous wound infusion of local anaesthetic agents following midline laparoto-my for major colorectal surgery. METHODS: Medline, Embase, trial registries, conference proceedings and article reference lists were searched to identify randomised, controlled trials of continuous wound infusion of local anaesthetic agents following colorectal surgery. The primary outcomes were opioid consumption, pain visual analogue scores (VASs), return to bowel function and length of hospital stay. Weighted mean difference were calculated for continuous outcomes. RESULTS: Five trials containing 542 laparotomy wounds were eligible for inclusion. There was a sig- nificant decrease in post-operative pain VAS at rest on day 3 (weighted mean difference: -0.43; 95% CI: -0.81 to -0.04; P = 0.03) but not on post-operative day 1 and 2. Local anaesthetic infusion was associated with a signifi cant reduction in pain VAS on movement on all three post-operative days (day 1 weighted mean difference: -1.14; 95% CI: -2.24 to -0.041; P = 0.04, day 2 weighted mean difference: -0.97, 95% CI: -1.91to -0.029; P = 0.04, day 3 weighted mean difference: -0.61; 95% CI: 1.01 to -0.20; P = 0.0038). Local an- aesthetic wound infusion was associated with a signifi - cant decrease in total opioid consumption (weighted mean difference: -40.13; 95% CI: -76.74 to -3.53; P = 0.03). There was no signifi cant decrease in length of stay (weighted mean difference: -20.87; 95% CI: -46.96 to 5.21; P = 0.12) or return of bowel function (weighted mean difference: -9.40; 95% CI: -33.98 to 15.17; P = 0.45). CONCLUSION: The results of this systematic re- view and meta-analysis suggest that local anaesthetic wound infusion following laparotomy for major color- ectal surgery is a promising technique but do not pro- vide conclusive evidence of benefi t. Further research is required including cost-effectiveness analysis. | Alan Karthikesalingam Stewart R Walsh Sheraz R Markar Umar Sadat Tjun Y Tang Charles M Malata | 2008 | World Journal of Gastroenterology2008，14，34： | 4 |
| 3 | Expression of MUC1 and MUC2 mucins in epithelial ovarian tumours显示文摘 | Dong Y Walsh MD Cummings MC | 1997 | J Pathol1997，183，3： | 2 |
| 4 | Micro-computed tomography evaluation of trabeular bone structure on loaded mice tail vertebrae显示文摘 | Walsh A Lu Y el at | 2003 | Spine2003，28，2： | 1 |
| 5 | Controlled release of platelet-derived growth factor using ethylene vinyl acetate copolymer(EVAc)coated on stainless-steel wires显示文摘 | Walsh W R Kim H D Jong Y S | 1995 | Biomaterials1995，16，17： | 1 |
| 6 | Ortho-phthalaldehyde:possible alternative to glutaralde-hyde for high level disinfection显示文摘 | Walsh S E Maillard J Y Ressell A D | 1999 | Appl Microbiol1999，86，： | 1 |
| 7 | In vivo degradation of three-dimensional silk fibroin scaffolds显示文摘 | Wang Y Rudym DD Walsh A | | 0，，24： | 1 |
| 8 | Response of a calcium sulfate bone graft substitute in a confined cancellous defect显示文摘 | WALSH W R MORBERG P YU Y | 2003 | Clin Orthop2003，，406： | 1 |
| 9 | TNF alpha concentrations and mRNA expressionare increased in preeclamptic placentas 显示文摘 | Wang Y Walsh SW | 1996 | J Reprod Immunol1996，32，： | 1 |
| 10 | Academic entrepre- neurship and exchange of scientific resources: Materi- al transfer in life and materials sciences in Japanese universities显示文摘 | Shibayama S Walsh J P Baba Y | 2012 | American Sociological Review2012，，7： | 1 |
| 11 | IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1 and IL-6 production through a caspase 1-dependent mechanism显示文摘 | Netea M G Azam T Ferwerda G Girardin S E Walsh M Park J S Abraham E Kim J M Yoon D Y Dinarello C A and Kim S H | | 0，，： | 1 |
| 12 | Coexisting ovarian malignancy in young women with endometrial cancer显示文摘 | Walsh C Holschneider C Hoang Y | 2005 | Obstetrics and Gynecology2005，106，4： | 1 |
| 13 | Wurtzite--derived polytypes of kesterite and stannite quaternary chalcogenide semi- conductors 显示文摘 | CHEN S WALSH A LUO Y | 2010 | Physical Review B2010，82，19： | 1 |
| 14 | Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies 显示文摘 | Du Y Walsh A Ehrick R | 2012 | MAbs2012，4，5： | 1 |
| 15 | Osteoimmunology: interplay between the immune system and bone metabolism显示文摘 | Walsh MC Kim N Kadono Y | 2006 | Annu Rev Immunol2006，24，： | 1 |
| 16 | Stability analysis ot' networked control systems 显示文摘 | WALSH G C HONG Y BUSHNELL L G | 2002 | IEEE Transactions on Con- trol Systems Technology2002，0，3： | 1 |
| 17 | Scheduling of networked control systems显示文摘 | Walsh G C Hong Y | 2001 | IEEE Control Systems Magazine2001，21，1： | 1 |
| 18 | Comparative study of coaxial phacoemulsification and microincision cataract surgery:one-year follow-up显示文摘 | Crema AS Walsh A Yamane Y | 2007 | J Cataract Refract Surg2007，33，6： | 1 |
| 19 | High-temperature metal coating for modification of photonic band edge position 显示文摘 | WALSH T A BUR J A KIM Y S | 2009 | J Opt Soc Am: B2009，26，7： | 1 |
| 20 | The many faces of filamin: a versatile molecu-lar scaffold for cell motility and signalling显示文摘 | Feng Y Walsh CA | 2004 | Nat Cell Biol2004，6，11： | 1 |
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