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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Application of games with incomplete information for pricing electricity in deregulated power pools显示文摘 | Fenrero R W Rivera J F | 1998 | IEEE Trans on Power Systems1998，13，1： | 2 |
| 3 | Application of games with incomplete information for pricing electricity in deregulated power pools显示文摘 | Ferrero R W Rivera J F Shahidehpour S M | 1998 | IEEE Trans on Power Systems1998，13，1： | 2 |
| 4 | Thermodynamic analysis of monomethylamine-water solutions in a single-stage solar absorption refrigeration cycle at low generator temperatures 显示文摘 | Pilatowsky I Rivera W Romero R J | 2001 | Solar Energy Mater Solar Cells2001，70，： | 1 |
| 5 | Novel function of complement C3d as an autologous helper T-cell target显示文摘 | Knopf PM Rivera DS Hai SH McMurry J Martin W De Groot AS | | 0，，03： | 1 |
| 6 | Performance evaluation of a monomethylamine/water solar absorption refrigeration system for milk cooling purposes 显示文摘 | Pilatowsky I Rivera W Romero RJ | 2004 | Applied Thermal Engineering2004，24，： | 1 |
| 7 | Short term wind speed forecasting in La Venta, Oaxaca, México, using artificial neural networks显示文摘 | Cadenas E Rivera W | 2009 | Renewable Energy2009，34，34： | 1 |
| 8 | DOTS-Plus for Multidrug-Resistant Tuberculosis in the Philippines: Global Assistance Urgently Needed显示文摘 | Tupasi TE Quelapio MI Orillaza RB Alcantara C Mira NR Abeleda MR Belen VT Arnisto NM Rivera AB Grimaldo ER Derilo JO Dimarucut W Arabit M Urboda D | 2003 | Tuberculosis (Edinb)2003，83，13： | 1 |
| 9 | A combined optimization of alloy composition and aging temperature in designing new UHS precipitation hardenable stainless steels显示文摘 | Xu W Rivera Diaz del Castillo P E J van der Zwaag S | 2009 | Computational Materials Science2009，45，2： | 1 |
| 10 | AmeriCan college of chest physicians,guidelines on treatment of stage Ⅲ B non-small cell Lung cancer显示文摘 | JETT J R SCOOT W J RIVERA M P | 2003 | Chest2003，123，1： | 1 |
| 11 | Heat transfer coefficients in two phase flow for the water/lithium bromide mixture used in solar absorption refrigeration systems显示文摘 | Rivera W Xicale A | 2001 | Solar Energy Materials & Solar Cells2001，70，3： | 1 |
| 12 | A Model Predictive Control framework for robust management of multi-product, multi-echelon demand networks显示文摘 | M W Braun D E Rivera M E Flores | 2003 | Annual Reviews in Control2003，，27： | 1 |
| 13 | Designing nanoprecipitation strengthened UHS stainless steels combining genetic algorithms and thermodynamics 显示文摘 | Xu W Rivera Diaz del Castillo P E J van der Zwaag S | 2008 | Computational Materials Science2008，44，2： | 1 |
| 14 | Ferrate(Ⅵ) oxidation of aqueous cyanide显示文摘 | Sharma V K Rivera W Smith J O | 1998 | Environ Sci Technol1998，32，： | 1 |
| 15 | Rapid detection of Clostridmatrices, and buffer using paramagnetic bead-based elecltrochemiluminescence detection 显示文摘 | RIVERA V R GAMEZ F J KEENER W K | 2006 | Anal Biochem2006，353，2： | 1 |
| 16 | Brain tissue microarrays in neurodegenerative diseases: validation of methodology and immunohistochemical study of growth- associated protein-43 and calretinin显示文摘 | Takei H Buckleair L W Rivera A | 2007 | Pathol2007，57，12： | 1 |
| 17 | A dynamic programming two-stage algorithm for long-term hydrothermal scheduling of multireservoir systems显示文摘 | Ferrero R W Rivera J F Shahidehpour S M | 1998 | IEEE Transactions on Power Systems1998，13，4： | 1 |
| 18 | A model predictive control framework for robust management of multi-product, multi-echelon demand networks 显示文摘 | Braun M W Rivera D E Flores M E Carlyle W M Kempf K G | 2003 | Annual Reviews in Control2003，27，2： | 1 |
| 19 | Single stage and double absorption heat transformers used to recover energy in a distillation column of butane and pentane显示文摘 | RIVERA W CEREZO J RIVERO R | 2003 | Int J Energy Res2003，27，14： | 1 |
| 20 | A model predictive control frame- work for robust management of multi-product, multi-echelon demand networks 显示文摘 | Braun M W Rivera D E | 2003 | Annual Reviews in Control2003，27，： | 1 |
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