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| 1 | Safety and efficacy of ledipasvir/sofosbuvir on hepatitis C eradication in hepatitis C virus/human immunodeficiency virus co-infected patients显示文摘AIM To evaluate the safety and efficacy of ledipasvir/sofosbuvir on hepatitis C eradication in patients with hepatitis C virus(HCV)/human immunodeficiency virus(HIV) co-infection in an urban HIV clinic.METHODS A retrospective cohort study of 40 subjects co-infected with HIV-1 and HCV treated with the fixed-dose combination of ledipasvir and sofosbuvir for 12 wk from 2014 to 2016.All patients included were receiving antiretroviral therapy(ART) with HIV RNA values of 100 copies/m L or fewer regardless of baseline HCV RNA level.The primary end point was a sustained virologic response of HCV at 12 wk(SVR12) after the end of therapy.RESULTS Of the 40 patients enrolled,55% were black,22.5% had been previously treated for HCV,and 25% hadcirrhosis.The patients were on a wide range of ART.Overall,39 patients(97.5%) had a SVR 12 after the end of therapy,including rates of 97.1% in patients with HCV genotype 1 a and 100% in those with HCV genotype 1 b.One patient with HCV genotype 3 a was included and achieved SVR12.Rates of SVR12 were similar regardless of previous treatment or the presence of compensated cirrhosis.Only 1 patient experienced relapse at week 12 following treatment and deep sequencing didn't reveal any resistance associated mutation in the NS5A or NS5B region.Interestingly,7(17.5%) patients who were adherent to ART experienced HIV viral breakthrough which resolved after continuing the same ART regimen.Two(5%) patients experienced HIV-1 virologic rebound due to noncompliance with HIV therapy,which resolved after resuming the same ART regimen.No severe adverse events were observed and no patient discontinued treatment because of adverse events.The most common adverse events included headache(12.5%),fatigue(10%),and diarrhea(2.5%).CONCLUSION This retrospective study demonstrated the high rates of SVR12 of ledipasvir/sofosbuvir on HCV eradication in patients co-infected with HCV and HIV,regardless of HCV baseline levels,HCV treatment history or cirrhosis condition.The oral combination of ledipasvir/sofosbuvir represents a safe and well tolerated HCV treatment option that does not require modification for many of the common HIV ART.Occasional HIV virologic rebound occurred but later resolved without the need to change ART. | Xiaoping He Lynne Hopkins George Everett Willie M Carter Cynthia SchroppDyce Khalid Abusaada Vincent Hsu | 2017 | World Journal of Hepatology2017，9，30： | 2 |
| 2 | Inhibition of fattyacid and cholesterol synthesis by stimulation of AMP-activatedprotein kinase 显示文摘 | Henin N Vincent MF Gruber HE | 1995 | FASEB J1995，9，： | 1 |
| 3 | Antiviral amento- avone from Selaginella sinensis显示文摘 | MA S C HE Y H VINCENT E O | 2001 | Biol Pharm Bull2001，24，3： | 1 |
| 4 | Pulmonary embolism following laparoscopic cholecystectomy:report of two cases and review of the literature显示文摘 | Mayol J Vincent HE Samiento JM | 1994 | Surg Endosc1994，8，： | 1 |
| 5 | Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase 显示文摘 | Henin N Vincent MF Gruber HE | 1995 | FASEB J1995，9，： | 1 |
| 6 | Targeting autophagy as a therapeutic strategy for identification of liganans from Peristrophe japonica in Parkinson’s disease显示文摘Dear Editor,PD is characterized by the loss of dopaminergic neurons in substantia nigra,and the loss of dopamine resulting in motor deficit.1 Its main pathological hallmarks include the genetic mutations of gene such as a-synudein.2 Increasing study showed that the dopaminergic neurons in midbrain are sensitive and damaged by the PD toxins. | An-Guo Wu Rong Pan Betty Yuen-Kwan Law Wen-Qiao Qiu Jian-Ming Wu Chang-Long He Vincent Kam-Wai Wong Chong-Lin Yu Xiao-Gang Zhou Da-Lian Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 7 | Breakdown of functional connec-tivity in frontoparietal networks underlies behavioral deficits in spatialneglect显示文摘 | He BJ Snyder AZ Vincent J | 2007 | Neuron2007，53，6： | 1 |
| 8 | Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase显示文摘 | Henin N Vincent MF Gruber HE | 1995 | FASEB J1995，9，7： | 1 |
| 9 | Breakdown of functional con- nectivity in frontoparietal networks underlies behavioral deficits in spatial neglect显示文摘 | He BJ Snyder AZ Vincent JL | 2007 | Neuron2007，53，6： | 1 |
| 10 | Pulmonary embolism following lsparacopic cholecysteetony;report of two cases and review of the literature显示文摘 | Vincent HE Sarmiento JM | 1994 | Sung Endose1994，8，2： | 1 |
| 11 | Breakdown of function- al connectivity in frnntoparietal networks underlies behavioral deficits in spatial neglect显示文摘 | He B J Snyder AZ Vincent JL | 2007 | Neuron2007，53，6： | 1 |
| 12 | Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP - activated protein kinase显示文摘 | Henin N Vincent MF Gnrber HE | 1995 | FASEB J1995，9，7： | 1 |
| 13 | Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase显示文摘 | Henin N Vincent MF Gruber HE | 1995 | FASEB J1995，9，7： | 1 |
| 14 | Breakdown of functional connectivity in frontoparietal networks underlies behavioral deficits in spatial neglect 显示文摘 | He B J Snyder AZ Vincent JL | 2007 | Neuron2007，53，6： | 1 |
| 15 | Breakdown of functional connectivity in frontoparietal networks underlies behavioral deficits in spatial neglect显示文摘 | He B J Snyder AZ Vincent JL | 2007 | Neuron2007，53，6： | 1 |
| 16 | The transcription factor FLC confers a flowering response to vernalization by repressing meristem competence and systemic signaling in Arabidopsis显示文摘 | Searle I He Y Turck F Vincent C | 2006 | Genes Dev2006，20，： | 1 |
| 17 | Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase显示文摘 | Henin N Vincent MF Gruber HE | 1995 | FASEB J1995，9，： | 1 |
| 18 | Breakdown of functional con- nectivity in frentoparietal networks underlies behavioral deficits in spatial neglect 显示文摘 | He B J Snyder AZ Vincent JL | 2007 | Neuron2007，53，6： | 1 |
| 19 | Pulmonary embolism following laparoscopic cholecystectomy:report of two cases and review of the literature显示文摘 | Mayol J Vincent HE Sarmiento JM | 1994 | Surg Endosc1994，8，： | 1 |
| 20 | Automatic Plankton Image Recognition显示文摘 | Xiaoou Tang W. Kenneth Stewart He Huang Scott M. Gallager Cabell S. Davis Luc Vincent Marty Marra | 1998 | Artificial Intelligence Review (-)1998，，1： | 1 |
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