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| 1 | The emergence of pandemic influenza viruses显示文摘Pandemic influenza has posed an increasing threat to public health worldwide in the last decade.In the 20th century,three human pandemic influenza outbreaks occurred in 1918,1957 and 1968,causing significant mortality.A number of hypotheses have been proposed for the emergence and development of pandemic viruses,including direct introduction into humans from an avian origin and reassortment between avian and previously circulating human viruses,either directly in humans or via an intermediate mammalian host.However,the evolutionary history of the pandemic viruses has been controversial,largely due to the lack of background genetic information and rigorous phylogenetic analyses.The pandemic that emerged in early April 2009 in North America provides a unique opportunity to investigate its emergence and development both in human and animal aspects.Recent genetic analyses of data accumulated through long-term influenza surveillance provided insights into the emergence of this novel pandemic virus.In this review,we summarise the recent literature that describes the evolutionary pathway of the pandemic viruses.We also discuss the implications of these findings on the early detection and control of future pandemics. | Yi Guan Dhanasekaran Vijaykrishna Justin Bahl Huachen Zhu Jia Wang Gavin J.D.Smith | 2010 | Protein & Cell2010，1，1： | 16 |
| 2 | 2010, Reassort- ment of pandemic H1N1/2009 influenza A virus in swine 显示文摘 | Vijaykrishna D Poon L L Zhu H C Ma S K Li 0 T Che- unq C L Smith G J Peiris J S Guan Y | 2010 | Science2010，328，5985： | 1 |
| 3 | Origins and evolutionary genomLcs ofthe 2009 swine-origin H1N1 influenza Aepidemic显示文摘 | Smith G J D Vijaykrishna D Bahl J | 2009 | Nature2009，459，7250： | 1 |
| 4 | Origins and evolutionary genomics of the 2009 swineorigin H1N1 influenza A epidemic 显示文摘 | SMITH G J D VIJAYKRISHNA J BAHL | 2009 | Nature2009，459，： | 1 |
| 5 | Reassortment of pandemic H1 N1/2009 influenza A virus in swine 显示文摘 | Vijaykrishna D Poon L Zhu HC | 2010 | Sci- ence2010，328，5985： | 1 |
| 6 | Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic显示文摘 | Smith G J Vijaykrishna D Baht J | 2009 | Nature2009，7250，459： | 1 |
| 7 | Dating the emergence of pandemic influenza viruses显示文摘 | Smith G J Bahl J Vijaykrishna D | 2009 | Proc Natl Acad Sci U SA2009，106，11： | 1 |
| 8 | Origins and evolutionary genomies of the 2009 swine-origin H1N1 influenza A epidemic 显示文摘 | Smith GJD Vijaykrishna D Bahl J | 2009 | Nature2009，459，7250： | 1 |
| 9 | Origins and evolutionary genomics of the 2009 swine origin H1N1 influenza A epidemic显示文摘 | SMITH G J VIJAYKRISHNA D BAHL J | 2009 | Nature2009，459，7250： | 1 |
| 10 | Ofigins and evolutionary genomies of the 2009 swine-origin H1N1 influenza A epidemic 显示文摘 | Smith GJ Vijaykrishna D Bahl J | 2009 | Nature2009，459，7250： | 1 |
| 11 | Origins and evo-lutionary genomics of the 2009swine-origin H1N1influenzaA epidemic显示文摘 | Smith GJ Vijaykrishna D Bahl J | 2009 | Nature2009，459，7250： | 1 |
| 12 | Origins and evolutionary genomics of the 2009 swine - origin H1N1 influenza A epidemic显示文摘 | Smith GJ Vijaykrishna D Bahl J | 2009 | Nature2009，459，7250： | 1 |
| 13 | Origins and evolutionary genomics of the 2009 swine-origin H 1N 1 influenza A epidemic显示文摘 | Smith GJD Vijaykrishna D Bahl J | 2009 | Nature2009，459，7250： | 1 |
| 14 | Origins and evolutionary ge- nomics of the 2009 swine-origin H1N1 influenza A epidemic 显示文摘 | Smith GJ Vijaykrishna D Bahl J | 2009 | Na- ture2009，459，7250： | 1 |
| 15 | Establishment of influenza a virus (H6N1) in minor poultry species in southern China 显示文摘 | Cheung C L Vijaykrishna D Smith G J D | 2007 | J Virol2007，81，10： | 1 |
| 16 | Characteriza- tion of avian infl uenza viruses A ( I-I5N1 ) from wildbirds, Hong Kong, 2004 - 2008 显示文摘 | SMITH G J VIJAYKRISHNA D ELLIS T M | 2009 | Emerg Infect Dis2009，15，3： | 1 |
| 17 | Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic显示文摘 | Smith GJ Vijaykrishna D Bahl J Lycett SJ Worobey M Pybus OG Ma SK Cheung CL Raghwani J Bhatt S Peiris JS Guan Y Rambaut A | 2009 | Nature2009，459，7250： | 1 |
| 18 | Establishment of influenza A virus (H6N1) in minor poultry species in southern China 显示文摘 | Cheung C L Vijaykrishna D Smith G J | 2007 | J Virol2007，81，10： | 1 |
| 19 | Establishment of influenza A virus (H6N1) in minor poultry species in southern China 显示文摘 | Cheung C L Vijaykrishna D Smith G J | 2007 | J Virol2007，81，10： | 1 |
| 20 | Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic 显示文摘 | Smith GJ Vijaykrishna D Bahl J | 2009 | Nature2009，459，7250： | 1 |
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