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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 3 | An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair显示文摘The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral repair.Both the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand rabbits.Thus,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the defects.Although both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline cartilage.In conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis. | Filippo Cipriani Blanca Arino Palao Israel Gonzalez de Torre Aurelio Vega Castrillo Hector Jose Aguado Hernandez Matilde Alonso Rodrigo Angel Jose Alvarez Barcia Ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena Jose Carlos Rodriguez-Cabello | 2019 | Regenerative Biomaterials2019，6，6： | 3 |
| 4 | Photocatalytic oxidation of organics in water using pure and silver-modifiedtitanium dioxide particles 显示文摘 | Veronica V Rose A Donia B | 2002 | Journal of Photochemistry and Photobiology A: Chemistry2002，148，： | 1 |
| 5 | Excitotoxic damage,disrupted energy metabolism,and oxidative stress in the rat brain:antioxidant and neuroprotective effects of L-carnitine显示文摘 | DANIELA S A VERONICA P D C MARA N H M | 2008 | Jonrnal of Neurochemistry2008，105，： | 1 |
| 6 | Preparation of porous chelating resin containing linear polymer ligand and the adsorption characteristics for harmful metal ions显示文摘 | Margot A Llosa Tanco David A Pacheco Tanaka Veronica C Flores | | 0，，： | 1 |
| 7 | The effect of dietary docosahexaenoic acid (DHA)on growth,survival and pigmentation of California halibut Paralichthys californicus larvae ( Ayres, 1810 ) 显示文摘 | Veronica V O Juan P L a Benjamin B S | 2010 | Aquaculture2010，302，： | 1 |
| 8 | High frequency hearing loss correlated with mutations in the GJB2 gene显示文摘 | Stephen A Wilcox Kerryn Saunders Amelia H Osborn Angela Arnold Julia Wunderlich Therese Kelly Veronica Collins Leah J Wilcox RJ McKinlay Gardner Maria Kamarinos Barbara Cone-Wesson Robert Williamson Hans-Henrik M. Dahl | 2000 | Human Genetics2000，，4： | 1 |
| 9 | Degradation of chlorophenols by means of advanced oxidation processes: a general review 显示文摘 | Marc P T Veronica G M Miguel A B | 2004 | Applied Catalysis B: Environmental2004，47，： | 1 |
| 10 | High doses of gonadotrophins combined with stop versus non-stop protocol of GnRH analogue administration in low-responder IVF patieuts:a prospective, randomized, controlled trial 显示文摘 | Juan A Veronica I Antonio R | 2000 | Hum Reprod2000，15，11： | 1 |
| 11 | Struc-tural evolution of the Neogene Gar Basin,western Tibet:Implications for releasing bend development and drainagepattems显示文摘 | Veronica I S Michael A M William R D | 2010 | GSA Bulletin2010，122，56： | 1 |
| 12 | The effect of mode of exercise on fat oxidation during exercise显示文摘 | STEPHEN C G VERONICA J S DEVONNA A | 1999 | J Strength Condition Res1999，13，1： | 1 |
| 13 | On the use of portfolio risk models and capital requirements in emerging markets:the case of Argentina显示文摘 | VERONICA B FALKENHEIM M POWELL A | 2002 | The World Bank Economic Review2002，，16： | 1 |
| 14 | The impact of a 100% smoke- free law on the health of hospitality workers from the city of Neuquen, Argentina显示文摘 | Veronica S Mariela A Ernesto R | 2010 | Tob Control2010，19，： | 1 |
| 15 | Inactivation of HIV in blood显示文摘 | ASA O VERONICA G SAIKA A | 2002 | Transfusion2002，42，10： | 1 |
| 16 | Degradation of chlorophenols by means of advanced oxidation processes: a general review 显示文摘 | Marc P T Veronica G M Miguel A B | 2004 | Applied Catalysis B : Environmental2004，47，4： | 1 |
| 17 | Chemoenzymatic preparation of enantiopure l -benzofuranyl- and l -benzo[ b ]thiophenyl alanines显示文摘 | Paula Veronica Podea Monica Ioana To?a Csaba Paizs Florin Dan Irimie | 2008 | Tetrahedron: Asymmetry2008，，4： | 1 |
| 18 | Photosynthesis during winter in ryegrass/white clover mixtures in the field显示文摘 | Jane Woledge I A Davidson Veronica Tewson | 1989 | New Phytol1989，113，： | 1 |
| 19 | Effects of Fe^3+ and Ag^+ Ions on the Photocatalytic Degradation of Sucrose in Water显示文摘 | Veronica V Helen T Rose A | 2001 | Catalysis Today2001，68，： | 1 |
| 20 | Olfactory responses of A naphes iole ( Hymenoptera : Mymaridae)to volatile signals derived from host habitats显示文摘 | Veronica M Walker A J Livy H W | 2005 | Journal of Insect Behavior2005，18，1： | 1 |
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