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| 1 | Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatory drugs through a reduction of mucosal oxidative damage显示文摘AIM: This study investigated the mechanisms of protection afforded by the proton pump inhibitor lansoprazole against gastric injury induced by different non-steroidal antiinflammatory drugs (NSAIDs) in rats.METHODS: Male Sprague-Dawley rats were orally treated with indomethacin (100 μmol/kg), diclofenac (60 μmol/kg),piroxicam (150 μmol/kg) or ketoprofen (150 μmol/kg).Thirty minutes before NSAIDs, animals were orally treated with lansoprazole 18 or 90 μmol/kg. Four hours after the end of treatments, the following parameters were assessed: gastric mucosal PGE2, malondialdehyde (MDA), myeloperoxidase (MPO) or non-proteic sulfhydryl compounds (GSH) levels; reverse transcription-polymerase chain reaction (RT-PCR) of mucosal COX-2 mRNA; gastric acid secretion in pylorus-ligated animals; in vitro effects of lansoprazole (1-300 μmol/L) on the oxidation of low density lipoproteins (LDLs) induced by copper sulphate.RESULTS: All NSAIDs elicited mucosal necrotic lesions which were associated with neutrophil infiltration and reduction of PGE2 levels. Increments of MPO and MDA contents, as well as a decrease in GSH levels were detected in the gastric mucosa of indomethacin- or piroxicam-treated animals. Indomethacin enhanced mucosal cyclooxygenase-2 expression, while not affecting cyclooxygenase-1. At the oral dose of 18 μmol/kg lansoprazole partly counteracted diclofenac-induced mucosal damage, whereas at 90 μmol/kg it markedly prevented injuries evoked by all test NSAIDs. Lansoprazole at 90 μmol/kg reversed also the effects of NSAIDs on MPO, MDA and GSH mucosal contents, without interfering with the decrease in PGE2 levels or indomethacin-induced cyclooxygenase-2 expression. However, both lansoprazole doses markedly inhibited acid secretion in pylorus-ligated rats. Lansoprazole concentration-dependently reduced the oxidation of LDLs in vitro.CONCLUSION: These results suggest that, besides the inhibition of acid secretion, lansoprazole protection against NSAID-induced gastric damage depends on a reduction in mucosal oxidative injury, which is also responsible for an increment of sulfhydryl radical bioavailability. It is also suggested that lansoprazole does not influence the downregulation of gastric prostaglandin production associated with NSAID treatment. | Corrado Blandizzi Matteo Fornai Rocchina Colucci Gianfranco Natale Valter Lubrano Cristina Vassalle Luca Antonioli Gloria Lazzeri Mario Del Tacca | 2005 | World Journal of Gastroenterology2005，11，26： | 9 |
| 2 | Oxidative status and cardiovascular risk in women:Keeping pink at heart显示文摘Although cardiovascular disease(CVD) has always been perceived as a pathology regarding essentially males,incidence and death from cardiovascular events dramatically increase after menopause in women.Obviously,while many aspects of CVD are similar in both sexes,it is now clear that there are significant differences as well.Exploration of these gender-related differences in CVD might provide a basis for the development of new strategies in the management of patients with CVD from a gender point of view.In particular,a growing amount of data suggested the possible major role of oxidative stress in female patients and the possibility to integrate this new biomarker in future study evaluating CVD risk in women. | Cristina Vassalle Antonella Mercuri Silvia Maffei | 2009 | World Journal of Cardiology2009，1，1： | 3 |
| 3 | Alkaline solid polymer electrolytes: application to secondary air-metal hydride batteries 显示文摘 | VASSAL N SALMON E FAUVARQUE J F | 1997 | Proc Electrochem Soc1997，97，18： | 2 |
| 4 | The pathogenic role of the coagulation process in rabbit Masugi nephritis显示文摘 | Vassalli P | 1964 | Am J path1964，45，： | 2 |
| 5 | Calcium overload and cardiac function显示文摘 | Vassalle M Lin CI | 2004 | Biomed Sci2004，11，5： | 1 |
| 6 | Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells 显示文摘 | Mandriota S J Seghezzi G Vassalli JD Ferrara N Wasi S Mazz- ieri R | 1995 | J Biol Chem1995，270，17： | 1 |
| 7 | Endotoxemia and bac- teremia in patients with sepsis syndrome in the intensive care unit显示文摘 | Guidet B Barakett V Vassal T | 1994 | Chest1994，106，4： | 1 |
| 8 | Hydrogen peroxidegas plasma sterilization is effective against Cryptosporidium parvumoocysts显示文摘 | VASSAL S FAVENNEC L BALLET J J | 1998 | Am J Infect Control1998，26，2： | 1 |
| 9 | Solitary fibrous tumors of the central nervous system:report of five cases with unusual clinicopathological and outcome patterns显示文摘 | Vassal F Manet R Forest F | 2011 | Acta Neurochir (Wien)2011，153，2： | 1 |
| 10 | Tumor necrosisfactor/cachectin plays a key role in bleomycin-inducedpneumopathy and fibrosis显示文摘 | Piguet PF Kapanci Y Vassalli P | 1989 | J Exp Med1989，170，3： | 1 |
| 11 | DNA repair gene polymorphisms predict favorable clinical outcme in advanced non-small cell lung cancer 显示文摘 | Kalikaki A Kanaki M Vassalou H | 2009 | Clin Lung Cancer2009，10，2： | 1 |
| 12 | Differentiation of benign from malignant superficial lymphadenopathy:the role of high-resolution US显示文摘 | Vassall P Wernecke K Roos N | 1992 | Radiology1992，183，： | 1 |
| 13 | Functional analysis of activins during mammalian development显示文摘 | Matzuk MM Kumar TR Vassalli A | 1995 | Nature1995，374，： | 1 |
| 14 | Gut intraepithelial lymphocyte development显示文摘 | Guy-Grand D Vassalli P | 2002 | Curr Opin Immunol2002，14，2： | 1 |
| 15 | Angiogenesis regulating cytokines:actions and interactions显示文摘 | Pepper MS Mandriota SJ Vassalli JD | 1996 | Curr Top Microbiol Immunol1996，213，： | 1 |
| 16 | The SYNTAX score predicts early mortality risk in the elderly with acute coronary syndrome having primary PCI显示文摘 | Scherff F Vassalli G Sürder D | 2011 | J Invasive Cardiol2011，23，12： | 1 |
| 17 | Normalization of left ventricular nonuniformity late after valve replacement for aortic stenosis显示文摘 | Bruno Villari Giuseppe Vassalli Sandro Betocchi Carlo Briguori Massimo Chiariello Otto M. Hess | 1996 | The American Journal of Cardiology1996，，： | 1 |
| 18 | DNA repair gene polymorphisms predict favorable clinical outcome in advanced non-small-cell lung cancer显示文摘 | Kalikaki A Kanaki M Vassalou H | 2009 | Clin lung cancer2009，10，2： | 1 |
| 19 | Can book-to-market, size and momentum be risk factors that predict economic growth显示文摘 | Maria Vassalou | 2000 | Journal of Financial Economics2000，，57： | 1 |
| 20 | Electrochemical properties of an alkaline solid polymer electrolyte based on P (ECH-co-EO)显示文摘 | Vassal N Salmon E Fauvarque J F | 2000 | Electrochimica Acta2000，45，： | 1 |
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