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| 1 | Factors determining delay in relaparotomy for anastomotic leakage after colorectal resection显示文摘AIM: To analyze the time interval ('delay') between the first occurrence of clinical parameters associated with anastomotic leakage after colorectal resection and subsequent relaparotomy. METHODS: In 36 out of 289 consecutive patients with colorectal anastomosis, leakage was confirmed at relaparotomy. The medical records of these patients were retrospectively analysed and type and time of appearance of clinical parameters suggestive of anastomotic leakage were recorded. These parameters included heart rate, body temperature, local or generalized peritoneal reaction, leucocytosis, ileus and delayed gastric emptying. Factors influencing delay of relaparotomy and consequences of delayed recognition and treatment were determined. RESULTS: First documentation of at least one of the predefined parameters for anastomotic leakage was after a median interval of 4 ± 1.7 d after the operation. The median number of days between first parameter(s) associated with leakage and relaparotomy was 3.5 ± 5.7 d. The time interval between the first signs of leakage and relaparotomy was significantly longer when a weekend was included (4.2 d vs 2.4 d, P = 0.021) or radiological evaluation proved to be false-negative (8.1 d vs 3.5 d, P = 0.007). No significant association between delay and number of additional relaparotomies, hospital stay or mortality could be demonstrated. CONCLUSION: An intervening weekend and negative diagnostic imaging reports may contribute to a delay in diagnosis and relaparotomy for anastomotic leakage. That delay was more than two days in two-thirds of the patients. | A Doeksen PJ Tanis BC Vrouenraets JJB Lanschot van WF Tets van | 2007 | World Journal of Gastroenterology2007，13，27： | 17 |
| 2 | Treatment of acute periprosthetic infections with prosthesis retention: Review of current concepts显示文摘Periprosthetic joint infection(PJI) is a devastating complication after total joint arthroplasty, occurring in approximately 1%-2% of all cases. With growing populations and increasing age, PJI will have a growing effect on health care costs. Many risk factors have been identified that increase the risk of developing PJI, including obesity, immune system deficiencies, malignancy, previous surgery of the same joint and longer operating time. Acute PJI occurs either postoperatively(4 wk to 3 mo after initial arthroplasty, depending on the classification system), or via hematogenous spreading after a period in which the prosthesis had functioned properly. Diagnosis and the choice of treatment are the cornerstones to success. Although different definitions for PJI have been used in the past, most are more or less similar and include the presence of a sinus tract, blood infection values, synovial white blood cell count, signs of infection on histopathological analysis and one ormore positive culture results. Debridement, antibiotics and implant retention(DAIR) is the primary treatment for acute PJI, and should be performed as soon as possible after the development of symptoms. Success rates differ, but most studies report success rates of around 60%-80%. Whether single or multiple debridement procedures are more successful remains unclear. The use of local antibiotics in addition to the administration of systemic antibiotic agents is also subject to debate, and its pro's and con's should be carefully considered. Systemic treatment, based on culture results, is of importance for all PJI treatments. Additionally, rifampin should be given in Staphylococcal PJIs, unless all foreign material is removed. The most important factors contributing to treatment failure are longer duration of symptoms, a longer time after initial arthroplasty, the need for more debridement procedures, the retention of exchangeable components, and PJI caused by Staphylococcus(aureus or coagulase negative). If DAIR treatment is unsuccessful, the following treatment option should be based on the patient health status and his or her expectations. For the best functional outcome, one- or two-stage revision should be performed after DAIR failure. In conclusion, DAIR is the obvious choice for treatment of acute PJI, with good success rates in selected patients. | Jesse WP Kuiper Robin Tjeenk Willink Dirk Jan F Moojen Michel PJ van den Bekerom Sascha Colen | 2014 | World Journal of Orthopedics2014，5，5： | 12 |
| 3 | Diagnosing syndesmotic instability in ankle fractures显示文摘The precise diagnosis of distal tibiofibular syndesmotic ligament injury is challenging and a distinction should be made between syndesmotic ligament disruption and real syndesmotic instability.This article summarizes the available evidence in the light of the author’s opinion.Pre-operative radiographic assessment,standard radiographs,computed tomography scanning and magnetic resonance imaging are of limited value in detecting syndesmotic instability in acute ankle fractures but can be helpful in planning.Intra-operative stress testing,in the sagittal,coronal or exorotation direction,is more reliable in the diagnosis of syndesmotic instability of rotational ankle fractures.The Hook or Cotton test is more reliable than the exorotation stress test.The lateral view is more reliable than the AP mortise view because of the larger displacement in this direction.When the Hook test is used the force should be applied in the sagittal direction.A force of 100 N applied to the fibula seems to be appropriate.In the case of an unstable joint requiring syndesmotic stabilisation,the tibiofibular clear space would exceed 5 mm on the lateral stress test.When the surgeon is able to perform an ankle arthroscopy this technique is useful to detect syndesmotic injury and can guide anatomic reduction of the syndesmosis.Many guidelines formulated in this article are based on biomechanical and cadaveric studies and clinical correlation has to be established. | Michel PJ van den Bekerom | 2011 | World Journal of Orthopedics2011，2，7： | 10 |
| 4 | Current concepts in the management of radial head fractures显示文摘Fracture of the radial head is a common injury. Over the last decades, the radial head is increasingly recognized as an important stabilizer of the elbow. In order to maintain stability of the injured elbow, goals of treatment of radial head fractures have become more and more towards restoring function and stability of the elbow. As treatment strategies have changed over the years, with an increasing amount of literature on this subject, the purpose of this article was to provide an overview of current concepts of the management of radial head fractures. | Iza?k F Kodde Laurens Kaas Mark Flipsen Michel PJ van den Bekerom Denise Eygendaal | 2015 | World Journal of Orthopedics2015，6，11： | 9 |
| 5 | Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity显示文摘AIM:To assess whether glutamate plays a similar role to glutamine in preserving gut wall integrity.METHODS:The effects of glutamine and glutamate on induced hyperpermeability in intestinal cell lines were studied.Paracellular hyperpermeability was induced in Caco2.BBE and HT-29CL.19A cell lines by adding phorbol-12,13-dibutyrate(PDB) apically,after which the effects of glutamine and glutamate on horseradish peroxidase(HRP) diffusion were studied.An inhibitor of glutamate transport(L-trans-pyrrolidine-2,4-dicarboxylic acid:trans-PDC) and an irreversible blocker(acivicin) of the extracellular glutamine to glutamate converting enzyme,γ-glutamyltransferase,were used.RESULTS:Apical to basolateral HRP flux increased significantly compared to controls not exposed to PDB (n=30,P<0.001).Glutamine application reduced hyperpermeability by 19%and 39%in the respective cell lines.Glutamate application reduced hyperpermeability by 30%and 20%,respectively.Incubation of HT29CL.19A cells with acivicin and subsequent PDB and glutamine addition increased permeability levels.Incubation of Caco2.BBE cells with trans-PDC followed by PDB and glutamate addition also resulted in high permeability levels.CONCLUSION:Apical glutamate-similar to glutaminecan decrease induced paracellular hyperpermeability.Extracellular conversion of glutamine to glutamate and subsequent uptake of glutamate could be a pivotal step in the mechanism underlying the protective effect of glutamine. | Mechteld AR Vermeulen Jeffrey de Jong Mathijs J Vaessen Paul AM van Leeuwen Alexander PJ Houdijk | 2011 | World Journal of Gastroenterology2011，17，12： | 9 |
| 6 | Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery. | Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen | 2008 | World Journal of Gastroenterology2008，14，45： | 4 |
| 7 | 血压难以控制的高血压患者临时停用降压药的安全性分析显示文摘血压控制成功依赖于有效鉴别出继发性病因和发现高血压的发病因素。由于抗高血压药物可能会干扰诊断调查,在一些研究中可能会要求患者临时停药。然而,对于血压难以控制的高血压患者,临时停用抗高血压药物的安全性令人担忧。 | 刘莉 叶鹏 Beeftink MM van der Sande NG Bots ML Doevendans PA Blankestijn PJ Visseren FL Voskuil M Spiering W | 2017 | 中华高血压杂志2017，25，4： | 2 |
| 8 | EGFR expression predicts BRCA1 status in patients with breast eancer显示文摘 | van Diest PJ van der Groep P van der Wall E | 2006 | Clin Cancer Res2006，12，2： | 1 |
| 9 | An increased polymerlc IgA level is not a prognostic marker for progressive IgA nephropathy显示文摘 | Van der Boog PJ Van Kooten C Van Seggelen A | 2004 | Nephrol Dial Transplant2004，19，10： | 1 |
| 10 | Steroid sex hormones regulate the release of tumor necrosis factor by macrophages 显示文摘 | Van Alten PJ Greager JA | 1995 | Cell Immunol1995，160，： | 1 |
| 11 | Analysis of human papillomavirus type 16 E6 variants in relation to p53 codon 72 polymorphism genotypes in cervical carcinogenesis 显示文摘 | van Duin M Snijders PJ Vossen MT | 2000 | J Gen Virol2000，81，： | 1 |
| 12 | Randomized, clinical trial comparison of trisodium citrate 30% and heparin as catheter-locking solution in hemodialysis patients 显示文摘 | Weijmer MC van den Dorpel MA Van de Ven PJ | 2005 | J Am Soc Nephrol2005，16，9： | 1 |
| 13 | Cardiac death and reinfarction after 1 year in the thrombus aspiration during percutaneous coronary intervention in acute myo- cardial infarction study (TAPAS): a 1-year follow-up study显示文摘 | Vlaar PJ Svilaas T van der Horst IC | 2008 | Lancet2008，371，15： | 1 |
| 14 | Expression of proliferation and apoptosis-related proteins in usual ductal hyperplasia of the breast显示文摘 | Mommers EC van Diest PJ Leonhart AM | 1998 | Hum Pathol1998，29，12： | 1 |
| 15 | Sentinel node detection in cervical cancer 显示文摘 | Verheijen RH Pijpers R van Diest PJ | 2000 | Obstet Gynecol2000，96，： | 1 |
| 16 | Endoscopic ligation of the sphenopalatine artery for refractory posterior epistaxis 显示文摘 | Wormald PJ Wee DT van Hasselt CA | 2000 | Am J Rhinol2000，14，4： | 1 |
| 17 | The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice 显示文摘 | Bieghs V Hendrikx T van Gorp PJ | 2013 | Gastroenterology2013，144，1： | 1 |
| 18 | Perina- tal programming of adult hippoeampal structure and func- tion: emerging roles of stress,nutrition and epigeneties显示文摘 | Lucassen PJ Naninck EF van Goudoever JB | 2013 | Trends Neurosci2013，36，11： | 1 |
| 19 | Thrombus aspiration during primary percutaneous coronary intervention显示文摘 | Svilaas T Vlaar PJ van der Horst IC | | 0，，06： | 1 |
| 20 | 1nsreased platelet activation in the chronic phase after cerebral ischemia and intracerebral hemorrhage显示文摘 | Van Kooten F Ciabatloni G Koudstal PJ | 1999 | Stroke1999，30，： | 1 |
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