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| 1 | 温度对美拉德反应的研究(英文)显示文摘本文报道了反应温度对以d-葡萄糖和l-甘氨酸水溶液模式体系美拉德反应的影响。研究了在不同反应温度(80、100、120℃)和不同反应时间下,体系中糖和氨基酸的降解程度,反应中间体:阿利德诺和有机酸的累积程度,类黑素的形成及pH变化程度。研究结果表明:随着反应温度和反应时间的增加,反应速率加快。 | 吴少雄 M A J S van Boeke S I F S Martins 郭祀远 李琳 | 2005 | 食品科学2005，26，7： | 54 |
| 2 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 3 | Diffusion weighted imaging in the liver显示文摘Diffusion weighted magnetic resonance imaging (DWI) is an imaging technique which provides tissue contrast by the measurement of diffusion properties of water molecules within tissues. Diffusion is expressed in an apparent diffusion coefficient (ADC), which reflects the diffusion properties unique to each type of tissue. DWI has been originally used in neuroradiology. More recently, DWI has increasingly been used in addition to conventional unenhanced and enhanced magnetic resonance imaging (MRI) in other parts of the body. The reason for this delay was a number of technical problems inherent to the technique, making DWI very sensitive to artifacts, which had to be overcome. With assessment of ADC values, DWI proved to be helpful in characterization of focal liver lesions. However, DWI should always be used in conjunction to conventional MRI since there is considerable overlap between ADC values of benign and malignant lesions. DWI is useful in the detection of hepatocellular carcinoma in the cirrhotic liver and detection of liver metastases in oncological patients. In addition, DWI is a promising tool in the prediction of tumor responsiveness to chemotherapy and the follow-up of oncological patients after treatment, as DWI may be capable of detecting recurrent disease earlier than conventional imaging.This review focuses on the most common applications of DWI in the liver. | Petra G Kele Eric J van der Jagt | 2010 | World Journal of Gastroenterology2010，16，13： | 48 |
| 4 | Nonalcoholic fatty liver disease: An overview of current insights in pathogenesis, diagnosis and treatment显示文摘Estimates of people suffering from overweight (one billion) and obesity (300 million) are increasing. The accumulation of triglycerides in the liver, in the absence of excess alcohol intake, has been described in the early sixties. It was not until 1980, however, that Ludwig et al named this condition nonalcoholic steatohepatitis (NASH). Subsequently, nonalcoholic fatty liver disease (NAFLD) has been used as a general name for conditions ranging from simple steatosis through steatohepatitis to end-stage liver disease (cirrhosis). Many studies have demonstrated the significant correlation with obesity and insulin resistance. Other studies have revealed a signifi- cant correlation between hepatic steatosis, cardiovascu- lar disease and increased intima-media thickness. WHO estimated that at least two million patients will develop cirrhosis due to hepatic steatosis in the years to come. Longitudinal cohort studies have demonstrated that those patients with cirrhosis have a similar risk to devel- op hepatocellular carcinoma as those with other causes of cirrhosis. Taken all together, NAFLD has become the third most important indication for liver transplantation. There- fore, training programmes in internal medicine, gastroen- terology and hepatology should stress the importance of diagnosing this entity and treat properly those at risk for developing complications of portal hypertension and con- comittant cardiovascular disease. This review will focus on the clinical characteristics, pathophysiology, imaging tech- niques and the readily available therapeutic options. | Tim CMA Schreuder Bart J Verwer Carin MJ van Nieuwkerk Chris JJ Mulder | 2008 | World Journal of Gastroenterology2008，14，16： | 35 |
| 5 | MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells显示文摘 | Godlewski J Nowicki MO Bronisz A Nuovo G Palatini J De Lay M Van Brocklyn J Ostrowskl MC Chlocca EA Lawler SE. | 2010 | 中国神经肿瘤杂志2010，8，1： | 37 |
| 6 | 世界胃肠病学组织全球指南——发展中国家幽门螺杆菌感染显示文摘世界上有一半人口感染幽门螺杆菌(H.pylori),其感染率因地理位置、种族、年龄和社会经济状况不同而存在很大差异.在发展中国家较高.发达国家较低。但总体而言,近年世界许多地区的H.pylori感染率均呈下降趋势。 | Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F van der Merwe S Vaz Coelho LG Fock M Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BCY Krabshuis J Le Mair A 杜颖 戴宁 | 2011 | 胃肠病学2011，16，7： | 27 |
| 7 | Obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma显示文摘Hepatobiliary cystadenomas (HBC) and cystadenocarci- nomas are rare cystic lesions. Most patients with these lesions are asymptomatic, but presentation with ob- structive jaundice may occur. The first patient presented with intermittent colicky pain and recurrent obstructive jaundice. Imaging studies revealed a polypoid lesion in the left hepatic duct. The second patient had recurrent jaundice and cholangitis. Endoscopic retrograde cholan- giopancreatography (ERCP) showed a cystic lesion at the confluence of the hepatic duct. In the third patient with intermittent jaundice and cholangitis, cholangioscopy re- vealed a papillomatous structure protruding into the left bile duct system. In the fourth patient with obstructive jaundice, CT-scan showed slight dilatation of the intrahe- patic bile ducts and dilatation of the common bile duct of 3 cm. ERCP showed filling of a cystic lesion. All patients underwent partial liver resection, revealing HBC in the specimen. In the fifth patient presenting with obstructive jaundice, ultrasound examination showed a hyperecho- genic cystic lesion centrally in the liver. The resection specimen revealed a hepatobiliary cystadenocarcinoma. HBC and cystadenocarcinoma may give rise to obstruc- tive jaundice. Evaluation with cross-sectional imaging techniques is useful. ERCP is a useful tool to differentiate extraductal from intraductal obstruction. | Deha Erdogan Olivier RC Busch Erik AJ Rauws Otto M van Delden Dirk J Gouma Thomas M van Gulik | 2006 | World Journal of Gastroenterology2006，12，35： | 26 |
| 8 | NLRP3炎症小体对急性胰腺炎小鼠全身炎症反应及代偿性抗炎反应综合征的调节作用显示文摘【据《Gastroenterology》2019年10月报道】题:NLRP3炎症小体对急性胰腺炎小鼠全身炎症反应及代偿性抗炎反应综合征的调节作用(作者Sendler M等)胰腺炎开始时主要是无菌的局部炎症,其引起全身性炎症反应综合征(SIRS),然后是代偿性抗炎反应综合征(CARS)。来自德国格赖夫斯瓦尔德大学的Sendler等通过研究探讨了小鼠和人类血清中该过程的机制。 | 李德钊 郭晓林 SENDLER M van den BRANDT C GLAUBITZ J | 2020 | 临床肝胆病杂志2020，36，3： | 24 |
| 9 | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘 | van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 22 |
| 10 | The ReaxFF reactive force-field: development, applications and future directions显示文摘The reactive force-field(ReaxFF)interatomic potential is a powerful computational tool for exploring,developing and optimizing material properties.Methods based on the principles of quantum mechanics(QM),while offering valuable theoretical guidance at the electronic level,are often too computationally intense for simulations that consider the full dynamic evolution of a system.Alternatively,empirical interatomic potentials that are based on classical principles require significantly fewer computational resources,which enables simulations to better describe dynamic processes over longer timeframes and on larger scales.Such methods,however,typically require a predefined connectivity between atoms,precluding simulations that involve reactive events.The ReaxFF method was developed to help bridge this gap.Approaching the gap from the classical side,ReaxFF casts the empirical interatomic potential within a bond-order formalism,thus implicitly describing chemical bonding without expensive QM calculations.This article provides an overview of the development,application,and future directions of the ReaxFF method. | Thomas P Senftle Sungwook Hong Md Mahbubul Islam Sudhir B Kylasa Yuanxia Zheng Yun Kyung Shin Chad Junkermeier Roman Engel-Herbert Michael J Janik Hasan Metin Aktulga Toon Verstraelen Ananth Grama Adri CT van Duin | 2016 | npj Computational Materials2016，，1： | 22 |
| 11 | Current status of laparoscopic and robotic ventral mesh rectopexy for external and internal rectal prolapse显示文摘External and internal rectal prolapse with their affiliated rectocele and enterocele, are associated with debilitating symptoms such as obstructed defecation, pelvic pain and faecal incontinence. Since perineal procedures are associated with a higher recurrence rate, an abdominal approach is commonly preferred. Despite the description of greater than three hundred different procedures, thus far no clear superiority of one surgical technique has been demonstrated. Ventral mesh rectopexy(VMR) is a relatively new and promising technique to correct rectal prolapse. In contrast to the abdominal procedures of past decades, VMR avoids posterolateral rectal mobilisation and thereby minimizes the risk of postoperative constipation. Because of a perceived acceptable recurrence rate, good functional results and low mesh-related morbidity in the short to medium term, VMR has been popularized in the past decade. Laparoscopic or robotic-assisted VMR is now being progressively performed internationally and several articles and guidelines propose the procedure as the treatment of choice for rectal prolapse. In this article, an outline of the current status of laparoscopic and robotic ventral mesh rectopexy for the treatment of internal and external rectal prolapse is presented. | Jan J van Iersel Tim JC Paulides Paul M Verheijen John W Lumley Ivo AMJ Broeders Esther CJ Consten | 2016 | World Journal of Gastroenterology2016，22，21： | 20 |
| 12 | Association of smoking, alcohol drinking and dietary factors with esophageal cancer in high- and low-risk areas of Jiangsu Province, China显示文摘瞄准:到环境的 main 和在食道的癌症(EC ) 说明地区性的差别的生活方式因素在江苏省的低风险、高风险的区域冒的风险的学习,中国。方法:自从 2003,基于人口的盒子控制研究同时被进行了在低风险(Ganyu 县) 并且高风险(Dafeng 县) 江苏省的区域,中国。使用相同协议和 pre-tested 标准化了问询表,跟随写的知情同意,合格题目被询问他们 EC 的潜在的决定因素的详细信息包括人口统计的信息,社会经济的地位,生活条件,疾病历史,家庭癌症历史,吸烟,酒精喝酒,饮食的习惯,频率,食物摄取的数量,等等。有最大的可能性评价的有条件的逻辑回归被用来获得机会比率(或) 并且 95 % 信心间隔(95% CI ) ,在为潜力的调整以后,反对失败。结果:在进行中的学习的初步的分析,我们招募了在 Ganyu 的在 Dafeng 的 291 个盒子和 240 个盒子和控制分别地。在低风险、高风险的区域, EC 相反地与社会经济的地位被联系,例如教育的水平,经过经济地位和身体团索引。然而,这疾病在有癌症的家庭历史或在过去的 10 年里遇到了不幸的那些之中是更经常的。EC 在吸烟者,白酒喝酒者和快食客之中也是更经常的。而且,有在吸烟,酒精喝酒和尽管有在低风险、高风险的区域的这些风险因素的类似的流行的 EC 风险之间的协会的一个地理变化。吸烟并且吸烟的剂量反应关系联系了变量,例如首先吸烟,持续时间和数量的年龄在高风险的区域仅仅是明显的。相反,在 EC 上喝的酒精的效果上的一种剂量反应关系仅仅在低风险的区域被观察。结论:环境风险因素,可能和基因因素和基因环境的相互作用是为在江苏省的这个高风险的坡度的主要原因,中国。 | Ming Wu Jin-Kou Zhao Xiao-Shu Hu Pei-Hua Wang Yu Qin Yin-Chang Lu Jie Yang Ai-Min Liu De-Lin Wu Zuo-Feng Zhang Kok J Frans Pieter van't Veer | 2006 | World Journal of Gastroenterology2006，12，11： | 18 |
| 13 | Strategies to reduce pulmonary complications after esophagectomy显示文摘Esophagectomy,the surgical removal of all or part of the esophagus,is a surgical procedure that is associated with high morbidity and mortality.Pulmonary complications are an especially important postoperative problem.Therefore,many perioperative strategies to prevent pulmonary complications after esophagectomy have been investigated and introduced in daily clinical practice.Here,we review these strategies,including improvement of patient performance and technical advances such as minimally invasive surgery that have been implemented in recent years.Furthermore,interventions such as methylprednisolone,neutrophil elastase inhibitor and epidural analgesia,which have been shown to reduce pulmonary complications,are discussed.Benefits of the commonly applied routine nasogastric decompression,delay of oral intake and prophylactic mechanical ventilation are unclear,and many of these strategies are also evaluated here.Finally,we will discuss recent insights and new developments aimed to improve pulmonary outcomes after esophagectomy. | Teus J Weijs Jelle P Ruurda Grard AP Nieuwenhuijzen Richard van Hillegersberg Misha DP Luyer | 2013 | World Journal of Gastroenterology2013，19，39： | 17 |
| 14 | Feedback-feedfor- ward individual pitch control for wind turbine load reduction显示文摘 | Selvarn K Kanev S van Wingerden J W | 2009 | International Journal of Robust and Nonlinear Control2009，19，1： | 17 |
| 15 | Management of recurrent rectal cancer:A population based study in greater Amsterdam显示文摘AIM: To analyze,retrospectively in a population-based study,the management and survival of patients with recurrent rectal cancer initially treated with a macroscopically radical resection obtained with total mesorectal excision (TME). METHODS: All rectal carcinomas diagnosed during 1998 to 2000 and initially treated with a macroscopically radical resection (632 patients) were selected from the Amsterdam Cancer Registry. For patients with recurrent disease,information on treatment of the recurrence was collected from the medical records. RESULTS: Local recurrence with or without clinically apparent distant dissemination occurred in 62 patients (10%). Thirty-two patients had an isolated local recurrence. Ten of these 32 patients (31%) underwent radical re-resection and experienced the highest survival (three quarters survived for at least 3 years). Eight patients (25%) underwent non-radical surgery (median survival 24 mo),seven patients (22%) were treated with radio-and/or chemotherapy without surgery (median survival 15 mo) and seven patients (22%) only received best supportive care (median survival 5 mo). Distant dissemination occurred in 124 patients (20%) of whom 30 patients also had a local recurrence. The majority (54%) of these patients were treated with radio-and/or chemotherapy without surgery (median survival 15 mo). Twenty-seven percent of these patients only received best supportive care (median survival 6 mo),while 16% underwent surgery for their recurrence. Survival was best in the latter group (median survival 32 mo). CONCLUSION: Although treatment options and survival are limited in case of recurrent rectal cancer after radical local resection obtained with TME,patients can benefit from additional treatment,especially if a radical resection is feasible. | Roel Bakx Otto Visser Judith Josso Sybren Meijer J Frederik M Slors J Jan B van Lanschot | 2008 | World Journal of Gastroenterology2008，14，39： | 17 |
| 16 | Evolving management of colorectal cancer显示文摘This article reviews recent advances in surgical techniques and adjuvant therapies for colorectal cancer, including total mesorectal excision, the resection of liver and lung metastasis and advances in chemoradiation and foreshadows some interventions that may lie just beyond the frontier. In particular, little is known about the intracellular and extracellular cascades that may influence colorectal cancer cell adhesion and metastasis. Although the phosphorylation of focal adhesion kinases and focal adhesion associated proteins in response to integrin-mediated cell matrix binding ('outside in integrin signaling') is well described, the stimulation of cell adhesion by intracellular signals activated by pressure prior to adhesion represents a different signal paradigm. However, several studies have suggested that increased pressure and shear stress activate cancer cell adhesion. Further studies of the pathways that regulate integrin-driven cancer cell adhesion may identify ways to disrupt these signals or block integrin-mediated adhesion so that adhesion and eventual metastasis can be prevented in the future. | Jochem van der Voort van Zijp Harald J Hoekstra Marc D Basson | 2008 | World Journal of Gastroenterology2008，14，25： | 16 |
| 17 | Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease显示文摘AIM: To evaluate the results of the treatment of simple liver cysts (solitary and multiple) and polycystic liver disease (PLD) using percutaneous sclerotherapy and/or surgical procedures in a single tertiary referral centre. METHODS: Retrospective analysis of 54 patients referred for evaluation and possible treatment of simple liver cysts (solitary and multiple) and PLD, from January 1997 to July 2006. RESULTS: Simple liver cysts were treated in 41 pts (76/) with a mean size of 12.6 cm. The most common reason for referral was abdominal pain or discomfort (85/). Percutaneous sclerotherapy was performed as initial treatment in 30 pts, showing cyst recurrence in 6 pts (20/). Surgical treatment was initially performed in 11 pts with cyst recurrence in 3 pts (27/). PLD was treated in 13 pts (24/) with a mean size of the dominant cyst of 13 cm. Percutaneous sclerotherapy for PLD was performed in 9 pts with recurrence in 7 pts (77.8/). Surgical treatment for PLD was undertaken in 4 pts (30.8/) with recurrence in all. Eventually, 2 pts with PLD in the presence of polycystic kidney disease underwent liver-and kidney transplantation because of deterioration of liver and kidney function. CONCLUSION: The majority of patients with simple liver cysts and PLD are referred for progressive abdominal pain. As initial treatment, percutaneous sclerotherapy is appropriate. Surgical deroofing is indicated in caseof cyst recurrence after percutaneous sclerotherapy. However, the results of percutaneous sclerotherapy and surgical treatment for PLD are disappointing. Partial liver resection is indicated when there is suspicion of a pre-malignant lesion. | Deha Erdogan Otto M van Delden Erik AJ Rauws Olivier RC Busch Johan S Lameris Dirk J Gouma Thomas M van Gulik | 2007 | World Journal of Gastroenterology2007，13，22： | 15 |
| 18 | Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets显示文摘 | Hommes D W Peppelenbosch M P van Deventer S J | 2003 | Gut2003，52，1： | 14 |
| 19 | 大别山双河和碧溪岭超高压变质岩流体包裹体研究显示文摘对大别山双河和碧溪岭含柯石英榴辉岩和硬玉石英岩进行了详细的流体包裹体研究。根据流体包裹体的成分和盐度的不同 ,可以划分出至少五种类型不同的气液包裹体 :( 1) N2 包裹体 ;( 2 )高盐度流体包裹体 ;( 3) CO2 包裹体 ;( 4) CO2 -H2 O包裹体 ;( 5 )低盐度流体包裹体。N2 包裹体仅见于含柯石英榴辉岩 ,而高盐度流体包裹体则几乎存在于所有的榴辉岩和硬玉石英岩中。 CO2 包裹体沿榴辉岩中微剪切带分布 ,或存在于强变形的硬玉石英岩中 ,而低盐度流体包裹体分布较为局限。N2 和高盐度流体被认为是超高压变质作用平衡的产物 ,来源于变质前的古孔隙流体。而且榴辉岩中含有一系列盐度不同的流体显微域 ,其大小与矿物颗粒相当。在板块折返过程中 ,包裹体中流体可能发生迁移 ,但是不会超出寄主晶体的范围。CO2流体明显是外来的 ,可能来自共生大理岩或含碳酸盐的变质沉积岩。这与菱镁矿和柯石英等共生组合所指示的进变质过程中大理岩不存在脱碳反应的结论相一致。而低盐度流体则可能系顶峰变质矿物分解而成 。 | 傅斌 肖益林 J L R Touret A M Van den Kerkhof JHoefs 郑永飞 | 2000 | 岩石学报2000，16，1： | 14 |
| 20 | 睾丸活检:临床操作及其诠释显示文摘睾丸活检许多年来被认为是不明病因男性不育和无精症诊断的基础。近来,男性不育指南都限定诊断性睾丸活检只能用于梗阻性无精子症(睾丸体积正常,生殖激素正常)的鉴别诊断。现今,睾丸活检取精技术与胞浆内单精子显微注射(ICSI)联用于非梗阻性无精子症患者的取精过程中。此外,睾丸活检还可以应用于有睾丸恶性肿瘤风险的患者的取精治疗中。研究一些不育男性后发现,不育患者患原位睾丸癌的风险越来越高,尤其是曾有隐睾症、睾丸恶性肿瘤病史,或患睾丸萎缩的患者。睾丸超声异常,比如睾丸微石症,实质内呈弥散分布,软细胞组织不均、睾丸组织损伤等,进一步增加了这些患者原位癌的发病率。准确的组织学分类,正确的组织处理和固定,样品准备和评估是必须的。同时,推荐使用标准的睾丸活检方法。另外,通过免疫组织化学法检测睾丸组织的肿瘤恶化程度是不可缺少的技术支持。本综述主要描述了睾丸活检用于男性不育临床诊断和治疗措施的最新进展。 | Gert R Dohle Saad Elzanaty Niels J van Casteren | 2012 | Asian Journal of Andrology2012，14，1： | 13 |
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