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| 1 | Obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma显示文摘Hepatobiliary cystadenomas (HBC) and cystadenocarci- nomas are rare cystic lesions. Most patients with these lesions are asymptomatic, but presentation with ob- structive jaundice may occur. The first patient presented with intermittent colicky pain and recurrent obstructive jaundice. Imaging studies revealed a polypoid lesion in the left hepatic duct. The second patient had recurrent jaundice and cholangitis. Endoscopic retrograde cholan- giopancreatography (ERCP) showed a cystic lesion at the confluence of the hepatic duct. In the third patient with intermittent jaundice and cholangitis, cholangioscopy re- vealed a papillomatous structure protruding into the left bile duct system. In the fourth patient with obstructive jaundice, CT-scan showed slight dilatation of the intrahe- patic bile ducts and dilatation of the common bile duct of 3 cm. ERCP showed filling of a cystic lesion. All patients underwent partial liver resection, revealing HBC in the specimen. In the fifth patient presenting with obstructive jaundice, ultrasound examination showed a hyperecho- genic cystic lesion centrally in the liver. The resection specimen revealed a hepatobiliary cystadenocarcinoma. HBC and cystadenocarcinoma may give rise to obstruc- tive jaundice. Evaluation with cross-sectional imaging techniques is useful. ERCP is a useful tool to differentiate extraductal from intraductal obstruction. | Deha Erdogan Olivier RC Busch Erik AJ Rauws Otto M van Delden Dirk J Gouma Thomas M van Gulik | 2006 | World Journal of Gastroenterology2006，12，35： | 26 |
| 2 | Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease显示文摘AIM: To evaluate the results of the treatment of simple liver cysts (solitary and multiple) and polycystic liver disease (PLD) using percutaneous sclerotherapy and/or surgical procedures in a single tertiary referral centre. METHODS: Retrospective analysis of 54 patients referred for evaluation and possible treatment of simple liver cysts (solitary and multiple) and PLD, from January 1997 to July 2006. RESULTS: Simple liver cysts were treated in 41 pts (76/) with a mean size of 12.6 cm. The most common reason for referral was abdominal pain or discomfort (85/). Percutaneous sclerotherapy was performed as initial treatment in 30 pts, showing cyst recurrence in 6 pts (20/). Surgical treatment was initially performed in 11 pts with cyst recurrence in 3 pts (27/). PLD was treated in 13 pts (24/) with a mean size of the dominant cyst of 13 cm. Percutaneous sclerotherapy for PLD was performed in 9 pts with recurrence in 7 pts (77.8/). Surgical treatment for PLD was undertaken in 4 pts (30.8/) with recurrence in all. Eventually, 2 pts with PLD in the presence of polycystic kidney disease underwent liver-and kidney transplantation because of deterioration of liver and kidney function. CONCLUSION: The majority of patients with simple liver cysts and PLD are referred for progressive abdominal pain. As initial treatment, percutaneous sclerotherapy is appropriate. Surgical deroofing is indicated in caseof cyst recurrence after percutaneous sclerotherapy. However, the results of percutaneous sclerotherapy and surgical treatment for PLD are disappointing. Partial liver resection is indicated when there is suspicion of a pre-malignant lesion. | Deha Erdogan Otto M van Delden Erik AJ Rauws Olivier RC Busch Johan S Lameris Dirk J Gouma Thomas M van Gulik | 2007 | World Journal of Gastroenterology2007，13，22： | 15 |
| 3 | 25-羟维生素D和甲状旁腺激素与高血压的相关性显示文摘有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高血压的进展。目前还没有前瞻性研究同时评估维生素D和PTH水平与高血压发病的关系。该研究分析多民族动脉粥样硬化研究的前瞻性数据,发现低水平25羟维生素D[25(OH)D]和高水平PTH与高血压发病相关,特别是在肥胖人群中。但在校正混杂因素后,25(OH)D水平与高血压发病的相关性无统计学意义,而PTH水平与高血压发病仍然相关。鉴于维生素D缺乏和PTH过量在人群中是普遍现象,该研究对于更好地了解高血压发病机制,在人群中开展高血压预防工作有重要意义。 | van Ballegooijen AJ Kestenbaum B Sachs MC de Boer IH Siscovick DS Hoofnagle AN Ix JH Visser M Brouwer IA 练桂丽 叶鹏 | 2014 | 中华高血压杂志2014，22，6： | 10 |
| 4 | 甲状旁腺激素在心血管疾病中的潜在作用显示文摘背景心血管疾病(CVD)已经成为主要的死亡原因之一。在过去的10年,维生素D在骨骼之外的其他多种疾病(包括CVD)中的作用引起了广泛的关注。血液循环中甲状旁腺激素(PTH)是骨骼与矿物质代谢的主要调节激素,可以刺激维生素D向活性形式转化。研究表明,PTH不仅是维生素D代谢状态的生物标记,而且是独立的心血管危险因素,参与了CVD的进展。目的该文主要对PTH与CVD相关的文献进行总结。结果越来越多的证据表明,较高浓度PTH与CVD相关。PTH过多可能影响潜在的CVD发病机制,包括心脏生物标记物、心脏结构及高血压等,进而促进CVD的发生。基于现有的证据,在一般人群中补充维生素D、抑制PTH是否对心血管健康有益,还需要进一步证实。结论老年人群中PTH过高比较常见。由于高浓度PTH可能对心血管健康不利,所以采用维生素D治疗或PTH特异性抑制剂治疗,以降低PTH浓度可能有利于阻止心脏疾病,降低CVD发生率。然而,目前的研究证据还不足以支持在一般人群中通过提高维生素D或降低PTH水平来预防CVD。 | AJ van Ballegooijen 张刘锋 | 2014 | 中华高血压杂志2014，22，11： | 5 |
| 5 | Self-expandable metal stents for malignant gastric outlet obstruction: A pooled analysis of prospective literature显示文摘AIM: To provide an overview of the clinical outcomes of self-expandable metal stent(SEMS) placement for malignant gastric outlet obstruction(MGOO).METHODS: A systematic literature search was performed in Pub Med of the literature published between January 2009 and March 2015. Only prospective studies that reported on the clinical success of stent placement for MGOO were included. The primary endpoint was clinical success,defined according to the definition used in the original article. Data were pooled and analyzed using descriptive statistics. Subgroup analyses were performed for partially covered SEMSs(PCSEMSs) and uncovered SEMSs(UCSEMSs) using Fisher's exact test.RESULTS: A total of 19 studies,including 1281 patients,were included in the final analysis. Gastric(42%) and pancreatic(37%) cancer were the main causes of MGOO. UCSEMSs were used in 76% of patients and PCSEMSs in 24%. The overall pooled technical success rate was 97.3% and the clinical success rate was 85.7%. Stent dysfunction occurred in 19.6% of patients,mainly caused by re-obstruction(12.6%) and stent migration(4.3%),and was comparable between PCSEMSs and UCSEMSs(21.2% vs 19.1%,respectively,P = 0.412). Re-obstruction was more common with UCSEMSs(14.9% vs 5.1%,P < 0.001) and stent migration was more frequent after PCSEMS placement(10.9% vs 2.2%,P < 0.001). The overall perforation rate was 1.2%. Bleeding was reported in 4.1% of patients,including major bleeding in 0.8%. The median stent patency ranged from 68 to 307 d in five studies. The median overall survival ranged from 49 to 183 d in 13 studies.CONCLUSION: The clinical outcomes in this large population showed that enteral stent placement was feasible,effective and safe. Therefore,stent placement is a valid treatment option for the palliation of MGOO. | Emo E van Halsema Erik AJ Rauws Paul Fockens Jeanin E van Hooft | 2015 | World Journal of Gastroenterology2015，21，43： | 5 |
| 6 | Long-term follow-up of quality of life in high-risk patients undergoing transcatheter aortic valve implantation for symptomatic aortic valve stenosis显示文摘BackgroundTranscatheter 大动脉的阀门培植(TAVI ) 与严重征兆的大动脉的狭窄为病人成为了标准治疗(作为) 为外科的大动脉的阀门代替在很高的风险考虑了。这亚学习的目的是评估长期的(> 4 年) 在 octogenarians 的生活(QoL ) 的健康相关的质量经历了 TAVI.MethodsA 单个中心在在 TAVI 以后经历了框架分析评价 4 年的二十个病人的观察登记。健康相关的 QoL 被评估,用短 Form-36 ( SF-36 ),吗 EuroQoL-5D ( EQ-5D )和 questionnaires.ResultsThe 平均数 SF-36 subscale 在后续获得的视觉类似物分数(EQ管)是物理的工作 40.8 ????????????????????????????搠?潮潶???吗?湡楧灯慬瑳?????????愠杮潩牧灡票?€ 敦潭潲潰汰瑩慥???????????????愠桴牥'啼蠹溃浚? | Marjo JAG De Ronde-Tillmans Tom AJ de Jager Jeannette A Goudzwaard Nahid El Faquir Nicolas M van Mieghem Felix Zijlstra Elisabeth MWJ. Utens Francesco US Mattace-Raso MaRie J Lenzen Peter PT de Jaegere | 2018 | Journal of Geriatric Cardiology2018，15，4： | 3 |
| 7 | WONCA研究论文摘要汇编——癌症晚期患者在家中临终前的症状及其难以忍受的程度与性质:基层医疗研究展望显示文摘背景基层医生可以在家中为癌症患者提供以缓解症状为目的的医疗服务。以荷兰为例,在家去世的癌症患者(占全部癌症患者的45%)大约每7人中就有1人在离世过程中表现出难以忍受的痛苦。本试验将从接受基层医疗服务的临终癌症患者的常见症状分布,症状及其难以忍受程度的强弱、随病程进展的变化情况及其性质之间的关系两个方面展开研究。方法 44名全科医生3年中不断选取预期寿命〈6个月的癌症患者。根据《痛苦状况-V》(SOS-V),每隔2个月对69种症状在选取患者中表现出的强弱及难以忍受程度进行量化。同样按照5分评价的方法〔从1分(一点不痛苦)到5分(不能更痛苦)〕,对总体症状难以忍受的程度也进行量化。 | Ruijs CD Kerkhof AJ van der Wal G 周淑新 | 2014 | 中国全科医学2014，17，17： | 2 |
| 8 | 老龄小鼠模型内皮细胞衰老导致射血分数保留的心力衰竭显示文摘由于全球老龄化,射血分数保留的心力衰竭(heart failure with preserved ejection fraction,HFpEF)发生率持续上升。虽然HFpEF的病理生理机制仍然不完全清楚,但通常认为内皮炎症发挥了核心作用。细胞衰老是一种与老化和炎症有关的细胞生长停滞过程。Gevaert等使用加速老化的小鼠(senescence-accelerated mice,SAM)模型探究细胞衰老在HFpEF发生发展中的作用。 | 刘莉 叶鹏 Gevaert AB Shakeri H Leloup AJ Van Hove CE De Meyer GRY Vrints CJ Lemmens K Van Craenenbroeck EM | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 9 | β-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas:role in the regulation of response to somatostatin analogue treatment in patients with acromegaly显示文摘Recent in vitro studies highlighted G protein-coupled receptor kinase(GRK)2 andβ-arrestins as important players in driving somatostatin receptor(SSTR)desensitization and trafficking.Our aim was to characterize GRK2 andβ-arrestins expression in different pituitary adenomas and to investigate their potential role in the response to somatostatin analog(SSA)treatment in GHsecreting adenomas(GHomas).We evaluated mRNA expression of multiple SSTRs,GRK2,β-arrestin 1,andβ-arrestin 2 in 41pituitary adenomas(31 GHomas,6 nonfunctioning[NFPAs],and 4 prolactinomas[PRLomas]).Within the GHomas group,mRNA data were correlated with the in vivo response to an acute octreotide test and with the GH-lowering effect of SSA in cultured primary cells.β-Arrestin 1 expression was low in all 3 adenoma histotypes.However,its expression was significantly lower in GHomas | Gatto F Feelders R van der Pas R Kros JM Dogan F van Koetsveld PM van der Lelij AJ Neggers SJ Minuto F de Herder W Lamberts SW Ferone D Hofland LJ | 2013 | 中国神经肿瘤杂志2013，11，4： | 2 |
| 10 | Early and long - term wear of conventional and resin - modified glass - ionomers 显示文摘 | de Gee AJ van Duinen RN Werner A | 1996 | JDentRes1996，75，8： | 1 |
| 11 | Allergen immunotherapy inhibits airway eosinophilia and hyperresponsiveness associated with decreased IL-4 production by lymphocytes in a murine model of allergic asthma显示文摘 | van Esch B Hofman G | 1998 | Am J Respir Cell Mol Biol1998，19，： | 1 |
| 12 | Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites显示文摘 | Zaidi SK Sullivan AJ van Wijnen AJ | 2002 | Proc Natl Acad Sci USA2002，99，12： | 1 |
| 13 | Histone deacetylases(HDACs):characterization of the classical HDAC family显示文摘 | de Ruijter AJ van Gennip All Caron HN | 2003 | Biochem J2003，370，： | 1 |
| 14 | Quantification of functional and inactivated alpha 2-macroglobulin in sepsis显示文摘 | Abbink JJ Nuijens JH Eerenberg AJ Huijbregts CC Strack van Schijndel RJ Thijs LG | 1991 | Thromb Haemost1991，65，1： | 1 |
| 15 | Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitisB using HBsAg and HBV DNA levels 显示文摘 | Rijckborst V Hansen BE Cakaloglu Y Ferenci P Tabak F Akdogan M Simon K Akarca US Flisiak R Verhey E Van Vuuren AJ Boucher CA ter Borg MJ Janssen HL | 2010 | Hepatology2010，52，2： | 1 |
| 16 | Bone volume after secondary bone grafting in unilateral and bilateral clefts determined by computed tomography scans显示文摘 | Van der Meij AJ Baart JA Prahl-Andersen B | 2001 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2001，92，2： | 1 |
| 17 | Osteogenic effects of rest inserted and continuous cyclic tensile strain on hASC lines with disparate osteodifferen-tiation capabilities显示文摘 | Hanson AD Marvel SW Bernacki SH Banes AJ van Aalst J Loboa EG | | 0，，： | 1 |
| 18 | The speed of blood pressure fluctuations in patients with chronic obstructive pulmonary disease显示文摘 | van Gestel AJ Clarenbach CF Stowhas AC | 2014 | Heart Lung Circ2014，23，3： | 1 |
| 19 | Ultrasound evaluation of the Cesarean scar:relation between a niche and postmenstrual spotting显示文摘 | Bij de Vaate AJ Brolmann HA van der Voet LF | 2011 | Ultrasound Obstet Gynecol2011，37，1： | 1 |
| 20 | Cardiopulmonary and gas-exchange responses during the six-minute walk test in patients with chronic obstructive pulmonary disease显示文摘 | van Gestel AJ Baty F Rausch-Osthof AK | 2014 | Respiration2014，88，4： | 1 |
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