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| 1 | 富含花青素天然产物延缓血管衰老的潜力:内皮衰老作用(英文)显示文摘Numerous clinical studies have indicated that regular intake of polyphenol-rich products such as red wine and green tea is associated with a reduced risk of cardiovascular diseases.The protective effect has been attributable,in particular,to their high level of polyphenols such as flavanols and anthocyanins.The beneficial effect of polyphenols on the vascular system involves their ability to improve the lipid profile and to prevent platelet activation and inflammatory responses,and possibly also by a direct action at blood vessels.Indeed,grape-derived polyphenols and tea catechins are potent inducers of endothelium-dependent relaxations of isolated blood vessels by causing a sustained stimulation of the endothelial formation of nitric oxide(NO)and endothelium-derived hyperpolarization,two potent vasoprotective mechanisms.Besides grape-derived and tea products,several red and black fruit-derived products induce also potent vasoprotective effects.Intake of polyphenol-rich products has been shown to retard the induction of aging-related endothelial dysfunction and to improve an established aging-related endothelial dysfunction in rats.The beneficial effect is mostly due to the normalization of the high level of oxidative stress in the arterial wall and of the local angiotensin system.Moreover,polyphenol-rich products prevented the induction of replicative senescence at indicated by levels of senescence-associated beta-galactosidase activity and of key cell cycle regulators p53/p21 and p16 in cultured endothelial cells.The induction of endothelial senescence is associated with the down-regulation of endothelial NO synthase expression and the up-regulation of tissue factor expression most likely triggered by NADPH oxidase-and cyclooxygenase-derived oxidative stress,and leads to a reduced ability of endothelial cells to effectively inhibit platelet aggregation.Thus,regular intake of polyphenol-rich products can delay the induction of aging-related endothelial dysfunction most likely by preventing endothelial senescence,and as a consequence help to maintain an optimal protective effect of endothelial cells on the vascular system. | ValérieSSCHINI-KERTH | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 1 |
| 2 | Focal nodular hyperplasia显示文摘 | Valérie Vilgrain | 2005 | European Journal of Radiology2005，，2： | 2 |
| 3 | Advancement in HCC imaging: diagnosis, staging and treatment efficacy assessments显示文摘 | Valérie Vilgrain | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，4： | 1 |
| 4 | Environmental impacts of soil remediation activities:Quantitative and qualitative tools applied on three case studies显示文摘 | Valérie Cappuyns | 2013 | Journal of Cleaner Production2013，52，： | 1 |
| 5 | Microwave-assisted solvent extraction of environmental samples显示文摘 | Valérie Camel | 2000 | Trends in Analytical Chemistry2000，，4： | 1 |
| 6 | A Physically-Based Scheme For The Urban Energy Budget In Atmospheric Models显示文摘 | Valéry Masson | 2000 | Boundary - Layer Meteorology2000，，3： | 1 |
| 7 | Product services: from a service supporting the product to a service supporting the client显示文摘 | Valérie Mathieu | 2001 | Journal of Business & Industrial Marketing2001，，1： | 1 |
| 8 | Advancement in HCC imaging: diagnosis, staging and treatment efficacy assessments显示文摘 | Valérie Vilgrain | 2010 | Journal of Hepato-Biliary-Pancreatic Sciences2010，，4： | 1 |
| 9 | Ultrasound of diffuse liver disease and portal hypertension显示文摘 | Valérie Vilgrain | 2001 | European Radiology2001，，9： | 1 |
| 10 | Targeting endothelial senescence by natural products to improve vascular health显示文摘It is well established in experimental animals and Humans that endothelial cells,which cover the luminal surface of all blood vessels,have a pivotal role in the control of vascular homeostasis.The protective effect of endothelial cells is mostly due to their ability to respond to circulating hormones,autacoids,blood-and platelet-derived factors,and also to blood flow by inducing potent vasoprotectivemechanismsincluding predominantlythe formation of nitric oxide(NO),and,often also to some extent,endothelium-derived hyperpolarization,and prostacyclin(PGI2).Besides being a potent vasodilator,NO also effectively prevents platelet activation and has anti-thrombotic and anti-atherosclerotic properties.An endothelial dysfunction characterized by a reduced generation of these endothelium-dependent vasodilator mechanisms associated with vascular oxidative stress and the formation of endothelium-derived contracting factors such as contractile prostanoids is often observed in most types of cardiovascular diseases including hypertension,hypercho⁃lesterolemia,diabetes,and also during physiological ageing in both experimental animals and Humans.Nutrition-derived polyphenols such as those from grapes,tea,cocoa,and berries have been shown to stimulate the endothelial formation of NO by activating the Src/PI3-kinase/Akt-dependent phosphorylation of endothelial NO synthase(eNOS)and to enhance eNOS expression.As a consequence,the active polyphenols will promote a sustained forma⁃tion of NO that contributes to protect the vascular system.Polyphenol-rich products have also been shown to improve an established endothelial dysfunction and to delay the onset of the induction of an endothelial dysfunction in several experimental models of cardiovascular diseases including hypertension and in ageing.Moreover,endothelial senescence characterized by cell cycle arrest and the acquisition of a pro-inflammatory and pro-atherothrombotic phenotype has been identified as an early event promotingthe development of endothelial dysfunc⁃tion.Premature endothelial senescence appears to affect,in particular,arterial sites at risk such as curvatures and bifur⁃cations that are characterized by disturbed flow and low shear stress.The pro-senescent process can be further increased in the presence of a high concentration of glucose,oxidized LDL,and angiotensinⅡ.Anthocyanin-rich products have been shown to accumulate preferentially in senescent endothelial cells,to reduce the expression of cell cycle regulators such as p16,p21 and p53,and to improve the endothelial function.The protective effect is mostly due to their ability to reduce vascular oxidative stress by inhibiting the overexpression of NADPH oxidase and the local angiotensin system.Thus,nutrition-derived polyphenols may be an interesting approach to delay the onset of risk factor-and ageing-related endothelial senescence and dysfunction and,hence,to promote vascular health. | Valérie SCHINI-KERTH | 2019 | 中国药理学与毒理学杂志2019，33，9： | 0 |
| 11 | Echocardiographic assessment of canine degenerative mitral valve disease显示文摘 | Valérie Chetboul Renaud Tissier | 2012 | Journal of Veterinary Cardiology2012，，1： | 1 |
| 12 | The multiple roles of the Mre11 complex for meiotic recombination显示文摘 | Valérie Borde | 2007 | Chromosome Research2007，，5： | 1 |
| 13 | Novel treatments for anxiety and depression: hurdles in bringing them to the market显示文摘 | Raimund Buller Valérie Legrand | 2001 | Drug Discovery Today2001，，23： | 1 |
| 14 | Maintenance of radiation-induced intestinal fibrosis:Cellular and molecular features显示文摘Recent advances in cell and molecular radiobiology clearly showed that tissue response to radiation injury cannot be restricted to a simple cell-killing process, but depends upon continuous and integrated pathogenic processes, involving cell differentiation and crosstalk between the various cellular components of the tissue within the extracellular matrix. Thus, the prior concept of primary cell target in which a single-cell type (whatever it’s epithelial or endothelial cells) dictates the whole tissue response to radiation injury has to be replaced by the occurrence of coordinated multicellular response that may either lead to tissue recovery or to sequel development. In this context, the present review will focus on the maintenance of the radiation-induced wound healing and fi brogenic signals triggered by and through the microenvironment toward the mesenchymal cell compartment, and will highlight how sequential and sustained modifi cations in cell phenotypes will in cascade modify cell-to-cell interactions and tissue composition. | Valérie Haydont Marie-Catherine Vozenin-Brotons | 2007 | World Journal of Gastroenterology2007，13，19： | 4 |
| 15 | Phase demodulation from a single fringe pattern based on a correlation technique显示文摘 | Eric Robin Valéry valle | 2004 | Applied Optics2004，43，22： | 1 |
| 16 | A Study on the Dispersion,Preparation,Characterization and Photo-degradation of Polypropylene Traced with Rare Earth Oxides显示文摘 | Feliks B Valérie M Jean B | 2010 | Polymer Degradation and Stability2010，96，： | 1 |
| 17 | Nanoemulsion formation by emulsion phase inversion显示文摘 | Fernandez Patrick André Valérie | 2004 | Colloids and Surfaces A:Physicochemical and Engineering Aspects2004，251，13： | 1 |
| 18 | Probabilistic failure assessment of ferritic steels using the master curve approach including constraint effects显示文摘 | Jorg H Jochen H Valérie F | 2007 | Engineering Fracture Mechanics2007，74，： | 1 |
| 19 | Pharmaceutical applications of chitosan显示文摘 | Vilivalam vinod D Dodane Valérie | 1998 | Pharmaceutical Science&Technology Today1998，1，6： | 1 |
| 20 | Anaesthetic binding sites for etomidate and propofol on a GABA A receptor model显示文摘 | Valérie Campagna-Slater Donald F. Weaver | 2007 | Neuroscience Letters2007，，1： | 1 |
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