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| 1 | Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus显示文摘Diabetes mellitus(DM) is the third most common noninfectious disease leading to early disability and high mortality. Moreover, the number of patients is growing every year. The main symptom of DM is hyperglycemia. Increased levels of blood glucose activate polyol, hexosamine, and protein kinase metabolic pathways cause the intensification of non-enzymatic glycosylation and nitration of macromolecules. This, in turn, leads to the development of oxidative and nitrative stresses and secondary complications, such as different kinds of microand macroangiopathies. Metabolic disorders caused by insulin deficiency in diabetes significantly impede the functioning of a homeostasis system, which change the physical, biochemical, morphological, and functional properties of blood cells. As a result, the oxygen-transport function of red blood cells(RBCs), rheological properties of the blood, and functions of immunocompetent cells as well as the process of apoptosis are primarily affected. Modern pharmacotherapy focuses on the search for new preparations that aim to decrease blood glucose levels. Undesirable side effects and adverse reactions caused by synthetic medicines led to the search and investigation of new preparations of natural origin. Medicinal mushrooms play an important role among such new preparations. They are a source of a large number of high-and lowmolecular compounds with pronounced biological effects. Our investigations show pronounced hypoglycemic and anti-anemic action of submerged cultivated mycelium powder of medicinal mushrooms Agaricus brasiliensis(A. brasiliensis) and Ganoderma lucidum(G. lucidum) on streptozotocin-induced DM in rats. Also, we showed that mycelium powders have membrane protective properties as evidenced by the redistribution of RBC populations towards the growth of full functional cell numbers. Normalization of parameters of leukocyte formula and suppression of apoptosis of white blood cells in diabeticrats treated with A. brasiliensis and G. lucidum mycelia indicates pronounced positive effects of these strains of mushrooms. Thus, the use of medicinal mushrooms for treatment of DM and in prevention development of its secondary complications might be a new effective approach of this disease's cure. This article is aimed at summarizing and analyzing the literature data and basic achievements concerning DM type 1 treatment using medicinal mushrooms and showing the results obtained in our research. | Taras Vitak Borys Yurkiv Solomon Wasser Eviatar Nevo Natalia Sybirna | 2017 | World Journal of Diabetes2017，8，5： | 6 |
| 2 | Mammography service screening and mortality in breast cancer patients :20 -year follow- up before and after introduction of screening 显示文摘 | Tabar L Yen MF Vitak B | 2003 | Lancet2003，361，： | 1 |
| 3 | Swedish two-county trial: impact of mammographic screening on breast cancer mortality during 3 decades显示文摘 | TABAR L VITAK B CHEN T H | 2011 | Radiology2011，260，3： | 1 |
| 4 | The natural history of breastcar- cinoma: what have we learned from screening?显示文摘 | Tabar L Duffy SW Vitak B | 1999 | Cancer1999，86，： | 1 |
| 5 | Personal internet use at work: understanding cyberslacking 显示文摘 | VITAK J CROUSE J LAROSE R | 2011 | Computers in Human Behavior2011，，27： | 1 |
| 6 | The natural history of breast carcinoma: what have we learned from screening 显示文摘 | Tabar L Duffy SW Vitak B | 1999 | Cancer1999，86，3： | 1 |
| 7 | Mammography service screening and mortality in breast cancer patients: 20-year follow-up before and after introduction of screening 显示文摘 | Tabar L Yen MF Vitak B | 2003 | Lancet2003，361，9367： | 1 |
| 8 | Beyond randomized controlled trials:organized mammographic screening substantially reduces breast carcinoma mortality显示文摘 | Tabar L Vitak B Chen HH | 2001 | Cancer2001，91，9： | 1 |
| 9 | Student Use of Facebook for Organizing Collaborative Classroom Activities显示文摘 | Lampe C Wohn D Y Vitak J | 2011 | International Journal of Computersupported Collaborative Learning2011，，6： | 1 |
| 10 | Time-ependent effects on survival in breast carcinoma: results of 20 years of follow-up from the Swedish Two-County Study 显示文摘 | Warwick J Tabar L Vitak B | 2004 | Cancer2004，100，7： | 1 |
| 11 | The natural history of breast carcinoma: What have we learned from screening显示文摘 | Duffy SW Vitak B | 1999 | Cancer1999，86，3： | 1 |
| 12 | Examining Social Adjustment to College in the Age of Social Media: Factors Influencing Successful Transitions and Persistence 显示文摘 | Gray R Vitak J Easton E W | 2013 | Computers & Education2013，67，： | 1 |
| 13 | Beyond randomized controlled trials: organized mammographic screening substantially reduces breast carcinoma mortality显示文摘 | TabOr L Vitak B Chen HH | 2001 | J Nail Cancer2001，91，9： | 1 |
| 14 | Beyond randomized controlled trials:organized mammographic screening substantially reduces breast cancer mortality显示文摘 | TABAR L VITAK B TONY H H | 2001 | Cancer2001，91，9： | 1 |
| 15 | The natural history of breast carcinoma:what have we learned from screening显示文摘 | Tabár L Duffy SW Vitak B | 1999 | Cancer1999，86，3： | 1 |
| 16 | Mammography sereening andmortality in breast cancer patients:20-year follow-up before andafter introduction of screeing显示文摘 | Tabar L Yen MF Vitak B | 2003 | Lancet2003，361，9367： | 1 |
| 17 | Beyond randomized controlled trials: organized ma-mmographic screening Substantially reduces breast carcinoma mortality 显示文摘 | Tabar L Vitak B Tony HH | 2001 | Cancer2001，91，9： | 1 |
| 18 | Beyond randomized controlled trials: organized mammographic screening substantially reduces breast carcinoma mortality 显示文摘 | Vitak B Tony HH | 2001 | Cancer2001，91，9： | 1 |
| 19 | Time-dependent effects on survival in breast carcinoma:results of 20 years of follow-up from the Swedish two-country显示文摘 | Warwick J Tabar L Vitak B | 2004 | Cancer2004，100，7： | 1 |
| 20 | Beyond randomized controlled trials: organized mammographic screening substantially reduces breast carcinoma mortality显示文摘 | TABAR L VITAK B CHEN H H | 2001 | Cancer2001，91，9： | 1 |
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