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| 1 | 甘草中光甘草定的提取和抗氧化活性研究显示文摘从光果甘草(Glycyrrhiza glabra L.)丙酮提取物中分离得到黄酮类单体成分-光甘草定(Glabridin),并对其抗氧化生物活性进行观察研究。以肝脏微粒体中的细胞色素P450/NADPH氧化系统作为体外抗氧化实验模型。微粒体中自由基诱发程度由探针物DCFH-DA的氧化产物DCF的浓度进行检测。以银杏叶提取物EGB761用作阳性对照物。结果显示,光甘草定以0.10,0.25和0.5 mg/mL浓度,分别抑制自由基浓度67%、73%和83%。在较低浓度时,其抗氧化活性强度与EGB761类似。以上结果说明,光甘草定在细胞色素P450/NADPH氧化系统中具有强抗自由基氧化作用。 | 木合布力.阿布力孜 热娜.卡斯木 马淑燕 Vincent loppinet Gérard siest | 2007 | 天然产物研究与开发2007，19，4： | 27 |
| 2 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 3 | Sphincter of Oddi dysfunction: Managing the patient with chronic biliary pain显示文摘Oddi 机能障碍(草皮) 的括约肌由于在 Oddi 的括约肌的水平的 pancreaticobiliary 流动的功能的阻塞是长期的胆汁的疼痛或周期性的胰腺炎的症候群。Milwaukee 分类成层病人根据他们的临床的图画基于腹的疼痛的提高的肝酶,扩大胆总管和存在。类型我病人们象反常的肝酶和扩大胆总管一样有疼痛。类型 II 草皮由疼痛和仅仅发现的一个目的组成,并且类型 III 仅仅由胆汁的疼痛组成。这个分类是有用的指导 Oddi 机能障碍的括约肌的诊断和管理。为诊断的当前的标准答案是测压法检测提高的括约肌压力,它与结果相关到括约肌切开术。然而,测压法不是广泛地可得到的并且是有胰腺炎的风险的一个侵略过程。包括丰满的饭 ultrasonography 和 scintigraphy,非侵略的测试方法与压力计的调查结果显示出有限关联,但是可能在预言结果到括约肌切开术有用。波特淋毒素的内视镜的注射嗯毒素出现到预言随后的结果到括约肌切开术,并且能在为治疗的病人的选择有用,特别在测压法是无法获得的背景。 | Lana Bistritz Vincent G Bain | 2006 | World Journal of Gastroenterology2006，12，24： | 19 |
| 4 | Physical rehabilitation for lung transplant candidates and recipients: An evidence-informed clinical approach显示文摘Physical rehabilitation of lung transplant candidates and recipients plays an important in optimizing physical function prior to transplant and facilitating recovery of function post-transplant. As medical and surgical interventions in lung transplantation have evolved over time, there has been a demographic shift of individuals undergoing lung transplantation including older individuals, those with multiple co-morbidites, and candidates with respiratory failure requiring bridging to transplantation. These changes have an impact on the rehabilitation needs of lung transplant candidates and recipients. This review provides a practical approach to rehabilitation based on research and clinical practice at our transplant centre. It focuses on functional assessment and exercise prescription during an uncomplicated and complicated clinical course in the pre-transplant, early and late post-transplant periods. The target audience includes clinicians involved in pre- and posttransplant patient care and rehabilitation researchers. | Lisa Wickerson Dmitry Rozenberg Tania Janaudis-Ferreira Robin Deliva Vincent Lo Gary Beauchamp Denise Helm Chaya Gottesman Polyana Mendes Luciana Vieira Margaret Herridge Lianne G Singer Sunita Mathur | 2016 | World Journal of Transplantation2016，6，3： | 8 |
| 5 | 美国苹果砧木育种历史、现状及其商业化砧木特性显示文摘综述美国苹果砧木的育种历史和现状,简介美国选育的苹果砧木特性,以期为我国苹果砧木的选育提供参考。美国从1968年开始苹果砧木育种,早期进行了资源的广泛评价和筛选,随后根据美国具体气候条件,将育种目标主要定为矮化和半矮化、抗火疫病、抗颈腐病、抗苹果绵蚜、抗重茬、早产丰产等,杂交后代进行深入、多层次的评价和筛选,最终成功选育出目前商业化和科研应用较广泛、已申请专利的14个苹果砧木品种,包括1个极矮化砧木、5个矮化砧木、8个半矮化砧木。主要特性:树体本身为小灌木,抗火疫病和苹果绵蚜,耐颈腐病和重茬,易繁殖;嫁接品种后致矮、早实丰产。可见,美国在矮化砧木选育之前的评价筛选及选育后的鉴定方面都具有系统的手段和方法,为苹果砧木选育的重要部分,可以作为我国苹果砧木育种的参考。 | 王大江 Bus Vincent G M 王昆 高源 赵继荣 刘立军 李连文 朴继成 | 2018 | 中国果树2018，0，6： | 7 |
| 6 | Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial显示文摘 | Ian M Gralnek Peter D Siersema Zamir Halpern Ori Segol Alaa Melhem Alain Suissa Erwin Santo Alan Sloyer Jay Fenster Leon M G Moons Vincent K Dik Ralph B D’Agostino Douglas K Rex | 2014 | Lancet Oncology2014，，3： | 6 |
| 7 | Impact of Preoperative Ureteral Stenting on Outcome of Ureteroscopic Treatment for Urinary Lithiasis显示文摘 | John M. Shields Vincent G. Bird Reid Graves Orlando Gómez-Marín | 2009 | The Journal of Urology2009，，6： | 3 |
| 8 | Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor显示文摘 | Vincent K A Shyu K G Luo Y | 2000 | Circulation2000，102，18： | 2 |
| 9 | Use of discrete fourier transform in the measurement of frequencies and levels of tones显示文摘 | Rife D C Vincent G A | | 0，，02： | 2 |
| 10 | Postoperative impairment mucous transport in the lung 显示文摘 | Gamsu G Singer M M Vincent H H | 1976 | Am Rev Respir Dis1976，114，： | 2 |
| 11 | Spatial and seasonal variations in soil respiration in a temperate deciduous forest with fluctuating water table显示文摘 | Vincent G Shahriari A R | 2006 | Soil Biology&Biochemistry2006，38，9： | 1 |
| 12 | Characterisation of dirithromycin and spiramyein using high performance liquid chromatography and direct infusion mass spectrometry显示文摘 | DE LA HUEBRA M J G VINCENT U BORDIN G | 2004 | Anal Chim Acta2004，503，2： | 1 |
| 13 | Minimizing interceptor size using neural networks for terminal guidance law synthesis显示文摘 | Gottell R G Vincent T L Sadati S H | 1996 | Journal of Guidance Control and Dynamics1996，19，3： | 1 |
| 14 | Optimal definition for PWI/DWI mismatch in acute ischemicstroke patients Journal of Cerebral Blood Flow&Metabolism显示文摘 | Wataru Kakuda Maarten G Lansherg Vincent N Thijs | 2008 | 28:8872008，28，： | 1 |
| 15 | Outcome of transurethral prostatectomy for the palliative management of lower urinary tract symptoms in men with prostate cancer显示文摘 | Vincent J G Vinod K David L | 2006 | Int J Urol2006，13，6： | 1 |
| 16 | FAS associatedphosphatase (FAP-1) block apoptosis of astrocytomas throughdephosphorylation of FAS 显示文摘 | Foehr ED Lomete G Vincent V | 2005 | J Nerooncol2005，74，3： | 1 |
| 17 | Antifilaggrin autoanti bodies in early rheumatoid arthritis 显示文摘 | Forslind K Vincent C Serre G | 2000 | Scand J Rheumatol2000，29，5： | 1 |
| 18 | Ossiculoplasty in missing malleus and stapes patients:experimental and preliminary clinical results with a new malleus replacement prosthesis with the otology-neurotology database显示文摘 | Vincent R Bittermann AJ Wenzel G | 2013 | Otol Neurotol2013，34，1： | 1 |
| 19 | Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient 显示文摘 | Stephen A Robert G Vincent W | 2009 | Journal of Parenteral and En- teral Nutrition2009，33，3： | 1 |
| 20 | Orphan nuclear receptors: from gene to function显示文摘 | Vincent G | 1999 | Endo Rev1999，20，5： | 1 |
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