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| 1 | Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans显示文摘AIM:To assess the risk of biliary and pancreatic cancers in a large cohort of patients with type 2 diabetes mellitus(DM) .METHODS:Eligibility for this study included patients with type 2 DM(ICD-9 code 250.0) who were discharged from Department of Veteran Affairs hospitals between 1990 and 2000.Non-matched control patients without DM were selected from the same patient treatment files during the same period.Demographic information included age,sex and race.Secondary diagnoses included known risk factors based on their ICD-9 codes.By multivariate logistic regression,the occurrence of biliary and pancreatic cancer was compared between case subjects with DM and controls without DM.RESULTS:A total of 1172496 case and control subjects were analyzed.The mean age for study and control subjects was 65.8 ± 11.3 and 64.8 ± 12.6 years,respectively.The frequency of pancreatic cancer in subjects with DM was increased(0.9%) in comparison to control subjects(0.3%) with an OR of 3.22(95% CI:3.03-3.42) .The incidence of gallbladder andextrahepatic biliary cancers was increased by twofold in diabetic patients when compared to controls.The OR and 95% CI were 2.20(1.56-3.00) and 2.10(1.61-2.53) ,respectively.CONCLUSION:Our study demonstrated that patients with DM have a threefold increased risk for developing pancreatic cancer and a twofold risk for developing biliary cancer. | M Mazen Jamal Eugene J Yoon Kenneth J Vega Mehrtash Hashemzadeh Kenneth J Chang | 2009 | World Journal of Gastroenterology2009，15，42： | 10 |
| 2 | Neuroendocrine tumors of the gastrointestinal tract: Case reports and literature review显示文摘Neuroendocrine tumors(NET)previously called carcinoid tumors are neoplasms of enterochromaffin/neuroendocrine cell origin which display neurosecretory capacity that may result in the carcinoid syndrome.The annual incidence of patients with NET is 8.4 per 100000;yet many NET remain asymptomatic and clinically undetected.A majority of NET follows a benign course;however,some will display malignant characteristics.NET most commonly occur in the gastrointestinal tract(67%)and bronchopulmonary system(25%).Gastrointestinal NET occur within the stomach,small intestine,liver,and rectum.We report a retrospective study of 11 subjects:Eight with benign carcinoid tumors:duodenal bulb(n=2),terminal ileum(n=1),sigmoid colon(n=2),and rectum(n=3);three with malignant carcinoid:liver(n=1)and intra-abdominal site(n=2).The diagnosis,endoscopic images,outcome,treatment and review of the literature are presented. | William J Salyers Kenneth J Vega Juan Carlos Munoz Bruce W Trotman Silvio S Tanev | 2014 | World Journal of Gastrointestinal Oncology2014，6，8： | 8 |
| 3 | Comparison of reflux esophagitis and its complications between African Americans and non-Hispanic whites显示文摘AIM: To determine the effect of ethnicity on the severity of reflux esophagitis (RE) and its complications. METHODS: A retrospective search of the endoscopy database at the University of Florida Health Science Center/Jacksonville for all cases of reflux esophagitis and its complications from January 1 to March 31, 2001 was performed. Inclusion criteria were endoscopic evidence of esophagitis using the LA classif ication, reflux related complications and self-reported ethnicity. The data obtained included esophagitis grade, presence of a hiatal hernia, esophageal ulcer, stricture and Barrett's esophagus, and endoscopy indication. RESULTS: The search identified 259 patients with RE or its complications, of which 171 were non-Hispanic whites and 88 were African Americans. The mean ages and male/female ratios were similar in the two groups. RE grade, esophageal ulcer, stricture and hiatal hernia frequency were likewise similar in the groups. Barrett's esophagus was present more often in non-Hispanic whites than in African Americans (15.8% vs 4.5%; P < 0.01). Heartburn was a more frequent indication for endoscopy in non-Hispanic whites with erosive esophagitis than in African Americans (28.1% vs 7.9%; P < 0.001). CONCLUSION: Distribution of RE grade and frequency of reflux-related esophageal ulcer, stricture andhiatal hernia are similar in non-Hispanic whites and African Americans. Heartburn was more frequently and nausea/vomiting less frequently reported as the primary endoscopic indication in non-Hispanic whites compared with African Americans with erosive esophagitis or its complications. African Americans have a decreased prevalence of Barrett's esophagus compared with non-Hispanic whites. | Kenneth J Vega Sian Chisholm M Mazen Jamal | 2009 | World Journal of Gastroenterology2009，15，23： | 4 |
| 4 | Intestinal stem cells and the colorectal cancer microenvironment显示文摘Colorectal cancer(CRC)remains a highly fatal condition in part due to its resilience to treatment and its propensity to spread beyond the site of primary occurrence.One possible avenue for cancer to escape eradication is via stem-like cancer cells that,through phenotypic heterogeneity,are more resilient than other tumor constituents and are key contributors to cancer growth and metastasis.These proliferative tumor cells are theorized to possess many properties akin to normal intestinal stem cells.Not only do these CRC'stem'cells demonstrate similar restorative ability,they also share many cell pathways and surface markers in common,as well as respond to the same key niche stimuli.With the improvement of techniques for epithelial stem cell identification,our understanding of CRC behavior is also evolving.Emerging evidence about cellular plasticity and epithelial mesenchymal transition are shedding light onto metastatic CRC processes and are also challenging fundamental concepts about unidirectional epithelial proliferation.This review aims to reappraise evidence supporting the existence and behavior of CRC stem cells,their relationship to normal stem cells,and their possible dependence on the stem cell niche. | Bryan A Ong Kenneth J Vega Courtney W Houchen | 2014 | World Journal of Gastroenterology2014，20，8： | 2 |
| 5 | Gastrointestinal Kaposi's sarcoma: Case report and review of the literature显示文摘Kaposi's sarcoma(KS) of the gastrointestinal tract is not an uncommon disease among individuals with acquired immunodeficiency syndrome(AIDS). The majority is asymptomatic, and for this reason, gastrointestinal KS(GI-KS) remains undiagnosed. With continued tumor growth, considerable variation in clinical presentation occurs including abdominal pain, nausea, vomiting, iron deficiency anemia(either chronic or frank gastrointestinal bleeding), and rarely mechanical obstruction alone or combined with bowel perforation. Endoscopy with biopsy allows for histological and immunohistochemical testing to confirm the diagnosis of GI-KS among those with clinical symptoms. In previous studies, dual treatment with highly active antiretroviral therapy and systemic chemotherapy have been associated with improved morbidity and mortality in individuals with visceral KS. Therefore, investigators have suggested performing screening endoscopies in select patients for early detection and treatment to improve outcome. In this review, we describe a 44 years old man with AIDS and cutaneous KS who presented for evaluation of postprandial abdominal pain, vomiting, and weight loss. On upper endoscopy, an extensive, infiltrative,circumferential, reddish mass involving the entire body and antrum of the stomach was seen. Histologic examination later revealed spindle cell proliferation, and confirmatory immunohistochemical testing revealed human herpes virus 8 latent nuclear antigen expression consistent with a diagnosis of gastric KS. Following this, we present a comprehensive review of literature on KS with emphasis on gastrointestinal tract involvement and management. | Ann Joo Lee Lacie Brenner Bashar Mourad Carmela Monteiro Kenneth J Vega Juan Carlos Munoz | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，3： | 2 |
| 6 | Phytoplankton structure and dynamics in Lake Sanabria and Valparaiso reservoir (NW Spain)显示文摘 | Negro A I Hoyos C D Vega J | 2000 | Hydrobiologia2000，424，： | 1 |
| 7 | Behavior of brain perfusion with SPECT tomography 99mTc ethylene dicysteine (ECD) in alcohol and cocaine dependents during abstinence显示文摘 | Pallavicini Gonzalez J Massardo Vega T Arancibia Soto P | 2002 | Rev Esp Med Nucl2002，21，6： | 1 |
| 8 | Perform ance of a LiBr-water absorption chiller operating with plate heat exchangers 显示文摘 | M de Vega J A Almendros-Iba flez G Ruiz | 2006 | Energy Conversion and Management2006，47，： | 1 |
| 9 | Retent ion of heavymetal ions in bentonites from Grau Reg ion (North crn Peru) 显示文摘 | AYALA J VEGA J L ALVAREZ R | 2008 | Environmental Geology2008，53，6： | 1 |
| 10 | Characterization of urinary tract symptoms and quality of life in patients with double pig tailed ureteral stents显示文摘 | Vega Vega A Garcia Alonso D Garcia Alonso C J | 2007 | Actas Urol Esp2007，31，7： | 1 |
| 11 | Graftversus-host disease,an eight case report and literature review 显示文摘 | de la Rosa Garcia E Bologna Molina R Vega Gonzflez Tde J | 2006 | Med Oral Patol Oral Cir Bucal2006，11，6： | 1 |
| 12 | Emergence of imipenem resistance in clinical Escherichia coli during therapy显示文摘 | Oteo J Delgado·lribarren A Vega D | 2008 | Int J Antimicrob Agents2008，32，6： | 1 |
| 13 | First report of bacterial blight caused by Pseudomonas viridiflava on pea in Spain显示文摘 | Martin-Sanz A Palomo J L Perez de la Vega M | 2010 | Plant Disease2010，94，1： | 1 |
| 14 | Emergence of imipenem resistance in clinical Escherichia coli during thera- py显示文摘 | Oteo J Delgado-Iribarren A Vega D | 2008 | Int Jantimicrob Agents2008，32，6： | 1 |
| 15 | Interactions between simvastatin and troglitazone or pioglitazone in healthy subjects 显示文摘 | Vega JM Zhao J etal | 2001 | J Clin Pharmacol2001，41，5： | 1 |
| 16 | Post-veraison sunlight exposure induces MYB-mediated transcriptional regulation of anthocyanin and flavonol synthesis in berry skins of Vitis vinifera显示文摘 | Matus J T Loyola R Vega A | 2009 | J Exp Bot2009，60，3： | 1 |
| 17 | Antigenic characterization of bovine viral diarrhoea virus isolates from spain with a panel of monoclonal antihodies显示文摘 | Vega S Rosell R Paton D J | 2000 | J Vet Med2000，47，： | 1 |
| 18 | Monitoring of pesticides in agricultural water and soil samples from Andalusia by liquid chromatography coupled to mass spectrometry 显示文摘 | Belmonte Vega A Garrido Frenich A Martfnnez Vidal J L | 2005 | Analytical Chimica Acta2005，538，： | 1 |
| 19 | A nonparametric VSS NLMS algorithm 显示文摘 | BENESTY J REY H VEGA L R | 2006 | IEEE Signal Processing Letters2006，13，： | 1 |
| 20 | The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution显示文摘 | Calvo D Dopazo J Vega MA | 1995 | Genomics1995，25，1： | 1 |
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