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| 1 | Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3显示文摘AIM: To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 (STAT3) activity in hepatocellular carcinoma (HCC).METHODS: Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation were assessed. Potential molecular mechanisms of STAT3 pathway inhibition by sorafenib were evaluated. In vivo antitumor action and STAT3 inhibition were investigated in an immunocompetent orthotopic rat HCC model.RESULTS: Sorafenib decreased STAT3 phosphorylationat the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phosphatase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Dephosphorylation of S727 was associated with attenuated extracellular signal-regulated kinase (ERK) phosphorylation, similar to the effects of a mitogen-activated protein kinase (MEK) inhibitor U0126, suggesting that sorafenib induced S727 dephosphorylation by inhibiting MEK/ERK signaling. Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway. Finally, in the rat HCC model, sorafenib signifi cantly inhibited STAT3 activity, reducing tumor growth and metastasis.CONCLUSION: Sorafenib inhibits growth and metastasis of HCC in part by blocking the MEK/ERK/STAT3 and PI3K/Akt/STAT3 signaling pathways, but independent of JAK2 and SHP2 activation. | Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian ZhouFang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian Zhou, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai 200032, China Author contributions: Gu FM, Li QL and Gao Q contributed equally to this work Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis Zhou J and Gao Q contributed to the conception and design of the study Gu FM, Gao Q, Li QL and Zhou J wrote the manuscript Jiang JH, Huang XY, Pan JF and Fan J made substantial contri- bution to the design and conception of the study and interpreta- tion of data all authors read and approved the f inal manuscript. | 2011 | World Journal of Gastroenterology2011，17，34： | 18 |
| 2 | Research on Benefit Distribution Mechanism of Farmers’ Specialized Cooperative Economic Organization显示文摘On the basis of conducting survey in Jiaonan City,the thesis analyzes benefit distribution mechanism of farmers’ specialized cooperative economic organizations:firstly,the benefit correlation is mainly the contract correlation;secondly,the profit distribution is mainly the dividend;thirdly,patronage refund has many connotations;fourthly,the public accumulation has not yet been quantified to individual;fifthly,the government support capital is ill-defined.Based on these,the measures are put forward in order to improve benefit distribution pattern of farmers’ specialized cooperative economic organizations:firstly,reform structure of property rights and realize farmers’ ownership;secondly,change mode of decision-making,and realize farmers’ control;thirdly,increase turnover rebate and realize farmers’ benefiting;fourthly,quantify public accumulation and government support fund. | SUN Hao-jie1,WANG Zheng-bing2,WANG Yun-hui3 1.School of Economics and Management,Chang’ an University,Xi’an 710064,China 2.College of Economics and Management,Northwest A & F University,Yangling 712100,China 3.Publicity Office of Party Committee,Xi’an Branch of the People’ Bank of China,Xi’an 710064,China | 2011 | Asian Agricultural Research2011，3，4： | 5 |
| 3 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 4 | Quality control measures for lowering the seroconversion rate of hemodialysis patients with hepatitis B or C virus显示文摘BACKGROUND: Hemodialysis (HD) patients are at high risk of infection by hepatitis B virus (HBV) or hepatitis C virus (HCV). The present study was designed to determine the impact of quality control measures on the prevention of transmission of blood-borne viruses. METHODS: A total of 6182 adult maintenance HD patients from all HD units in Zhejiang Province were recruited on January 1, 2007. The baseline demographic and clinical characteristics were recorded and all patients were followed up until death or survival at 4 years later. The Quality Control Standards of Hemodialysis were gradually implemented in HD units. The HBV or HCV seroconversion rates of the recruited patients were calculated and compared every year during the observation period. RESULTS: The prevalence of HBV was 8.3% at the beginning of the study, and 6.6% for HCV. With the implementation of the HD quality control measures, the HBV seroconversion rate tended to decrease year by year (χ 2 =6.620, P=0.085), and the HCV seroconversion rate decreased significantly (χ 2 =10.41, P=0.015). Compared with the data in 2007, the HBV seroconversion rate (χ 2 =4.204, P=0.040, relative risk ratio 0.393, 95% CI 0.156-0.991) and the HCV seroconversion rate (χ 2 =7.373, P=0.007, relative risk ratio 0.386, 95% CI 0.189-0.787) decreased significantly in 2010. CONCLUSION: Quality control measures for HD decreased the seroconversion rates of HBV or HCV in HD patients, showing that updated quality control measures reduce the risk for transmission of blood-borne viruses in the HD population. | Jing Yuan,Yi Yang, Fei Han, Ping Zhang, Xiao-Ying Du, Hua Jiang and Jiang-Hua Chen The Kidney Disease Center, First Affiliated Hospital, Zhejiang University School of Medicine (Yuan J, Yang Y, Han F, Zhang P, Du XY, Jiang H and Chen JH) and Hemodialysis Quality Control Center of Zhejiang Province (Yuan J, Zhang P, Du XY and Chen JH), Hangzhou 310003, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 2 |
| 5 | Lates polyamine and proline metabolismin leaves of Medicago avancat/aLa plants 显示文摘 | Panagiota F Chrystalla A Vasileios E The nitricoxide donor sodium nitroprusside regp | 2013 | Free Radic Biol Med2013，56，： | 1 |
| 6 | patient with multiple sclerosis显示文摘 | Valsasina P Rocca MA Agosta F Mean diffusivity and frac- tional anisotropy histograms of the cervical cord in MS patients | 2005 | Neuroimage2005，26，3： | 1 |
| 7 | A role for gene Myf5 in adult regenerative myogenesis显示文摘 | Gayraud-Morel B Chretien the myogenic determination F Flamant P | 2007 | Dev Biol2007，312，1： | 1 |
| 8 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lüddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 9 | cell makeover rather than cell death显示文摘 | Cecconi F Levine B The role of autophagy in mammalian develop-ment | 2008 | Dev Cell2008，15，： | 1 |
| 10 | Cost- t of ventilator- associated pneumonia with linezolid or vancomycin in Spain显示文摘 | Grau S Alvarez-Lerma F del Castillo effectiveness analysis of the treatmen A | 2005 | J Chemother2005，17，2： | 1 |
| 11 | Stimulation of the vagus nerve attenuates macro- phage activation by activating the Jak2-STAT3 signa- ling pathway显示文摘 | DE JONGE W J DER ZANDEN EP V THE F O | 2005 | Nat Immunol2005，6，： | 1 |
| 12 | 查看详情显示文摘 | Song S D Zou X L Giruzzi G Xiao W W Ding X T Ding B J Ségui J L Elbèze D Clairet F Fenzi C Aniel T Artaud J F Basiuk V Bouquey F Magne R Corbel E the Tore Supra Team | | 0，，： | 1 |
| 13 | Undrained cavity expansion in modified Cam clay I:Theoretical analysis显示文摘 | CAO L F THE C I CHANG M F | 2001 | Geotechnique2001，51，4： | 1 |
| 14 | Diagnosis and management of cerebral venous thrombosis: a statement for heatthcare professionals from the American Heart Association/American Stroke Association 显示文摘 | Saposmk G Barinagarrementeria F Brown RD Jr American Heart Association Stroke Council and the Council on Epidemiology and Prevention | 2011 | Stroke2011，42，4： | 1 |
| 15 | Mierocell nucleation显示文摘 | Baldwin D F Park C B Sub N E A microcellular processing study of poly(ethylene terephthalate) in the amorphous and semicrystalline states: Part I | 1996 | Polym Eng Sci1996，36，11： | 1 |
| 16 | Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure 显示文摘 | Jalan R Saliba F Pavesi M CANONIC study investigators of the EASL-CLIF Consortium | 2014 | J Hepatol2014，61，5： | 1 |
| 17 | Innovative behavior in the of performance and image out- come expectations显示文摘 | Yuan F Woodman R workplace: The role W | 2010 | Academy of Management Jour- nal2010，53，2： | 1 |
| 18 | of infantile laryngotracheal haemangioma 显示文摘 | Denoyelle F Leboulanger N Enjolras O Role of propranolol in the therapeutic strategy | 2009 | Int J Pediatr Otorhinolaryngo12009，73，8： | 1 |
| 19 | Pro up regulation: a diagn illicit use of oestrog ens in adult beef cattle显示文摘 | Divari S Mulasso C Spada F De Maria R gesterone receptor ostic tool for the Uslenghi F Cannizzo FT Brina N Biolatti B | 2011 | Tumour Biol2011，28，12： | 1 |
| 20 | Amiodarone interaction with beta-blockers: analysis of the merged EMIAT and CAMIAT databases显示文摘 | Boissel JP Connolly SJ and the EMIAT and CAMIAT investigators | 1999 | Circulation1999，99，： | 1 |
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