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| 1 | Idarubicin vs doxorubicin in transarterial chemoembolization of intermediate stage hepatocellular carcinoma显示文摘BACKGROUND Liver cancer is the fifth most common cancer and the second cause of cancerrelated deaths worldwide.Transarterial chemoembolization(TACE)is the best treatment of intermediate hepatocellular carcinoma(HCC).Doxorubicin is the most commonly used drug despite a low level of evidence.AIM To compare the objective response rate of idarubicin-based TACE(Ida-TACE)against doxorubicin-based TACE(Dox-TACE)in intermediate stage HCC.METHODS Between January 2012 and December 2014,all patients treated with TACE at our academic hospital were screened.Inclusion criteria were patients with Child-Pugh score A or B,a performance status below or equal to 1,and no prior TACE.Either lipiodol TACE or drug-eluting beads TACE could be performed with 10 mg of idarubicin or 50 mg of doxorubicin.Each patient treated with idarubicin was matched with two doxorubicin-treated patients.The TACE response was assessed by independent radiologists according to the mRECIST criteria.RESULTS Sixty patients were treated with doxorubicin and thirty with idarubicin.There were 93%and 87%of cirrhotic patients and 87%and 70%of Child-Pugh A in the doxorubicin and idarubicin groups,respectively.The median number of HCC per patient was two in both groups with 31%and 26%of single nodules in doxorubicin and idarubicin groups,respectively.Objective response rate after first TACE was 76.7%and 73.3%(P=0.797)with 41.7%and 40.0%complete response in doxorubicin and idarubicin groups,respectively.Progression-free survival was 7.7 mo in both groups,and liver transplant-free survival was 24.9 mo and 21.9 mo in doxorubicin and idarubicin groups,respectively.Safety profiles were similar in both groups,with grade 3-4 adverse events in 35%of Dox-TACE and 43%of Ida-TACEs.CONCLUSION Ida-TACE and Dox-TACE showed comparable results in terms of efficacy and safety.Ida-TACE may represent an interesting alternative to Dox-TACE in the management of patients with intermediate stage HCC. | Gael Stephane Roth Yann Teyssier Melodie Abousalihac Arnaud Seigneurin Julien Ghelfi Christian Sengel Thomas Decaens | 2020 | World Journal of Gastroenterology2020，26，3： | 3 |
| 2 | Cell cycle regulation after exposure to ionizing radiation 显示文摘 | Teyssier F Bay JO Dionet C | 1999 | Bull Cancer1999，86，4： | 1 |
| 3 | Testing for Bubbles and Change-Points显示文摘 | TEYSSIERE G | 2005 | Journal of Economic Dynamics & Control2005，29，4： | 1 |
| 4 | Functional analysis of the ClpATPase ClpA of Brucella suis, and persistence of a knockout mutant in BALB/c mice显示文摘 | Ekaza E Guilloteau L Teyssier J | 2000 | Microbiology2000，146，： | 1 |
| 5 | Over-expression of MDR1 gene withy no DNA amplification in a multiple-drug-resistant human ovarian carcinoma c ell line 显示文摘 | Da Silva J Teyssier JR | 1989 | Int J Cancer1989，43，3： | 1 |
| 6 | Cell cycle regulation agents exposure to ionizing radiation显示文摘 | Teyssier F Bay JO Dionet C | 1999 | Bull Cancer1999，86，4： | 1 |
| 7 | Economies of Scale and Economies of Diversification in Insurance Business:Some Elements of Valuation 显示文摘 | Teyssier R | 1991 | Geneva Papers on Risk and Insurance-Issues and Practice1991，16，60： | 1 |
| 8 | Rescaled variance and related tests for long memory in volatility and levels显示文摘 | Giraitis L Kokoszkab P Leipusc R Teyssiere G | 2003 | Journal of Econometrics2003，112，： | 1 |
| 9 | Strain modeling of displacement-field partitioning in transpressional orogens显示文摘 | TIKOFF B TEYSSIER C | 1994 | Journal of Structural Geology1994，16，： | 1 |
| 10 | Gravitational collapse of the continental crust: definitions, regimes, mechanismsand modes 显示文摘 | Rey P Vanderhaeghe O Teyssier C | 2001 | Tectonophysics2001，342，： | 1 |
| 11 | Participation of the molecular chaperone DnaK in intracellular growth of Brucella suis within U937-derived phagocytes显示文摘 | Kohler S Teyssier J Cloeckaert A | 1996 | Mol Microbiol1996，20，： | 1 |
| 12 | Relationship between cord blood vitamin D level and group B Streptococcus vaginal carriage rate in pregnant women显示文摘 | Chhin D Pozzetto B Teyssier G | 2013 | e-SPEN Journal2013，8，： | 1 |
| 13 | Palaeostress stratigraphy: a new technique for analyzing tectonic control on sedimentary-basin subsidence显示文摘 | KLEINSPEHN K PERSHING J TEYSSIER C | 1989 | Geology1989，17，： | 1 |
| 14 | Effect of onion consumption by rats on hepatic drug-metabolizing enzymes显示文摘 | Teyssier C Amiot MJ Mondy N | 2001 | Food Chem Toxicol2001，39，10： | 1 |
| 15 | Role of protein methylation in regulation of transcription 显示文摘 | Lee DY Teyssier C Strahl BD | 2005 | Endocr Rev2005，26，2： | 1 |
| 16 | Self-selection and the Efficiency of Tournaments 显示文摘 | Eriksson T Teyssier S Villeval M C | 2009 | Economic Inquiry2009，47，3： | 1 |
| 17 | Fabric stability in oblique convergence and divergence显示文摘 | TEYSSIER C TIKOFF B | 1999 | Journal of Structural Geology1999，21，： | 1 |
| 18 | Intra-chromosomal heterogeneity between the four 16S rRNA gene copies in the genus Veillonella: implications for phylogeny and taxonomy显示文摘 | Marchandin H Teyssier C Simdon De Buoehberg M | 2003 | Microbiology2003，149，： | 1 |
| 19 | Tissue dependent variations of DNA methylation and endoreduplication levels during tomato fruit development and ripening显示文摘 | TEYSSIER E BERNACCHIA G MAURY S | 2008 | Planta2008，228，3： | 1 |
| 20 | Role of protein methylation in regulation of transcription 显示文摘 | Lee D J Teyssier C Strahl B D | 2005 | Endocr Rev2005，26，2： | 1 |
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