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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study显示文摘Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. | Li-Li Ren Ye-Ming Wang Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang | 2020 | Chinese Medical Journal2020，，9： | 99 |
| 3 | Parallel Driving in CPSS:A Unified Approach for Transport Automation and Vehicle Intelligence显示文摘The emerging development of connected and automated vehicles imposes a significant challenge on current vehicle control and transportation systems. This paper proposes a novel unified approach, Parallel Driving, a cloud-based cyberphysical-social systems(CPSS) framework aiming at synergizing connected automated driving. This study first introduces the CPSS and ACP-based intelligent machine systems. Then the parallel driving is proposed in the cyber-physical-social space,considering interactions among vehicles, human drivers, and information. Within the framework, parallel testing, parallel learning and parallel reinforcement learning are developed and concisely reviewed. Development on intelligent horizon(iHorizon)and its applications are also presented towards parallel horizon.The proposed parallel driving offers an ample solution for achieving a smooth, safe and efficient cooperation among connected automated vehicles with different levels of automation in future road transportation systems. | Fei-Yue Wang Nan-Ning Zheng Dongpu Cao Clara Marina Martinez Li Li Teng Liu | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，4： | 41 |
| 4 | The crustal structure under Sanjiang and its dynamic implications:Revealed by seismic reflection/refraction profile between Zhefang and Binchuan,Yunnan显示文摘The fault belts in Sanjiang mainly include Jinshajiang-Honghe fault, Lancangjiang fault and Nujiang fault (called Sanjiang faults) in western Yunnan Province, China. By interpreting the wide-angle seismic reflection/refraction profile between Zhefang and Binchuan, which crosses Tengchong and Baoshan blocks in Dianxi (western Yunnan) tectonic zone, we recon- struct the crustal structure with seismic traveltime tomography for crustal P-wave velocity and the seismic scattering image for crustal seismic reflection structure. In this paper, we firstly present the crustal structure images of P-wave velocity and seismic reflection under the wide-angle seismic profile. These results demonstrate that, the crustal velocity structure and seismic reflec- tion structure along the profile can be divided into 3 segments, and there is an obvious difference of crustal structure among the eastern, the western and the middle segment. Generally, crustal P-wave velocities in the Baoshan segment are 0.1―0.2 km/s slower and seismic reflection am- plitudes from Moho discontinuity are stronger than the other 2 segments. In the studied area, crustal thickness is about 40 km, and shows the thickening tendency from west to east along the profile. Additionally, it can be seen that there is one strong-amplitude seismic reflection event as bright points at the depths of 8―10 km, along the segment of 80―115 km of the profile (south- ward of Tengchong); and seismic reflection wave-field from Moho discontinuity varies obviously along the lateral direction. Finally, we make some discussions on the crustal thickening pattern in the Sanjiang fault belt, structural environment of earthquake development and the contact rela- tionship between the Tengchong block, Banshan block and Luxi trough. | ZHANG Zhongjie1, BAI Zhiming1, WANG Chunyong2, TENG Jiwen1, Lü Qingtian3, LI Jiliang1, LIU Yifeng1 & LIU Zhenkuan4 1. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2. Institute of Geophysics, China Seismological Bureau, Beijing 100085, China 3. Institute of Deposition Resource, Chinese Academy of Geosciences, Beijing 100037, China 4. School of Exploration and Information, China University of Geosciences, Beijing 100083, China | 2005 | Science China Earth Sciences2005，48，9： | 39 |
| 5 | Crustal velocity structure in the Emeishan large igneous province and evidence of the Permian mantle plume activity显示文摘The Emeishan large igneous province(ELIP) in SW China is interpreted to be associated with an ancient mantle plume. Most of the constraints on the role of mantle plume in the generation of the Emeishan flood basalts were provided by geological and geochemical methods, but the geophysical investigation is very limited. In order to better understand the deep structure and features of ELIP, we have studied the crustal velocity structure using the data acquired from the Lijiang-Panzhihua-Qingzhen wide-angle seismic profile. This profile crosses the three sub-zones of the ELIP(the inner, intermediate, and outer zones), divided based on the differential erosion and uplift of the Maokou limestone. The results provided by the active source seismic experiment demonstrate:(1) The average depth of the crystalline basement along the profile is about 2 km.(2) The middle crust in the Inner Zone is characterized by high-velocity anomalies, with the average velocity of 6.2-6.6 km/s, which is about 0.1– 0.2 km/s higher than the normal one. The velocity of the lower crust in the inner zone is 6.9-7.2 km/s, higher than those observed in the intermediate and outer zones(6.7-7.0 km/s). Relatively low velocity anomalies appear in the upper, middle and lower crusts near the junction of the inner zone and intermediate zone, probably due to the effect of the Xiaojiang fault(XJF).(3) The average velocity of the crust is comparatively low on both sides of XJF, especially on the east side, and the average velocity of the consolidated continental crust is also low there. This may suggest that the XJF extends at least down to 40 km deep, even beyond through the crust.(4) The depth to the Moho discontinuity decrease gradually from 47-53 km in the inner zone, via 42-50 km in the intermediate zone to 38-42 km in the outer zone. In the inner zone, the Moho uplifts locally and the(consolidated) crust is characterized by high-velocity anomalies, which are likely related to intensive magma intrusion and underplating associated with melting of plume head. Overall the crustal velocity structure in the study area recorded the imprint left by the Permian Emeishan mantle plume. | XU Tao ZHANG ZhongJie LIU BaoFeng CHEN Yun ZHANG MingHui TIAN XiaoBo XU YiGang TENG JiWen | 2015 | Science China Earth Sciences2015，58，7： | 36 |
| 6 | Multi-UAV reconnaissance task allocation for heterogeneous targets using an opposition-based genetic algorithm with double-chromosome encoding显示文摘This paper presents a novel multiple Unmanned Aerial Vehicles(UAVs) reconnaissance task allocation model for heterogeneous targets and an effective genetic algorithm to optimize UAVs' task sequence. Heterogeneous targets are classified into point targets, line targets and area targets according to features of target geometry and sensor's field of view. Each UAV is regarded as a Dubins vehicle to consider the kinematic constraints. And the objective of task allocation is to minimize the task execution time and UAVs' total consumptions. Then, multi-UAV reconnaissance task allocation is formulated as an extended Multiple Dubins Travelling Salesmen Problem(MDTSP), where visit paths to the heterogeneous targets must meet specific constraints due to the targets' feature. As a complex combinatorial optimization problem, the dimensions of MDTSP are further increased due to the heterogeneity of targets. To efficiently solve this computationally expensive problem, the Opposition-based Genetic Algorithm using Double-chromosomes Encoding and Multiple Mutation Operators(OGA-DEMMO) is developed to improve the population variety for enhancing the global exploration capability. The simulation results demonstrate that OGADEMMO outperforms the ordinary genetic algorithm, ant colony optimization and random search in terms of optimality of the allocation results, especially for large scale reconnaissance task allocation problems. | Zhu WANG Li LIU Teng LONG Yonglu WENa | 2018 | Chinese Journal of Aeronautics2018，31，2： | 35 |
| 7 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 8 | Engineering a New Chloroplastic Photorespiratory Bypass to In crease Photosynthetic Efficiency and Productivity in Rice显示文摘Over the past few years, three photorespiratory bypasses have been introduced into plants, two of which led to observable in creases in photos yn thesis and biomass yield. However, most of the experiments were carried out using Arabidopsis under controlled environmental conditions, and the increases were only observed under low-light and short-day conditions. In this study, we designed a new photorespiratory bypass (called GOC bypass), characterized by no reducing equivalents being produced during a complete oxidation of glycolate into CO2 catalyzed by three rice-self-originating enzymes, i.e., glycolate oxidase, oxalate oxidase, and catalase. We successfully established this bypass in rice chloroplasts using a multi-gene assembly and transformation system. Transgenic rice plants carrying GOC bypass (GOC plants) showed significant increases in photosynthesis efficiency, biomass yield, and nitrogen content, as well as several other CO2-enriched phe no types under both greenhouse and field conditions .Grain yield of GOC plants varied depending on seeding season and was increased significantly in the spring. We further demonstrated that GOC plants had significant advantages under high-light conditions and that the improvements in GOC plants resulted primarily from a photosynthetic CO2-concentrating effect rather than from improved energy balance. Taken together, our results reveal that engineering a newly designed chloroplastic photorespiratory bypass could increase photosynthetic efficiency and yield of rice plants grown in field conditions, particularly under high light. | Bo-Ran Shen Li-Min Wang Xiu-Ling Lin Zhen Yao Hua-Wei Xu Cheng-Hua Zhu Hai-Yan Teng Li-Li Cui E.-E. Liu Jian-Jun Zhang Zheng-Hui He Xin-Xiang Peng | 2019 | Molecular Plant2019，12，2： | 30 |
| 9 | Biological effects of low-dose-rate irradiation of pancreatic carcinoma cells in vitro using ^(125)I seeds显示文摘AIM:To determine the mechanism of the radiationinduced biological effects of 125I seeds on pancreatic carcinoma cells in vitro.METHODS:SW1990 and PANC-1 pancreatic cancer cell lines were cultured in DMEM in a suitable environment.Gray’s model of iodine-125(125I)seed irradiation was used.In vitro,exponential phase SW1990,and PANC-1cells were exposed to 0,2,4,6,and 8 Gy using 125I radioactive seeds,with an initial dose rate of 12.13c Gy/h.A clonogenic survival experiment was performed to observe the ability of the cells to maintain their clonogenic capacity and to form colonies.Cell-cycle and apoptosis analyses were conducted to detect the apoptosis percentage in the SW1990 and PANC-1 cells.DNA synthesis was measured via a tritiated thymidine(3H-Td R)incorporation experiment.After continuous low-dose-rate irradiation with 125I radioactive seeds,the survival fractions at 2 Gy(SF2),percentage apoptosis,and cell cycle phases of the SW1990 and PANC-1 pancreatic cancer cell lines were calculated and compared.RESULTS:The survival fractions of the PANC-1 andSW1990 cells irradiated with 125I seeds decreased exponentially as the dose increased.No significant difference in SF2 was observed between SW1990 and PANC-1 cells(0.766±0.063 vs 0.729±0.045,P<0.05).The 125I seeds induced a higher percentage of apoptosis than that observed in the control in both the SW1990and PANC-1 cells.The rate of apoptosis increased with increasing radiation dosage.The percentage of apoptosis was slightly higher in the SW1990 cells than in the PANC-1 cells.Dose-dependent G2/M cellcycle arrest was observed after 125I seed irradiation,with a peak value at 6 Gy.As the dose increased,the percentage of G2/M cell cycle arrest increased in both cell lines,whereas the rate of DNA incorporation decreased.In the 3H-Td R incorporation experiment,the dosimetry results of both the SW1990 and PANC-1cells decreased as the radiation dose increased,with a minimum at 6 Gy.There were no significant differences in the dosimetry results of the two cell lines when they were exposed to the same dose of radiation.CONCLUSION:The pancreatic cancer cell-killing effects induced by 125I radioactive seeds mainly occurred via apoptosis and G2/M cell cycle arrest. | Zhong-Min Wang Jian Lu Li-Yun Zhang Xiao-Zhu Lin Ke-Min Chen Zhi-Jin Chen Fen-Ju Liu Fu-Hua Yan Gao-Jun Teng Ai-Wu Mao | 2015 | World Journal of Gastroenterology2015，21，8： | 27 |
| 10 | Incidence of Pleural Effusion in Patients with Pulmonary Embolism显示文摘 | Min Liu Ai Cui Zhen-Guo Zhai Xiao-Juan Guo Man Li Lei-Lei Teng Li-Li Xu Xiao-Juan Wang Zhen Wang Huan-Zhong Shi | 2015 | Chinese Medical Journal2015，，8： | 25 |
| 11 | Prognostic value of clinical and pathological factors for surgically treated localized clear cell renal cell carcinoma显示文摘 | Teng Jingfei Gao Yi Chen Ming Wang Kai Cui Xingang Liu Yushan Xu Danfeng | 2014 | Chinese Medical Journal2014，，9： | 23 |
| 12 | Clinical and experimental study on regional administration of phosphorus32 glassmicrospheres in treating hepatic carcinoma显示文摘AIM To study the therapeutical effectiveness, dosage range and toxic adverse effects of domestic phosphorus 32 glass microsphere and evaluate its clinical significance. METHODS Ⅰ. Fifty two BALB/*!c tumor bearing male nude mice were allocated into treatment group( n =38) and control group( n =14). In the former group different doses of 32 P GMS were injected into the tumor mass, while in the latter 31 P GMS or no treatment was given. The experimental animals were sacrificed in batches, and then the tumors and their nearby tissues were examined by light and electron microscopy. Ⅱ. Through selective catheterization of hepatic artery, 32 P GMS was infused to 5 healthy domestic pigs in a dosage equivalent to the therapeutic dose for human being, and 31 P GMS was infused to another 5 healthy domestic pigs. Two pigs infused with contrast medium served as whole course blank controls. One pig from each group was surrendered to euthanasia at week 1, 4, 8 and 16 respectively. The ultrastructural histopath ological changes in liver tissues taken from different sites were evaluated semiquan titatively. Ⅲ. One hundred and twenty seven times of 32 P GMS intrahepatic artery interventional therapies were performed on 93 patients with hepatic carcinoma, including 79 cases of primary hepatic carcinoma and 14 cases of secondary hepatic carcinoma. 32 P GMS ( n =30), and group B, 32 P GMS and half dose of trans hepatic artery embolization (TAE) ( n =49) , and 18 patients with HCC by TAE only as control group C. Fourteen patients with secondary hepatic carcinoma were treated in the same way as group B or C. RESULTS Ⅰ. Comparing with the control group, the treatment group of tumor bearing nude mice attained the tumor inhibition rates of 59 7%-93 7% ( F =579 62, P <0 01) at 14*!d . At an absorbed dose of 7320Gy, the tumor cells were completely destroyed. When the absorbed doses ranged from 1830Gy to 3660Gy, most of the tumor cells showed the evidences of injury or necrosis, but there appeared some well differentiated tumor cells and enhanced effect of the autoimmunocytes. At an absorbed dose of 366Gy or less, some tumor cells still remained active proliferative ability. The definite anticancer effect appeared as early as 3d after intratumoral injection of 32 P GMS. Ⅱ. The cumulative amount of 32 P GMS in the target tissue after trans hepatic artery instillation attained more than 90% of the total dose administrated. Semiquantitative analysis of ultrastructral morphology in the experimental group showed no statistical difference between the nuclear abnormality (N abn ) and mitochondrial variability (M var ) at week 1 or 2, but revealed prominent difference (χ 2=6 70-9 68, P <0 01 , χ 2=65 09-115 09, P <0 001 ) as compared with those in the other groups. In the experimental group the N abn in tissues showed no significant difference between week 8 and week 16. No apparent changes were found in the stomach, spleen, kidney and lung tissues of the experimental pigs. Ⅲ. The therapeutical results of HCC patients in group A were closely approximated to those of group C, no hematological toxic side effects were noted, and the systemic reaction was mild. In some patients 2*!mos - 3*!mos after treatment some secondary foci appeared around the periphery of the primary lesion. In general better effectiveness was obtained in patients with small lesion. After analyzing by RIDIT method, the therapeutic result in group B was significantly better than that in group C, and secondary foci around the original lesion were rarely seen at 3*!mos after treatment. In group C the collateral circulation was reestablished along the periphery of primary foci and the secondary foci appeared more frequently, and required to undergo several courses of treatment. In group B, 4 cases of HCC were treated surgically as their mass decreased in size after 32 P GMS treatment. | LIU Lu, JIANG Zao, TENG Gao Jun, SONG Ji Zhi, ZHANG Dong Sheng, GUO Qing Ming, FANG Wen, HE Shi Cheng and GUO Jin He | 1999 | World Journal of Gastroenterology1999，5，6： | 21 |
| 13 | Regulation of demethylation and re-expression of RASSF1A gene in gastric cancer cell lines by combined treatment of 5-Aza-CdR and NaB显示文摘AIM: To investigate the changes of methylation state and expression of RASSF1A gene in human gastric cancer cell lines SGC7901 and BGC823 which were treated in vitro with demethlylating agent 5-Aza-CdR in combination with histone deacetylase inhibitor NaB. METHODS: After SGC7901 and BGC823 cells were treated with 5-Aza-CdR and/or NaB,the methylation state of RASSF1A gene was detected by methylation-specific PCR,and the changes in expression of mRNA and protein level of RASSF1A gene were observed by RT-PCR and Western-blotting before and after drug treatment. RESULTS: Hypermethylation was detected in the promoter region of RASSF1A gene in both SGC7901 and BGC823 cells,and there was no expression of this gene at both mRNA and protein level. After treatment with 5-Aza-CdR,demethylation occurred in the promoter region of RASSF1A gene,which subsequently induced re-expression of this gene. The treatment with NaB alone showed no effect on the methylation state and expression of RASSF1A gene. The combined treatment of 5-Aza-CdR and NaB induced complete demethylation of RASSF1A gene,leading to a significantly higher re-expression of the mRNA and protein of RASSF1A than those treated with 5-Aza-CdR alone (P < 0.05). CONCLUSION: Hypermethylation in the promoter region is related to inactivation of RASSF1A gene in human gastric cancer cell lines SGC7901 and BGC823,while demethlylating agent 5-Aza-CdR can reverse the methylation state of RASSF1A gene and induce its re-expression. Histone deacetylase inhibitor NaB had a synergistic effect with 5-Aza-CdR in both demethylation and gene transcriptional regulation. | Wen-Jing Shen Dong-Qiu Dai Yue Teng Hong-Bo Liu | 2008 | World Journal of Gastroenterology2008，14，4： | 21 |
| 14 | Transplantation of magnetically labeled mesenchymal stem cells improves cardiac function in a swine myocardial infarction model显示文摘背景:间充质的干细胞(MSC ) 移植为心肌的修理提供一条新途径。然而,关于 MSC 移植的许多重要基本问题仍然保持未答复。有迫切需要从跳动的心识别 MSC 并且分析这条新途径的功效。试图本地化有磁力地标记的 MSC (MR-MSCs ) 并且监视补药的这研究与磁性的回声(先生) MR-MSCs 完成成像。方法:尖锐心肌的梗塞(AMI ) 被左前面的下降冠的动脉的汽球吸藏在猪创造。房间在心肌的梗塞以后经由 intracoronary 注入被交付。梗塞尺寸变化和心脏的功能与 3.0T 先生扫描仪被估计。结果然后被组织学、西方的污点分析证实。所有统计过程与 Systat (社会科学统计套装软体版本 12.01 ) 被执行。结果:26 猪的一个总数被划分成四个组(假冒操作组, n=6;有 PBS 移植的 AMI 组, n=6;标记的 MSC 组, n=7;未标记的 MSC 组, n=7 ) 。MSC, MR-MSCs (10 (7 ) 房间) 或在 MI 和连续心脏的先生成像研究在移植以后在 0, 4 和 8 个星期被执行以后, PBS 被 intracoronary 注射交付。先生成像证明 MI 尺寸在 MSC 移植以后减少了在标记并且未标记的组然而,增加在 MI 以后在 8 个星期在 AMI 组被看见。左室的喷射部分( LVEF )稍微在 AMI 组被增加(( 41.87+/-2.45 )%对( 39.04+/-2.80 )%, P>0.05 ),但是显著地在 MR-MSCs 组改善了(( 56.85+/-1.29 )%对( 40.67+/-2.00 )%, P<0.05 )并且未标记的组(( 55.38+/-1.07 )%对( 41.78+/-2.08 )%, P<0.05 )在 8 星期术后疗法。MR-MSCs 被普鲁士的蓝色和免疫进一步证实荧光灯的染色。西方的污点分析证明在 MSC 处理组和矩阵 metalloproteinase 的比率有象肌浆球蛋白重链和 troponin T 那样的 cardiomyocyte 标记的增加的表情 2 到 metalloproteinase 的织物禁止者, 1 与 AMI 组和假冒操作组相比在标记的组和未标记的组减少了。结论:移植 MR-MSCs 能改革新心肌层并且在 2 月的后续在一个 MI 模型阻止 remolding 并且代表一个比较喜欢的方法更好在未来理解干细胞治疗的机制临床的研究。 | QI Chun-mei MA Gen-shan LIU Nai-feng SHEN Cheng-xing CHEN Zhong LIU Xiao-jun HU Yao-peng ZHANG Xiao-li TENG Gao-jun JU Sheng-hong MA Ming TANG Yao-liang | 2008 | Chinese Medical Journal2008，，6： | 19 |
| 15 | Predictive factors for the local recurrence and distant metastasis of phyllodes tumors of the breast: a retrospective analysis of 192 cases at a single center显示文摘The local recurrence rate of phyllodes tumors of the breast varies widely among different subtypes, and distant metastasis is associated with poor survival. This study aimed to identify factors that are predictive of local recurrence-free survival(LRFS), distant metastasis-free survival(DMFS), and overall survival(OS) in patients with phyllodes tumors of the breast. Clinical data of all patients with a phyllodes tumor of the breast(n = 192) treated at Sun Yat-sen University Cancer Center between March 1997 and December 2012 were reviewed. The Pearson χ2 test was used to investigate the relationship between clinical features of patients and histotypes of tumors. Univariate and multivariate Cox regression analyses were performed to identify factors that are predictive of LRFS, DMFS, and OS. In total, 31(16.1%) patients developed local recurrence, and 12(6.3%) developed distant metastasis. For the patients who developed local recurrence, the median age at the diagnosis of primary tumor was 33 years(range, 17-56 years), and the median size of primary tumor was 6.0 cm(range, 0.8-18 cm). For patients who developed distant metastasis, the median age at the diagnosis of primary tumor was 46 years(range, 24-68 years), and the median size of primary tumor was 5.0 cm(range, 0.8-18 cm). In univariate analysis, age, size, hemorrhage, and margin status were found to be predictive factors for LRFS(P = 0.009, 0.024, 0.004, and 0.001, respectively), whereas histotype, epithelial hyperplasia, margin status, and local recurrence were predictors of DMFS(P = 0.001, 0.007, 0.007, and < 0.001, respectively). In multivariate analysis, independent prognostic factors for LRFS included age [hazard ratio(HR) = 3.045, P = 0.005], tumor size(HR = 2.668, P = 0.013), histotype(HR = 1.715, P = 0.017), and margin status(HR = 4.530, P< 0.001). Histotype(DMFS: HR = 4.409, P = 0.002; OS: HR = 4.194, P = 0.003) and margin status(DMFS: HR = 2.581, P = 0.013; OS: HR = 2.507, P = 0.020) were independent predictors of both DMFS and OS. In this cohort, younger age, a larger tumor size, a higher tumor grade, and positive margins were associated with lower rates of LRFS. Histotype and margin status were found to be independent predictors of DMFS and OS. | Jing Wei Yu-Ting Tan Yu-Cen Cai Zhong-Yu Yuan Dong Yang Shu-Sen Wang Rou-Jun Peng Xiao-Yu Teng Dong-Geng Liu Yan-Xia Shi | 2014 | Chinese Journal of Cancer2014，33，10： | 18 |
| 16 | Adenovirus-mediated expression of both antisense ODC and AdoMetDC inhibited colorectal cancer cell growth in vitro显示文摘瞄准:为了构造 recombinant 侵入人体气管粘膜的病菌,那能同时表示两反感觉鸟氨酸脱羧酶(ODC ) 和 adenosylmethionine 脱羧酶(AdoMetDC ) 并且在细胞内部的聚胺水池上检测它的禁止的效果并且渲染表面的癌症房间生长。方法:AdoMetDC 的 A 205-bp cDNA 是插入颠倒的进 recombinant pAdTrack-ODCas 向量并且在 AdEasy-1 房间与 pAdEasy-1 向量重新结合。积极克隆被选择并且 transfected 进包装房间 HEK293 在以后他们被 PacI 线性化。格林荧光灯的蛋白质表示被用来监视包装的侵入人体气管粘膜的病菌的进程。ODC 和 AdoMetDC 蛋白质层次被西方的弄污识别,并且细胞内部的聚胺内容被反向阶段的高效液相色谱法检测。一个可行房间计数被用来决定 HT-29 房间的生长与或没有外长的聚胺。结果:定序证实 AdoMetDC cDNA 成功地被绑扎进 pAdTrack-ODCas 向量。在 293 个房间的 GFP 表示被萤光显微镜检查在病毒收拾行李和扩大期间观察。西方的弄污证明 ODC 和 AdoMetDC 低由 Ad-ODC-AdoMetDCas 调整了,并且因而, 3 种聚胺(腐胺,亚精胺和精胺) 被归结为很底层。当与控制条件,和生长相比拘捕没被外长的腐胺颠倒, HT-29 细胞生长显著地被禁止。结论:成功地构造的 recombinant 侵入人体气管粘膜的病菌, Ad-ODC-AdoMetDCas,堵住的聚胺合成并且为对待颜色有治疗学的潜力表面的癌症在试管内。 | Bing ZHANG Xian-xi LIU Yan ZHANG Chun-ying JIANG Qing-shan TENG Hai-yan HU Wei WANG Lei GONG | 2006 | Acta Pharmacologica Sinica2006，27，3： | 17 |
| 17 | Hepatitis B virus and hepatocellular carcinoma at the miRNA level显示文摘AIM: To study Hepatitis B virus (HBV) infection and its association with hepatocellular carcinoma (HCC) at the miRNA level.METHODS: Three cellular models were used to investigate miRNA expression changes during HBV infection: human HepG2 hepatoblastoma cell line as a model without HBV infection;HepG2 cell line transfected with a 1.3-fold full-length HBV genome as an acute infection model;and HepG2.2.15 cell line,which is derived from HepG2 and stably transfected with a complete HBV genome,as a chronic infection model.The miRNA levels were examined using microarray technology.To explore the relationship between HBV infection and HCC genesis at the miRNA level,we downloaded from national center for biotechnology information Gene Expression Omnibus an miRNA expression dataset derived from HCC patients,most of whom are HBV carriers.We compared the miRNA expression alterations during HBV infection with those in HCC patients,by analyzing miRNA expression change profiles statistically.RESULTS: Seventy-seven and 48 miRNAs were differentially expressed during acute and chronic HBV infection,respectively.Among these miRNAs,25 were in common,the intersection of which was significant under the hypergeometric test (P = 1.3 × 10-11).Fourteen miRNAs were observed to change coherently in the acute and chronic infections,with one upregulated and 13 downregulated.Eleven showed inverse changes during the two phases of infection;downregulated in the acute infection and upregulated in the chronic infection.The results imply that common and specific mechanisms exist at the miRNA level during acute and chronic HBV infection.Besides,comparative analysis of the miRNA expression changes during HBV infection with those in HCC indicates that,although miRNA expression changes during HBV infection are distinct from those in HCC patients (P < 2.2 × 10-16),they exhibited significant correlations (P = 0.0229 for acute infection;P = 0.0084 for chronic infection).Perturbation of miRNA expression during chronic HBV infection was closer to that in HCC patients than that during acute HBV infection.This observation implies the contribution of miRNAs to HCC genesis from HBV infection.According to their patterns of differential expression in acute and chronic HBV infection,as well as in HCC,miRNAs of potential research interest could be identified,such as miR-18a/miR-18b,miR-106a,miR-221 and miR-101.For instance,the gradient expression alteration of miR-221 in the above three phases,which is downregulated in acute HBV infection,normally expressed in chronic HBV infection,and upregulated in HCC,indicates that it may be a key effector for progression of the disease.CONCLUSION: Our analysis provides insights into HBV infection and related HCC in relation to miRNAs,and reveals some candidate miRNAs for future studies. | Zhen-Zhen Zhang Xiang Liu De-Qiang Wang Mai-Kun Teng Li-Wen Niu Ai-Long Huang Zhi Liang | 2011 | World Journal of Gastroenterology2011，17，28： | 17 |
| 18 | Advanced technology of high-resolution radar: target detection, tracking, imaging, and recognition显示文摘In recent years, the performances of radar resolution, coverage, and detection accuracy have been significantly improved through the use of ultra-wideband, synthetic aperture and digital signal processing technologies. High-resolution radars(HRRs) utilize wideband signals and synthetic apertures to enhance the range and angular resolutions of tracking, respectively. They also generate one-, two-, and even threedimensional high-resolution images containing the feature information of targets, from which the targets can be precisely classified and identified. Advanced signal processing algorithms in HRRs obtain important information such as range-Doppler imaging, phase-derived ranging, and micro-motion features. However, the advantages and applications of HRRs are restricted by factors such as the reduced signal-to-noise ratio(SNR)of multi-scatter point targets, decreased tracking accuracy of multi-scatter point targets, high demands of motion compensation, and low sensitivity of the target attitude. Focusing on these problems, this paper systematically introduces the novel technologies of HRRs and discusses the issues and solutions relevant to detection, tracking, imaging, and recognition. Finally, it reviews the latest progress and representative results of HRR-based research, and suggests the future development of HRRs. | Teng LONG Zhennan LIANG Quanhua LIU | 2019 | Science China(Information Sciences)2019，62，4： | 17 |
| 19 | WAVE-CURRENT INTERACTIONS WITH THREE-DIMENSIONAL FLOATING BODIES显示文摘A Time-domain Higher-Order Boundary Element Method(THOBEM) is developed for simulating wave-current interactions with 3-D floating bodies.Through a Taylor series expansion and a perturbation procedure,the model is formulated to the first-order in the wave steepness and in the current velocity,respectively.The boundary value problem is decomposed into a steady double-body flow problem and an unsteady wave problem.Higher-order boundary integral equation methods are then used to solve the proposed problems with a fourth-order Runge-Kutta method for the time marching.An artificial damping layer is adopted to dissipate the scattering waves.Different from the other time-domain numerical models,which are often focused on the wave-current interaction with restrained bodies,the present model deals with a floating hemisphere.The numerical results of wave forces,wave run-up and body response are all in a close agreement with those obtained by frequency-domain methods.The proposed numerical model is further applied to investigate wave-current interactions with a floating body of complicated geometry.In this work,the regular and focused wave combined with current interacting with a truss-spar platform is investigated. | LIU Zhen TENG Bin NING De-zhi GOU Ying | 2010 | Journal of Hydrodynamics2010，22，2： | 14 |
| 20 | Parallel Reinforcement Learning-Based Energy Efficiency Improvement for a Cyber-Physical System显示文摘As a complex and critical cyber-physical system(CPS),the hybrid electric powertrain is significant to mitigate air pollution and improve fuel economy.Energy management strategy(EMS)is playing a key role to improve the energy efficiency of this CPS.This paper presents a novel bidirectional long shortterm memory(LSTM)network based parallel reinforcement learning(PRL)approach to construct EMS for a hybrid tracked vehicle(HTV).This method contains two levels.The high-level establishes a parallel system first,which includes a real powertrain system and an artificial system.Then,the synthesized data from this parallel system is trained by a bidirectional LSTM network.The lower-level determines the optimal EMS using the trained action state function in the model-free reinforcement learning(RL)framework.PRL is a fully data-driven and learning-enabled approach that does not depend on any prediction and predefined rules.Finally,real vehicle testing is implemented and relevant experiment data is collected and calibrated.Experimental results validate that the proposed EMS can achieve considerable energy efficiency improvement by comparing with the conventional RL approach and deep RL. | Teng Liu Bin Tian Yunfeng Ai Fei-Yue Wang | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，2： | 14 |
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