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| 1 | Glutamine analogs promote cytoophidium assembly in human and Drosophila cells显示文摘CTP synthase is compartmentalized within a subcellular structure,termed the cytoophidium,in a range of organisms including bacteria, yeast,fruit fly and rat.Here we show that CTP synthase is also compartmentalized into cytoophidia in human cells.Surprisingly,the occurrence of cytoophidia in human cells increases upon treatment with a glutamine analog 6-diazo-5-oxo-L-norleucine(DON),an inhibitor of glutamine-dependent enzymes including CTP synthase.Experiments in flies confirmed that DON globally promotes cytoophidium assembly.Clonal analysis via CTP synthase RNA interference in somatic cells indicates that CTP synthase expression level is critical for the formation of cytoophidia.Moreover,DON facilitates cytoophidium assembly even when CTP synthase level is low.A second glutamine analog azaserine also promotes cytoophidum formation.Our data demonstrate that glutamine analogs serve as useful tools in the study of cytoophidia. | mr Yilmaz Tastan Zillah Anne Deussen Mayte Yu-Yin Siswick | 2011 | Journal of Genetics and Genomics2011，38，9： | 10 |
| 2 | Effectiveness of breathing exercises during the second stage of labor on labor pain and duration: a randomized controlled trial显示文摘BACKGROUND: Some research exists on the effect of non-pharmacological approaches for labor pain relief. However, there is limited information about effectiveness of breathing exercises in pregnant women to reduce maternal pain during labor.OBJECTIVE: To determine whether breathing exercises for pregnant women during the second stage of labor have beneficial effects on maternal pain, duration of labor, and the first-minute Appearance, Pulse, Grimace, Activity and Respiration(APGAR) scores. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: This randomized clinical trial involved 250 pregnant women, who were randomly divided into two groups: intervention group(IG; n = 125) and control group(CG; n = 125). IG received one session breathing exercise training and performed breathing exercises during the second stage of labor versus the CG that did not receive any breathing exercise training.MAIN OUTCOME MEASURES: The effects of breathing exercises on maternal pain were determined by Visual Analogue Scale(VAS), duration of the second stage of labor, and the first-minute APGAR scores.RESULTS: The mean age of the participants was(23.2 ± 4.2)(range: 18 to 42) years. Both IG and CG had similar baseline characteristics in terms of age, education level, occupation, and smoking(P > 0.05). The mean VAS scores of IG and CG were(88.2 ± 6.3) and(90.5 ± 7.0), respectively(P < 0.001). The duration of the second stage of labor was(369.6 ± 92.0) s for IG and(440.7 ± 142.5) s for CG(P < 0.001). The mean first-minute APGAR scores were(8.84 ± 0.50) for IG and(8.73 ± 0.89) for CG(P > 0.05).CONCLUSION: Based on this study, breathing exercises with deep inhalation and exhalation in pregnant women are effective in reducing the perception of labor pain and shortening the duration of the second stage of delivery. Therefore, we recommend breathing exercises as an effective modality for labor pain management and shortening the duration of labor.TRIAL REGISTRATION: This study is registered on the website of ClinicalT rials.gov(www.clinicaltrials.gov) with the number of NCT03066973. | hilal yuksel yasemin cayir zahide kosan kenan tastan | 2017 | Journal of Integrative Medicine2017，15，6： | 6 |
| 3 | Efficacy and safety of serial glycohc acid peels and a topical, regimen in the treatment of recalcitrant melasma显示文摘 | Erbil H Sezer E Tastan B | 2007 | J Dermatol2007，34，1： | 1 |
| 4 | Effectiveness of dual-source CT coronary angiography for the evaluation of coronary artery disease in patients with atrial fibrillation:initial experience显示文摘 | OncellD OncellG Tastan A | | 0，，： | 1 |
| 5 | An open,randomized,comparative study of oral fluconazole,itraconazole and terbinafine therapy in onychomycosis显示文摘 | Arca E Tastan HB Akal A | 2002 | J Dennatolog Treat2002，13，1： | 1 |
| 6 | Effectiveness of dual-source CT coronary angiogra- phy for the evaluation of coronary artery disease in patients with atrial fibrilla- tion : initial experience 显示文摘 | Oncel D Oncel G Tastan A | 2007 | Radiology2007，245，3： | 1 |
| 7 | Bilateral internal jugular vein phlebectasia显示文摘 | Aydogan F Tastan E Aydin E | 2011 | Ear nose & throat journal2011，90，： | 1 |
| 8 | Association of HLA class I antigens and HLA class II alleles with vitiligo in a Turkish popula - tion显示文摘 | Tastan HB AkarA Orkunoglu FE | 2004 | Pigment Cell Res2004，17，2： | 1 |
| 9 | Influence of Bacillus Calmette-Guerin vaccination at birth and 2 months old age on the peripheral blood T-cell subpopulations 显示文摘 | Tastan Y Arvas A Demir G | 2005 | Pediatr Allergy Immunol2005，16，8： | 1 |
| 10 | Effective bioremoval of reactive dye and heavy metals by Aspergillus versicolor显示文摘 | Tastan BE Ertugrul S Donmez G | 2010 | Bioresource Technology2010，101，3： | 1 |
| 11 | An open,randomized,compar-ative study of oral fluconazole,it raconazole and teibinafinetherapy in onychomycosis显示文摘 | Area E’Tastan HB Akar A | 2002 | J Dermatolog Treat2002，13，： | 1 |
| 12 | Association of HLA class Ⅰ antigens and HLA class Ⅱ alleles with vitiligo in a Turkish population 显示文摘 | Tastan H B Akar A Orkunoglu F E | 2004 | Pigment Cell Res2004，17，2： | 1 |
| 13 | An open, randomized, comparative study of oral finasteride and 5% topical minoxidil in male androgenetic alopecia显示文摘 | Arca E Acikgoz G Tastan HB | 2004 | Dermatology2004，209，2： | 1 |
| 14 | Association of HLA class I antigens and HLA class II alleles with vitiligo in a Turkish population显示文摘 | Tastan HB Akar A Orkunoglu FE | 2004 | Pigment Cell Res2004，17，2： | 1 |
| 15 | Comparison of angiographic and clinical outcome after cutting balloon and Conventional balloon angioplasty in vessels smaller than 3mm in diameter:A randomized trial显示文摘 | Ergene O Seyithanoglu BY Tastan A | 1998 | J Invasive Cardiol1998，10，： | 1 |
| 16 | Long-term pate- ncy of complex bilobular, bisaccular, and broad-neck aneury- sms in the rabbit microsurgical venous pouch bifurcation model 显示文摘 | Marbacher S Tastan I Neuschmelting V | 2012 | Neurol Res2012，34，6： | 1 |
| 17 | Estimating time-varying conditional correla- tions between stock and foreign exchange markets显示文摘 | Tastan H | 2006 | Physica2006，360，2： | 1 |
| 18 | Parathyroid hormone improves contractile performance of adult rat ventricular cardiomyocytes at low concentrations in a non-acute way显示文摘 | Tastan I Schreckenberg R Mufti S | 2009 | Cardiovasc Res2009，82，： | 1 |
| 19 | An open,randomized,comparative study of oral fluconazole,itraconazole and terbinafine therapy in onychomycosis显示文摘 | Arca E Tastan HB Akar A | 2002 | J Dermatolog Treat2002，13，： | 1 |
| 20 | Detection of significant coronary artery stenosis with 64-section MDCT angiography显示文摘 | Oncel D Oncel G Tastan A | 2007 | Eur J Radio12007，62，： | 1 |
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