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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Defensin-like polypeptide LUREs are pollen tube attractants secreted from synergid ceils显示文摘 | Okuda S Tsutsui H Shiina K Sprunck S Takeuchi H Yui R Kasahara R D HamamuraY Mizukami A S usaki D Kawano N Sakakibara T Namiki S Itoh K Otsuka K Matsuzaki M Nozaki H Kuroiwa T Nakano A Kanaoka M M Dresselhaus T Sasaki N Higashiyama T | | 0，，7236： | 1 |
| 3 | Molecular process in acute liver iniury and regeneration induced by carbon tetrachloride显示文摘 | Taniguchi M Takeuchi T Nakatsuka R | 2004 | Life Sci2004，75，13： | 1 |
| 4 | A1- and N-polar A1N layers grown on c-plane sapphire substrates by modified flow-modulation MOCVD 显示文摘 | TAKEUCHI M SHIMIZU H KAJITANI R | 2007 | J Cryst Growth2007，305，2： | 1 |
| 5 | Advanced lithium batteries for implantable medical devices:mechanistic study of SVO cathode synthesis显示文摘 | Takeuchi K J Leising R A Palazzo M J | 2003 | Journal of Power Sources2003，119，121： | 1 |
| 6 | reduced passive measles immunity in infants of mother have not been exposed to measles outbreaks显示文摘 | Tsutsumi H Takeuchi R | 1999 | Scand J Infect Dis1999，31，1： | 1 |
| 7 | FR180204,a novel and selective inhibitor of extracellular signal-regulated kinase,ameliorates collagen-induced arthritis in mice显示文摘 | Ohori M Takeuchi M Maruki R | 2007 | Naunyn Schmiedebergs Arch Pharmacol2007，374，4： | 1 |
| 8 | Molecular process in acute liver injury and regeneration induced by carbon tetrachloride 显示文摘 | Taniguchi M Takeuchi T Nakatsuka R | 2004 | Life Sci2004，75，13： | 1 |
| 9 | Load characteristics of ultrasonic rotary motor using a longitudinal-torsional vibration converter with diagonal slits-large torque ultrasonic rotary motor显示文摘 | Tsujino J Takeuchi M Suzuki R | 1996 | Ultrasonics1996，34，： | 1 |
| 10 | Respiratory syncytical virus infection of human respiratory epithelial cells enhances inducible nitric oxide synthase gene expression显示文摘 | Tsutsumi H Takeuchi R Ohsaki M | 1999 | J Leukoc Biol1999，66，1： | 1 |
| 11 | New Arabidopsis cue mutants suggest a closeconnection between plastid and phytochrome regulation of nuclear gene expression显示文摘 | Lopez-Juez E Jarvis R P Takeuchi A Page A M Chory J | 1998 | Plant Physiol1998，118，： | 1 |
| 12 | Recent increase in the frequency of infant measles in Japan显示文摘 | Ohsaki M Tsutsumi H Takeuchi R | 2000 | pediatrtnt2000，42，： | 1 |
| 13 | Pdxl and Ngn3 overexpression enhances pancreatic differentiation of mouseES cell-derived endoderm population显示文摘 | Kubo A Stull R Takeuchi M | 2011 | PLoS One2011，6，24： | 1 |
| 14 | Extending the Chain of Relationships Among Organizational Justice,Social Exchange,and Employee Reactions:The Role of Contract Violation显示文摘 | TEKLEAB A G TAKEUCHI R TAYLOR M S | 2005 | Academy of Management Journal2005，48，3： | 1 |
| 15 | Role of endogenous nitric oxide(No)and NO synthasea in healing of indomethacin-induced intestinal ulcers in rats显示文摘 | Takeuchi K Hatazawa R Tanigami M | 2007 | Life Sci2007，80，4： | 1 |
| 16 | Abuse Testing of Lithium-Ion Batteries Characterization of the Overcharge Reaction of LiCoO2-Graphite Cells显示文摘 | Leising R A Palazzo M J Takeuchi E S | 2001 | J Electrochem Soc2001，148，8： | 1 |
| 17 | Medial opening wedge high tibial osteotomy with early full weight bearing显示文摘 | Takeuchi R Ishikawa H Aratake M | | 0，，： | 1 |
| 18 | Defensin-like polypeptide LUREs are pollen tube attractants secreted from synergid cells显示文摘 | Okuda S Tsutsui H Shiina K Sprunck S Takeuchi H Yui R Kasahara R D Hamamura Y Mizukami A Susaki D Kawano N Sakakibara T Namiki S Itoh K Otsuka K Matsuzaki M Nozaki H Kuroiwa T Nakano A Kanaoka M M Dresselhaus T Sasaki N Higashiyama T | 2009 | Nature2009，458，7236： | 1 |
| 19 | Reduced passive measles immunity in infants of mothers who have not seen exposed to measles outbreaks 显示文摘 | Ohsaki M Tsutsumi H Takeuchi R | 1999 | Scand J Infect Dis1999，31，1： | 1 |
| 20 | Magnetic and magnetocaloric properties of La(Fe,Co)11 4SP1 6 compounds (SP=A1 or Si)显示文摘 | Passamani E C Larica C Proveti J R Takeuchi A Y Gomes A M Ghivelder L | | 0，，： | 1 |
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