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| 1 | Portopulmonary hypertension and serum endothelin levels in hospitalized patients with cirrhosis显示文摘BACKGROUND:Cirrhosis is associated with several extrahepatic manifestations including portopulmonary hypertension (PPHT).Recent data suggest that endothelins (ETs) are related to the pathophysiology of PPHT.The study aimed to measure serum ET levels in hospitalized cirrhotic patients and to determine their association with PPHT and patient outcome.METHODS:Fifty-seven cirrhotic patients [43 males;median age 58 (28-87) years] underwent Doppler echocardiography.Patients with systolic pulmonary arterial pressure ≥40 mmHg and pulmonary acceleration time <100 ms were deemed to have PPHT.ET-1,2,and 3 serum levels were measured with an ELISA assay.All-cause mortality was recorded over a median period of 24 months.RESULTS:Nine out of 57 patients (15.8%) had PPHT.Among various clinical variables,only autoimmune hepatitis was associated with PPHT (OR=11.5;95% CI,1.58-83.4;P=0.01).ET-1 levels [9.1 (1.6-20.7) vs 2.5 (1.4-9.2) pg/mL,P=0.02] and the ET-1/ET-3 ratio [4.73 (0.9-22.4) vs 1.6 (0.3-10.7),P=0.02] were significantly higher in patients with PPHT than in those without.ET-2 and ET-3 levels did not differ between the two groups.There was no difference in survival between the two groups,although ET-1 levels were associated with an adverse outcome in Cox regression analysis (HR=1.11;95% CI,1.02-1.22;P=0.02 per unit increase in ET-1).CONCLUSION:Our data suggest that ET-1 and the ET-1/ET-3 ratio are elevated in patients with PPHT and that ET-1 is associated with a poor outcome irrespective of PPHT. | Aristotelis Tsiakalos Gregorios Hatzis Ioannis Moyssakis Aggelos Karatzaferis Panayiotis D Ziakas George E Tzelepis | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 7 |
| 2 | Addressing Frequency Control Challenges in Future Low-Inertia Power Systems:A Great Britain Perspective显示文摘The ambitious global targets on decarbonization present the need for massive integration of renewable generation in power systems,resulting in a significant decrease in the system inertia.In addition to the reduction in system inertia,the transmission system in Great Britain(GB)faces some unique challenges owing to its relatively small capacity,while being decoupled from other transmission systems and with the renewable resources largely non-uniformly distributed across the system.This paper presents opinions and insights on the challenges associated with frequency control in a low-inertia system and the potential solutions from a GB perspective.In this paper,we focus on three main techniques that act over different time scales:synchronous condensers,inertia emulation,and fast frequency response.We evaluate their relative advantages and limitations with learnings from recent research and development projects in GB,along with the opinions on their roles in addressing the frequency control challenges in future low-inertia systems. | Qiteng Hong Md Asif Uddin Khan Callum Henderson AgustíEgea-Àlvarez Dimitrios Tzelepis Campbell Booth | 2021 | Engineering2021，7，8： | 2 |
| 3 | Occult connective tissue diseases mimicking idiopathic interstitial pneumonias 显示文摘 | Tzelepis GE Toya SP Moutsopoulos HM | 2008 | Eur Respir J2008，31，： | 1 |
| 4 | Expression of ERalpha,ERbeta and co-regulator PELP1/MNAR in colorectal cancer:prognostic significance and clinicopathologic correlations显示文摘 | Grivas PD Tzelepi V Sotiropoulou-Bonikou G | 2009 | Cell Oncol2009，31，3： | 1 |
| 5 | Panresistance in VIM-1- producing Klebsiella pneumoniae 显示文摘 | Miriagou V Tzelepi E Daikos GL etal | 2005 | J Antimicrob Chemother2005，55，5： | 1 |
| 6 | Fetus amorphous acar- dious : report of a rare case and differential diagnosis from placental teratoma with review of the literature 显示文摘 | Tzelepi V Zolota V Mavromati E | 2007 | Eur Rev Med Pharmacol Sci2007，11，6： | 1 |
| 7 | Occulh connective tissue diseases mimicking idiopathic interstitial pneumonias显示文摘 | Tzelepis GE Toya SP Moutsopoules HM | 2008 | Eur Respir J2008，31，1： | 1 |
| 8 | Chest wall motion during speech production in patients with advanced ankylosing spondylitis显示文摘 | KALLIAKOSTA G MANDROS C TZELEPIS G E | 2007 | J Speech Lang Hear Res2007，50，10： | 1 |
| 9 | Comparative biochemi- cal and computational study of the role of naturally occurring muta- tions at Ambler positions 104 and 170 in GES 13 -lactamases显示文摘 | Kotsakis SD Miriagou V Tzelepi E | 2010 | Antimicrob Agents Chemother2010，54，11： | 1 |
| 10 | An integron-associated β-lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extended-spectrum β-lactamase IBC-1显示文摘 | Mavroidi A Tzelepi E Tsakris A | 2001 | J Antimicrob Chemother2001，48，： | 1 |
| 11 | Expression of ERα, ERβ and co regulator PELP1/ MNAR in colorectal cancer: prognostic significance and clini- copathologie correlations 显示文摘 | GRIVAS P D TZELEPI V SOTIROPOULU-BONIKOU G | 2009 | Cellular Oncology2009，31，： | 1 |
| 12 | Expression of hedgehog pathway compo - nents in prostate carcinoma micro- environment: shifting the balance towards autocrine signaling 显示文摘 | Vassiliki Tzelepi Maria Karlou Sijin | 2011 | Histopathology2011，58，7： | 1 |
| 13 | Panresistance in VIM-1-producing Klebsiella pneumoniae显示文摘 | Miriagou V Tzelepi E Daikos GL | | 0，，05： | 1 |
| 14 | Histo- logic-type specific role of cell cycle regulators in non- small cell lung carcinoma显示文摘 | Zolota VG Tzelepi VN Leotsinidis M | 2010 | J Surg Res2010，164，2： | 1 |
| 15 | Identification of a novel plasmid-mediated beta-lactamase with chromosomal cephalosporinase characteristics from Klebsiella pneumoniae 显示文摘 | Tzouvelekis LS Tzelepi E Mentis AF | 1993 | J Antimicrob Chemother1993，31，： | 1 |
| 16 | Panresistance in VIM- 1-producing Klebsiella pneumoniae 显示文摘 | Miriagou V Tzelepi E Daikos GL | 2005 | J Antimicrob Chernother2005，55，5： | 1 |
| 17 | Detection of extencle-speetrum -lactamases in clinical isolates of Enterobacter cloacae and Enterobacter aerogenes 显示文摘 | Tzelepi E Giakkoupi P Sofianou D | 2000 | J Clin Microbiol2000，38，： | 1 |
| 18 | Emergence of an inhibitor-resistant β-lactamase (SHV-10)derived from an SHV-5 variant 显示文摘 | Prinarakis E E Miriagou V Tzelepi E | 1997 | Antimicrob Agents and Chemother1997，41，： | 1 |
| 19 | Pattern and distribution of myocardial ibrosis in systemic sclerosis : a delayed enhanced mag- netic resonance imaging study显示文摘 | Tzelepis GE Kelekis NL Plastiras SC | 2007 | Arthritis Rheum2007，56，11： | 1 |
| 20 | CTX-M-type beta-lactamases:an emerging group of extended-spectrum enzymes显示文摘 | Tzouvelekis L S Tzelepi E Tassios P T | 2000 | Int J Antimicrob Agents2000，14，2： | 1 |
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