|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Corrigendum to “Properties improvement of SPEEK based proton exchange membranes by doping of ionic liquids and Y_2O_3”[Prog. Nat. Sci.: Mater. Int. 22 (1) (2012) 26-30] | Jianbin Chen a, Qiang Guo a, Dan Li a, Juying Tong a,b, Xia Li a a School of Materials Science and Engineering, Shanghai University, Shanghai 201800, China b School of Wenling, Zhejiang TV University, Wenling 317500, China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 33 |
| 2 | m^6A mRNA methylation sustains Treg suppressive functions显示文摘 | Jiyu Tong Guangchao Cao Ting Zhang Esen Sefik Maria Carolina Amezcua Vesely James P Broughton Shu Zhu Huabin Li Bin Li Lei Chen Howard Y Chang Bing Su Richard A Flavell Hua-Bing Li | 2018 | Cell Research2018，28，2： | 30 |
| 3 | Mi R-122 in hepatitis B virus and hepatitis C virus dual infection显示文摘Hepatitis B virus(HBV) and hepatitis C virus(HCV) infections are the most common causes of chronic liver diseases and hepatocelluar carcinomas. Over the past few years, the liver-enriched micro RNA-122(mi R-122) has been shown to differentially regulate viral replication of HBV and HCV. It is notable that thelevel of mi R-122 is positively and negatively regulated by HCV and HBV, respectively. Consistent with the welldocumented phenomenon that mi R-122 promotes HCV accumulation, inhibition of mi R-122 has been shown as an effective therapy for the treatment of HCV infection in both chimpanzees and humans. On the other hand, mi R-122 is also known to block HBV replication, and HBV has recently been shown to inhibit mi R-122 expression; such a reciprocal inhibition between mi R-122 and HBV suggests an intriguing possibility that mi R-122 replacement may represent a potential therapy for treatment of HBV infection. As HBV and HCV have shared transmission routes, dual infection is not an uncommon scenario, which is associated with more advanced liver disease than either HBV or HCV mono-infection. Thus, there is a clear need to further understand the interaction between HBV and HCV and to delineate the role of mi R-122 in HBV/HCV dual infection in order to devise effective therapy. This review summarizes the current understanding of HBV/HCV dual infection, focusing on the pathobiological role and therapeutic potential of mi R-122. | Kyoungsub Song Chang Han Srikanta Dash Luis A Balart Tong Wu | 2015 | World Journal of Hepatology2015，7，3： | 6 |
| 4 | Consensus on the digestive endoscopic tunnel technique显示文摘With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) tract.At present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative treatment.The International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations). | Ning-Li Chai Hui-Kai Li En-Qiang Linghu Zhao-Shen Li Shu-Tian Zhang Yu Bao Wei-Gang Chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-Xiang He Bing Hu1 Bing Hu2 Xiao-Jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang Liu Hai-Feng Liu Jun Liu Xiao-Gang Liu Zhi-Guo Liu Ying-Cai Ma Gui-Yong Peng Long Rong Wei-Hong Sha Pateek Sharma Jian-Qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun Gui-Qi Wang Wen Wang Qi Wu Hong Xu Mei-Dong Xu Ai-Ming Yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang Xiao-Feng Zhang Ya-Qi Zhai | 2019 | World Journal of Gastroenterology2019，25，7： | 5 |
| 5 | Neonatal colon perforation due to anorectal malformations: Can it be avoided?显示文摘Anorectal malformations (ARM) are common anomalies in neonates. Diagnostic and therapeutic delays in the management of ARM may lead to colonic perforation, and even death. Physical examination of the perineum is often sufficient to diagnose ARM in neonates. Notwithstanding, delayed diagnosis of ARM has become increasingly familiar to surgeons, as evidenced by the number of recent publications on this topic in the literature. In this commentary, we discuss spontaneous colonic perforation due to delayed diagnosis of ARM in neonates, and highlight the importance of early diagnosis in assuring good outcomes with surgical management. At this point, a thorough examination of the perineum during the initial newborn assessment is mandatory, particularly in those patients presenting with abdominal signs or symptoms. | Wei-Dong Tong Kirk A Ludwig | 2013 | World Journal of Gastroenterology2013，19，25： | 3 |
| 6 | 世界家庭医生组织(WONCA)研究论文摘要汇编——居住在“冷点社区”与健康欠佳、享有卫生服务质量欠佳间的关系显示文摘目的患者居住的社区情况与其所享有的卫生服务质量之间的关系尚未完全明确。本研究旨在调查居住在'冷点社区'(经普查证实的低收入、低文化程度以及不享有多种福利的社区)与享有的卫生服务质量间的关系。方法在12个全科诊所中选取152 962例患者进行调查。将患者所住社区(根据普查所得结果)按照全科诊所服务范围进行编码,并根据低收入(收入低于联邦贫困线水平的2倍被认定为低收入)人群比例、低于高中文化人群比例以及社会剥夺指数水平的四分位数进行分类,具有最低收入、低学历人群比例或最高社会剥夺指数的社区被认定为'冷点社区'。采用双变量回归和Logistic回归分析患者所住'冷点社区'情况与患者慢性病患病情况(肥胖、未得到有效控制的糖尿病)、享有的卫生服务情况[肺炎疫苗接种、癌症(结肠癌、宫颈癌、前列腺癌)筛查以及应用阿司匹林防治心血管疾病情况]间的关系。结果各'冷点社区'患者的分布比例不同,最高比例是最低比例的10倍(29.1%比2.6%)。除了应用阿司匹林之外,享受其他卫生服务情况以及慢性病患病情况均受到了'冷点社区'状况的影响。居住在低学历'冷点社区'的患者患有未得到有效控制的糖尿病的比例高于居住在非'冷点社区'的患者(15%比13%,P<0.05)。回归分析表明,与居住在非'冷点社区'的患者相比,居住在贫困'冷点社区'、低学历'冷点社区'、社会剥夺指数高'冷点社区'的患者享有的宫颈癌筛查服务比例稍高,但享有的结肠癌筛查服务比例较低[OR(95%CI)分别为0.88(0.83,0.93)、0.87(0.82,0.92)、0.89(0.83,0.95)]。结论居住在冷点社区的患者拥有较高的慢性病患病率,且其享有的部分筛查服务质量较差。全科医生可应用领域数据来分配资源,主动积极筛查出此类社区中的慢性病患者以及应该享有却未能享受到筛查服务的患者。 | LIAW W KRIST A H TONG S T 本刊编辑部 | 2018 | 中国全科医学2018，21，19： | 3 |
| 7 | Iron in the NEEM ice core relative to Asian loess records over the last glacial–interglacial cycle显示文摘Mineral dust can indirectly affect the climate by supplying bioavailable iron(Fe)to the ocean.Here,we present the records of dissolved Fe(DFe)and total Fe(TDFe)in North Greenland Eemian Ice Drilling(NEEM)ice core over the past 110 kyr BP.The Fe records are significantly negatively correlated with the carbon-dioxide(CO_(2))concentrations during cold periods.The results suggest that the changes in Fe fluxes over the past 110 kyr BP in the NEEM ice core are consistent with those in Chinese loess records because the mineral-dust distribution is controlled by the East Asian deserts.Furthermore,the variations in the dust input on a global scale are most likely driven by changes in solar radiation during the last glacial–interglacial cycle in response to Earth’s orbital cycles.In the last glacial–interglacial cycle,the DFe/TDFe ratios were higher during the warm periods(following the post-Industrial Revolution and during the Holocene and last interglacial period)than during the main cold period(i.e.the last glacial maximum(LGM)),indicating that the aeolian input of iron and the iron fertilization effect on the oceans have a non-linear relationship during different periods.Although the burning of biomass aerosols has released large amounts of DFe since the Industrial Revolution,no significant responses are observed in the DFe and TDFe variations during this period,indicating that severe anthropogenic contamination has no significant effect on the DFe(TDFe)release in the NEEM ice core. | Cunde Xiao Zhiheng Du Mike J Handley Paul A Mayewski Junji Cao Simon Schüpbach Tong Zhang Jean-Robert Petit Chuanjin Li Yeongcheol Han Yuefang Li Jiawen Ren | 2021 | National Science Review2021，8，7： | 2 |
| 8 | Effects of Preheating Temperature, Moisture and Sodium Metabisulfite Content on Property of Maize Flour Dough显示文摘Processing temperature, maze flour particle size, and level of water and sodium metabisulfite were varied during the preparation of maize noodles. Preheated to 90—95 ℃ a mixture of maize flour or meal, water(43%—45% moisture) and salt enabled the preparation of noodles using a pasta extruder. Maize flour with smaller particle size yielded better noodles than did maize meal. The addition of sodium metabisulfite enabled the production of noodles at lower processing temperatures; however, cooking losses increased. Processing maize flour with higher water absorption yielded noodles that required longer cooking time but with decreased losses. The functionalities of starch and protein in raw ingredients and in products were determined. Starch gelatinized and retorgraded during processing maize noodles, as indicated by changes in pasting viscosity curves. Maize proteins contributed to the increased viscosity of dough above 40 ℃. The increased integrity of cooked maize noodles, however, corresponded to the increased amounts of gelatinized and retrograded starch. | TONG Yi 1, Waniska Ralph D. 2 and LI Wei 1** (1. College of Life Science, Jilin University, Changchun, 130023 2. Cereal Quality Laboratory, Department of Soil & Crop Sciences, Texas A & M University, College Station, Texas, 77843 24474) | 2000 | Chemical Research in Chinese Universities2000，16，3： | 2 |
| 9 | Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair显示文摘AIM To determine endothelin-1(ET-1)concentration before and after surgical coarctectomy and evaluate its association with left ventricular geometric change.METHODSA prospective,cohort study of 24 patients aged 2 d to 10years with coarctation of the aorta undergoing surgical repair.A sub-cohort of patients with age<1 mo was classified as'neonates'.Echocardiograms were performed just prior to surgery and in the immediate post-op period to assess left ventricle mass index and relative wall thickness(RWT).Plasma ET-1 levels were assessed at both time points.Association between ET-1 levels and ventricular remodeling was assessed.RESULTSPatients<1 year demonstrated higher pre-op ET-1 than post-op(2.8 pg/m L vs 1.9 pg/m L,P=0.02).Conversely,patients>1 year had no change in ET-1 concentration before and after surgery(1.1 vs 1.4,NS).Pre-op,patients<1 year demonstrated significantly higher ET-1 than older children(2.8 vs 1.1,P=0.001).Post-op there was no difference between the age groups(1.9 vs 1.4,NS).Neither RWT nor left ventricle mass index(LVMI)varied from pre-op to post-op.The subset of neonates showed a strong positive correlation between pre-op ET-1 and RWT(r=0.92,P=0.001).Patients with ET-1>2 pg/m L preop demonstrated higher LVMI(65.7 g/m^(2.7) vs 38.5 g/m^(2.7),P=0.004)and a trend towards higher RWT(45%vs39%,P=0.07)prior to repair than those with lower ET-1concentration.CONCLUSIONET-1 concentration is significantly variable in the perioperative period surrounding coarctectomy.Older children and infants have different responses to surgical repair suggesting different mechanisms of activation. | Benjamin Steven Frank Tracy T Urban Suhong Tong Courtney Cassidy Max B Mitchell Christopher S Nichols Jesse A Davidson | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 10 | Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo显示文摘Objective: To determine the in vitro and in vivo absorption properties of active ingredients of the Chinese medicine, baicalein, to enrich mechanistic understanding of oral drug absorption.Methods: The Biopharmaceutic Classification System(BCS) category was determined using equilibrium solubility, intrinsic dissolution rate, and intestinal permeability to evaluate intestinal absorption mechanisms of baicalein in rats in vitro. Physiologically based pharmacokinetic(PBPK) model commercial software GastroPlus~(TM) was used to predict oral absorption of baicalein in vivo.Results: Based on equilibrium solubility, intrinsic dissolution rate, and permeability values of main absorptive segments in the duodenum, jejunum, and ileum, baicalein was classified as a drug with low solubility and high permeability. Intestinal perfusion with venous sampling(IPVS) revealed that baicalein was extensively metabolized in the body, which corresponded to the low bioavailability predicted by the PBPK model. Further, the PBPK model predicted the key indicators of BCS, leading to reclassification as BCS-II. Predicted values of peak plasma concentration of the drug(C_(max)) and area under the curve(AUC)fell within two times of the error of the measured results, highlighting the superior prediction of absorption of baicalein in rats, beagles, and humans. The PBPK model supported in vitro and in vivo evidence and provided excellent prediction for this BCS class II drug.Conclusion: BCS and PBPK are complementary methods that enable comprehensive research of BCS parameters, intestinal absorption rate, metabolism, prediction of human absorption fraction and bioavailability, simulation of PK, and drug absorption in various intestinal segments across species. This combined approach may facilitate a more comprehensive and accurate analysis of the absorption characteristics of active ingredients of Chinese medicine from in vitro and in vivo perspectives. | Yang Liu Jing Sun Linying Zhong Yu Li A Na Er Tong Li Le Yang Ling Dong | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，3： | 2 |
| 11 | Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs. | Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 12 | Protective effect and mechanisms of action of Mongolian medicine Sulongga-4 on pyloric ligation-induced gastroduodenal ulcer in rats显示文摘BACKGROUND Sulongga-4(SL-4)is a herbal formula used in traditional Mongolian medical clinics for the treatment of peptic ulcers and gastroenteritis,even though its pharmacological mechanism has not been well characterized.AIM To evaluate the protective effect and identify the mechanisms of action of SL-4 on gastroduodenal ulcer induced by pyloric ligation(PL)in rats.METHODS PL was performed to induce gastric and duodenal ulcers in rats,which were then treated with oral SL-4(1.3,2.6,or 3.9 g/kg per day)for 15 d.PL-induced gastroduodenal ulceration.Therapeutic effects were characterized by pathological and histological evaluations and inflammatory indicators were analyzed by enzyme-linked immunosorbent assay.Microarray analyses were conducted to identify gene expression profiles of gastroduodenal tissue in PL rats with or without SL-4 treatment.The candidate target genes were selected and verified by quantitative reverse transcription polymerase chain reaction(qRT-PCR).RESULTS SL-4 decreased histopathological features in the PL-induced ulcerated rats.SL-4 significantly (P < 0.05) decreased expression of tumor necrosis factor-α,interleukin (IL)-1β, IL-6, endotoxin, platelet-activating factor, and increasedprostaglandin E2 and epidermal growth factor in ulcer tissue. Microarray analysiswas used to identify a panel of candidate target genes for SL-4 acting on PLinducedulceration. Genes included some complement and coagulation cascadeand retinol metabolism pathways that are closely associated with inflammatoryresponses and gastric mucosal protective mechanisms. qRT-PCR showed thataltered expression of the selected genes, such as CYP2b2, UGT2b1, A2m, andMASP1 was consistent with the microarray results.CONCLUSIONSL-4 exerts protective effects against PL-induced gastroduodenal ulcers viareducing inflammatory cytokines and elevating expression of gastric acidinhibitory factors. Downregulation of CYP2b2 and UGT2b1 genes in retinolmetabolism and upregulation of A2m and MASP1 genes in the complement andcoagulation cascades pathways are possibly involved in SL-4-mediated protectionagainst gastroduodenal ulcer. | Shan Tong Huan Wang Li-Sha A Ta-Na Bai Ju-Hua Gong Wen-Jie Jin Li-Li Dai Gen-Na Ba Sung-Bo Cho Ming-Hai Fu | 2021 | World Journal of Gastroenterology2021，27，16： | 2 |
| 13 | Contracting and information sharing under supply chain competition显示文摘 | Ha A Tong S | 2008 | Management Science2008，54，： | 1 |
| 14 | Thermophilic Aerobic Digestion - a Reliable and Effective Process for Sludge Treatment at Small Works 显示文摘 | Murray K C Tong A | 1990 | Wat Sci Tech1990，22，34： | 1 |
| 15 | Diffuse axonal injury in children:clinical correlation with hemorrhagic lesions显示文摘 | Tong K A Ashwal S Holshpuser B A | 2004 | Ann Neurol2004，56，1： | 1 |
| 16 | Use of advanced neuroimaging techniques in the evaluation of pediatric traumatic brain injury (Review)显示文摘 | Ashwal S Holshouser B A Tong K A | 2006 | Dev Neurosci2006，28，45： | 1 |
| 17 | Age-invariant face recognition 显示文摘 | Unsang P Tong Yi-ying Jain A K | 2010 | IEEE Trans Pattern Anal Math Intell2010，32，5： | 1 |
| 18 | Hybird wavelet - Kalman fil- ter method for forecasting显示文摘 | Tong X Girgis A Makram E | 2000 | Electric Power Systems Research2000，54，1： | 1 |
| 19 | Switching from repression to activation:microRNAs can up-regulate translation显示文摘 | Vasudevan S Tong Y Steitz J A | 2007 | Science2007，318，5858： | 1 |
| 20 | Cellular and physiological effects of arginine显示文摘 | Tong BC Barbul A | 2004 | Mini Rev Med Chem2004，4，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员