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| 1 | Clinical outcomes of Clutch Cutter endoscopic submucosal dissection for older patients with early gastric cancer显示文摘AIM To evaluate the clinical outcome of endoscopic submucosal dissection using the Clutch Cutter(ESDCC) in older patients. METHODS We reviewed 232 consecutive patients with early gastric cancer who underwent ESDCC between June 2010 and February 2014 at Aso Iizuka Hospital. We divided patients into two groups according to age: Older patients(> 80 years, n = 64) and non-older patients(≤ 80 years, n = 168). We retrospectively compared the prevalence rates of pre-existing comorbidities, anticoagulant therapy, en bloc resection, mean duration of hospitalization, incidence of ESDCC-related complications, change in performance status(PS) before and after ESDCC, and financial cost of admission. RESULTS The older group comprised 64 patients with a mean age of 84.1 years, and the non-older group comprised 168 patients with a mean age of 69.5 years. Older patients had significantly more pre-existing comorbidities than did non-older patients, specifically heart disease(P < 0.05). The en bloc resection rate in non-older patients was significantly higher than that in older patients(100% vs 95.3%, P = 0.02). There were no significant differences between the older and non-older groups in the incidence of ESDCC-related complications(i.e., postoperative bleeding and perforation) and the post-ESDCC change in PS. There were also no significant differences between the older and non-older groups in the mean duration of hospitalization(11.4 and 10.7 d, respectively) and financial cost of admission(657040 JPY and 574890 JPY, respectively).CONCLUSION ESDCC has a good clinical outcome in older patients. | Yoshihiro Otsuka Kazuya Akahoshi Kayoko Yasunaga Masaru Kubokawa Junya Gibo Shigeki Osada Kayo Tokumaru Kazuaki Miyamoto Takao Sato Yuki Shiratsuchi Masafumi Oya Hidenobu Koga Eikichi Ihara Kazuhiko Nakamura | 2017 | World Journal of Gastrointestinal Oncology2017，9，10： | 4 |
| 2 | A new aspect on the origin of an anomalous substituent effect on the azomethine proton chemical shifts in 4-substituted N-benzylideneanilines显示文摘 | Akaba R Sakuragi H Tokumaru K | 1985 | Bull Chem Soc Jpn1985，58，： | 2 |
| 3 | Cervical dural sac and spinal cord in juvenile muscular atrophy of distal upper extremity 显示文摘 | Hirayama K Tokumaru Y | 2000 | Neurology2000，54，10： | 1 |
| 4 | Activation of Induc- ible NOS in peripheral vessels and Outcomes in Heart Failure Patients 显示文摘 | Ishibashi Y Takahashi N Tokumaru A | 2008 | Journal of Cardiac Failure2008，9，14： | 1 |
| 5 | Cervical Dural Sac and Spinal Cord in Juvenile Muscular Atrophy of Distal Upper Extremity显示文摘 | HIRAYAMA K TOKUMARU Y | 2000 | Neurology( S0028 - 3878)2000，54，： | 1 |
| 6 | Activation of matrix melal- loproteinase-2 in head and neck squamous cell carcinoma: studies of clinical samples and in vitro cell lines co-cultured with fibro- blasts 显示文摘 | Tokumaru Y Fujii M Otani Y | 2000 | Cancer Lett2000，150，1： | 1 |
| 7 | Cervical duralsac andspinal cord in juvenilemuscular atrophy of distal upper extremity显示文摘 | Hirayama K Tokumaru Y | 2000 | Neurology2000，54，10： | 1 |
| 8 | Nuclear transloeation of phosphorylated STAT3 is essential for VEGF-induced human dermal microvascular endothelial cell migration and tube formation 显示文摘 | Yahata Y Shirakata Y Tokumaru $ | 2003 | J Biol Chem2003，21，： | 1 |
| 9 | Collapse of extracellular glutamate regulation during epileptpgenesis:down -regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid 显示文摘 | Ueda Y Doi T Tokumaru J | 2001 | J Neurochem2001，76，： | 1 |
| 10 | 显示文摘 | Tokumaru O Y | 1984 | J Appl Phys1984，56，： | 1 |
| 11 | Gene promter hypermethylation in tumors and lymph nodes of stage Ⅰ lung cancer patients显示文摘 | Harden S V Tokumaru Y Westra W H | 2003 | Clin Cancer Res2003，9，4： | 1 |
| 12 | Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing显示文摘 | Tokumaru Y Yamashita K Osada M | 2004 | Cancer Res2004，，17： | 1 |
| 13 | A real-time learning algorithm for a muhilayered neural network based on the extended kalman filter 显示文摘 | IIGUNI Y SAKAI H Tokumaru H | 1992 | ieee transaction on signal processing1992，40，4： | 1 |
| 14 | Cervical dural sac and spinal cord injuvenile muscular atrophy of distal upper extremity显示文摘 | HIRAYAMA K TSUKABI T TOKUMARU Y | 2000 | Neurology2000，54，： | 1 |
| 15 | Cervical dural sac and spinal cord in juvenile muscular atrophy of distal upper extremity显示文摘 | Hirayama K Tokumaru Y | 2000 | Neurology2000，54，10： | 1 |
| 16 | Let-7 regulates Dicer expression and constitutes a negative feedback loop显示文摘 | Tokumaru S Suzuki M Yamada H | 2008 | Carcinogenesis2008，29，： | 1 |
| 17 | Cervical collar therapy for juvenile muscular atrophy of distal upper extremity (Hirayama disease):results from 38 cases显示文摘 | Tokumaru Y Hirayama K | | 0，，4： | 1 |
| 18 | Gene promoter hypermethylation in tumors and lymph nodes of stage Ⅰ lung cancer patients显示文摘 | HARDEN SV TOKUMARU Y WESTRA WH etal | 2003 | Clin Cancer Res2003，9，4： | 1 |
| 19 | Cervical dural sac and spinal cord in ju-venile muscular atrophy of distal upper extremity 显示文摘 | Hirayama K Tokumaru Y | 2000 | Neurology2000，54，10： | 1 |
| 20 | Imaging spectrum of sporadic cerebral amyloid angiopathy: multi- faceted features of a single pathological condition 显示文摘 | Sakurai K Tokumaru A M Nakatsuka T | 2014 | In- sights Imaging2014，5，3： | 1 |
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