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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Effect of film-hole shape on turbine-blade heat-transfer coefficient distribution 显示文摘 | TENG S HAN J C POINSATTE P E | 2001 | Jour- nal of Thermophysics and Heat Transfer2001，15，3： | 1 |
| 3 | Arthroscopic reduction and suture fixation of displaced tibial intercondylar eminence fractures in adults显示文摘 | Yang S W Lu Y C Teng H P | 2005 | Arch Orthop Trauma Surg2005，125，4： | 1 |
| 4 | Experimen- tal and numerical investigations of effect of col- umn length on retardation factor determination: A case study of cesium transport in crushed gran- ite显示文摘 | LI M H WANG T H TENG S P | 2009 | Journal of Hazardous Materials2009，162，1： | 1 |
| 5 | New C2-symmetric 2,2′-bipyridine crown macrocycles for enantioselective recognition of amino acid derivatives显示文摘 | LEE C S TENG P F WONG W L | 2005 | Tetrahedron2005，61，： | 1 |
| 6 | Multi-objective simulation-based evolutionary algorithm for an aircraft spare parts allocation problem显示文摘 | Lee L H Chew E P Teng S | 2008 | European Journal of Operational Research2008，112，2： | 1 |
| 7 | Synergism between phospholipaseD2 and sorbitol accumulation in diabetic cataract formation through modulation ofNa, K-ATPase activity and osmotic stress 显示文摘 | Huang P Jiang Z Teng S | 2006 | Exp Eye Res2006，83，4： | 1 |
| 8 | Pan-drug-resistant Pseudomonas aeruginosa causing nosocomial infection at a university hospital in Taiwan显示文摘 | Hsueh P R Tseng S P Teng L J | 2005 | Clin Microbiol Infect2005，11，8： | 1 |
| 9 | Climate change: potential impact on plant disease显示文摘 | Chakraborty S Tiedemann A V Teng P S | 2000 | Environmental Pollution2000，108，3： | 1 |
| 10 | Release Kinetics Studies of Aromatic Molecules into Water from Block Polymer Micelles 显示文摘 | Teng Y Morrisson M E Mubk P Webber S E | 1998 | Marcromolecules1998，31，： | 1 |
| 11 | In situ growth of LiFePO4 nanorod arrays under hydrothermal condition 显示文摘 | TENG F SANTGANGOPALAN S LEMMENS R GENG X B PATEL P MENG D D | 2010 | Solid State Sci2010，12，5： | 1 |
| 12 | Ciprofloxacin-resistant Salmonella enterica typhimurium and choleraesuis from pigs to humans, Taiwan显示文摘 | Hsueh P R Teng L J Tseng S P | 2004 | Emerg Infect Dis2004，10，1： | 1 |
| 13 | Genetic diversity and disease control in rice 显示文摘 | Zhu Y Y Chen H R Fan J H Wang Y Y Li Y Chert J B Fan J X Yang S S Hu L P Leung H Mew T W Teng P S Wang Z H Mundt C C | 2000 | Nature2000，406，： | 1 |
| 14 | 查看详情显示文摘 | Jiang B H Li D F Deng Y P Teng F K Chen J Xue S Kong X Q Luo C Shen X Xu F Yang W G Yin J Wang Y H Chen H Wu W Liu X Guo D A | | 0，，03： | 1 |
| 15 | 查看详情显示文摘 | Doneddu D Guy O J Dunstan P R Maffeis G G Teng K S Wilks S P Lgic P Twitchen D Clement R M | | 0，，： | 1 |
| 16 | Modelling sheath blightepidemics on rice tillers显示文摘 | Savary S Willocquet L Teng P S | 1997 | Agricultural Systems1997，55，3： | 1 |
| 17 | Synergistic inhibition of enterovirus 71replication by interferon and rupintrivir显示文摘 | Hung H C Wang H C Shih S R Teng I F Tseng C P Hsu J T | 2011 | J Infect Dis2011，203，12： | 1 |
| 18 | Multi-objective simulation- based evolutionary algorithm for an aircraft spare parts alloca- tion problem显示文摘 | Lee L H Chew E P Teng S | 2008 | European Journal of Operational Research2008，189，21： | 1 |
| 19 | Simulation of multiple species pest damage in rice using CERES - rice 显示文摘 | Pinnsehmidt H O Batchelo W D Teng P S | 1995 | Agricultural Systems1995，48，2： | 1 |
| 20 | In vitro activites of antimicrobial combinations against clinical isolates of Stenotrophomonas maltophilia显示文摘 | Liaw S J Teng L J Hsueh P R | 2002 | Formos Med Assoc2002，101，7： | 1 |
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