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| 1 | Vascular endothelial growth factor 165b expression in stromal cells and colorectal cancer显示文摘AIM:To characterize the implications of vascular endothelial growth factor(VEGF)-A in stromal cells and colorectal cancer and the expression of VEGF-A splice variants.METHODS:VEGF-A expression in tumor and stromal cells from 165 consecutive patients with colorectal cancer was examined by immunohistochemistry.The association between VEGF-A expression status and clinicopathological factors was investigated.Twenty freshfrozen samples were obtained for laser capture microdissection to analyze the splice variants of VEGF-A.RESULTS:VEGF-A was expressed in 53.9% and 42.4% of tumor and stromal cells,respectively.VEGF-A expression in tumor cells(t-VEGF-A) was associated with advanced clinical stage(stage 0,1/9;stage 1,2/16;stage 2,32/55;stage 3,38/66;stage 4,16/19,P < 0.0001).VEGF-A expression in stromal cells(s-VEGF-A) increased in the earlier clinical stage(stage 0,7/9;stage 1,6/16;stage 2,33/55;stage 3,22/66;stage 4,5/19;P = 0.004).Multivariate analyses for risk factors of recurrence showed that only s-VEGF-A expression was an independent risk factor for recurrence(relative risk 0.309,95% confidence interval 0.141-0.676,P = 0.0033).The five-year disease-free survival(DFS) rates of t-VEGF-A-positive and-negative cases were 51.4% and 62.9%,respectively.There was no significant difference in t-VEGF-A expression status.The five-year DFS rates of s-VEGF-A-positive and-negative cases were 73.8% and 39.9%,respectively.s-VEGFA-positive cases had significantly better survival than s-VEGF-A-negative cases(P = 0.0005).Splice variant analysis revealed that t-VEGF-A was mainly composed of VEGF165 and that s-VEGF-A included both VEGF165 and VEGF165b.In cases with no venous invasion(v0),the level of VEGF165b mRNA was significantly higher(v0 204.5 ± 122.7,v1 32.5 ± 36.7,v2 2.1 ± 1.7,P = 0.03).The microvessel density tended to be lower in cases with higher VEGF165b mRNA levels.CONCLUSION:s-VEGF-A appears be a good prognostic factor for colorectal cancer and includes VEGF165 and VEGF165b. | Makoto Tayama Tomohisa Furuhata Yoshiko Inafuku Kenji Okita Toshihiko Nishidate Toru Mizuguchi Yasutoshi Kimura Koichi Hirata | 2011 | World Journal of Gastroenterology2011，17，44： | 10 |
| 2 | Obstruction of st jude medical valves in the aortic position: histology and immunohistochemistry of pannus显示文摘 | Hideki Teshima Nobuhiko Hayashida Hirohisa Yano Masaru Nishimi Eiki Tayama Shuji Fukunaga Hidetoshi Akashi Takemi Kawara Shigeaki Aoyagi | 2003 | The Journal of Thoracic and Cardiovascular Surgery2003，，2： | 2 |
| 3 | Biocompatibility of heparin-coated extracorporeal bypass circuits: new heparin bonded bioline system 显示文摘 | Tayama E | 2000 | Art if Organs2000，24，8： | 1 |
| 4 | Evaluation of lesion in a spontaneous osteonecrosis of the knee using lgF-fluoride positron emission tomography显示文摘 | Aratake Masato Yoshifumi Tayama Takahashi Akira | 2009 | Knee Surg Sports Traumatol Arthrosc2009，17，： | 1 |
| 5 | Relationship between plasma soluble thrombomodulin levels and insulin resistance syndrome in type 2 diabetes: a comparison with yon Willebrand factor 显示文摘 | Aso Y Fujiwara Y Tayama K | 2001 | Exp Clin Endoerinol Diabetes2001，109，4： | 1 |
| 6 | An experimental study of atrial natriuretic peptide levels and the effect of inhaled nitric oxide after pneumonectomy显示文摘 | Takamori S Mifune H Tayama K | 2000 | Surg Today2000，30，： | 1 |
| 7 | Resolution of nitrogen-centered chiral tetraalkylammonium salts:application toStevens rearrangements with N-to-C chirality transmission显示文摘 | Tayama E J Otoyama S J Tanaka H | 2009 | Tetrahedron:Asymmetry2009，20，22： | 1 |
| 8 | Application for optical sensor to fish sorting显示文摘 | Tayama M Shimadate N Kubota N | | 0，，： | 1 |
| 9 | Metabolism and cytotoxicity of bisphenol A and other bisphenols in isolated rat hepatocytes 显示文摘 | Nakagawa Y Tayama S | 2000 | Arch Toxicol2000，74，2： | 1 |
| 10 | Effect of a corti- cotropin releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome 显示文摘 | Sagami Y Shimada Y Tayama J | 2004 | Gut2004，53，： | 1 |
| 11 | High-dose cimetidine reduces proinflammatory reaction after cardiac surgery with cardiopulmonary hypass显示文摘 | Tayama E Hayashida N Fukunaga S | 2001 | Ann Thorac Surg2001，72，6： | 1 |
| 12 | 显示文摘 | Aso Y Fujiwara Y Tayama K | 2002 | Diabet Med2002，19，1： | 1 |
| 13 | The connection between QT dispersion and autonomic neuropathy in patients with type 2 diabetes 显示文摘 | Takebayashi K Sugita R Tayama K | 2003 | Exp Clin Endocrinol Diabetes2003，111，6： | 1 |
| 14 | The connection between QT dispersion and autonomic neuropathy In patients with type 2 diabetes显示文摘 | Takebayashi k Sugita R Tayama K | 2003 | Exp Clin Endocrinol Diabetes2003，111，4： | 1 |
| 15 | On the mechanism of butylated hydroxytoluene-induced hepatic toxicity in rats 显示文摘 | Nakagawa Y Tayama K Nakao T | 1984 | Biochem Pharmacol1984，33，： | 1 |
| 16 | Cloning and characterization of groESL operon in Acetobacter aceti显示文摘 | Okamoto-Kainuma A Yan W Kadono S Tayama K Koizumi Y Yanagida F | | 0，，： | 1 |
| 17 | Effect of a corticotropin releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome显示文摘 | Sagami Y Shimada Y Tayama J | 2004 | Gut2004，53，7： | 1 |
| 18 | Arginine vasopressin is an ideal drug after cardiac surgery for the management of low systemic vascular resistant hypotension concomitant with pulmonary hypertension 显示文摘 | Tayama E Ueda T Shojima T | 2007 | Interact Cardiovasc Thorac Surg2007，6，6： | 1 |
| 19 | Benzophenone-induced estrogenic potency in ovariectomized rats 显示文摘 | Nakagawa Y Tayama K | 2002 | Arch Toxicol2002，76，12： | 1 |
| 20 | Higher plasma homocysteine concentration is associated with more advanced systemic arterial stiffness and greater blood pressure response to stress in hypertensive patients显示文摘 | Tayama J Munakata M Yoshinaga K | 2006 | Hypertension Research2006，29，： | 1 |
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