|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Air pollution characteristics and their relationship with emissions and meteorology in the Yangtze River Delta region during 2014–2016显示文摘With rapid economic growth and urbanization, the Yangtze River Delta(YRD) region in China has experienced serious air pollution challenges. In this study, we analyzed the air pollution characteristics and their relationship with emissions and meteorology in the YRD region during 2014–2016. In recent years, the concentrations of all air pollutants, except O3,decreased. Spatially, the PM2.5, PM10, SO2, and CO concentrations were higher in the northern YRD region, and NO2 and O3 were higher in the central YRD region. Based on the number of non-attainment days(i.e., days with air quality index greater than 100), PM2.5 was the largest contributor to air pollution in the YRD region, followed by O3, PM10, and NO2.However, particulate matter pollution has declined gradually, while O3 pollution worsened.Meteorological conditions mainly influenced day-to-day variations in pollutant concentrations. PM2.5 concentration was inversely related to wind speed, while O3 concentration was positively correlated with temperature and negatively correlated with relative humidity.The air quality improvement in recent years was mainly attributed to emission reductions.During 2014–2016, PM2.5, PM10, SO2, NOx, CO, NH3, and volatile organic compound(VOC)emissions in the YRD region were reduced by 26.3%, 29.2%, 32.4%, 8.1%, 15.9%, 4.5%, and0.3%, respectively. Regional transport also contributed to the air pollution. During regional haze periods, pollutants from North China and East China aggravated the pollution in the YRD region. Our findings suggest that emission reduction and regional joint prevention and control helped to improve the air quality in the YRD region. | Tao Ma Fengkui Duan Kebin He Yu Qin Dan Tong Guannan Geng Xuyan Liu Hui Li Shuo Yang Siqi Ye Beiyao Xu Qiang Zhang Yongliang Ma | 2019 | Journal of Environmental Sciences2019，31，9： | 26 |
| 2 | Comparison of Undernutrition Prevalence of Children under 5 Years in China between 2002 and 2013显示文摘Objective To describe the undernutrition status of children under 5-year in China, and study the trend between 2002 and 2013. Methods The study was based on two national surveys. Undernutrition was determined against WHO's 2006 growth standards. The prevalence in 2013 and 2002 was weighted by China sixth National Population Census(2010). The relationship between undernutrition and gender/age groups/different areas use weighted logistic regression. Results The results indicated the overall prevalence of stunting, underweight, and wasting of Chinese children under 5-year was 8.1%, 2.4%, and 1.9% in 2013, respectively. The prevalence of stunting was higher for children aged 12-47 month, while underweight was higher for children aged 48-59 month. The prevalence of undernutrition was higher in rural areas than in urban areas, especially in poor rural areas. There was a decline of stunting, underweight, and wasting between 2002 and 2013 among the children, with greater reduction in rural areas than in urban areas. Conclusion The prevalence of undernutrition of children under 5-year remains high in rural areas especially in poor rural areas in China. It is urgent to take action to control undernutrition in the vulnerable areas and subgroups. | YU Dong Mei ZHAO Li Yun YANG Zhen Yu CHANG Su Ying YU Wen Tao FANG Hong Yun WANG Xun YU Dan GUO Qi Ya XU Xiao Li FANG Yue Hui ZHAO Wen Hua YANG Xiao Guang DING Gang Qiang LIANG Xiao Feng | 2016 | Biomedical and Environmental Sciences2016，29，3： | 18 |
| 3 | Screening of QHF formula for effective ingredients from Chinese herbs and its anti-hepatic cell cancer effect in combination with chemotherapy显示文摘背景:最近的研究证明了中国植物的有效成分在治疗越来越广泛地被使用或然而,他们通常是的癌症的合作处理独立使用了并且在那里被限制了关于在多模式的治疗的中国植物的联合申请的研究。这研究的目的是屏蔽 QHF (Q:Qingrejiedu, H:Huoxuehuayu 和 F:Fuzhengguben ) 为从中国药的有效成分的公式并且估计它癌症(HCC ) 与化疗在联合完成的反肝的房间。方法:从中国药的六有效成分基于以前的文学被选择并且在学习使用了。QHF 公式和成分的最好的比率在老鼠(千米;公里) 由一致设计和肿瘤生长和幸存的监视抑制与稳固的肿瘤和腹水肿瘤建模的 H (22 ) 被评估。当在老鼠(Balb/c ) 与稳固的肿瘤和腹水肿瘤建模的 H (22 ) 与 cisplatin (DDP ) 结合了时,我们然后观察了 QHF 的反肝的房间癌症(HCC ) 效果。治疗学的效果评估包括了老鼠,肿瘤生长的抑制,幸存,在体重的变化,胸腺索引,怒气索引和白血球计数的一般条件。结果:为反肝的房间癌症治疗的最佳的 QHF 剂量比率是:800 mg/kg Cinobufotalin, 14 mg/kg 人参皂甙 Rg3, 5.5 mg/kg PNS 和 100 mg/kg Lentinan。治疗在当比用使用 QHF 公式(55.91%) 时,在 H (22 ) 老鼠禁止移植肿瘤的生长是更有效的 Cinobufotalin (33.25%) ,人参皂甙 Rg3 (35.11%) , PNS (27.12%) 或 Lentinan (4.97%) 独立。QHF 也延长了 H (22 ) 腹水的生活肝的癌症老鼠更高效地(38.13%) 比 Cinobufotalin (25.00%) ,人参皂甙 Rg3 (27.27%) , PNS (23.30%) 或 Lentinan (24.43%) 。与 DDP 相结合的 QHF 能减少导致 DDP 的白血球减少症,怒气和胸腺萎缩和另外的有毒的反应。有 DDP 的联合 QHF 肿瘤生长抑制随幸存的 66.83% 增加到达了 82.54% 。结论:QHF 比组成公式的单个药在反肝的房间癌症治疗是更有效的。与 DDP 相结合的 QHF 能稀释肿瘤生长并且压制导致 DDP 的有毒的反应。 | CHEN Tao LI Dan FU Ya-ling HU Wei | 2008 | Chinese Medical Journal2008，，4： | 17 |
| 4 | Rapid improvement of PM2.5 pollution and associated health benefits in China during 2013–2017显示文摘Exposure to fine particulate matter(PM2.5)is known to harm public health.In China,after implementation of aggressive emissions control measures under the Action Plan of Air Pollution Prevention and Control(2013-2017),air quality has significantly improved.In this work,we investigated changes in PM2.5 exposure and the associated health impacts in China for the period 2013-2017.We used an optimal estimator of PM2.5 combining in-situ observations,satellite measurements,and simulations from a chemical transport model to derive the spatial and temporal variations in PM2.5 exposure,and then used welldeveloped exposure-response functions to estimate the premature deaths attributable to PM2.5 exposure.We found that national population-weighed annual mean PM2.5 concentrations decreased from 67.4μgm-3 in 2013 to 45.5μgm-3 in 2017(32%reduction).This rapid decrease in PM2.5 pollution led to a 14%reduction in premature deaths due to long-term exposure.We estimated that,during 2013-2017,the premature deaths attributable to long-term PM2.5 exposure decreased from 1.2 million(95%CI:1.0,1.3;fraction of total mortality:13%)in 2013 to 1.0 million(95%CI:0.9,1.2;10%)in 2017.Despite the rapid decrease in annual mean PM2.5 concentrations,health benefits associated with reduced long-term exposure were limited,because for many cities,the PM2.5 levels remain at the portion where the exposure-response function is less steeper than that at the lowconcentration end.We also found that the deaths associated with acute exposure decreased by 61%during 2013-2017 due to rapid reduction in the number of heavily polluted days.Our results confirm that clean air policies in China have mitigated the air pollution crisis;however,continuous emissions reduction efforts are required to protect citizens from air pollution. | Tao XUE Jun LIU Qiang ZHANG Guannan GENG Yixuan ZHENG Dan TONG Zhu LIU Dabo GUAN Yu BO Tong ZHU Kebin HE Jiming HAO | 2019 | Science China Earth Sciences2019，62，12： | 17 |
| 5 | USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy显示文摘Macrophage polarization to proinflammatory M1-like or anti-inflammatory M2-like cells is critical to mount a host defense or repair tissue.The exact molecular mechanisms controlling this process are still elusive.Here,we report that ubiquitin-specific protease 19(USP19)acts as an anti-inflammatory switch that inhibits inflammatory responses and promotes M2-like macrophage polarization.USP19 inhibited NLRP3 inflammasome activation by increasing autophagy flux and decreasing the generation of mitochondrial reactive oxygen species.In addition,USP19 inhibited the proteasomal degradation of inflammasome-independent NLRP3 by cleaving its polyubiquitin chains.USP19-stabilized NLRP3 promoted M2-like macrophage polarization by direct association with interferon regulatory factor 4,thereby preventing its p62-mediated selective autophagic degradation.Consistent with these observations,compared to wild-type mice,Usp19−/−mice had decreased M2-like macrophage polarization and increased interleukin-1βsecretion,in response to alum and chitin injections.Thus,we have uncovered an unexpected mechanism by which USP19 switches the proinflammatory function of NLRP3 into an anti-inflammatory function,and suggest that USP19 is a potential therapeutic target for inflammatory interventions. | Tao Liu Liqiu Wang Puping Liang Xiaojuan Wang Yukun Liu Jing Cai Yuanchu She Dan Wang Zhi Wang Zhiyong Guo Samuel Bates Xiaojun Xia Junjiu Huang Jun Cui | 2021 | Cellular & Molecular Immunology2021，18，10： | 15 |
| 6 | Effect and mechanism of Irbesartan on occurrence of ventricular arrhythmias in rats with myocardial ischemia through connexin43(cx43)显示文摘Objective: To explore the effect and mechanism of angiotensin Ⅱ receptor blockers-Irbesartan on occurrence of ventricular arrhythmias in rats with myocardial ischemia. Methods: Rats with embryonic cardiomyocytes-H9c2 were randomly divided into control group, ischemia group, Irbesartan group and Irbesartan+ischemia group. The cell viability of rats in each group was tested using MTT. Real-time PCR was employed to detect the expression of connexin43(Cx43) mR NA and western blot to detect the expression of Cx43 and phosphorylated Cx43. SD rats were randomly divided into the sham-operation group(SO), myocardial infarction group(MI), Irbesartan group and MI+ Irbesartan group, with 10 rats in each group. HE staining was employed to observe the change in the pathomorphology of left ventricular tissue and TUNEL method to analyze the cell apoptosis in the tissue. The immunofluorescence was adopted to observe the expression and distribution of Cx43 in the left ventricular myocardium and study the change in the expression of Cx43 in the cardiac muscular tissue at mR NA and protein level. Results: The intervention of Irbesartan in the condition of ischemia indicated the significant decrease in the number of necrotic cells. The expression of Cx43 was significantly decreased under the culture of ischemia(P<0.05), but in the presence of Irbesartan, the expression of Cx43 was increased compared with the ischemia group(P<0.01). The results of WB assay showed the similar trend of change at mRNA level. There was the significant difference in the score of ventricular arerythmia between MI group and SO group(P<0.01). The incidence of ventricular tachycardia or ventricular fibrillation was significantly increased compared with the one in SO group(P<0.05). There was the significant difference in the overall score between MI+Irbesartan group and MI group(P<0.05). The expression of Cx43 in the cardiac muscular tissue in MI group was significantly decreased(P<0.01 vs SO group). But the expression of Cx43 was increased after the treatment with Irbesartan. Conclusions: Irbesartan can inhibit the injury of H9c2 cardiomyocytes and the decreased expression of Cx43 that are induced by the ischemic myocardial infarction. Irbesartan can also improve the reconstruction of Cx43 in rats with ischemic myocardium to inhibit the myocardial infarction-induced arrhythmias. | Tao Wu Dan Wu Qinghua Wu Bing Zou Xiao Huang Xiaoshu Cheng Yanqing Wu Kui Hong Ping Li | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，10： | 15 |
| 7 | A new bone repair scaffold combined with chitosan/ hydroxyapatite and sustained releasing icariin显示文摘Icariin, a plant-derived flavonol glycoside, has been proved as an osteoinductive agent for bone tissue engineering. A new bone repair scaffold was generated by thorough mixing of icariin and chitosan/ hydroxyapatite (icariin-CS/HA) using freeze-drying technigue. Characteristics of morphology, mechanical properties, biocompatibility, drug release behavior and bone repair abilities in vivo were evaluated. The results show that drug loading process of icariin did not affect physical structure of CS/HA composite significantly but decreased mechanical properies of CS/HA composite, which happened with a high dosage; icariin-CS/HA had favorable cell compatibility and promoted osteogenic differentiation of hBMSCs; the controlled release of icariin was satisfactory and the release retained after 90 d in vitro. In addition, icariin-CS/HA scaffolds had favorable osteoconduction and osteoinduction in vivo, and could fill bone defect sites and stimulate newborn bone tissues formation at early stage. On the basis of these data, icariin-CS/HA is believed to be an optical bone repair scaffold for tissue engineering. | WU Tao NAN KaiHui CHEN JingDi JIN Dan JIANG Shan ZHAO PeiRan XU JunChang DU Hao ZHANG XiaoQiang LI JianWei PEI GuoXian | 2009 | Chinese Science Bulletin2009，54，17： | 14 |
| 8 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 9 | Recurrence risk model for esophageal cancer after radical surgery显示文摘Objective:The aim of the present study was to construct a risk assessment model which was tested by disease-free survival(DFS)of esophageal cancer after radical surgery.Methods:A total of 164 consecutive esophageal cancer patients who had undergone radical surgery between January 2005 and December 2006 were retrospectively analyzed.The cutpoint of value at risk(VaR)was inferred by stem-and-leaf plot,as well as by independent-samples t-test for recurrence-free time,further confirmed by crosstab chi-square test,univariate analysis and Cox regression analysis for DFS.Results:The cutpoint of VaR was 0.3 on the basis of our model.The rate of recurrence was 30.3%(30/99)and 52.3%(34/65)in VaR<0.3 and VaR≥0.3(chi-square test,χ2=7.984,P=0.005),respectively.The 1-,3-,and 5-year DFS of esophageal cancer after radical surgery was 70.4%,48.7%,and 45.3%,respectively in VaR≥0.3,whereas 91.5%,75.8%,and 67.3%,respectively in VaR<0.3(Log-rank test,χ2=9.59,P=0.0020),and further confirmed by Cox regression analysis[hazard ratio=2.10,95%confidence interval(CI):1.2649-3.4751;P=0.0041].Conclusions:The model could be applied for integrated assessment of recurrence risk after radical surgery for esophageal cancer. | Jincheng Lu Hua Tao Dan Song Cheng Chen | 2013 | Chinese Journal of Cancer Research2013，25，5： | 12 |
| 10 | Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway显示文摘Glioblastoma 是最好攻击的大脑肿瘤,并且它的预后仍然保持差。因此,新奇治疗学的策略为 glioma 治疗被需要。Polyphyllin 我(PPI ) ,从巴黎 polyphylla 提取的 bioactive 成分,被报导有反肿瘤活动。然而,为这项活动的详细机制仍然保持不清楚。这里,我们在 vitro 在 glioma 房间和它的机制上调查了 PPI 的禁止的效果。U251 房间为 24 ~ 72 h 与 PPI (2-9 M ) 的各种各样的集中被对待。由 PPI 的 U251 房间增长的抑制被 MTT 试金估计。房间周期和 apoptosis 上的效果被流动 cytometry 与 PI 和 annexin V-FITC/PI 检验双染色,并且房间 mitochondrial 膜潜力水平被荧光显微镜学评估, JC-1 染色。apoptosis 相关的蛋白质和 JNK 信号小径蛋白质的表达式层次被西方的污点分析评估。结果证明 PPI 显著地以一种集中依赖者方式禁止了 U251 房间的增长。PPI 导致了 G 2/M 阶段拘捕和 apoptosis,并且它 upregulated Bax,细胞色素 c,和 p-JNK 的表情,而是 downregulated 在 U251 房间的 anti-apoptotic 蛋白质 Bcl-2 的表示。而且, PPI 挑起了 mitochondrial 膜潜力的去极。另外, PPI 导致的 apoptosis 被 JNK 禁止者 SP600125 显著地压制。我们的数据提供 PPI 禁止增长并且在 U251 房间导致 apoptotic 房间死亡的证据。这效果可以与 JNK 小径被联系。这些结果建议 PPI 是与潜在的 anti-glioma 效果表明小径的 JNK 的使活跃之物。 | Jiaxin Liu Yueting Zhang Li Chen Fei Yu Xiaojin Li Dan Tao Jianhua Zhao Shuai Zhou | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 11 |
| 11 | Protective Effects of Chaihu Shugan San(柴胡疏肝散) on Nonalcoholic Fatty Liver Disease in Rats with Insulin Resistance显示文摘Objective: To investigate the protective effects of Chinese medicine formulation Chaihu Shugan San(柴胡疏肝散, CHSGS) on nonalcoholic fatty liver disease(NAFLD) in rats with insulin resistance(IR) and its molecular mechanisms. Methods: Male Sprague-Dawley rats were randomly divided into six groups: the control group, the model group, Dongbao Gantai group(东宝肝泰, DBGT, 0.09 g methionine/kg), CHSGS high-dose group(CHSG-H, 12.6 g crude drug/kg), CHSGS medium-dose group(CHSG-M, 6.3 g crude drug/kg), and CHSGS low-dose group(CHSG-L, 3.15 g crude drug/kg). After establishing the NAFLD rat model and treatment for 8 weeks, total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C), free fatty acid(FFA), fasting blood glucose(FBG), fasting insulin(FINS) contents in blood serum, and TC, TG contents in the hepatic homogenate were measured by an automatic biochemical analyzer, and a homeostasis model assessment was applied to assess the status of IR, insulin sensitivity index(ISI), and homeostasis model assessment for insulin secretion(HOMA-IS). The expression levels of adiponectin and leptin mRNA in liver tissue were analyzed by reverse transcription polymerase chain reaction. Pathological changes of livers were observed by hematoxylineosin staining of paraffin section. Results: Compared with the model group, the serum levels of TC, TG, FFA, FBG, FINS, IRI, ISI, and the liver levels of TC and TG in CHSG-H, CHSG-M, CHSG-L groups showed significant declines(P<0.01 or P<0.05); the serum levels of HDL-C, HOMA-IS were significantly increased(P<0.01 or P<0.05); the expression of leptin mRNA was dramatically decreased and the expression of adiponectin mRNA was increased in the hepatic tissue(P<0.01 or P<0.05). The fatty deposition of liver cells could also be alleviated. Conclusion: CHSGS could up-regulate the expression of adiponectin mRNA and down-regulate the expression of leptin mRNA on the liver, suggesting the CHSGS had positive therapeutic effect on NAFLD in rats with IR. | JIANG Wei-ning LI Dan JIANG Tao GUO Jiao CHEN Yan-fen WANG Jie ZHOU Yun YANG Chao-yan TANG Chun-ping | 2018 | Chinese Journal of Integrative Medicine2018，24，2： | 10 |
| 12 | Effect of Integrated Chinese and Western Medicine Therapy on Severe Hand, Foot and Mouth Disease: A Prospective, Randomized, Controlled Trial显示文摘Objective: To evaluate the efficacy and safety of Chinese medicine(CM) plus Western medicine(WM) in the treatment of pediatric patients with severe hand, foot and mouth disease(HFMD) by conducting a prospective, controlled, and randomized trial. Methods: A total of 451 pediatric patients with severe HFMD were randomly assigned to receive WM therapy alone(224 cases, WM therapy group) or CM [Reduning Injection(热毒宁注射液) or Xiyanping Injection(喜炎平注射液)] plus WM therapy(227 cases, CM plus WM therapy group) for 7–10 days, according to a web-based randomization system. The primary outcome was fever clearance time, which was presented as temperature decreased half-life time. The secondary outcomes included the rate of rash/herpes disappearance within 120 h, as well as the rate for cough, runny nose, lethargy and weakness, agitation or irritability, and vomiting clearance within 120 h. The drug-related adverse events were also recorded. Results: The temperature decreased half-life time was 40.4 h in the WM therapy group, significantly longer than 27.2 h in the CM plus WM therapy group(P<0.01). Moreover, the rate for rash/herpes disappearance within 120 h was 43.6%(99/227) in the CM plus WM therapy group, significantly higher than 29.5%(66/224) in the WM therapy group(P<0.01). In addition, the rate for cough, lethargy and weakness, agitation or irritability disappearance within 120 h was 32.6%(74/227) in the CM plus WM therapy group, significantly higher than 19.2%(43/224) in the WM therapy group(P<0.01). No drug-related adverse events were observed during the course of the study. Conclusions: The combined CM and WM therapy achieved a better therapeutic efficacy in treating severe HFMD than the WM therapy alone. Reduning or Xiyanping Injections may become an important complementary therapy to WM for relieving the symptoms of severe HFMD. | LI Xiu-hui LI Shuang-jie XU Yi WEI Dan SHI Qing-sheng ZHU Qing-xiong YANG Tong DING Jian-bo TIAN Yi-mei HUANG Ji-han WANG Kun WEN Tao ZHANG Xi | 2017 | Chinese Journal of Integrative Medicine2017，23，12： | 10 |
| 13 | MicroTom Metabolic Network: Rewiring Tomato Metabolic Regulatory Network throughout the Growth Cycle显示文摘Tomato(Solanum lycopersicum)is a major horticultural crop worldwide and has emerged as a preeminent model for metabolic research.Although many research efforts have focused on the analysis of metabolite differences between varieties and species,the dynamics of metabolic changes during the tomato growth cycle and the regulatory networks that underlie these changes are poorly understood.In this study,we integrated high-resolution spatio-temporal metabolome and transcriptome data to systematically explore the metabolic landscape across 20 major tomato tissues and growth stages.In the resulting MicroTom Metabolic Network,the 540 detected metabolites and their co-expressed genes could be divided into 10 distinct clusters based on their biological functions.Using this dataset,we constructed a global map of the major metabolic changes that occur throughout the tomato growth cycle and dissected the underlying regulatory network.In addition to verifying previously well-established regulatory networks for important metabolites,we identified novel transcription factors that regulate the biosynthesis of important secondary metabolites such as steroidal glycoalkaloids and flavonoids.Our findings provide insights into spatiotemporal changes in tomato metabolism and generate a valuable resource for the study of metabolic regulatory processes in model plants. | Yan Li Yang Chen Lu Zhou Shengjie You Heng Deng Ya Chen Saleh Alseekh Yong Yuan Rao Fu Zixin Zhang Dan Su Alisdair R.Fernie Mondher Bouzayen Tao Ma Mingchun Liu Yang Zhang | 2020 | Molecular Plant2020，13，8： | 10 |
| 14 | Redox-sensitive prodrug nanoassemblies based on linoleic acid-modified docetaxel to resist breast cancers显示文摘Prodrug nanoassemblies, which can refrain from large excipients, achieve higher drug loading and control drug release, have been placed as the priority in drug delivery system. Reasoning that glutathione(GSH) and reactive oxygen species(ROS) are highly upgraded in tumor tissues which makes them attractive targets for drug delivery system, we designed and synthetized a novel prodrug which utilized mono thioether bond as a linker to bridge linoleic acid(LA) and docetaxel(DTX). This mono thioether-linked conjugates(DTX-S-LA) could self-assemble into nanoparticles without the aid of much excipients. The mono thioether endowed the nanoparticles redox sensitivity resulting in specific release at the tumor tissue. Our studies demonstrated that the nanoassemblies had uniform particle size, high stability and fast release behavior. DTX-S-LA nanoassemblies outperformed DTX solution in pharmacokinetic profiles for it had longer circulation time and higher area under curve(AUC). Compared with DTX solution, the redox dual-responsive nanoassemblies had comparable cytotoxic activity. Besides, the antitumor efficacy was evaluated in mice bearing 4 T1 xenograft. It turned out this nanoassemblies couldenhance anticancer efficacy by increasing the dose because of higher tolerance. Overall, these results indicated that the redox sensitivity nanoassemblies may have a great potential to cancer therapy. | Meng Li Liwen Zhao Tao Zhang Yue Shu Zhonggui He Yan Ma Dan Liu Yongjun Wang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 10 |
| 15 | Association of NOD1 and NOD2 genes polymorphisms with Helicobacter pylori related gastric cancer in a Chinese population显示文摘AIM:To investigate the association between the tag single nucleotide polymorphisms(TagSNPs) of NOD1 and NOD2 and the risk of developing gastric cancer.METHODS:We conducted a hospital-based case-control study including 296 incident gastric cancer patients and 160 gastritis controls.Eight TagSNPs in the NOD1 and NOD2 genes were selected from the Hapmap database using the haploview software and genotyped by the Sequenom MassArray system.The serum levels of anti-Helicobacter pylori(H.pylori) IgG were measured by enzyme-linked immunosorbent assay to indicate H.pylori infection.The odds ratios(OR) and 95% confidence intervals(CI) were calculated by unconditional logistic regression,including sex and age as confounding factors.RESULTS:The NOD1 rs2907749 GG genotype showed a decreased risk for gastric cancer(OR 0.50,95% CI:0.26-0.95,P = 0.04) while the rs7789045 TT genotype showed an increased risk(OR 2.14,95% CI:1.20-3.82,P = 0.01).An elevated susceptibility to gastric cancer was observed in the subjects with H.pylori infection and the NaOD1 rs7789045 TT genotype(OR 2.05,95% CI:1.07-3.94,P = 0.03) or the NOD2 rs7205423 GC genotype(OR 2.52,95% CI:1.05-6.04,P = 0.04).Haplotype analysis suggested that the distribution of AGT(rs2907749,rs2075820 and rs7789045) in NOD1 between the cases and control groups was significantly different(P corrected:0.04),and the diplotype AGT/AGT was associated with an elevated gastric cancer risk(OR 1.98,95% CI:1.04-3.79,P = 0.04).The association of the NOD1 rs7789045 TT genotype and the diplotype AGT/AGT was significant with H.pylori-related diffuse-type gastric cancer(OR 3.00,95% CI:1.38-6.53,P = 0.01;OR 4.02,95% CI:1.61-10.05,P < 0.01,respectively).CONCLUSION:Genetic polymorphisms in NOD1 and NOD2 may interact with H.pylori infection and may play important roles in promoting the development of gastric cancer in the Chinese population. | Peng Wang Li Zhang Jian-Ming Jiang Dan Ma Hao-Xia Tao Sheng-Ling Yuan Yan-Chun Wang Ling-Chun Wang Hao Liang Zhao-Shan Zhang Chun-Jie Liu | 2012 | World Journal of Gastroenterology2012，18，17： | 9 |
| 16 | Effects of single nucleotide polymorphisms 869 T/C and 915 G/C in the exon 1 locus of transforming growth factor-β1 gene on chronic obstructive pulmonary disease susceptibility in Chinese显示文摘背景为长期的妨碍的肺的疾病(COPD ) 的主要风险因素是香烟吸烟。然而,仅仅长期的重吸烟者的 10%-20% 开发系统的 COPD。我们假设了基因多型性的继承能影响 COPD 的发展,它被在 exon 学习二单个核苷酸多型性( SNP )调查 1 转变生长 factor-1 ( TGF-1 ) gene.Methods 我们作为控制组,作为研究组和 148 个健康的人与 COPD 注册了 219 个病人所有谁是中国汉人。 TGF-1 基因, 869T/C 和 915G/C 的多型性,用扩大的方法被分析在有 COPD 的病人的 TGF-1 基因 869T/C 多型性的出现是的倔强的变化系统聚合酶链反应( ARMS-PCR ) .Results 与控制组显著地不同( P < 0.05 ),在哪个这疾病的相对风险在情况中增加了有 C 等位基因(或:1.131, 95% Cl:1.101-1.539 ) 。与控制题目相比没有在 COPD 病人的 TGF-1 915G/C 基因的增加的频率(P > 0.05 ) 在 TGF-1 基因的多型性 869T/C 有的 .Conclusions 有在 COPD 病人和 C 等位基因的疾病出现的一个重要协会可能是一个风险因素。TGF1 上的 869T/C 的同型结合的野类型的 CC 能是在 COPD 的一个预先安排的因素,带 C 等位基因的那些可能特别地有危险性到开发 COPD。 | LIU Dai-shun LI Xiao-ou YING Bin-wu CHEN Lei WANG Tao XU Dan WEN Fu-qiang | 2010 | Chinese Medical Journal2010，，4： | 9 |
| 17 | Effect of co-transfection of miR-520c-3p and miR-132 on proliferation and apoptosis of hepatocellular carcinoma Huh7显示文摘Objective:To investigate the effects of co-transfection of miR-520c-3p and miR-132 on proliferation and apoptosis of hepatocellular carcinoma Huh7.Methods:Hepatocellular carcinoma Huh7 was cultured in vitro and lipidosome was used to transfect miR-520c-3p and miR-132 respectively or together.The effects of transfection of miR-520c-3p and miR-132 on proliferation and apoptosis of Huh7 were detected by CCK8 and Annexin V staining and flow cytometry,and the expression level of the targeted gene of over-expressed miR-520c-3p and miR-132 was determined by Western blot and realtime PCR.Results:Compared with the control group,the proliferation ability of Huh7 of the single transfected and co-transfected miR-520c-3p and miR-132 decreased significantly,and the apoptosis ratio increased distinctly(P<0.05).Besides,the affect of the co-transfection group was better than that of the single transfection group.The protein levels of GPC3(Glypican-3) and YAP(Yes-associated protein),the target genes transfected only by miR-520c-3p and miR-132,respectively,reduced obviously(P<0.05),which was similar with the co-infected cells,but cells transfected by miR-132 only showed a decrease of YAP.Conclusions:The co-transfection of miR-520c-3p and miR-132 can target-regulate the expression of GPC3 and YAP,enhance the exhibition effect on proliferation of hepatocellular carcinoma Huh7 and induce cell apoptosis synergistically. | Chang-Jiang Lei Chun Yao De-Ke Li Zhi-Xiong Long Yuan Li Dan Tao Yan-Ping Liou Jiang-Zhou Zhang Ning Liu | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，9： | 9 |
| 18 | In vivo and in vitro effects of QHF combined with chemotherapy on hepatocellular carcinoma显示文摘Objective:To investigate the synergistic anti-tumor effect of QHF (a Chinese medicine formula with antitumor active ingredients, including 800 mg/kg Cinobufotalin, 14 mg/kg Ginsenoside Rg3, 5.5 mg/kg Notoginseng and 100 mg/kg Lentinan) when combined with the chemotherapy drug cisplatin (DDP). Methods: Hepatocellular carcinoma H22 cells were implanted into mice and after the transplants were successfully established the animals were divided into four groups, namely a normal saline(NS) control group, QHF group, DDP group and QHF+DDP group. The tumor growth was monitored and the survival time determined. In vitro studies employing H22 cells used the first three groups, and determined the effects of QHF and DDP on tumor cell cycle distribution, apoptosis and morphologic changes in vitro. Results: QHF significantly inhibited the growth of tumors and prolonged the survival time of mice with hepatocellular carcinomas. QHF combined with DDP could attenuate DDP-induced leucopenia, spleen and thymus atrophy and other indicators of toxicity. The inhibition rate of tumor growth reached 82.54% with QHF+DDP, and QHF prolonged the life span of DDP-treated mice by 66.83%. In the in vitro experiments tumor cells showed morphological changes characteristic of apoptosis by both light and transmission electron microscopy in the QHF group, and the apoptosis rate was 33.85%. Moreover, the proportion of cells in the G0/G1 phase was increased and those in the S-phase decreased. Conclusion: QHF combined with DDP could significantly inhibit tumor growth, induce the apoptosis of tumor cells and effectively attenuate DDP toxicity. | Chen Tao Li Dan Fuya ling Gongzi Peng | 2010 | The Journal of Biomedical Research2010，24，2： | 9 |
| 19 | Self-supported CoMoS4 nanosheet array as an efficient catalyst for hydrogen evolution reaction at neutral pH显示文摘 | Xiang Ren Dan Wu Ruixiang Ge Xu Sun Hongmin Ma Tao Yan Yong Zhang Bin Du Qin Wei Liang Chen | 2018 | Nano Research2018，11，4： | 8 |
| 20 | Antiapoptotic Effect of Gene Therapy with Recombinant Adenovirus Vector Containing Hypoxia-inducible Factor-1α after Cerebral Ischemia and Reperfusion in Rats显示文摘 | Ming-Lang Yang Tao Tao Jian Xu Zhi Liu Dan Xu | 2017 | Chinese Medical Journal2017，，14： | 8 |
您所在的机构暂未开通此部分的功能，请联系管理员