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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Study on the rinetics of surface migration of surface modifying macromolecules in membrane preparation显示文摘 | Daniel E S Geeta C Takeshi M | 2002 | Macromolecules2002，35，： | 1 |
| 3 | Biphasic and dually coordinated expression of the genes encoding major shell matrix proteins in the pearl oyster Pinctada fucata显示文摘 | TAKESHI T KAZUYOSHI E | | 0，，01： | 1 |
| 4 | Comparison of accurate measurement of left ventricular mass in patients with hypertrophied hearts by real-time three-dimensional echocardiography versus magnetic resonance imaging显示文摘 | HIROKI O E TAKESHI H KOTARO A | 2005 | Am J Cardiol2005，95，： | 1 |
| 5 | Quantita- tive pollen-based climate reconstruction in central Japan : application to surface and Late Quaternary spectra显示文摘 | Nakagawa Takeshi Tarasov P E & Nishida Kotoba | 2002 | Quaternary Science Reviews2002，21，： | 1 |
| 6 | A rabidopsis AtMYC2 (bHLH)and AtMYB2(MYB)function as transcriptional activators in abscisic acid signaling显示文摘 | Hiroshi A Takeshi U Takuya I e t al | 2003 | The Plant Cell2003，15，： | 1 |
| 7 | Novel polycationic biocides : synthesis and antibacterial activity of polymeric phosphonium salts显示文摘 | Kanazawa A Tomiki I Takeshi E | 1993 | Polymer Science1993，31，2： | 1 |
| 8 | Aromatic hydrogenation of distillates over SiO2-Al2O3-supported noble metal catalysts显示文摘 | Takashi F Kazuo I Takeshi E | 2000 | Appllied Catalysis A: General2000，192，： | 1 |
| 9 | Photoinitiated Ring-Opening Polymerization of 2-Methylene-1,3-Dioxepane 显示文摘 | Bailey W J Takeshi E Makoto O | 1983 | J Polym Sci : Polym Letters Edition1983，21，： | 1 |
| 10 | Nucleophilic polyaddition in water based on chemo-selective reaction of cyclic carbonate with amine 显示文摘 | Bungo O Yuriko S Takeshi E | 2005 | Green Chemistry2005，7，： | 1 |
| 11 | Delection in a gene associated with grain size increased yield during rice domestication显示文摘 | AYAHIKO S TAKESHI I KAWORU E | 2005 | Nat Genet2005，40，8： | 1 |
| 12 | Salt stress-induced lipid peroxidation is reduced by glutathione S-transferase, but this reduction of lipid peroxides is not enough for a recovery of root growth in Arabidopsis显示文摘 | Maki K Takeshi O Bunichi E | 2005 | Plant Science2005，169，2： | 1 |
| 13 | Diffractive/refractive hybrid f θ lens for laser drilling显示文摘 | KEIJI F TAKESHI O KEIJI E | 2002 | SEI Technical Review2002，53，： | 1 |
| 14 | Synthesis of a novel epoxy resin containing naphthalene moiety and properties of its cured polymer with phenol novolac 显示文摘 | Masashi K Takeshi E | 1999 | Journal of Polymer Science:Part A:Polymer Chemistry1999，37，： | 1 |
| 15 | Polymeric phosphonium salts as a novel class of cationic biocides 显示文摘 | Akihiko K Tomiki I Takeshi E | 1993 | J Memberane Sci1993，31，12： | 1 |
| 16 | Effect of Initial pH on Formation of Hollow Calcium Carbonate Particles by Continuous CO2 Gas Bubbling into CaCl2 Aqueous Solution显示文摘 | Hideo W Yoshiaki M Takeshi E | 2009 | Advanced Powder Technology2009，20，： | 1 |
| 17 | Antibacterial activity of fibers surface - treated with phosphonium saltscontaining trimethoxysilane groups 显示文摘 | Akihiko K Tomiki I Takeshi E | 1994 | JAppl PolymSci1994，52，5： | 1 |
| 18 | Synthesis and Polymerization of 4-O-vinylbenzyl-2,2,6,6-tetramethlpiperidine显示文摘 | Takeo M Takeshi E Makoto O | 1985 | Journal of Polymer Science:Polymer Chemistry Edition1985，23，： | 1 |
| 19 | New Clinical Signs of Cervical Cord Damage显示文摘 | Keiro O Sohei E Takeshi F | 1987 | J Bone and Joint Surg (Br)1987，69，2： | 1 |
| 20 | Effect of vanadium on USY zeolite destruction in the presence of sodium ions and steam-studies by solid-state NMR显示文摘 | Kazuhiko H Takeshi E Nobuki U | 2003 | Applied catalysis A: General2003，249，： | 1 |
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