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1084篇 您的检索式:作者名="TA H"
    题名 作者 年代 出处 被引量
1脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 2018神经损伤与功能重建2018,13,4:4
2The elephant in uremia:Oxidant stress as a unifying concept of cardiovascular disease in uremia显示文摘Jonathan H Stenvinkel P Ikizler TA 2002Kidney Int2002,62,:2
3Intraneuronal beta-amyloid is a major risk factor - novel evidence from the APP/PS1KI mouse model 显示文摘Bayer TA Breyhan H Duan K 2008Neurodegener Dis2008,5,34:1
4Anti-allergic effects of Sanguisorba officinalis on animal models of allergic reactions显示文摘SHIN T Y LEE K B KIM S H TA Y 2002Immunopharmacology & Immunotoxicology2002,24,3:1
5Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation显示文摘Ding H Matthews TA Johnson GV 2006J Biol Chem2006,281,19:1
6Localization of the motor hand area to a knob on the precentral gyrus,a new land- mark显示文摘Yousry TA Schmid UD Alkhadhi H 1997Brain1997,120,1:1
7The oncogenic LIM protein Rbtn2 causes thymic developmental aberrations that precede malignancy in transgenic mice 显示文摘Larson RC Osada H Larson TA 1995Oncogene1995,11,:1
8The strength of distal fixation of flexor digitorum profundus tendon grafts in human cadavers显示文摘McNally TA Hamman JJ Heminger H 2002Hand Surg2002,27,4:1
9Perceptions of workplace bullying in the New Zealand travel industry:Prevalence and management strategies 显示文摘Bentley TA Catley B Cooper-Thomas H 2012Tourism Management2012,33,2:1
10Family history of diabetes as a potential public health tool显示文摘Harrison TA Hindorff LA Kim H 2003Am J Prev Med2003,24,2:1
11Phenylbutazone toxicosis in equidae a biochemical and pathophysiologic study显示文摘Snow DH Douglas TA Thompson H 1981Am J Vet Res1981,42,10:1
12Calcium anidotrihydroborate:a hydrogen storage material显示文摘Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K 0,,47:1
13Contrast-ultrasound dispersion imaging for prostate cancer localization by improved spatiotemporal similarity analysis显示文摘KUENEN MP SAIDOV TA WIJKSTRA H 2013Ultrasound Med Biol2013,39,9:1
14Thrombocytopenia com- plicating treatment with intravenous glycoprotein IIb/IIIa receptor in- hibitor: a pooled analysis显示文摘Dasgup ta H Blankenship JC Wood GC 2000Am Heart J2000,140,:1
15The sclerostin- bone protein interactome显示文摘Devarajan-Ketha H Craig TA Madden BJ 2012Biochem Biophys Res Commun2012,417,2:1
16Malignant melanoma of the penis显示文摘Stillwell TJ Zincke H Gaffey TA 1988J Urol1988,140,1:1
17Optimization of humanized IgGs in glycoengineered Pichia pastoris 显示文摘LI H SETHURAMAN N STADHEIM TA 2006Nat Biotechnol2006,24,2:1
18Correspondence analysis of microarray time-course data in case-control design 显示文摘QIHUA TA KLAUS B DANIEL H 2004Journal of Biomedical Informatics2004,37,5:1
19Cell surface expression of a chimeric protein containing mouse immunoglobulin GI Fc domain and its immunological显示文摘Batanova TA Ota H Kitoh K 2006J Vet Med Sci2006,68,1:1
20Critical evaluation of Mirels' rating system for impending pathologic fractures 显示文摘Damron TA Morgan H Prakash D 2003Clin Orthop Relat Res2003,,415:1
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