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| 1 | Quantitative Analysis of Paleoatmospheric CO2 Level Based on Stomatal Characters of Fossil Ginkgo from Jurassic to Cretaceous in China显示文摘更好理论的 A 并且在地质的历史期间的在 paleo-CO_2 和气候之间的连接的实际理解是重要的提高现代人的社会的持续发展。自从 1980 年代,在植物生理学的开发导致了石块植物能为 paleoatmosphere 和 paleobiosphere 作为一个代理服务的实现。作为有进化壅滞的寡妇裸子植物,白果树很好适合 paleoenvironmental 重建。这篇论文用植物生理学的解剖数据在中国的北方从综合阶层分析石块白果树种类。用有气孔的参数,为 paleo-C0_2 水平的一个趋势在早中间的侏罗记和早白垩纪期间被获得,它与由 GEOCARB 的估计一致。趋势也类似于在地质的时间的吝啬的全球表面温度的。与三个另外的大气的 CO_2 集中参数相比, paleo-CO_2 水平的趋势基于从三个连续阶层的石块白果树标本的有气孔的参数是更多准确。 | SUN Bainian XIAO Liang XIE Sanping DENG Shenghui WANG Yongdong JIA Hui Susan Tumer | 2007 | Acta Geologica Sinica(English Edition)2007，81，6： | 23 |
| 2 | Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine显示文摘A tooth is a complex biological organ and consists of multiple tissues including the enamel, dentin, cementum and pulp. Tooth loss is the most common organ failure. Can a tooth be regenerated? Can adult stem cells be orchestrated to regenerate tooth structures such as the enamel, dentin, cementum and dental pulp, or even an entire tooth? If not, what are the therapeutically viable sources of stem cells for tooth regeneration? Do stem cells necessarily need to be taken out of the body, and manipulated ex vivo before they are transplanted for tooth regeneration? How can regenerated teeth be economically competitive with dental implants? Would it be possible to make regenerated teeth affordable by a large segment of the population worldwide? This review article explores existing and visionary approaches that address some of the above-mentioned questions. Tooth regeneration represents a revolution in stomatology as a shift in the paradigm from repair to regeneration: repair is by metal or artificial materials whereas regeneration is by biological restoration. Tooth regeneration is an extension of the concepts in the broad field of regenerative medicine to restore a tissue defect to its original form and function by biological substitutes. | Sibel Yildirim Susan Y. Fu Keith Kim Hong Zhou Chang Hun Lee Ang Li Sahng Gyoon Kim Shuang Wang Jeremy J. Mao | 2011 | International Journal of Oral Science2011，3，3： | 16 |
| 3 | Impact of a nationwide training program for neonatal resuscitation in China显示文摘 | XU Tao WANG Hui-shan YE Hong-mao YU Ren-jie HUANG Xing-hua WANG Dan-hua Wang Li-xin FENG Qi GONG Li-min MA Yi William Keenan Susan Niermeyer | 2012 | Chinese Medical Journal2012，，8： | 13 |
| 4 | Application of community-based and integrated strategy to reduce malaria disease burden in southern Tanzania:the study protocol of China-UK-Tanzania pilot project on malaria control显示文摘Background:During the past six decades,remarkable success on malaria control has been made in China.The major experience could be shared with other malaria endemic countries including Tanzania with high malaria burden.Especially,China’s 1-3-7 model for malaria elimination is one of the most important refined experiences from many years’efforts and key innovation measures for malaria elimination in China.Methods:The China-UK-Tanzania pilot project on malaria control was implemented from April,2015 to June,2018,which was an operational research with two communities receiving the proposed interventions and two comparable communities serving as control sites.The World Health Organization'Test,Treat,Track'(WHO-T3)Initiative,which calls for every suspected case to receive a diagnostic test,every confirmed case to be treated,and for the disease to be tracked,was integrated with Chinese experiences on malaria control and elimination for exploration of a proper model tailored to the local settings.Application of China’s 1-3-7 model integrating with WHO-T3 initiative and local resources aiming at reducing the burden of malaria in terms of morbidity and mortality by 30%in the intervention communities in comparison with that at the baseline survey.Discussion:The China-UK-Tanzania pilot project on malaria control was that at China’s first pilot project on malaria control in Africa,exploring the feasibility of Chinese experiences by China-Africa collaboration,which is expected that the strategies and approaches used in this project could be potential for scaling up in Tanzania and African countries,and contribute to the acceleration of malaria control and elimination in Africa. | Duoquan Wang Prosper Chaki Yeromin Mlacha Tegemeo Gavana Mihayo Gabriel Michael Rashid Khatibu Jun Feng Zheng-Bin Zhou Kang-Ming Lin Shang Xia He Yan Deus Ishengoma Susan Rumisha Sigbert Mkude Renata Mandike Frank Chacky Charles Dismasi Salim Abdulla Honorati Masanja Ning Xiao Xiao-Nong Zhou | 2019 | Infectious Diseases of Poverty2019，8，1： | 12 |
| 5 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 6 | Estimation and Projection of the HIV Epidemic Trend among the Migrant Population in China显示文摘Objective The migrant population is a vulnerable group for HIV infection in China.Understanding potential epidemic trends among migrants is critical for developing HIV preventative measures in this population.Methods The Estimation and Projection Package (EPP) model was used to process prefecture and county-level surveillance data to generate HIV prevalence and epidemic trends for migrant populations in China.Results The prevalence of HIV among migrants in 2009 was estimated at 0.075% (95% CI:0.042%,0.108%) in China.The HIV epidemic among migrants is likely to increase over the next 5 years,with the prevalence expected to reach 0.110% (95% CI:0.070%,0.150%) by 2015.Conclusion Although the 2009 estimates for the HIV/AIDS epidemic in China indicate a slower rate of increase compared with the national HIV/AIDS epidemic,it is estimated to persistently increase among migrants over the next 5 years.Migrants will have a strong impact on the overall future of the HIV epidemic trend in China and evidence-based prevention and monitoring efforts should be expanded for this vulnerable population. | MENGXiaoJun WANG Lu Susan CHAN Kathleen Heather REILLY PENG ZhiHang GUO Wei DING GuoWei DING ZhengWei QIN QianQian | 2011 | Biomedical and Environmental Sciences2011，24，4： | 8 |
| 7 | Duloxetine versus placebo in the treatment of patients with generalized anxiety disorder in China显示文摘背景 Duloxetine 在试图估计功效的美国和 elsewhere.This 学习为概括焦虑混乱(荡者)的治疗被同意, tolerability ,并且在有 GAD.Methods 的中国病人的 duloxetine 的安全这9地点研究与至少中等严重的荡者和 Sheehan 残疾规模( SDS )与 duloxetine 60-120 mg 或与 placebo.Patients 由双窗帘治疗组成了 15 个星期全球工作缺陷总数分数 12 在这研究被包括。在那个点,为 nonresponders ,剂量为留下被增加到 120 mg 主要功效措施是的 8 weeks.The 医院焦虑和消沉规模焦虑 subscale 分数上的端点的从基线的吝啬的变化( HADS --一) .Secondary 功效措施包括了哈密尔顿焦虑等级规模( HAMA ), SDS ,和疼痛 measures.Safety 和 tolerability 是 assessed.Results 基线特征没在这些题目( n=210 )的治疗 groups.Mean 年龄之间显著地不同是 37.6 | WU Wen-yuan WANG Gang Susan G Ball Durisala Desaiah ANG Qiu-qing | 2011 | Chinese Medical Journal2011，，20： | 8 |
| 8 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 9 | Multiscale computational understanding and growth of 2D materials:a review显示文摘The successful discovery and isolation of graphene in 2004,and the subsequent synthesis of layered semiconductors and heterostructures beyond graphene have led to the exploding field of two-dimensional(2D)materials that explore their growth,new atomic-scale physics,and potential device applications.This review aims to provide an overview of theoretical,computational,and machine learning methods and tools at multiple length and time scales,and discuss how they can be utilized to assist/guide the design and synthesis of 2D materials beyond graphene. | Kasra Momeni Yanzhou Ji Yuanxi Wang Shiddartha Paul Sara Neshani Dundar E.Yilmaz Yun Kyung Shin Difan Zhang Jin-Wu Jiang Harold S.Park Susan Sinnott Adri van Duin Vincent Crespi Long-Qing Chen | 2020 | npj Computational Materials2020，，1： | 4 |
| 10 | Selective influence of plant species on microbial diversity in the rhizosphere显示文摘 | Susan J. Grayston Shenquiang Wang Colin D. Campbell Anthony C. Edwards | 1997 | Soil Biology and Biochemistry1997，，3： | 3 |
| 11 | Effects of aging on time course of neovascularization-related gene expression following acute hindlimb ischemia in mice显示文摘neovascularization 的背景分子的分析到响应局部缺血的路线没在老化的上下文被描述的时间联系了基因。我们试图提供老化怎么损害 neovascularization.Methods 幼仔的日益增多地更深的理解(3 月) 并且旧(18 月) C57BI 老鼠受到左 hindlimb 局部缺血。坏死 20 在小牛肌肉被评估。小牛肌肉,外部血,骨头髓在不同时间点被收获。矩阵 metalloproteiniase-9 ( MMPg )的表情, endothelial 氮的氧化物 synthase ( eNOS ),脉管的 endothelial 生长因素( VEGF ), stromal 导出生长 factor-1 ( SDF1 ),组织缺氧可诱导的 factor-1 ( HIF1 ), VEGF receptor-1 ( Fit1 ), VEGF receptor-2 ( Flk1 ), angiopoietin-1 ( Ang1 ), CD133 , CD26 被 RT-PCR 检测或西方的 blotting.White 血房间在外部血被数。基因表达式数据被 variance.Results MMP9, HIF-1 和 SDF-1 的双向分析比较,思考是更多的 upregulated 在老化鼠标在在年老对小的鼠标的尖锐局部缺血期间增加了局部缺血。然而, VEGF 和 eNOS 在年老对小的老鼠展出了更低的表示,尽管有更大的局部缺血紧张。Ang1 和 Flk1 在年老对小的鼠标显示出类似的表示。MMP9 在小对年老的老鼠在外部血更早达到顶点。在老化 bonemarrow 的并发的减少 CD26 和增加的 CD133 表示建议老化损害祖先房间动员,我们的结果显示那的结论缺点的一个复杂数组与变老发生防碍最佳的 neovascularization。这些包括祖先房间的潜在的损害动员到 ischemic 织物,到 ischemia.ZLEr 的 eNOS 和 VEGF 和推迟的回答的减少的层次。王金松,脉管的外科的分割,首先隶属于的医院,孙中山大学,广州,广东 510080,中国(Tel:86-20-87333440.Fax:86-20-87333242。Email:wangjs@mail.sysu.edu.cn ) 这个工作被 NIH RO1 HL085003-01A2 支持, NNSF30100179。 | WANG Jin-song LIU Xia XUE Zhen-yi Lee Alderman Justin U. Tilan Remi Adenika Stephen E. Epstein Mary Susan Bumett | 2011 | Chinese Medical Journal2011，，7： | 3 |
| 12 | Jurassic-Cretaceous Herpetofaunas from the Jehol Associated Strata in NE China:Evolutionary and Ecological Implications显示文摘Jurassic - Cretaceous herpetofaunas have recently been recovered from tuff-interbedded lacustrine strata in northeastern (NE) China. Most of them are from the Early | WANG Yuan DONG Liping Susan E. EVANS | 2010 | Bulletin of the Chinese Academy of Sciences2010，24，2： | 3 |
| 13 | Taxonomic revision of lizards from the Paleocene deposits of the Qianshan Basin, Anhui, China显示文摘 | DONG Li-Ping Susan E. EVANS WANG Yuan | 2016 | 古脊椎动物学报2016，54，3： | 2 |
| 14 | Evaluation of 3-day smoking cessation training course for doctors from 38 cities in China显示文摘 | ZHANG Chun-mei XIAO Dan Robea West Susan Michie Ronald Troughton Peter Hajek WANG Chen | 2012 | Chinese Medical Journal2012，，7： | 2 |
| 15 | QTL analysis and candidate gene mapping for skin and flesh color in sweet cherry fruit ( Prunus avium L.)显示文摘 | Suneth S. Sooriyapathirana Amjad Khan Audrey M. Sebolt Dechun Wang Jill M. Bushakra Kui Lin-Wang Andrew C. Allan Susan E. Gardiner David Chagné Amy F. Iezzoni | 2010 | Tree Genetics & Genomes2010，，6： | 2 |
| 16 | Binding of carbonyl flavours to canola, pea and wheat proteins using GC/MS approach显示文摘 | Kun Wang Susan D. Arntfield | 2014 | Food Chemistry2014，，： | 2 |
| 17 | The safety parameters of the study on intraductal cytotoxic agent delivery to the breast before mastectomy显示文摘Background: Intraductal administration of cytotoxic agents has been shown to inhibit the development of breast cancer in animal models. The object of this study was to demonstrate the safety of intraductal delivery cytotoxic agents in patients prior to mastectomy. This method is hopeful to be developed as a chemoprevention approach in patients with pre-malignant or non-invasive ductal lesions to prevent breast cancer which will be further developed.Methods: Two drugs, pegylated liposomal doxorubicin(PLD) and carboplatin were administered at three dose levels(PLD: 10, 20, 50 mg and carboplatin 60, 120, 300 mg). There were five subjects in each group with 15 subjects treated with each drug once. Venous blood samples were obtained for pharmacokinetic analysis. The breast was removed surgically 2-5 days post administration and the treated ducts were marked to enable identification on pathological evaluation. Results: Intraductal administration was generally well-tolerated with mild, transient breast discomfort. In the carboplatin arm, three women at the 300 mg dose experienced mild nausea and vomiting. In the PLD arm most women had mild erythema and swelling of the breast over the 72 hours following the drug administration. Patients receiving the 50 mg dose experienced local erythema until the time of surgery. Pharmacokinetic analysis showed that carboplatin rapidly entered systemic circulation with an early peak time(T max ~30 min) with a corresponding plasma ultrafiltrate area under the curve(AUC) consistent with the Calvert Formula using estimated glomerular filtration rate(GFR). Total plasma doxorubicin had delayed peak concentration times(T max >48 hours) with a linear dose response and peak concentrations substantially lower than expected from equivalent intravenous injection dosing. No doxorubicinol metabolite was detected in the plasma. Conclusions: This study demonstrates that cytotoxic drugs can be safely administered into breast ducts with minimal toxicity. | Bailin Zhang Susan M. Love Guoji Chen Jing Wang Jidong Gao Xiaozhou Xu Zhongzhao Wang Xiang Wang | 2014 | Chinese Journal of Cancer Research2014，26，5： | 2 |
| 18 | Family history and disease outcomes in patients with Crohn's disease:A comparison between China and the United States显示文摘AIM To investigate the differences in family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn's disease(CD) residing in China and the United States.METHODS We performed a survey-based cross-sectional study of participants with CD recruited from China and the United States.We compared the prevalence of IBD family history and history of ileal involvement,CD-related surgeries and IBD medications in China and the United States,adjusting for potential confounders.RESULTS We recruited 49 participants from China and 145 from the United States.The prevalence of family history of IBD was significantly lower in China compared with the United States(China:4.1%,United States:39.3%).The three most commonly affected types of relatives were cousin,sibling,and parent in the United States compared with child and sibling in China.Ileal involvement(China:63.3%,United States:63.5%) and surgery for CD(China:51.0%,United States:49.7%) were nearly equivalent in the two countries.CONCLUSION The lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United States.Despite the potential difference in etiology,surgery and ileal involvement were similar in the two countries.Examining the changes in family history during the continuing rise in IBD may provide further insight into the etiology of CD. | Pei-Qi Wang Jun Hu Elie S Al Kazzi Eboselume Akhuemonkhan Min Zhi Xiang Gao Raquel Holand de Paula Pessoa Sami Ghazaleh Tuhina Cornelius Suhel Abbas Sabunwala Shadi Ghadermarzi Kartikeya Tripathi Mark Lazarev Pin-Jin Hu Susan Hutfless | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 19 | Structural characteristics and rheological properties of partially hydrolyzed oat β-glucan: The effects of molecular weight and hydrolysis method显示文摘 | Tosh Susan M Wood Peter J Wang Qi weisz John | 2004 | Carbohydrate Polymers2004，55，4： | 1 |
| 20 | Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population显示文摘 | Hao Zhang Ling-Hong Liao Shuk-Ming Liu Kwok-Wai Lau Albert Kai-Cheong Lai Jin-Hui Zhang Qi Wang Xiao-Qian Chen Wei Wei Hua Liu Jian-Hua Cai Maria Li Lung Susan S. W. Tai Madeline Wu | 2007 | International Journal of Colorectal Disease2007，，10： | 1 |
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