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| 1 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 2 | Saferner effects on acetochlor toxicity,uptake,metabolism and glutathione S-transferase activity in maize显示文摘 | Ekler Z Dutka F Stephenson G R | 1993 | Weed Research1993，33，： | 1 |
| 3 | The male determinant of self-incompatibility in Brassica oleracea is located in the pollen coating显示文摘 | STEPHENSON A G DOUGHTY J DIXON S | 1997 | Plant J1997，12，6： | 1 |
| 4 | Persistence of 2,4-Dichlorophenoxy Acetic Acid and 2-(2,4-Dichlorophenoxy)Propionic Acid in Agricultural and Forest Soils of Northen and Southern Ontario显示文摘 | THOMPSON D G STEPHENSON G R | | 0，，03： | 1 |
| 5 | Lumping errors of heat conduction transients with time- dependent inputs显示文摘 | Stephenson D G Mitalas G P | 1980 | Journal of Heat Transfer1980，，： | 1 |
| 6 | Persistence and leachability of glufosinate-ammonium in a Northern Ontario terrestrial environment显示文摘 | Faber M J Stephenson G R Thompson D G | 1997 | Agric Food Chem1997，45，： | 1 |
| 7 | Falcon: A production quality distributed memory reservoir simulator 显示文摘 | Shiralkar G S Stephenson R E | 1998 | SPE Reservoir Evaluation and Engineering1998，10，2： | 1 |
| 8 | Dissipation of glufosinate ammonium in two Ontario soils显示文摘 | Gallina M A Stephenson G R | 1992 | Agric Food chem1992，40，： | 1 |
| 9 | Development of diagnosis and recommendation integrated system norms for bahiagrass显示文摘 | Payne G G Rechdgl J E Stephenson R J | 1990 | Agron J1990，82，： | 1 |
| 10 | Transformation of and Heterologous Protein Expression in,Lactobacillus agilis and Lactobacillus vaginalis Isolates from the Chicken Gastrointestinal Tract显示文摘 | STEPHENSON D P MOORE RJ ALLISON G E | | 0，，1： | 1 |
| 11 | Ul-traviolet (UV) disinfetion of grey water: Particle size effects显示文摘 | Winward G P Avery L M Stephenson T | 2008 | Enviromental Technology2008，29，2： | 1 |
| 12 | Safener effects on acetochlor toxicity, uptake, metabolism and glutathione S-transferase activity in maize 显示文摘 | Ekler Z Dutka F Stephenson G R | 1993 | Weed Research1993，33，4： | 1 |
| 13 | Glutathione conjugation: a detoxification pathway for fenoxapropethyl in barley, crabgrass, oat and wheat显示文摘 | TAL J A ROMANO M L STEPHENSON G R | 1993 | Pestic Biochem Physiol1993，46，： | 1 |
| 14 | Mycorrhizae form Denali National Park and Reserve, Alaska 显示文摘 | Treu R Laursen G A Stephenson S L | 1996 | Mycorrhiza1996，6，： | 1 |
| 15 | Room thermal response factors 显示文摘 | Stephenson D G Mitalas G P(1967) | 1967 | ASHRAE Transactions1967，73，1： | 1 |
| 16 | Flower and fruit abortion: proximate causes and ultimate functions显示文摘 | STEPHENSON A G | 1981 | Annual Review of Ecology and Systematics1981，12，： | 1 |
| 17 | The effect of track and vehicle parameters on wheel/rail vertical dynamic forces显示文摘 | JENKINS H STEPHENSON J CLAYTON G | 1974 | Railway Engineering Journal1974，，1： | 1 |
| 18 | Magnamosis: magnet- ic compression anastomosis with compar- ison to suture and staple techniques 显示文摘 | JAMSHIDI R STEPHENSON J T CLAY J G | 2009 | J Pediatr Surg2009，44，1： | 1 |
| 19 | Ferro- electricity in uhrathin perovskite films 显示文摘 | Fong D D Stephenson G B Streiffer S K | 2004 | Science2004，304，5677： | 1 |
| 20 | Evaluation of fungicides and tobacco cultivar resistance to Rhizoctonia solani incited target spot,damping off and sore shin显示文摘 | CSINOS A S STEPHENSON M G | 1999 | Crop Protection1999，18，： | 1 |
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