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| 1 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 2 | Non-surgical management of live ectopic pregnancy with ultrasound-guided local injection :a case series显示文摘 | Monteagudo A Minior VK Stephenson C | 2005 | Ultrasound Obstet Gynecol2005，25，3： | 1 |
| 3 | Production of measles nucleoprotein in different expression systems and its use as a diagnostic reagent显示文摘 | Warnes A Fooks A R Stephenson J R | 1994 | J Virol Meth1994，49，： | 1 |
| 4 | Analysitcal and experimental studies of drill temperatures显示文摘 | AGAPIOU J S STEPHENSON D A | 1994 | Journal of Engineering for Industry1994，116，1： | 1 |
| 5 | Estimating the insertion site daring retrograde intramedullary tibiotaloealeaneal arthrodesis 显示文摘 | Stephenson K A Kile T A Graves S C | 1996 | Foot Ankle Int1996，17，12： | 1 |
| 6 | Boosting immunity to influenza H5N1 with MF 59-adjuvanted H5N3 A/ Duck/Singapore/97 vaccine in a primed human population显示文摘 | Stephenson I Nicholson KG Colegate A | 2003 | Vaccine2003，21，15： | 1 |
| 7 | Performance of floating and sunken media biological aerated filters under unsteady state conditions显示文摘 | Mann A T Mendoza-Espinosa L Stephenson T | 1999 | Water Research1999，33，4： | 1 |
| 8 | Repetitive functionalization of water-soluble single-walled carbon nanotubes: Addition of acid-sensitive addends 显示文摘 | Stephenson J J Hudson J L Leonard A D | 2007 | Chem-istry of Materials2007，19，14： | 1 |
| 9 | Simple sequence repeat(SSR)marker survey of the cassava(Manihot esculenta Crantz)genome:toward a SSR-based molecular genetic map of cassava显示文摘 | Mba R E C Stephenson P Edwards K Mezer S Nkumbira J Gulberg U Apel K Gale M Tohme J Fregene M A | | 0，，： | 1 |
| 10 | Phosphorusremoval by chemical precipitation in biological aerated fil-ter显示文摘 | CLARK T STEPHENSON T PEARCE P A | 1997 | Water Research1997，31，10： | 1 |
| 11 | Issues in the Development of the Neo-classical Theory of Investment Behavior显示文摘 | Jorgenson D W and J A Stephenson | 1969 | Review of Economics and Statistics1969，，51： | 1 |
| 12 | The male determinant of self-incompatibility in Brassica oleracea is located in the pollen coating显示文摘 | STEPHENSON A G DOUGHTY J DIXON S | 1997 | Plant J1997，12，6： | 1 |
| 13 | Life-cy- cle Assessment of Potential Algal Biodiesel Production in the United Kingdom:A Comparison of Raceways and Air-lift Tubular Bioreactors显示文摘 | STEPHENSON A L KAZAMIA E DENNIS J S | 2010 | Energy & Fuels2010，24，7： | 1 |
| 14 | Towards rice genome scanning by map-based AFLP fingerprinting 显示文摘 | STEPHENSON P LAURIE D A | 1999 | Mol Gen Genet1999，261，2： | 1 |
| 15 | Does transurethral resection of the prostate compromise the radical treatment of the prostate cancer显示文摘 | Stephenson R A | 1996 | Semin Urol Oncol1996，14，： | 1 |
| 16 | Trastuzumab in the treatment of advanced non-small-cell lung cancer:is there a role? Focus on Eastern Cooperative Oncology Group study 2598显示文摘 | Langer CJ Stephenson P Thor A | 2004 | J Clin Oncol2004，22，7： | 1 |
| 17 | Drug-induced neuroprotection from global ischemia is associated with prevention of persistent but not transient activation of nuclear factor-kappaB in rats显示文摘 | CLEMENS J A STEPHENSON D T YIN T | 1998 | Stroke1998，29，3： | 1 |
| 18 | Proteolysis in human breast cancer 显示文摘 | Garbett E A Reed M W Stephenson T J | 2000 | Mol Pathol2000，53，2： | 1 |
| 19 | Dissipation of glufosinate ammonium in two Ontario soils显示文摘 | Gallina M A Stephenson G R | 1992 | Agric Food chem1992，40，： | 1 |
| 20 | High-resolution ^13C CP/MAS NMR spectra of solid cellulose oligomers and the structure of cellulose II显示文摘 | DUDLEY R L FYFE C A STEPHENSON P J | 1983 | Journal of the American Chemical Society1983，105，8： | 1 |
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