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| 1 | Immunohistochemical analysis of p53,cyclinD1,RB1,c-fos and N-ras gene expression in hepatocellular carcinoma in Iran显示文摘AIM: To study the effect of some genes especially those involved in cell cycle regulation on hepatocellular carcinoma. METHODS: Paraffin-embedded tissue samples of 25 patients (18 males and 7 females) with hepatocellular carcinoma were collected from 22 pathology centers in Tehran during 2000-2001, and stained using immunohistochemistry method (avidin-biotin-peroxidase) for detection of p53, cyclinD1, RB1, c-fos and N-ras proteins. RESULTS: Six (24%), 5 (20%), 12 (48%) and 2 samples (8%) were positive for p53, cyclinD1, C-fos and N-ras expression, respectively. Twenty-two (88%) samples had alterations in the G1 cell-cycle checkpoint protein expression (RB1 or cyclinD1). P53 positive samples showed a higher (9 times) risk of being positive for RB1 protein than p53 negative samples. Loss of expression of RB1 in association with p53 over-expression was observed in 4 (66.7%) of 6 samples. Loss of expression of RB1 was seen in all cyclinD1 positive, 20 (90.9%) N-ras negative, and 11 (50%) C-fos positive samples, respectively. CyclinD1 positive samples showed a higher (2.85 and 4.75 times) risk of being positive for c-fos and N-ras expression than cyclinD1 negative samples. CONCLUSION: The expression of p53, RB1 and c-fos genes appears to have a key role in the pathogenesis of hepatocellular carcinoma in Iran. Simultaneous overexpression of these genes is significantly associated with their loss of expression during development of hepatocellular carcinoma. | SJ Moghaddam EN Haghighi S Samiee N Shahid AR Keramati S Dadgar MR Zali | 2007 | World Journal of Gastroenterology2007，13，4： | 73 |
| 2 | Effect of hypnotherapy and educational intervention on brain response to visceral stimulus in the irritable bowel syndrome显示文摘 | M. B. O. Lowén E. A. Mayer M. Sj?berg K. Tillisch B. Naliboff J. Labus P. Lundberg M. Str?m M. Engstr?m S. A. Walter | 2013 | Aliment Pharmacol Ther2013，，12： | 4 |
| 3 | 视网膜病变、视网膜微血管异常与脑卒中、脑血管病的关系显示文摘视网膜循环异常可能与脑血管病有关。该研究基于英国的三民族人口的基础队列调查了视网膜微血管异常与脑卒中和亚临床脑梗死及脑白质病变之间的相关性。方法:纳入1185名受试者[年龄(68.8±6.1)岁,77%为男性]进行视网膜成像和脑磁共振成像。利用磁共振成像识别脑梗死和脑白质高信号,对视网膜病变进行分级,并测量视网膜血管参数。 | 刘莉 叶鹏 Hughes AD Falaschetti E Witt N Wijetunge S Thom SA Tillin T Aldington SJ Chaturvedi N | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 4 | Five new saponins from the root bark of Aralia elata 显示文摘 | Song SJ Nakamula N Ma | 2001 | Phytochemistry2001，56，： | 2 |
| 5 | 与有机食品相关联的消费者行为的决定因素显示文摘对于消费者来说,在他们决定购买或消费有机食品(主要为新鲜的有机食品)时,哪些因素会影响他们的购物决定?学者们对这一问题的研究已经很多了。研究的结果均表明:人们的态度和实际的行为之间有一些矛盾,对于有机食品,人们往往态度上是积极的但是常常却不购买它们。这一矛盾主要源于消费者并不把'有机生产'当作一项重要的采购标准,另外,有机食品在口味及贮藏限期(食品的两种非常重要的品质)上也并不比常规的食品具有优越性。此外,有机食品在价格上被认为比常规食品明显偏贵也是一个重要的因素。根据两个瑞典实例研究发现,人们对有机食品的态度及行为与其健康收益具有非常紧密的关系,并且超过了其正面的环境影响。一个新的欧盟项目将对新鲜的以及加工的有机食品的影响进行调查,并且还将对八个欧盟国家的人们在选择有机食品时,道德、伦理及情感因素所产生的影响进行调查。 | Richard Shepherd Maria Magnusson Per-Olow Sjdén 刘宝林 | 2005 | AMBIO-人类环境杂志2005，34，4： | 2 |
| 6 | PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals显示文摘 | Maria Antonella Burza Carlo Pirazzi Cristina Maglio Kajsa Sj?holm Rosellina Margherita Mancina Per-Arne Svensson Peter Jacobson Martin Adiels Marco Giorgio Baroni Jan Borén Stefano Ginanni Corradini Tiziana Montalcini Lars Sj?str?m Lena Mariana Susann Car | 2012 | Digestive and Liver Disease2012，，12： | 2 |
| 7 | Functional improvement by electro-acupuncture after transient middle cerebral artery occlusion in rats显示文摘 | Wang SJ Omori N Li F | 2003 | Neurol Res2003，25，5： | 1 |
| 8 | Effects of race and hypertension on flow-mediated and nitroglycerin mediated dilation of the brachial artery显示文摘 | Gokce N Holbrook M Duffy SJ | 2001 | Hypertension2001，38，： | 1 |
| 9 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 10 | Protein-tyrosine phosphatase activity regulates osteoclast formation an function:inhibition by alendronate显示文摘 | Schmidt A Rutledge SJ Endo N | 1996 | Proc Natl Acad Sci USA1996，93，7： | 1 |
| 11 | Effect of atorvastatin on endothe- lium dependent vasodilation in patients with coronary artery disease 显示文摘 | Vita JA Gokee N Duffy SJ | 2003 | Am J Cardiol2003，91，7： | 1 |
| 12 | Evaluation of human enterovirus 71 and coxsackievirus A16 specific immunoglobulin M antibodies for diagnosis of hand foot and mouth disease显示文摘 | Yu N Guo M He SJ | 2012 | Virol J2012，912，： | 1 |
| 13 | Relationship of circulating tu- mor cells to rumor response progression-free survival and overall survival in patients with metastatic colorectal cancer显示文摘 | Cohen SJ Punt CJ Iannotti N | 2008 | J Clin On- col2008，26，19： | 1 |
| 14 | Relationship between plasma leptin lev?els and clinical outcomes of pediatric traumatic brain injury显示文摘 | Lin C Huang SJ Wang N | 2012 | Peptides2012，35，2： | 1 |
| 15 | Patterns of home mechanical ventilation use in Europe:results from the Eurovent survey显示文摘 | Lloyd-Owen SJ Donaldson GC Ambrosino N | | European Respiratory Journal0，，： | 1 |
| 16 | A pilot study of colonic B cell pattern in irritable bowel syndrome显示文摘 | Johan Forshammar Stefan Isaksson Hans Strid Per-Ove Stotzer Henrik Sj?vall Magnus Simrén Lena ?hman | 2008 | Scandinavian Journal of Gastroenterology2008，，12： | 1 |
| 17 | Radiobiologically optimized couch shift:A new localization paradigm using cone-beam CT for prostate radiotherapy显示文摘 | Huang Y Gardner SJ Wen N | 2015 | Med Phys2015，42，10： | 1 |
| 18 | 一般人群中发生心力衰竭的10年风险方程显示文摘目前急需能减轻心力衰竭负担的一级预防策略,但未见实用有效的风险预测工具。该研究旨在得出一个计算心力衰竭事件发生的10年风险方程。研究者根据7个社区队列,至少12年随访的个体水平数据,推导并验证了心力衰竭的种族和性别特异性10年风险方程。1985-2000年间招募年龄30~79岁在基线时无心血管病的研究对象,创建一个集合队列并随机分组以进行方程推导和内部验证。在另两个队列中也评估了该模型的性能。 | Khan SS Ning H Shah SJ Yancy CW Carnethon M Berry JD Mentz RJ O’Brien E Correa A Suthahar N de Boer RA Wilkins JT Lloyd-Jones DM 刘青 叶鹏 | 2019 | 中华高血压杂志2019，27，6： | 1 |
| 19 | Fear-avoidance beliefs and catastrophizing: occurrence and risk factor in back pain and ADL in the general population显示文摘 | Buer N Linton SJ | 2002 | Pain2002，99，3： | 1 |
| 20 | Multiple cycles of recombinant human thrombopoietin therapy in a patient with chronic refractory idiopathic thrombocytopenic purpura 显示文摘 | Hua BL Zou N Wang SJ | 2005 | Blood Coagul Fibrinol2005，16，4： | 1 |
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