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| 1 | Research Progress in Improving the Cycling Stability of High-Voltage LiNi0.5Mn1.5O4 Cathode in Lithium-Ion Battery显示文摘High-voltage lithium-ion batteries(HVLIBs) are considered as promising devices of energy storage for electric vehicle, hybrid electric vehicle, and other high-power equipment. HVLIBs require their own platform voltages to be higher than 4.5 V on charge. Lithium nickel manganese spinel LiNi_(0.5)Mn_(1.5)O_4(LNMO) cathode is the most promising candidate among the 5 V cathode materials for HVLIBs due to its flat plateau at 4.7 V. However, the degradation of cyclic performance is very serious when LNMO cathode operates over 4.2 V. In this review, we summarize some methods for enhancing the cycling stability of LNMO cathodes in lithium-ion batteries, including doping, cathode surface coating,electrolyte modifying, and other methods. We also discuss the advantages and disadvantages of different methods. | XiaoLong Xu SiXu Deng Hao Wang JingBing Liu Hui Yan | 2017 | Nano-Micro Letters2017，9，2： | 9 |
| 2 | Redox proteomics of tomato in response to Pseudomonas syringae infection显示文摘Unlike mammals with adaptive immunity,plants rely on their innate immunity based on pattern-triggered immunity(PTI)and effector-triggered immunity(ETI)for pathogen defense.Reactive oxygen species,known to play crucial roles in PTI and ETI,can perturb cellular redox homeostasis and lead to changes of redox-sensitive proteins through modification of cysteine sulfhydryl groups.Although redox regulation of protein functions has emerged as an important mechanism in several biological processes,little is known about redox proteins and how they function in PTI and ETI.In this study,cysTMT proteomics technology was used to identify similarities and differences of protein redox modifications in tomato resistant(PtoR)and susceptible(prf3)genotypes in response to Pseudomonas syringae pv tomato(Pst)infection.In addition,the results of the redox changes were compared and corrected with the protein level changes.A total of 90 potential redox-regulated proteins were identified with functions in carbohydrate and energy metabolism,biosynthesis of cysteine,sucrose and brassinosteroid,cell wall biogenesis,polysaccharide/starch biosynthesis,cuticle development,lipid metabolism,proteolysis,tricarboxylic acid cycle,protein targeting to vacuole,and oxidation–reduction.This inventory of previously unknown protein redox switches in tomato pathogen defense lays a foundation for future research toward understanding the biological significance of protein redox modifications in plant defense responses. | Kelly Mayrink Balmant Jennifer Parker Mi-Jeong Yoo Ning Zhu Craig Dufresne Sixue Chen | 2015 | Horticulture Research2015，2，1： | 7 |
| 3 | Research Progress in Improving the Rate Performance of LiFePO_4 Cathode Materials显示文摘Olivine lithium iron phosphate(Li Fe PO4) is considered as a promising cathode material for high power density lithium ion battery due to its high capacity, long cycle life, environmental friendly, low cost, and safety consideration. The theoretical capacity of Li Fe PO4 based on one electron reaction is 170 m Ah g-1at the stable voltage plateau of 3.5 V vs. Li/Li+. However, the instinct drawbacks of olivine structure induce a poor rate performance, resulting from the low lithium ion diffusion rate and low electronic conductivity.In this review, we summarize the methods for enhancing the rate performance of Li Fe PO4 cathode materials,including carbon coating, elements doping, preparation of nanosized materials, porous materials and composites,etc. Meanwhile, the advantages and disadvantages of above methods are also discussed. | Sixu Deng Hao Wang Hao Liu Jingbing Liu Hui Yan | 2014 | Nano-Micro Letters2014，6，3： | 6 |
| 4 | Experimental and numerical simulation of bird-strike performance of lattice-material-infilled curved plate显示文摘The anti-bird-strike performance of a lattice-material-infilled curved plate is investigated herein.Since automatically filling the curved structure by classical lattice material filling methods will cause a large number of manufacturing defects,a space-dependent lattice material filling method for the curved plate is firstly proposed in this paper Next,using a face-centered cubic lattice,a lattice-material-infilled test piece with a hollow ratio of 40.8%is built.The test pieces are manufactured via additive manufacturing using titanium alloy.In bird-strike experimental tests,the test pieces are crashed against gelatin birds at an impact velocity of 200 m/s.Dynamic strain gauges are used to record the crash history and the results are discussed.Furthermore,a numerical analysis to simulate the bird-strike experiment is performed.The results from the experimental tests and numerical simulation agree well.This work shows that the lattice-material-infilled curved plate yields promising bird-strike resistance.Therefore,lattice-infilled materials are feasible for protecting aerospace components against bird-strike as well as for reducing the component weight. | Jun YAN Chenguang ZHANG Sixu HUO Xianghai CHAI Zhihui LIU Kun YAN | 2021 | Chinese Journal of Aeronautics2021，34，8： | 4 |
| 5 | Confined Ni-In intermetallic alloy nanocatalyst with excellent coking resistance for methane dry reforming显示文摘Carbon dioxide and methane are two main greenhouse gases which are contributed to serious global warming.Fortunately,dry reforming of methane(DRM),a very important reaction developed decades ago,can convert these two major greenhouse gases into value-added syngas or hydrogen.The main problem retarding its industrialization is the seriously coking formation upon the nickel-based catalysts.Herein,a series of confined indium-nickel(In-Ni)intermetallic alloy nanocatalysts(In_(x)Ni@SiO_(2))have been prepared and displayed superior coking resistance for DRM reaction.The sample containing 0.5 wt.%of In loading(In_(0.5)Ni@SiO_(2))shows the best balance of carbon deposition resistance and DRM reactivity even after 430 h long term stability test.The boosted carbon resistance can be ascribed to the confinement of core–shell structure and to the transfer of electrons from Indium to Nickel in In-Ni intermetallic alloys due to the smaller electronegativity of In.Both the silica shell and the increase of electron cloud density on metallic Ni can weaken the ability of Ni to activate C–H bond and decrease the deep cracking process of methane.The reaction over the confined InNi intermetallic alloy nanocatalyst was conformed to the Langmuir-Hinshelwood(L-H)mechanism revealed by in situ diffuse reflectance infrared Fourier transform spectroscopy(in-situ DRIFTS).This work provides a guidance to design high performance coking resistance catalysts for methane dry reforming to efficiently utilize these two main greenhouse gases. | Wenming Liu Le Li Sixue Lin Yiwei Luo Zhenghong Bao Yiru Mao Kongzhai Li Daishe Wu Honggen Peng | 2022 | Journal of Energy Chemistry2022，31，2： | 3 |
| 6 | Negative association of time in range and urinary albumin excretion rate in patients with type 2 diabetes mellitus:a retrospective study of inpatients显示文摘Background:Time in range(TIR)refers to the time an individual spends within their target glucose range,which now has been popularized as an important metric to classify glycemic management and also recognized as an important outcome of current diabetes therapies.This study aimed to investigate the association between TIR and the severity of the urinary albumin excretion rate(UAER)in patients with type 2 diabetes mellitus(T2DM).Methods:We retrospectively analyzed the data of 1014 inpatients with T2DM at the Department of Endocrinology and Metabolism of Peking University International Hospital,China.TIR was defined as the percentage of blood glucose within the target range of 3.90-10.00 mmol/L.Urine samples for assessment of UAER were collected for 3 consecutive days from the start of hospitalization.Results:The TIR values for patients with normal urine levels of albumin,microalbuminuria,and macroalbuminuria were 70%±20%,50%±20%,and 30%±20%,respectively(allP<0.001).The patients were stratified according to quartiles of TIR as follows:quartile(Q)1,<55%;Q2,55%-72%;Q3,73%-83%;and Q4,>83%.The incidences of microalbuminuria in Q1,Q2,Q3,and Q4 were 41.1%,21.6%,7.1%,and 5.5%(allP<0.001),respectively.The respective incidences of macroalbuminuria were 24.2%,1.1%,1.4%,and 0%(allP<0.001).In multinomial logistic regression analyses,TIR was significantly correlated with microalbuminuria(odds ratio[OR]0.58,95%confidence interval[CI]:0.52-0.65,P<0.001)and macroalbuminuria(OR 0.26,95%CI:0.18-0.38,P<0.001)after adjusting for age,sex,body mass index,diabetes duration,systolic blood pressure,and levels of triglycerides,glycosylated hemoglobin A1c,and creatinine.Conclusion:The proportion of blood glucose in TIR is closely related to the severity of UAER in patients with T2DM. | Sanbao Chai Shanshan Wu Sixu Xin Ning Yuan Jianbin Sun Xiaomei Zhang Linong Ji | 2022 | Chinese Medical Journal2022，，9： | 3 |
| 7 | Proteomics and Metabolomics of Arabidopsis Responses to Perturbation of Glucosinolate Biosynthesis显示文摘为了理解,种 glucosinolate 新陈代谢的分子的网络,脂肪族的 glucosinolate 生合成的不安在 Arabidopsis 用可诱导的 RNA 干扰(RNAi ) 被建立。二根 RNAi 线为用互补 proteomics 检验全球蛋白质和代谢物变化被选择, metabolomics 来临。包括光合作用和荷尔蒙新陈代谢,蛋白质绑定,精力,应力,和防卫涉及新陈代谢的蛋白质显示出显著回答到 glucosinolate 不安。在平行, metabolomics 在氨基酸,糖类,肽,和荷尔蒙的层次揭示了主要变化。metabolomics 数据与 proteomics 结果被相关并且揭示了在细胞的小径 / 过程和 glucosinolate 新陈代谢之间的亲密分子的连接。这研究提供了 glucosinolate 新陈代谢的分子的网络的一个崭新的看法并且向为提高的防卫和质量设计的基本原理 glucosinolate 打了一个基础。 | Ya-zhou Chen Qiu-Ying Pang Yan He Ning Zhu Isabel Branstrom Xiu-Feng Yan Sixue Chen | 2012 | Molecular Plant2012，5，5： | 3 |
| 8 | Bioinformatic analysis for potential biological processes and key targets of heart failure-related stroke显示文摘This study aimed to uncover underlying mechanisms and promising intervention targets of heart failure(HF)-related stroke.HF-related dataset GSE42955 and stroke-related dataset GSE58294 were obtained from the Gene Expression Omnibus(GEO)database.Weighted gene co-expression network analysis(WGCNA)was conducted to identify key modules and hub genes.Gene Ontology(GO)and pathway enrichment analyses were performed on genes in the key modules.Genes in HF-and stroke-related key modules were intersected to obtain common genes for HF-related stroke,which were further intersected with hub genes of stroke-related key modules to obtain key genes in HF-related stroke.Key genes were functionally annotated through GO in the Reactome and Cytoscape databases.Finally,key genes were validated in these two datasets and other datasets.HF-and stroke-related datasets each identified two key modules.Functional enrichment analysis indicated that protein ubiquitination,Wnt signaling,and exosomes were involved in both HF-and stroke-related key modules.Additionally,ten hub genes were identified in stroke-related key modules and 155 genes were identified as common genes in HF-related stroke.OTU deubiquitinase with linear linkage specificity(OTULIN)and nuclear factor interleukin 3-regulated(NFIL3)were determined to be the key genes in HF-related stroke.Through functional annotation,OTULIN was involved in protein ubiquitination and Wnt signaling,and NFIL3 was involved in DNA binding and transcription.Importantly,OTULIN and NFIL3 were also validated to be differentially expressed in all HF and stroke groups.Protein ubiquitination,Wnt signaling,and exosomes were involved in HF-related stroke.OTULIN and NFIL3 may play a key role in HF-related stroke through regulating these processes,and thus serve as promising intervention targets. | Chiyu LIU Sixu CHEN Haifeng ZHANG Yangxin CHEN Qingyuan GAO Zhiteng CHEN Zhaoyu LIU Jingfeng WANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，9： | 3 |
| 9 | An experimental and modeling study of n-hexadecane autoignition under low-to-intermediate temperatures显示文摘N-hexadecane is a potential candidate of diesel surrogate fuels and is also the largest linear alkane(n-alkanes)with known chemical kinetic models.The objective of this study is to investigate the autoignition characteristics of n-hexadecane in the lowto-intermediate temperature region and to validate the existing kinetic models.In this study,the ignition delay times(IDTs)of nhexadecane were measured using a heated rapid compression machine(RCM)at two pressures of 7 and 10 bar,and over equivalence ratios ranging from 0.5 to 1.3.Two-stage ignition characteristic and the negative temperature coefficient(NTC)behavior of total ignition delay time were experimentally captured.This study paid special attention to the influence of pressure,equivalence ratio,and oxygen content on the IDTs of n-hexadecane.It is observed that both the total IDTs and the first-stage IDTs decrease with the rise of those parameters.It is worth noting that the first-stage IDT is found to show a greater dependence on temperature but a weaker dependence on other parameters compared to the total IDT.The observed IDT dependence in the lowtemperature region(LTR)were quantitatively described by ignition delay time correlations.The newly measured IDTs were then validated against two kinetic models(LLNL and CRECK).Simulation results show that both models underpredict the first-stage IDT but generally capture the temperature dependence.The CRECK model well predicts the total IDTs of n-hexadecane while the LLNL model significantly underpredicts the total IDTs at most investigated conditions.To the best of our knowledge,this study is the first investigation on n-hexadecane autoignition under low-to-intermediate temperatures,which deepens the understanding of large n-alkane oxidation and contributes to the improvement of the existing kinetic models. | YU Liang WANG WenYu WANG SiXu FENG Yuan QIAN Yong LU XingCai | 2020 | Science China(Technological Sciences)2020，63，5： | 2 |
| 10 | Isobaric Tags for Relative and Absolute Quantificationbased Comparative Proteomics Reveals the Features of Plasma Membrane-Associated Proteomes of Pollen Grains and Pollen Tubes from Lilium davidii显示文摘Mature pollen grains (PGs) from most plant species are metabolically quiescent. However, once pollinated onto stigma, they quickly hydrate and germinate. A PG can give rise to a vegetative cell-derived polarized pollen tube (PT), which represents a specialized polar cell. The polarized PT grows by the tip and requires interaction of different signaling molecules localized in the apical plasma membrane and active membrane trafficking. The mechanisms underlying the interaction and membrane trafficking are not well understood. In this work, we purified PG and PT plasma-membrane vesicles from Lilium davidii Duch. using the aqueous two-phase partition technique, then enriched plasma membrane proteins by using Brij58 and KCl to remove loosely bound contaminants. We identified 223 integral and membrane-associated proteins in the plasma membrane of PGs and PTs by using isobaric tags for relative and absolute quantification (iTRAQ) and 2-D high-performance liquid chromatography-tandem mass spectrometry. More than 68% of the proteins have putative transmembrane domains and/or lipid-modified motifs. Proteins involved in signal transduction, membrane trafficking and transport are predominant in the plasma-membrane proteome. We revealed most components of the clathrin-dependent endocytosis pathway. Statistical analysis revealed 14 proteins differentially expressed in the two development stages: in PTs, six upregulated and eight downregulated are mainly involved in signaling, transport and membrane trafficking. These results provide novel insights into polarized PT growth. | Bing Han Sixue Chen Shaojun Dai Ning Yang Tai Wang | 2010 | Journal of Integrative Plant Biology2010，52，12： | 2 |
| 11 | Synthesis and electrochemical properties of MnO 2 nanorods/graphene composites for supercapacitor applications显示文摘 | SiXu Deng Dan Sun ChunHui Wu Hao Wang JingBing Liu YuXiu Sun Hui Yan | 2013 | Electrochimica Acta2013，，： | 1 |
| 12 | Studies of Submicro-gold and Lattice- gold in Some Minerals显示文摘 | Zhang Zhenru Yang Sixue | 1987 | Cent -South Inst Min Metals1987，18，4： | 1 |
| 13 | 显示文摘 | Zhang Jiantao Cheng Sixue Zhuo Renxi | 2003 | Colloid Polym Sei2003，281，： | 1 |
| 14 | Macroporous poly(N-isopropylacrylamide) hydrogels with fast response rates and improved protein release properties显示文摘 | Cheng Sixue Zhang Jiaotao Zhuo Renxi | 2003 | Journal of Biomedical Materials Research A2003，67，1： | 1 |
| 15 | Advances in quantitative proteomics显示文摘Large-scale protein quantification has become a major proteomics application in many areas of biological and medical research.During the past years,different techniques have been developed,including gel-based such as differential in-gel electrophoresis(DIGE)and liquid chromatography-based such as isotope labeling and labelfree quantification.These quantitative proteomics tools hold significant promise for biomarker discovery,diagnostic and therapeutic applications.They are also important for research in functional genomics and systems biology towards basic understanding of molecular networks and pathway interactions.In this review,we summarize current technologies in quantitative proteomics and discuss recent applications of the technologies. | Yuguang WANG Haiying LI Sixue CHEN | 2010 | Frontiers in Biology2010，5，3： | 1 |
| 16 | Degradation and drug re- lease property of star poly(a-caprolactone)s with dendritic cores显示文摘 | Miao Zhimei Cheng Sixue | 2007 | J Bio Mater IRes Part I3: Appl Biomater2007，81，1： | 1 |
| 17 | Dianostic testing as a supportive measure of treatment strategy 显示文摘 | Sixu M | 2003 | Oral-Dis2003，9，1： | 1 |
| 18 | Fern spore germination in response to environmental factors显示文摘蕨纲植物孢子萌芽产生假根并且通过不对称的房间分割的 protonemal 房间,然后发展成配偶体。孢子萌芽也是为原子极的运动,不均匀的房间部门,极性建立和假根的尖端生长的调查的一个代表性的单个房间的模型。这些过程被各种各样的环境因素影响,例如光,严肃,植物激素,金属离子,和温度。这里,我们在场响应不同环境因素的孢子萌芽的一个目录。他们如下:(1 ) 从不同蕨纲植物种类影响孢子萌芽的光的代表性的模式在黑暗中包括红刺激光、远的红禁止光的孢子萌芽,远红的光不受禁令约束的孢子萌芽,蓝禁止光的孢子萌芽,和孢子萌芽。孢子萌芽的最佳的轻紧张和照明时间在各种各样的蕨纲植物种类之中是不同的。在孢子萌芽之上的轻反应从由 phytochromes (PHY ) 和 cryptochromes (叫喊) 调整了的房间有丝分裂被开始。AcPHY2, AcCRY3 或 AcCRY4 被假设涉及孢子萌芽;(2 ) 严肃和钙对早原子的运动和孢子的极性建立关键;(3 ) 赤霉素和 antheridiogen 能在酸, jasmonic 酸,和乙烯提出的许多种类,而是 abscisic 开始并且支持孢子萌芽仅仅次要的效果;(4 ) 孢子能在他们的有利生长媒介获得最大的萌芽率。而且,在文化媒介的金属离子, pH,和孢子密度也影响孢子萌芽;(5 ) 大多数蕨纲植物孢子在 25 点发芽 ? 敢吗? | Jinwei Suo Sixue Chen Qi Zhao Lei Shi Shaojun Dai | 2015 | Frontiers in Biology2015，10，4： | 1 |
| 19 | Preparation of macroporous poly(N-isopropylacrylamide) hydrogel with im- proved temperature sentivity显示文摘 | Zhang Jiantao Cheng Sixue Zhuo Renxi | 2003 | J Polym Sci Pol Chem2003，41，15： | 1 |
| 20 | Preparation and properties of poly(N-isopropylacrylamide)/poly (N-isopropylacrylamide)interpenetrating polymer networks for drug delivery显示文摘 | Zhang Jiantao Huang Shiwen Cheng Sixue | 2004 | Journal of Polymer Science:Part A:Polymer Chemistry2004，42，： | 1 |
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