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| 1 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 2 | Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor,ENMD-2076,against multiple myeloma显示文摘 | WANG X J SINN A L POLLOK K | 2010 | Br J Haematol2010，150，3： | 1 |
| 3 | Adherens junc- tion protein nectim4 is the epithelial receptor for measles virus 显示文摘 | Mtihlebach M D Mateo M Sinn P L | 2011 | Nature2011，7378，7378： | 1 |
| 4 | Gene therapy progress and pros- pects: development of improved lentiviral and retroviral vectors: de- sign, biosafety, and production显示文摘 | Sinn P L Sauter S L McCray P B | 2005 | Gene Ther2005，12，14： | 1 |
| 5 | T-cell immunoglobulin and mucin domain 1 (TIM-l) is a receptor for Zaire Ebola virus and lake victoria marburgvirus 显示文摘 | Kondratowicz A S Lennemarm N J Sinn P L | 2011 | Proc Natl Acad Sci USA2011，108，20： | 1 |
| 6 | Human mammary carcinomas express homo logues of rat metastasis-associated vari ants of CD44显示文摘 | Sinn HP Heider KH Skroch P et a l | 1995 | Breast Cancer Res Treat1995，36，： | 1 |
| 7 | Gene therapy progress and prospects:development of improved of lentiviral and retroviral vectors-design,biosafety,and production显示文摘 | SINN P L SAUTER S L MCCRAY P B | 2005 | Gene Ther2005，12，14： | 1 |
| 8 | e-FLIP gene silencing elimi- nates tumor cells in breast cancer xenografts without affecting stro- real ceils显示文摘 | Day T W Sinn A L Huang S | 2009 | Anticancer Res2009，29，10： | 1 |
| 9 | Genetherapy progress and prospects: development of improved lentiviral and retroviral vectors design, biosaftey and production显示文摘 | Sinn P L Santer S L McCray P B Jr | 2005 | Gene Ther2005，12，14： | 1 |
| 10 | Contrast sensitivity and tear layer aberrometiy in diy eyepatients显示文摘 | Ridder WH 3rd LaMotte J Hail JQ Jr Sinn R Nguyen AL Abu-farie L | 2009 | Optom Vis Sci2009，86，9： | 1 |
| 11 | Gene therapy progressand prospects: development of improved lentiviral and retrovi-ral vectors-design, biosafety, and production显示文摘 | Sinn P L Sauter S L McCray P B Jr | 2005 | Gene Ther2005，12，14： | 1 |
| 12 | Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma 显示文摘 | WANG X SINN A L POLLOK K | 2010 | Br J Haematol2010，150，3： | 1 |
| 13 | Design of self-learning fuzzy sliding mode controllers based on genetic algorithms显示文摘 | Sinn C L Yung Y C | 1997 | Fuzzy Sets and Systems1997，86，： | 1 |
| 14 | Adherens junction protein nectin-4 is the epithelial receptor for measles virus显示文摘 | Muhlebach M D Mateo M Sinn P L | 2011 | Nature2011，480，7378： | 1 |
| 15 | Gene therapy progress and prospects,development of improved of lentiviral and retrovira vectors- desfgn,biosafety, and production显示文摘 | Sinn PL Sauter S L Mccray PB | 2005 | Geee Ther2005，12，14： | 1 |
| 16 | Adherens junction protein nectin-4 is the epithelial receptor for measles virus 显示文摘 | MUHLEBACH M D MATEO M SINN P L | 2011 | Nature2011，480，7378： | 1 |
| 17 | Gene therapy progress and prospects:development ofimproved lentiviral and retroviral vectors-design,biosafety,and production显示文摘 | Sinn P L Sauter S L McCray P B Jr | 2005 | GeneTher2005，12，： | 1 |
| 18 | Stent-supported angioplasty of severe atherosclerotic renal artery stenosis preserves renal function and improves blood pressure control:long-term results from a prospective registry of 456 lesions显示文摘 | Zeller T Frank U Müller C Bürgelin K Sinn L Horn B | | 0，，： | 1 |
| 19 | Compromise the Compromise Effect:Brands Matter显示文摘 | SINN F MILBERG S J EPSTEIN L D | 2007 | Marketing Letters2007，18，4： | 1 |
| 20 | Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma 显示文摘 | WANG X J SINN A L POLLOK K | 2010 | Br J Haematol2010，150，3： | 1 |
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