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| 1 | Validation of a solid-phase microextraction method for the determination of organophosphorus pesticides in fruits and fruit juice显示文摘 | Simplício A L Boas V L | 1999 | Journal of Chromatography A1999，833，1： | 1 |
| 2 | In-vivo effects of fluoridated antiplaque dentifrice and bonding material on enamel demineralization adjacent to orthodontic appliances显示文摘 | de Moura MS de Melo Simplício AH Cury JA | | 0，，03： | 1 |
| 3 | A survey onkey management mechanisms for distributed wireless sensor networks显示文摘 | Jr SIMPLíCIO M A BARRETO P S MARGI C B | 2010 | Computer Networks2010，54，15： | 1 |
| 4 | An acceleration measurements-based approach for helicopter nonlinear flight control using incremental nonlinear dynamic inversion显示文摘 | Simplício P Pavel M D Van Kampen E | 2013 | Control Engineering Practice2013，21，8： | 1 |
| 5 | Preparation of controlled release microspheres using supercritical fluid technology for delivery of anti-inflammatory drugs显示文摘 | Costa M S Simplício A L | 2006 | International Journal of Pharmaceutics2006，308，： | 1 |
| 6 | Patients with hepatitis C infection and normal liver function: an evaluation of cognitive function显示文摘 | Jefferson Abrantes Daniel Simplício Torres Carlos Eduardo Brand?o de Mello | 2013 | Postgraduate Medical Journal2013，，1054： | 1 |
| 7 | Endophytic Fungi from Sorghum bicolor(L.)Moench:Influence of Genotypes and Crop Systems and Evaluation of Antimicrobial Activity显示文摘Endophytic fungi(EF)colonize plant tissues without causing damage;this relationship brings benefits to both,including a greater resistance to environmental stresses,but the influence of genotypes and culture system in endophytic community is still unraveled.Thus,this work aimed to study EF from Sorghum bicolor and correlate to its genotypes submitted to different culture systems;their potential to produce antimicrobial compounds was also evaluated.To optimize the production of metabolites,four isolates were submitted to liquid medium and the crude extracts of different culture times were analyzed.EF of leaves of Qualimax and SF15 genotypes were isolated after superficial disinfection.Fungal identification was made using classical taxonomy.As results,the traditional system presented the lowest number EF isolates,while the minimum system showed the highest.The genera Aspergillus,Fusarium,Penicillium,Cladosporium,Curvularia and Syncephalastrum were found;Aspergillus spp.was pointed out as a predominant endophyte of genotype Qualimax.Among the 25 endophytes submitted antimicrobial activity assay in solid medium,21 presented antibacterial activity against at least one bacterium with the highest inhibition zone of 29.3 mm of diameter against Staphylococcus aureus.All EF submitted to liquid medium kept the capacity to produce antibacterial metabolites.In conclusion,regardless of genotype and culture system,sorghum is colonized by different EF,mainly Aspergillus spp.EF from leaves of S.bicolor produce antibacterial compounds and their biotechnological applications can be explored in future. | Ruth Terezinha Rodrigues Márcia Marília de Souza Silva Douglas Moreira de Oliveira Josimar Bento Simplício Cynthia Maria Carneiro Costa Virginia Medeiros de Siqueira | 2018 | Journal of Agricultural Science and Technology(B)2018，8，5： | 0 |
| 8 | Chagas heart disease:An overview of diagnosis,manifestations,treatment,and care显示文摘Chagas heart disease(CHD)affects approximately 30%of patients chronically infected with the protozoa Trypanosoma cruzi.CHD is classified into four stages of increasing severity according to electrocardiographic,echocardiographic,and clinical criteria.CHD presents with a myriad of clinical manifestations,but its main complications are sudden cardiac death,heart failure,and stroke.Importantly,CHD has a higher incidence of sudden cardiac death and stroke than most other cardiopathies,and patients with CHD complicated by heart failure have a higher mortality than patients with heart failure caused by other etiologies.Among patients with CHD,approximately 90%of deaths can be attributed to complications of Chagas disease.Sudden cardiac death is the most common cause of death(55%–60%),followed by heart failure(25%–30%)and stroke(10%–15%).The high morbimortality and the unique characteristics of CHD demand an individualized approach according to the stage of the disease and associated complications the patient presents with.Therefore,the management of CHD is challenging,and in this review,we present the most updated available data to help clinicians and cardiologists in the care of these patients.We describe the clinical manifestations,diagnosis and classification criteria,risk stratification,and approach to the different clinical aspects of CHD using diagnostic tools and pharmacological and non-pharmacological treatments. | Roberto M Saraiva Mauro Felippe F Mediano Fernanda SNS Mendes Gilberto Marcelo Sperandio da Silva Henrique H Veloso Luiz Henrique C Sangenis Paula Simplício da Silva Flavia Mazzoli-Rocha Andréa S Sousa Marcelo T Holanda Alejandro M Hasslocher-Moreno | 2021 | World Journal of Cardiology2021，13，12： | 1 |
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