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| 1 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | 植物鞣剂/MUF树脂鞣制时皮革的耐光性及鞣剂的抗老化性显示文摘制备了一种蜜胺含量相对较低的新型磺化蜜胺-脲-甲醛(MUF)缩聚树脂,此树脂与不同的天然植物鞣质复合鞣革,成革具有和铬鞣革一样良好的性能。提出了不同的鞣质/MUF树脂复合物鞣制的皮革,在长时间的紫外线辐射下,以革色的变化作为老化时间的函数,建立并阐明了此函数的预测模型和公式。此函数不仅与固态纯鞣质的抗老化能力有关,还与其在皮革内总体的抗老化能力有关。 | B George A Pizzi C Simon M C Triboulot 张业聪 付丽红 | 2007 | 中国皮革2007，36，15： | 2 |
| 3 | The role of oxygen availability in em- bryonic development and stem cell function显示文摘 | Simon M C Keith B | 2008 | Nat Rev2008，9，： | 1 |
| 4 | Open systems: panoramic views of gene expression 显示文摘 | Green C D Simons J F Taillon B E | 2001 | Journal of Immunological Methods2001，250，12： | 1 |
| 5 | Telemedieal treatment at home of diabetic显示文摘 | Jane C Simon B L Niels E | 2005 | Journal of Telemedicine and Telecare2005，11，2： | 1 |
| 6 | An analytical solution for the transient response of saturated porous elastic solids显示文摘 | SIMON B R ZIENKIEWICZ O C PAUL D K | 1984 | International Journal for Numerical and Analytical Methods in Geomechanics1984，8，： | 1 |
| 7 | Self-help housing strategy for temporary population in Guangzhou, China 显示文摘 | Roger C K Chan Y M Yao Simon X B Zhao | 2003 | Habitat International2003，，27： | 1 |
| 8 | Polyethylene made with in situ supported ni-diimine/SMAO: replication phenomenon and effect of polymerization conditions on polymer microstructure and morphology 显示文摘 | Simon L C Patel H Soares J B P | 2001 | Macromol Chem Phys2001，202，17： | 1 |
| 9 | Gitelman s variant of Bartter s syndrome, inherited hypokalaemie alkalosis, is caused by mutations in the hiazide-sensitive Na-C1 eotransporter显示文摘 | Simon D B Nelson-Williams C Bia M J | 1996 | Nat Genet1996，12，： | 1 |
| 10 | The lunar regolith:Chemistry,mineralogy and petrology显示文摘 | Papike J J Simon S B Laul J C | 1982 | Review of Geophysical Space Physics1982，20，： | 1 |
| 11 | Thermochemical sulphate reduction (TSR):experiment determination of reaction kinetics and implications of the observed reaction rates for petroleum reservoirs显示文摘 | David A C M Simon H B | 2004 | Organic Geochemistry2004，35，： | 1 |
| 12 | Characterization ofthe nitrite reductase gene Nii and the nitrate-assimilation gene cluster of StagonosPora (SePtoria)nodorum显示文摘 | Simon B C Christopher E C | 1999 | Curr Genet1999，，36： | 1 |
| 13 | Ecosystem response to antibiotics entering the aquatic environment 显示文摘 | Simon D C John M John B | 2005 | Marine Pollution Bulle- tin2005，51，： | 1 |
| 14 | Quantum computing and information Extraction for dynamical quantum systems显示文摘 | GIULIANO B GIULIO C SIMONE M | 2004 | Quantum Information Processing2004，3，10： | 1 |
| 15 | A QTL affecting milk yield and composition maps to bovine chromosome 20: A confirmation 显示文摘 | Arranz J J Coppieters W Berzi P Cambisano N Grisart B Karim L Marcq F Moreau L Mezer C Riquet J Simon P Vanmanshoven P Wagenaar D and Georges M | 1998 | Animal Genetics1998，29，： | 1 |
| 16 | An analytical solution for the transient response of saturated porous elastic solids显示文摘 | SIMON B R ZIENKIEWICZ O C PAUL D K | | 0，，04： | 1 |
| 17 | Plasma adiponectin is an independent predictor of type 2 diabetes in Asian Indians 显示文摘 | Snehalatha C Mukesh B Simon M | 2003 | Diabetes Care2003，26，12： | 1 |
| 18 | The role of probiotics in modulation of the immune system in man and in animals 显示文摘 | De Simone C Bianchi Salvadori B Jirillo E | 1993 | Int J Immunol1993，9，： | 1 |
| 19 | Quasilinear viscoelastic properties of normal articular cartilage显示文摘 | Woo S L Simon B R Kuei S C | 1980 | J Biomech Eng1980，102，2： | 1 |
| 20 | Inhibition of uterine contractions human myometrinm显示文摘 | Bardou M Loustalot C Simon B | 2001 | Therapie2001，56，： | 1 |
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