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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Multiple system atrophy显示文摘 | | | Med Clin Am0，83，3： | 1 |
| 3 | Early development of karst aquifers on percolation networks of fractures in limestone显示文摘 | Siemers J Dreyhrodt W | 1998 | Water Re- sources Research1998，34，3： | 1 |
| 4 | A Novel Waste Form for Disposal of Spent-nuclear-fuel Reprocessing Waste: a Vitrifiable Cement显示文摘 | Gougar M L D Scheetz B E Siemer D D | 1999 | Nuel Technol1999，125，1： | 1 |
| 5 | Role of estrogen and progesterone in the regulation of uterine peristalsis: results from perfused non-pregnant swine uteri 显示文摘 | Mueller A Siemer J Sehreiner S | 2006 | Hum Reprod2006，21，7： | 1 |
| 6 | Multiple system atrophy显示文摘 | Siemers ER | 1999 | Med Clin North Am1999，83，： | 1 |
| 7 | Adrenal metastasis in 1635 patients with renal cell carcinoma: outcome and indication for adrenalectomy 显示文摘 | Siemer S Lehmann J Kamradt J | 2004 | J Urol2004，171，： | 1 |
| 8 | The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis显示文摘 | Li J Mcquade T Siemer AB | 2012 | Cell2012，150，2： | 1 |
| 9 | Excellent long-term cancer control with elective nephron-sparing surgery for selected renal cell carcinomas measuring more than 4 cm显示文摘 | Becker F Siemer S Hack M | 2006 | Eur Urol2006，49，6： | 1 |
| 10 | Amygdala volume in major depressive disorder:a meta-analysis of magnetic resonance imaging studies显示文摘 | Hamilton JP Siemer M Gotlib IH | 2008 | Mol Psychiatry2008，13，11： | 1 |
| 11 | Efficient CuInS2 solar cells from a rapid thermal process (RTP)显示文摘 | SIEMER K KLAER J LUCK I | 2001 | Sol Energy Mater Solar Cells2001，67，14： | 1 |
| 12 | Long-term outcome of conser- vative surgery for kidney cancer: survival, blood pressure, and re- nal function显示文摘 | Humke U Siemer S Uder M | 2002 | Ann Urol(Paris)2002，36，3： | 1 |
| 13 | Nephron-sparlng surgery显示文摘 | BECKER F SIEMER S ROTERING J | 2008 | Urologe A2008，47，2： | 1 |
| 14 | Fetal adrenal haemor- rhage-two-dimensional and three-dimensional imaging显示文摘 | Schrauder M G t-Iammersen G Siemer J | 2008 | Fetal Diagn Ther2008，23，1： | 1 |
| 15 | Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with alzheimer disease显示文摘 | Siemers ER Friedrich S Dean RA | 2010 | Clin Neuropharmacol2010，33，2： | 1 |
| 16 | Long-term outcome of conser- vative surgery for kidney cancer: survival, blood pressure, and re- nal function显示文摘 | Humke U Siemer S Uder M | 2002 | Ann Urol(Paris)2002，36，4： | 1 |
| 17 | Pharmacological approaches to disease-modifying therapies in Parkinson s disease显示文摘 | O Neill MJ Siemers ER | 2002 | Expert Rev Neurotherapeutics2002，2，6： | 1 |
| 18 | Identification and molecular epidemiology of Campylobacter coli isolates from human gastroenteritis, food, and animal sources by amplified fragment length polymorphism analysis and Penner serotyping显示文摘 | SIEMER B L NIELSEN E M ON S L | 2005 | Appl Environ Microbiol2005，71，4： | 1 |
| 19 | Adrenal metastases in 1635 patients with renal cell carcinoma:outcome and indication for adrenalectomy显示文摘 | Siemer S Lehmann J Kamradt J | 2004 | J Urol2004，171，61： | 1 |
| 20 | Effects of a γ-secretase inhibitor in a randomized study of patients with Alzheimer disease 显示文摘 | SIEMERS E R QUINN J F KAYE J | 2006 | Neurology2006，66，4： | 1 |
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