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| 1 | The early Holocene optimum inferred from a high-resolution pollen record of Huguangyan Maar Lake in southern China显示文摘A high-resolution pollen record of the past 13000 a from Huguangyan Maar Lake reveals the vegetation and environment changes in southern China during the Holocene. It shows that (i) pollen percentage of trees and shrubs reached 56% during the early Holocene (11600―7800 cal a BP), of which the pollen percentage of tropical trees reached a maximum at 9500―8000 cal a BP, reflecting a hot and wet envi- ronment; (ii) during the mid-Holocene (7800―4200 cal a BP), the pollen percentage of montane conif- erous trees and herbs increased, while the percentage of tropical-subtropical trees decreased, indi- cating lower temperature and humidity; (iii) in the late Holocene spanning from 4200 to 350 cal a BP, the pollen percentage of herbs and montane conifer increased significantly, indicating a marked decrease of temperature and humidity. Our pollen data reveal that the time period 9500―8000 cal a BP in south- ern China represents a climatic optimum for the Holocene characterized by hot and wet conditions. This is consistent with the Holocene optimum found in lower latitude regions globally. We speculate that strong insolation might cause the northward migration of the ITCZ and subtropical summer mon- soon front, which resulted in an early Holocene optimum in the Huguangyan area. The dry tendency and climate fluctuations of the middle and late Holocene could be associated with a decrease in solar insolation and frequent ENSO event. | WANG ShuYun LUE HouYuan LIU JiaQi Joerg F. W. NEGENDANK | 2007 | Chinese Science Bulletin2007，52，20： | 36 |
| 2 | New composite grouting materials:Modified urea-formaldehyde resin with cement显示文摘A new composite two component grout comprised of modified urea-formaldehyde resin and cement was formulated to take account of the advantages and disadvantages of both the cement grout and the chemical grout.The new grout is designed for water blocking by reinforcing as well as seepage control by bore grouting.The A component consists of a modified urea-formaldehyde resin A component,some cement,and some water.The B component is an alkaline coagulant.An orthogonal test of four factors at three levels showed that gel time increased with increased water content and with urea-formaldehyde resin content.Gel time decreased at increased levels of alkaline coagulant.The A component of this new composite grout is stable over time.A mixed cross-over test showed that as the volume ratio of A to B increases the gel time falls at first but then increases.The solid strength decreases with increasing levels of the B component.The solid strength increases over time and becomes stable by the 28th day after mixing.The viscosity increases with increasing levels of resin A component.The increase is exponential and may be fit to:l = 8.162e0.0286x. | Duan Hongfei Jiang Zhenquan Zhu Shuyun Yao Pu Sun Qiang | 2012 | International Journal of Mining Science and Technology2012，22，2： | 22 |
| 3 | Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction显示文摘Inflammation may play a role in postoperative cognitive dysfunction. 5′ Adenosine monophosphate-activated protein kinase, nuclear factor-kappa B, interleukin-1β, and tumor necrosis factor-α are involved in inflammation. Therefore, these inflammatory mediators may be involved in postoperative cognitive dysfunction. Western immunoblot analysis revealed 5′ adenosine monophosphate-activated protein kinase and nuclear factor-kappa B in the hippocampus of aged rats were increased 1–7 days after splenectomy. Moreover, interleukin-1β and tumor necrosis factor-α were upregulated and gradually decreased. Therefore, these inflammatory mediators may participate in the splenectomy model of postoperative cognitive dysfunction in aged rats. | Yanlin Bi Shuyun Liu Xinjuan Yu Mingshan Wang Yuelan Wang | 2014 | Neural Regeneration Research2014，9，5： | 17 |
| 4 | Gait analysis of patients with knee osteoarthritis before and after Chinese massage treatment显示文摘The objective of this study was to evaluate the effectiveness of Chinese massage therapy in patients with knee osteoarthritis(OA) by measuring lower-limb gait parameters. We recruited 20 women with knee OA,who then underwent Chinese massage therapy three times per week for 2 weeks. The patients underwent gait evaluation using a six-camera infrared motion analysis system. They completed Western Ontario and Mc Master Universities Osteoarthritis Index questionnaires before and after treatment. We calculated the forward speed,step width,step length,total support time percentage,initial double support time percentage,and single support time percentage. We also measured the angles at the knee,hip,and ankle during the stance phase of walking. The results showed statistically significant mean differences in knee pain relief,alleviation of stiffness,and physical function enhancement after therapy(P < 0.05). The patients gained significantly faster gait speed,greater step width,and increased total support time percentage after the Chinese massage therapy(P < 0.05). There were no significant differences in the range of motion or initial contact angles of the knee,hip,or ankle during the stance phase of walking. We concluded that Chinese massage is a beneficial complementary treatment and an alternative therapy choice for patients with knee OA for short-term pain relief. Chinese massage may improve walking ability for these patients. | Zhu Qingguang Fang Min Gong Li Jiang Shuyun Sun Wuquan Li Jianhua Li Yong | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 16 |
| 5 | Micro-and submicrostructural evidence for high-temperature brittle-ductile transition deformation of hornblende: Case study of high-grade mylonites from Diancangshan, western Yunnan显示文摘OM (optical microscope)/TEM (transmission electron microscope) micro- and submicrostructural analysis of hornblende rocks sheared at high temperatures from the Diancangshan area, western Yunnan reveals evidence for deformation in the brittle-ductile transition of hornblende at middle crustal level (about 637℃ and 0.653 GPa) and mechanisms of deformation in the transitional regime are further discussed. Sheared hornblende rocks at middle crustal level have typical mylonitic microstructures, shown by coarse porphyroclasts and fine matrix grains. Different mineral phases in the rocks show distinct deformation characteristics. Hornblende and feldspar grains are intensely deformed with ob- vious grainsize reduction, but quartz grains are recrystallized dominantly by grain growth. Hornblende grains show typical brittle-ductile transition nature. Initial crystallographic orientations of porphyro- clasts have strong effects on the behavior of grains during deformation. There are mainly two types of porphyroclasts, type I 'hard' porphyroclasts and type II 'soft' porphyroclasts, with [001] perpendicular and parallel to external shear stresses respectively. 'Hard' porphyroclasts generally occur as compe- tent grains that are rarely deformed or sometimes deformed by fracturing and dislocation tangling. 'Soft' porphyroclasts are highly deformed primarily by dislocation tangling (as shown in the cores of the porphyroclasts), but twinning, dislocation glide and climb probably due to hydrolytic weakening also contribute to dynamic recrystallization of the porphyroclasts into fine grains in the matrix. The micro- and submicrostructures of the two types of porphyroclasts and fine-grained matrix provide powerful evidence for the behavior of brittle-ductile transition of hornblende grains. It is concluded that twinning nucleation is one of the most important processes that operate during dynamic recrystalliza- tion of hornblende crystals at the brittle-ductile transition. (100) [001] twin gliding and dislocation creep (dislocation glide and climb) are mutually enhanced during twinning nucleation. As a newly discovered mechanism of dynamic recrystallization, it may have played more important roles than ever recognized during dynamic recrystallization of crystals with twins in the brittle-ductile transition. | CAO ShuYun, LIU JunLai? & HU Ling State Key Laboratory of Geological Processes and Mineral Resources (GPMR), China University of Geosciences, Beijing 100083, China Key Laboratory of Lithosphere Tectonics and Lithoprobing Technology of Ministry of Education, China University of Geo- sciences, Beijing 100083, China | 2007 | Science China Earth Sciences2007，50，10： | 13 |
| 6 | Chemical Compositions and Distribution Characteristics of Cements in Longmaxi Formation Shales, Southwest China显示文摘Shale gas resources have been regarded as a viable energy source, and it is of great significance to characterize the shale composition of different cements, such as quartz and dolomite. In this research, chemical analysis and the multifractal method have been used to study the mineral compositions and petrophysical structures of cements in shale samples from the Longmaxi Formation, China. X-ray diffraction, electron microprobe, field emission scanning electron microscopy, cathodoluminescence microscopy and C-O isotope analyses confirmed that cements in the Longmaxi Formation shales are mainly composed of Fe-bearing dolomite and quartz. Fe-bearing dolomite cements concentrate around dolomite as annuli, filling micron-sized inorganic primary pores. Quartz cements in the form of nanoparicles fill primary inter-crystalline pores among clay minerals. Theoretical calculation shows that the Fe-bearing dolomite cements formed slightly earlier than the quartz cements, but both were related to diagenetic illitization of smectite. Moreover, multifractal analysis reveals that the quartz cements are more irregularly distributed in pores than the Fe-bearing dolomite cements. These results suggest that the plugging effect of the quartz cements on the primary inoraganic pore structures is the dominant factor resulting in low interconnected porosity of shales, which are unfavorable for the enrichment of shale gas. | Wenda Zhou Shuyun Xie Zhengyu Bao Emmanuel John M. Carranza Lei Lei Zhenzhen Ma | 2019 | Journal of Earth Science2019，30，5： | 12 |
| 7 | High Temperature Strain Structures and Quartz C-Axis Fabrics from Mylonitic Rocks in the Ailaoshan-Red River Shear Zone,Yunnan,and Their Tectonic Implication显示文摘Ailaoshan 红的河(ASRR ) 砍地区是考虑了东方西藏的现在的构造框架的主要东南亚洲构造断绝之一。几座变形山岳沿着 shear 地区线性地是分布式的,例如从北方的 Xuelongshan, Diancangshan, Ailaoshan 和到南方的天 Nui 反对 Voi。他们为构造进化忍受证据的很多线东方在在不同构造舞台的不同外壳的层次西藏。争吵仍然沿着 ASRR 在有变态的变丑结构,微观结构和他们的关系上存在。在这,纸详细说明了微结构和 EBSD (电子 Backscattered 衍射) 从沿着 ASRR 的不同山岳的一些高度砍的花岗石的岩石的织物分析被进行。高温度结构和微观结构在 unsheared 片麻岩被保存,在微弱地砍的捕虏体或在高度砍的岩石(糜棱岩) 的一些部分。高温度石英 c 轴织物的几种类型显示出对称的模式或转变从对不均匀的模式对称。前者在在印第安人欧亚的构造相互作用的一个早阶段的地区性的弄短期间被归因于同轴的变丑,后者与从同轴的压缩的转变有关到在让侧面的 post-collisional ASRR 期间砍的 noncoaxial 砍。 | LIU Junlai TANG Yuan XIA Haoran GUO Qiang TRAN My Dung CAO Shuyun WU Hujun WU Wenbin ZHANG Zhaochong ZHAO Zhidan | 2010 | Acta Geologica Sinica(English Edition)2010，84，6： | 12 |
| 8 | Silurian Seismites in Hanxia,Yumen,North Qilian Mountains,and Their Tectonic Significance显示文摘The Caledonian orogenic belt of the North Qilian Mountains is anintensely active structure belt. In the process of the Late Caledonian syn-orogeny, the North Qilian-Hexi Corridor area was situated on the tectonic background of a syn-orogenic basin. In response to the orogenic process of the North Qilian Mountains, typical earthquake event deposits-seismites of the Silurian were widely distributed around Hanxia of Yumen City, the Liyuan River of Sunan County and Biandukou of Minle County. In the Hanxia area, where seismites are typically developed, clastic deposits of tidal-flat facies are the background deposits of the Hanxia Formation. The earthquake event deposits are characterized by sandy mudstone veins, synsedimentary microfractures, micro-corrugated laminations and earthquake breccias, which in turn constitute complex seismites, featuring seismic corrugation, shattering and liquefied sandy mudstone veins, auto clastic breccias and intraclastic parabreccias. The seismites and tidal flat deposits formed typical sequences of earthquake event deposits. | DU Yuansheng, GONG Shuyun, HAN Xin, WANG Jiasheng, GU Songzhuand LIN Wenjiao Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, Hubei | 2001 | Acta Geologica Sinica(English Edition)2001，75，4： | 11 |
| 9 | Enhancement of acellular cartilage matrix scaffold by Wharton’s jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration显示文摘Articular cartilage defect repair is a problem that has long plagued clinicians.Although mesenchymal stem cells(MSCs)have the potential to regenerate articular cartilage,they also have many limitations.Recent studies have found that MSC-derived exosomes(MSC-Exos)play an important role in tissue regeneration.The purpose of this study was to verify whether MSC-Exos can enhance the reparative effect of the acellular cartilage extracellular matrix(ACECM)scaffold and to explore the underlying mechanism.The results of in vitro experiments show that human umbilical cord Wharton’s jelly MSC-Exos(hWJMSC-Exos)can promote the migration and proliferation of bone marrow-derived MSCs(BMSCs)and the proliferation of chondrocytes.We also found that hWJMSC-Exos can promote the polarization of macrophages toward the M2 phenotype.The results of a rabbit knee osteochondral defect repair model confirmed that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration.We demonstrated that hWJMSC-Exos can regulate the microenvironment of the articular cavity using a rat knee joint osteochondral defect model.This effect was mainly manifested in promoting the polarization of macrophages toward the M2 phenotype and inhibiting the inflammatory response,which may be a promoting factor for osteochondral regeneration.In addition,microRNA(miRNA)sequencing confirmed that hWJMSC-Exos contain many miRNAs that can promote the regeneration of hyaline cartilage.We further clarified the role of hWJMSC-Exos in osteochondral regeneration through target gene prediction and pathway enrichment analysis.In summary,this study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. | Shuangpeng Jiang Guangzhao Tian Zhen Yang Xiang Gao Fuxin Wang Juntan Li Zhuang Tian Bo Huang Fu Wei Xinyu Sang Liuqi Shao Jian Zhou Zhenyong Wang Shuyun Liu Xiang Sui Quanyi Guo Weimin Guo Xu Li | 2021 | Bioactive Materials2021，6，9： | 11 |
| 10 | A Modeling Study of Effective Radiative Forcing and Climate Response Due to Tropospheric Ozone显示文摘This study simulates the effective radiative forcing(ERF) of tropospheric ozone from 1850 to 2013 and its effects on global climate using an aerosol–climate coupled model, BCC AGCM2.0.1 CUACE/Aero, in combination with OMI(Ozone Monitoring Instrument) satellite ozone data. According to the OMI observations, the global annual mean tropospheric column ozone(TCO) was 33.9 DU in 2013, and the largest TCO was distributed in the belts between 30°N and 45°N and at approximately 30°S; the annual mean TCO was higher in the Northern Hemisphere than that in the Southern Hemisphere;and in boreal summer and autumn, the global mean TCO was higher than in winter and spring. The simulated ERF due to the change in tropospheric ozone concentration from 1850 to 2013 was 0.46 W m^(-2), thereby causing an increase in the global annual mean surface temperature by 0.36℃, and precipitation by 0.02 mm d^(-1)(the increase of surface temperature had a significance level above 95%). The surface temperature was increased more obviously over the high latitudes in both hemispheres, with the maximum exceeding 1.4?C in Siberia. There were opposite changes in precipitation near the equator,with an increase of 0.5 mm d^(-1)near the Hawaiian Islands and a decrease of about-0.6 mm d^(-1)near the middle of the Indian Ocean. | Bing XIE Hua ZHANG Zhili WANG Shuyun ZHAO Qiang FU | 2016 | Advances in Atmospheric Sciences2016，33，7： | 10 |
| 11 | New Zircon U-Pb Geochronology of the Post-kinematic Granitic Plutons in the Diancang Shan Metamorphic Massif along the Ailao Shan-Red River Shear Zone and Its Geological Implications显示文摘Ailao 掸人红河差错地区是在到东北和印度支那块的 Yangtze 块之间的边界到西南。它由于它在印度支那块的向东南的挤出的角色是一个重要构造地区在期间并且对印第安人欧亚的碰撞随后。Diancang 掸人(DCS ) 高级变形建筑群,沿着 Ailao 掸人红河(ASRR ) 在西北延期定位了砍地区,是 ASRR 构造的带的代表性的变形建筑群。结构并且在高级变形岩石中的砍的岩石的微结构分析表明他们是协调的与固态高温度的可锻的变丑,它被归因于沿着 ASRR 的左侧面的砍砍地区。新 LA-ICP-MS 锆石 U-Pb geochronological 和微结构 kinematic 以后学习花岗石的 plutons 在结束上提供直接时间限制在 ASRR 的可锻的左侧面的砍和变形山岳的发掘砍地区。这被建议沿着 ASRR 的左侧面的砍砍在 ca 结束的地区。以相对降低温度或减少的温度条件的 21 妈。在期间或在在 ca 的年轻的堤的炮兵阵地以后。21 妈,快速的易碎的变丑事件发生了,它让 DCS 山岳开始快 uplift/exhumation 并且冷却到浅外壳的水平。 | CAO Shuyun LIU Junlai Bemd LEISS ZHAO Chunqiang | 2010 | Acta Geologica Sinica(English Edition)2010，84，6： | 9 |
| 12 | Geochronology and Geochemistry of the Radiolarian Cherts of the Mada'er Area,Southwestern Tianshan:Implications for Depositional Environment显示文摘在西南的 Tianshan,因为复杂结构,许多阶层和他们的 depositional 环境的地质的年龄仍然糟糕被抑制。Mada'er 区域位于 Kuokesaleling 带,西南的 Tianshan。从以前的 Wupata'erkan 组的燧石包含丰富的放散虫类的各类动物石块,包括作为迟了被识别的 10 种类泥盆纪到在年龄早含碳。十一件燧石样品有 SiO2 内容为 Al2O3 从 88.80 wt%到 93.28 wt% ,和 2.02 wt% 到 3.72 wt% 。所有样品的 SiO2/Al2O3 比率从 23.84 ~ 46.11 变化,纯燧石(801400 ) 的比那些低的大部分。这些价值建议燧石包含源自陆地的材料的高比率。Al2O3/(Al2O3+Fe2O3 ) 比率在 0.64 和 0.77 之间变化,而 V 和 Cu 集中分别地从 10.92 ppm 到 26.7 ppm 并且从 2.15 ppm 到 34.1 ppm。Ti/V 比率从 25.53 ~ 44.93 变化。燧石的全部的 REE 集中在 30.78 ppm 和 59.26 ppm 之间,平均 45.46 ppm。(La/Ce ) N 比率从 0.81 ~ 1.12,和 0.881.33 为(La/Yb ) N,平均 1.09,它建议大陆人边缘环境。因而,燧石在迟了的泥盆纪期间在剩余海环境形成了到早含碳的时间,这被推断,它建议在 Karakum-Tarim 和 Kazakhstan-Junggar 盘子之间的碰撞没那时发生。另外,地区性的地质的信息显示学习区域经历了一个碰撞以后的阶段在期间早二叠,并且这样在二个盘子之间的碰撞发生了在,是可能的晚含碳。 | KANG Jianli ZHANG Zhaochong ZHANG Dongyang HUANG He DONG Shuyun ZHANG Su | 2011 | Acta Geologica Sinica(English Edition)2011，85，4： | 8 |
| 13 | The Liaonan Metamorphic Core Complex: Constitution, Structure and Evolution显示文摘Liaonan 变形核心建筑群(mcc ) 有三层的结构并且被五部分组成,即在更低的板中的一个滑脱断层地区,在断层带上面的本土的上面的板和 ansupradetachment 盆,和高度变形的岩石和侵入岩。属曾被地壳动力搬的上面的板主要具有微弱地在 pre-Indosinan 舞台使变形并且变形的 Neoproterozoic 和古生代的岩石。在这些岩石上面是沉积的白垩纪和火山岩的 small-scalesupradetachment 盆。更低的板被太古代的 TTG 片麻岩与在上的次要的数量统治外壳的岩石。太古代的岩石被迟了的中生代 synkinematic monzogranitic 和花岗石的 plutons 侵入。差错岩石的不同类型,提供线索给滑脱断层地区的进化,在断层带是保存得很好的, e.g.mylonitic 片麻岩,糜棱岩,角砾岩晒糜棱岩,微角砾岩和 pseudotachylites。在更低的板中的线条花岗石的侵入有一致取向沿着主要滑脱断层地区显示一致 top-to-NWshearing。这也在更低的板中为花岗石的 plutons 的 synkinematiccharacteristics 提供证据。mcc 的那发掘由于外壳的块旋转并且正切的砍以地区性的外壳的扩展开始了的在 mcc 并且从从滑脱断层地区的岩石建议的更低的板和 mylonitic 的深成岩的同位素的标明日期的不同部分的结构的分析。延期触发了岩浆形成,在 welling 和炮兵阵地上面。以 pseudotachylite 和差错计量器的外观结束的这个事件形成了在最高外壳的水平。在更低的板中从花岗石的岩石单个锆石谷物标明日期的 U-Pb 给 130 + 的年龄 - 从主要滑脱断层地区的 5 妈,和 blotite 谷物有 Ar-^(39 ) Ar 108-119 变老的 ^(40 ) 妈。几个方面可以为 Liaonan mcc 的发掘提供限制。这些包括地区性的扩展一!设置,封面 / 地下室接触,时间、空间扩展和岩浆酌联合,盆开发和差错 tectonitesalong 的进化滑脱断层地区。我们建议 Liaonan mcc 的发掘源于地区性的扩展,高举并且在东方诺思中国,和花岗石的 plutons 的伴随的 withsynkieematic 侵入外壳或岩石圈变瘦,滑脱断层地区的形成并且降低板的岩石的发掘,和在上分开的外观盆。 | LIU Junlai GUAN Huimei JI Mo CAO Shuyun HU Ling | 2006 | Acta Geologica Sinica(English Edition)2006，80，4： | 8 |
| 14 | Conversion between polarization states based on a metasurface显示文摘Transmission of an anisotropic metasurface is analyzed in a polar base relying on the Jones calculus, and polarization conversion from the spatial uniform polarization to the spatial nonuniform polarization is explored.Simple and compact polarization converters based on rectangular holes or cross holes etched in silver film are designed, and polarization conversions from the linear and circular polarization to the radial and azimuthal polarization are realized. Numerical simulations of three designed polarization converters consisting of rectangular holes equivalent to polarizers and quarter-and half-wave plates, exhibit the perfect polarization conversion.The experiment results consistent with the simulations verify theoretic predictions. This study is helpful for designing metasurface polarization converters and expanding the application of a metasurface in polarization manipulations. | SHUYUN TENG QI ZHANG HAN WANG LIXIA LIU HAORAN LV | 2019 | Photonics Research2019，7，3： | 7 |
| 15 | Geochemical Characteristics of Selenium and Its Correlation to Other Elements and Minerals in Selenium-Enriched Rocks in Ziyang County,Shaanxi Province,China显示文摘Ziyang County, Shaanxi Province, China is a world known selenium(Se)-enriched area, and a severe selenosis incident was reported in Naore Village during the 1990 s. This study investigated the geochemical characteristics of Se and its fractions in Se-enriched rocks from Ziyang. Se distribution is uneven, ranging from 0.23 to 57.00 μg/g(17.29±15.52 μg/g). Se content is higher in slate than chert, and even lower in carbonate rocks. Cd, As and V are enriched but Pb is depleted in Se-enriched strata. Se has different correlations both with TS(total sulfur)(R^2=0.59 for chert) and TC(total carbon)(R^2=0.77 for slate, R^2=0.87 for carbonate). Se has significant positive correlations with V(r=0.65), As(r=0.485), Cd(r=0.459) and Pb(r=0.405). The Se level correlates with mineral content, positively with pyrite, chlorite and illite, negatively with albite. Se associated with sulfide/selenide and elemental Se are the predominant fractions of total recovered Se, suggesting that a reducing environment and the formation of sulfides were significant to Se deposition during its geochemical cycle. Although low concentration of bio-available Se(average 5.62%±3.69%) may reduce the risk of Se poisoning in the target area, utilization of Se-rich rock as natural fertilizer should be restricted. | Huan Tian Zhenzhen Ma Xiaolei Chen Hongyu Zhang Zhengyu Bao Changhua Wei Shuyun Xie Shitou Wu | 2016 | Journal of Earth Science2016，27，5： | 7 |
| 16 | Advances and prospects in biomimetic multilayered scaffolds for articular cartilage regeneration显示文摘Due to the sophisticated hierarchical structure and limited reparability of articular cartilage(AC),the ideal regeneration of AC defects has been a major challenge in the field of regenerative medicine.As defects progress,they often extend from the cartilage layer to the subchondral bone and ultimately lead to osteoarthritis.Tissue engineering techniques bring new hope for AC regeneration.To meet the regenerative requirements of the heterogeneous and layered structure of native AC tissue,a substantial number of multilayered biomimetic scaffolds have been studied.Ideal multilayered scaffolds should generate zone-specific functional tissue similar to native AC tissue.This review focuses on the current status of multilayered scaffolds developed for AC defect repair,including design strategies based on the degree of defect severity and the zone-specific characteristics of AC tissue,the selection and composition of biomaterials,and techniques for design and manufacturing.The challenges and future perspectives of biomimetic multilayered scaffold strategies for AC regeneration are also discussed. | Liwei Fu Zhen Yang Cangjian Gao Hao Li Zhiguo Yuan Fuxin Wang Xiang Sui Shuyun Liu Quanyi Guo | 2020 | Regenerative Biomaterials2020，7，6： | 7 |
| 17 | Combination of anti-PD-1 antibody with P-GEMOX as a potentially effective immunochemotherapy for advanced natural killer/T cell lymphoma显示文摘Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced NKTL.Nine patients underwent six 21-day cycles of anti-PD-1 antibody(day 1),pegaspargase 2000 U/m^(2)(day 1),gemcitabine 1 g/m^(2)(days 1 and 8)and oxaliplatin 130 mg/m^(2)(day 1),followed by anti-PD-1 antibody maintenance every 3 weeks.Programmed death-ligand 1(PD-L1)expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)analysis.Responses were assessed using 18F-fluorodeoxyglucose positron emission tomography(18FDG-PET)and computed tomography or magnetic resonance imaging.Eight patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 10.6 months,6/9 patients(66.7%)remained in complete remission.The most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and resolved.Immunochemotherapy produced a high response rate in patients with positive PD-L1 expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1 alterations and ARID1A mutation were associated with immunochemotherapy efficacy.Mutation in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1 might indicate a poor response to immunochemotherapy.In conclusion,the anti-PD-1 antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced NKTL.PD-L1 expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy. | Jun Cai Panpan Liu Huiqiang Huang Yajun Li Shuyun Ma Hui Zhou Xiaopeng Tian Yuchen Zhang Yan Gao Yi Xia Xuanye Zhang Hang Yang Lirong Li Qingqing Cai | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 6 |
| 18 | Study on electromechanical coupling nonlinear vibration of flywheel energy storage system显示文摘The electromechanical coupling dynamics of the flywheel energy storage system (FESS) with a hybrid permanent magnetic-dynamic spiral groove bearing has been studied. The functions of the kinetic energy, the potential energys, the magnetic field energy in air gap of the flywheel motor and the energy dissipation of the whole system were obtained, and the differential equations set with electromagnetic parameters of FESS was established by applying the extended Lagrange-Maxwell equation. The four-order implicit Runge-Kutta formula to the equations was derived, and the nonlinear algebraic equations were solved by using the Gauss-Newton method. The analytical solution of an example shows that the upper damping coefficient, the lower damping coefficient and the residual magnetic induction of the rare earth permanent magnet play an important role in electromechanical resonance of the flywheel rotor system. There is a small change for the electromechanical coupling resonance frequency with the upper damping coefficient in-creasing, but the resonance amplitude decreases with the upper damping coefficient in-creasing. With the lower damping coefficient increasing, the resonance frequency in-creases, and the resonance amplitude decreases. With the residual magnetic induction of the permanent magnet increasing, the resonance frequency decreases, and the reso-nance amplitude increases. | JIANG Shuyun JU Lihua | 2006 | Science China(Technological Sciences)2006，49，1： | 6 |
| 19 | Grain-size reduction of feldspar and flow of deformed granites within the Gaoligong shear zone, southwestern Yunnan, China显示文摘Mineral deformation and rock flow mechanism in the lithosphere are related to the rheological behavior and weakening mechanism of the continent. Natural deformation behaviors of feldspars are not well understood due to the complexity of their mineral compositions, crystal structures, as well as changing deformation conditions. The refined microstructure,fabric and composition of major minerals in the deformed granitic rocks within the Gaoligong shear zone(GLGSZ), southwestern Yunnan, China, were studied. With increasing mylonitization, two fabric types of end-members have been distinguished(type-I banded granitic mylonite and type-II banded ultramylonite). The two types of deformed granitic rocks have the same mineral assemblage, but different mineral modes. The type-I banded granitic mylonite has a greater proportion of K-feldspar(mostly present as porphyroclasts)>plagioclase>quartz±biotite, however, the type-II banded ultramylonite has a greater proportion of fine-grained plagioclase>K-feldspar>quartz±biotite. The crystallographic preferred orientation(CPO) patterns of quartz combined with two-feldspar geothermometer, confirm that the quartz grains in the type-I and type-II granitic rock have undergone high-temperature dislocation creep deformation. The K-feldspar grains in the matrix of type-II banded ultramylonite show a dominant(100)[010] slip system with dislocation creep recrystallization, while the fine-grained plagioclase grains present a weak CPO pattern with superplastic flow. The K-feldspar porphyroclasts show grain-size reduction associated with mineral composition and fabric transformation. The myrmekite formation with the fine-grained neocrystallization of plagioclase and quartz significally replaced the K-feldspar porphyroclasts. Finally, the fine-grained neocrystallization plagioclases were formed further into the high strain localized ultramylonites with superplastic flow. | Yanlong DONG Shuyun CAO Xuemei CHENG Junlai LIU Hanchen CAO | 2019 | Science China Earth Sciences2019，62，9： | 6 |
| 20 | Metamorphic, deformation, fluids and geological significance of low-temperature retrograde mylonites of Diancangshan metamorphic massif along Ailaoshan-Red River strike-slip fault zone, Yunnan, China显示文摘Diancangshan metamorphic massif is one of the four metamorphic massifs developed along the Ailaoshan-Red River strike-slip fault zone, Yunnan, China. It has experienced multi-stage metamorphism and deformation, especially since the late Oligocene it widely suffered high-temperature ductile shear deformation and exhumation of the metamorphic rocks from the deep crust to the shallow surface. Based on the previous research and geological field work, this paper presents a detailed study on deformation and metamorphism, and exhumation of deep metamorphic rocks within the Diancangshan metamorphic massif,especially focusing on the low-temperature overprinted retrogression metamorphism and deformation of mylonitic rocks. With the combinated experimental techniques of optical microscope, electron backscatter diffraction attachmented on field-emission scanning electron microscopy and cathodoluminescence, our contribution reports the microstructure, lattice preferred orientations of the deformed minerals, and the changes of mineral composition phases of the superposition low-temperature retrograde mylonites. All these results indicate that:(1) Diancangshan deep metamorphic rock has experienced early high-temperature leftlateral shear deformation and late extension with rapid exhumation, the low-temperature retrogression metamorphism and deformation overprinted the high-temperature metamorphism, and the high-temperature microstructure and texture are in part or entirely altered by subsequent low-temperature shearing;(2) the superposition of low-temperature deformation-metamorphism occurs at the ductile-brittle transition; and(3) the fluid is quite active during the syn-tectonic shearing overprinted lowtemperature deformation and metamorphism. The dynamic recrystallization and/or fractures to micro-fractures result in the strongly fine-grained of the main minerals, and present strain localization in micro-domians, such as micro-shear zones in the mylonites. It is often accompanied by the decrease of rock strength and finally influences the rheology of the whole rock during further deformation and exhumation of the Diancangshan massif. | Xuemei CHENG Shuyun CAO Junyu LI Zunpu YU Yanlong DONG Meixia LV Junlai LIU | 2018 | Science China Earth Sciences2018，61，8： | 4 |
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