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	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	Outcome prediction of emergency patients by noninvasive hemodynamic monitoring 显示文摘	Shoemaker WC Wo CCJ Chan L	2001	Chest2001，11，：	1
3	Experimental annotation of the human genome using microarray technology显示文摘	Shoemaker D D Schadt E E Armoar L	2001	Nature2001，409，22：	1
4	A new integrated genetic linkage map of the soybean显示文摘	Song Q J Marek L F Shoemaker R C	2004	Theoretial and Applied Genetics2004，109，：	1
5	A new integrated ge-netic linkage map of the soybean显示文摘	Song Q J Marek L F Shoemaker R C	2004	Theoretical and Applied Ge-netics2004，109，：	1
6	Lunar surface topography显示文摘	Rennilson J J Dragg J L Morris E C Shoemaker E M Turkevich A	1966	Surveyor I mission report part Ⅱ:Scientific data and results NASA JPL Technical Report1966，32，：	1
7	gene analogs are conserved and clusteredin soybean 显示文摘	KANAZIN V MAREK L F SHOEMAKER R	1996	Proc Natl Acad Sci USA1996，93，11：	1
8	A new integrated genetic linkage map of the soybean 显示文摘	Song Q J Marek L F Shoemaker R C	2004	Theoretical and App lied Genetics2004，109，1：	1
9	Transmission and detection of Flavobacterium columnare in channel catfish Ictalurus punctatu 显示文摘	Welker T L Shoemaker C A Arias C R	2005	Dis Aquat Organ2005，63，23：	1
10	Resistance gene analogs are conserved and clustered in soybean 显示文摘	Kanazin V Marek L F Shoemaker R C	1996	Proceedings of the National Academy of Sciences of the USA1996，93，11：	1
11	A new integrated ge- netic linkage map of the soybean显示文摘	Song Q J Marek L F Shoemaker R C	2004	Theoretical and Applied Ge-netics2004，109，：	1
12	A new inte- grated genetic linkage map of the soybean 显示文摘	Song Q J Marek L F Shoemaker R C	2004	Theoreti- cal and Applied Genetics2004，109，1：	1
13	A new integrated genetic linkage map of the soybean 显示文摘	Song Q J Marek L F Shoemaker R C	2004	Theor Appl Genet2004，109，：	1
14	A new integrated genetic linkage map of the soybean显示文摘	Song Q J Marek L F Shoemaker R C	2004	Theor Appl Genet2004，109，：	1
15	Resistance gene analogs are conserved and clustered in soybean 显示文摘	Kanazin V M Marek L F Shoemaker R C	1996	Proc Natl Acad Sei USA1996，93，11：	1
16	A new integrated ge- netic linkage map of the soybean显示文摘	Song Q J Marek L F Shoemaker R C	2004	Theoretical and Applied Ge- netics2004，109，1：	1
17	Measurement of tissue perfusion by oxygen transport patterns in experimental shock and in high risk surgical patients 显示文摘	Shoemaker W C Appel P L Kram H B	1990	Intensive Care Med1990，16，2：	1
18	Symptom Man-agement:An Important Part of Cancer Care显示文摘	Shoemaker L K Estfan B Induru R	2011	Clere Clin JMed2011，78，1：	1
19	Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients 显示文摘	Shoemaker W C Appel P L Kram H B Waxman K Lee T S	1988	Chest1988，94，：	1
20	A new integrated genetic linkage map of soybean 显示文摘	Song Q J Marek L F Shoemaker R C	2004	Theor Appl C enet2004，109，：	1

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