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1The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China.Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao 2016Translational Neurodegeneration2016,5,1:23
2A Novel Secure Data Transmission Scheme in Industrial Internet of Things显示文摘The industrial Internet of Things(IoT)is a trend of factory development and a basic condition of intelligent factory.It is very important to ensure the security of data transmission in industrial IoT.Applying a new chaotic secure communication scheme to address the security problem of data transmission is the main contribution of this paper.The scheme is proposed and studied based on the synchronization of different-structure fractional-order chaotic systems with different order.The Lyapunov stability theory is used to prove the synchronization between the fractional-order drive system and the response system.The encryption and decryption process of the main data signals is implemented by using the n-shift encryption principle.We calculate and analyze the key space of the scheme.Numerical simulations are introduced to show the effectiveness of theoretical approach we proposed.Hongwen Hui Chengcheng Zhou Shenggang Xu Fuhong Lin 2020China Communications2020,17,1:19
3Free cholesterol-induced macrophage apoptosis is mediated by inositol-requiring enzyme 1 alpha-regulated activation of Jun N-terminal kinase显示文摘在先进动脉粥样硬化患者损害的巨噬细胞死亡导致 lesional 坏死,可能的匾破裂,和尖锐脉管的吸藏。巨噬细胞死亡的一个可能的原因是导致 endoplasmic 蜂窝胃的激活的免费胆固醇(FC ) 的累积(嗯) 导致压力的 apoptosis。1 alpha (IRE1 ) 是的要求肌醇的酶 ERthat 的不可分的膜蛋白质是在在巨噬细胞的导致胆固醇的 apoptosis 的关键发信号步,在 ER 由应力激活。然而,在规定的 IRE1 的角色嗯为这个过程的导致压力的巨噬细胞死亡和机制大部分是不清楚的。在这研究,一个房间文化模型被用来探索涉及导致 FC 的巨噬细胞死亡的 ER 压力小径的机制。结果此处证明巨噬细胞装载的 FC 导致部分依赖于由 IRE1 的激活的开始的 apoptotic 回答。一起拿,这些结果证明 IRE1-apoptosis-signaling kinase 1-c-Jun NH2 终端 kinase 串联小径在这个过程被要求。而且,数据在先进动脉粥样硬化患者损害为导致胆固醇的巨噬细胞死亡建议了新奇细胞的机制。这发信号的串联的批评功能被预防显示嗯在 IRE1 的抑制以后的导致压力的 apoptosis,或 c6 月 NH2 终端 kinase。Fangming Li Yi Guo Shenggang Sun Xin Jiang Bingshan Tang Qizhang Wang Ling Wang 2008Acta Biochimica et Biophysica Sinica2008,40,3:7
4Nitrogen Deep Placement Combined with Straw Mulch Cultivation Enhances Physiological Traits,Grain Yield and Nitrogen Use Efficiency in Mechanical Pot-Seedling Transplanting Rice显示文摘To assess the effects of straw return coupled with deep nitrogen(N)fertilization on grain yield and N use efficiency(NUE)in mechanical pot-seedling transplanting(MPST)rice,the seedlings of two rice cultivars,i.e.,Yuxiangyouzhan and Wufengyou 615 transplanted by MPST were applied with N fertilizer at 150 kg/hm2 and straw return at 6 t/hm2 in early seasons of 2019 and 2020.The experiment comprised of following treatments:CK(no fertilizer and no straw return),MDS(deep N fertilization and straw return),MBS(broadcasting fertilizer and straw return),MD(deep N fertilization without straw return),MB(broadcasting fertilizer without straw return).Results depicted that the MDS treatment significantly increased the rice yield by 41.69%-72.22%due to total above-ground biomass,leaf area index and photosynthesis increased by 54.70%-55.80%,38.52%-52.17%and 17.89%-28.40%,respectively,compared to the MB treatment.In addition,the MDS treatment enhanced the total N accumulation by 37.74%-43.69%,N recovery efficiency by 141.45%-164.65%,N agronomic efficiency by 121.76%-134.19%,nitrate reductase by 46.46%-60.86%and glutamine synthetase by 23.56%-31.02%,compared to the MB treatment.The average grain yield and NUE in both years for Yuxiangyouzhan were higher in the MDS treatment than in the MD treatment.Hence,deep N fertilization combined with straw return can be an innovative technique with improved grain yield and NUE in MPST in South China.LI Lin ZHANG Zheng TIAN Hua Umair ASHRAF Yousef Alhaj HAMOUD Al Aasmi ALAA TANG Xiangru DUAN Meiyang WANG Zaiman PAN Shenggang 2022Rice science2022,29,1:5
5Generating 0.42 THz radiation from a second harmonic gyrotron显示文摘Gyrotrons are high powered coherent electromagnetic radiation sources, and are considered to be available powerful sources that have the potential to bridge the so-called terahertz gap. In the University of Electronic Science and Technology of China, a second harmonic gyrotron has been designed, manufactured, and tested. The gyrotron generated radiation at a 0.423 THz frequency in 5μs pulses with an 8.1 Tesla magnetic field, with a power per pulse of about 4.4 kW. To date this is the highest frequency recorded for vacuum electronic devices in China. The gyrotron design, operation and measurements are presented.FU WenJie YAN Yang LI XiaoYun YUAN XueSong LIU ShengGang 2011Chinese Science Bulletin2011,56,33:5
6Deep placement of nitrogen fertilizer increases rice yield and nitrogen use efficiency with fewer greenhouse gas emissions in a mechanical direct-seeded cropping system显示文摘Deep placement of nitrogen fertilizer is a key strategy for improving nitrogen use efficiency. A two-year field experiment was conducted during the early rice growing seasons(March–July) of 2016 and 2017.The experimental treatments comprised two rice cultivars: Wufengyou 615(WFY 615) and Yuxiangyouzhan(YXYZ), and three N treatments: mechanical deep placement of all fertilizers as basal dose at 10 cm soil depth(one-time deep-placement fertilization, namely OTDP fertilization);manual surface broadcast(the common farmer practice) of 40% N fertilizer at one day before sowing(basal fertilizer)followed by broadcast application of 30% each at tillering and panicle initiation stages;and no fertilizer application at any growth stage as a control. One-time deep-placement fertilization increased grain yield of both rice cultivars by 11.8%–19.6%, total nitrogen accumulation by 10.3%–13.1%, nitrogen grain production efficiency by 29.7%–31.5%, nitrogen harvest index by 27.8%–30.0%, nitrogen agronomic efficiency by 71.3%–77.2%, and nitrogen recovery efficiency by 42.4%–56.7% for both rice cultivars, compared with the multiple-broadcast treatment. One-time deep-placement fertilization reduced CH4-induced global warming potential(GWP) by 20.7%–25.3%, N2O-induced GWP by 7.2%–12.3%, and total GWP by 14.7%–22.9% for both rice cultivars relative to the multiple-broadcast treatment. The activities of glutamine synthetase and nitrate reductase were increased at both panicle-initiation and heading stages in both rice cultivars following one-time deep-placement fertilization treatment. Larger leaf area index at heading stage and more favorable root morphological traits expressed as larger total root length, mean root diameter, and total root volume per hill were also observed. One-time deep-placement fertilization could be an effective strategy for increasing grain yield and nitrogen use efficiency and lowering greenhouse-gas emissions under mechanical direct-seeded cropping systems.Lin Li Hua Tian Minghua Zhang Pingshan Fan Umair Ashraf Haidong Liu Xiongfei Chen Meiyang Duan Xiangru Tang Zaiman Wang Zheng Zhang Shenggang Pan 2021The Crop Journal2021,9,6:4
7Theoretical investigation of a terahertz transmission line in bipolar coordinate system显示文摘It has been demonstrated that the dual-wire waveguide(DWW)can be used in terahertz(THz) frequency regime with many advantages.However,the existent research approaches for the DWW are based on the electrostatic theory.In this paper,making use of the bipolar coordinate system(BCS),a rigorous analytical theory of DWW is worked out,and some important physical and optical characters of DWW including the rotating behavior etc.are revealed,the equivalent impendence and the ohmic loss for the gold DWW are calculated.An eigenvalue problem is presented from the point of view of Mathematical-Physics for TE and TM modes.The obtained results will help get a deep-going understanding of DWW and explore its application in high frequency range including THz.ZHONG RenBin ZHOU Jun LIU WeiHao LIU ShengGang 2012Science China(Information Sciences)2012,55,1:4
8Efficacy and safety of rasagiline in Chinese patients with early Parkinson’s disease:a randomized, double-blind,parallel,placebo-controlled,fixed-dose study显示文摘Background:Rasagiline is a monoamine oxidase-B inhibitor used for Parkinson’s disease(PD)treatment,but its effectiveness on Chinese patients is unclear.This study aimed to evaluate the efficacy and safety of rasagiline monotherapy in Chinese patients with early PD.Methods:A 26-weeks,randomized,double-blind,placebo-controlled study has been performed at 15 sites in China and enrolled outpatients(≥35 years old)with idiopathic PD without a history of using any dopaminergic drugs.Participants were randomized 1:1 to receive rasagiline 1 mg once daily or placebo.The primary endpoint was the change of the Unified Parkinson’s Disease Rating Scale(UPDRS)total score from baseline to 26 weeks treatment.Secondary endpoints included changes in UPDRS subscale scores from part Ⅰ to Ⅲ.Health status was assessed with the PD Questionnaire(PDQ)-39 and EuroQol-Five-Dimension(EQ-5D)questionnaire.Safety profile was collected until 30 weeks after randomization.Results:A total of 130 patients(n=65/group)were recruited,and 127(rasagiline,n=64;placebo,n=63)were included in the full analysis set.Baseline characteristics were comparable between the two groups.The decrease in the mean UPDRS total score was greater in the rasagiline group than in the placebo group(−3.18±0.95 vs.−0.18±0.98,P=0.025),and the mean UPDRS part I non-motor symptoms score(−0.54±0.15 vs.-0.08±0.15,P=0.003)were significantly decreased in the rasagiline group compared with placebo treated patients.An improvement trend was observed in the active treatment group for the subscales evaluation with parts Ⅱ and Ⅲ,while the difference to placebo was not statistically significant.Life quality assessed by the EQ-5D visual analog scale improved in the rasagiline group but worsened in placebo treated patients.The overall incidence of treatment-emergent adverse events(AEs)was slightly lower in the rasagiline group(41.5%)than in the placebo group(46.2%).Conclusions:Rasagiline is effective,safe,and well tolerated as monotherapy for the treatment of Chinese PD patients.Zhenxin Zhang Jian Wang Shengdi Chen Chunfeng Liu Baorong Zhang Rong Peng Shenggang Sun Xiangru Sun Gang Zhao Qiumin Qu Yansheng Li Suiqiang Zhu Xiaoping Pan Ming Shao Yanping Wang 2018Translational Neurodegeneration2018,7,1:3
9The efficacy and safety of pramipexole ER versus IR in Chinese patients with Parkinson’s disease: a randomized, double-blind, double-dummy, parallel-group study显示文摘Objective:To evaluate the non-inferiority of pramipexole extended-release(ER)versus immediate-release(IR)in Chinese patients with Parkinson’s disease(PD)in a double-blind,randomized,parallel-group study.Methods:Subjects were Chinese patients with idiopathic PD with diagnosis≥2 years prior to trial,age≥30 years old at diagnosis,and Modified Hoehn and Yahr score 2-4 during‘on’-time.Subjects received treatment with pramipexole ER(n=234)or IR(n=239).Non-inferiority was based on the primary endpoint,the change from baseline to end of maintenance(week 18)in the UPDRS(Parts II+III)total score.Results:For the primary endpoint,the adjusted mean changes(standard error)of UPDRS Parts II+III at week 18 were−13.81(0.655)and−13.05(0.643)for ER and IR formulations,respectively,using ANCOVA adjusted for treatment and centre(fixed effect)and baseline(covariate).The adjusted mean between group difference was 0.8 for the 2-sided 95%CI(−1.047,2.566).Since the lower limit of the 2-sided 95%CI(−1.047)for treatment difference was higher than the non-inferiority margin of−4,non-inferiority between pramipexole ER and IR was demonstrated.The incidence of adverse events(AEs)was 68.8%in the ER arm and 73.6%in the IR arm with few severe AEs(ER:2.1%;IR:3.8%).Conclusion:Based on the UPDRS II+III score,pramipexole ER was non-inferior to pramipexole IR.The safety profiles of pramipexole ER and IR were similar.These results were based on comparable mean daily doses and durations of treatment for both formulations.Ying Wang Shenggang Sun Suiqiang Zhu Chunfeng Liu Yiming Liu Qing Di Huifang Shang Yan Ren Changhong Lu Mark Forrest Gordon Nolwenn Juhel Shengdi Chen for the Pramipexole ER Study Team 2014Translational Neurodegeneration2014,3,1:3
10Lodging Resistance Related to Root Traits for Mechanized Wet-Seeding of Two Super Rice Cultivars显示文摘Mechanical hill wet-seeded rice machine is beneficial for establishing and growing uniform rows of seedlings.However,there is limited knowledge regarding the effects of the establishment of furrows on growth,lodging and yield,and their relationships with root traits.In this study,field experiments were conducted during 2012 and 2013 using two super rice varieties(hybrid rice Peizataifeng and inbred rice Yuxiangyouzhan)under three furrow establishment treatments(T1,both water and seed furrows were established by the machine;T2,only seed furrows were established by the machine;and T3,neither water nor seed furrows were established by the machine).Lodging index,lodging-related traits,grain yield,above-ground dry weight and root traits were measured.The results showed that the lodging index was significantly affected by the treatments with furrows(T1 and T2).The strongest lodging resistance was detected in the mechanical hill wet-seeded rice with furrow treatment(T1)in both 2012 and 2013.Lodging resistance was strongly related to the breaking resistance.No significant difference was found in grain yield or dry weight of the mechanical hill wet-seeded rice.Therefore,the mechanical hill wet-seeded rice with furrow treatment increased rice lodging resistance,which was related to root traits.ZHANG Minghua MO Zhaowen LIAO Juan PAN Shenggang CHEN Xiongfei ZHENG Le LUO Xiwen WANG Zaiman 2021Rice science2021,28,2:3
11Study on the effects of thrombin on AQP4 mRNA and AQP4 protein expression in rat primary astrocytes显示文摘Objective:To study the biologic effects of various concentrations of thrombin on aquaporin 4(AQP4)expression in rat primary cultured astrocytes,and to explore the regulation mechanism of transmembrane water transportation in astrocytes after intracerebral hemorrhage(ICH).Methods:Primary cultured astrocytes were incubated in culture mediums containing various concentrations of thrombin for 24 h and harvested.AQP4 mRNA and AQP4 protein expression were determined by reverse transcription polymerase chain reaction(RT-PCR)and immunohistochemical technique.Cell apoptosis was detected by TdT-mediated dUTP nick end labeling(TUNEL)technique.Cell morphology was observed by phase contrast microscope,and cell viability was assayed by MTT.Results:AQP4 mRNA and AQP4 protein showed a low expression in normal astrocytes.The expression of AQP4 mRNA and AQP4 protein significantly increased in the astrocytes treated with 100 U/ml or 200 U/ml thrombin(P < 0.01),and these astrocytes swelled.The number of TUNEL positive cells significantly increased.On the other hand,AQP4 mRNA and AQP4 protein expression were down-regulated in the astrocytes treated with 0.5 U/ml or 1 U/ml thrombin(P < 0.05),and the cell morphology did not change.Few TUNEL positive cells were observed.Conclusion:AQP4 over-expression induced by high concentrations of thrombin causes an increased permeability of water in astrocytic membrane.On the contrary,the decreased AQP4 expression prevents the astrocytes from swelling and apoptosis.Jinghua Zhou Xuebing Cao Shenggang Sun 2006Journal of Nanjing Medical University2006,20,4:3
12Radon-Nikodym Theorem in Signed Loeb Space显示文摘This paper gives the Radon-Nikodym theorem in signed Loeb space under 1-saturated nonstandard model. First,the nonstandard characterization of absolute continuity is discussed,on which Radon-Nikodym theorem in signed Loeb space is obtained. Then,some facts about a finite signed Loeb measure and its variation are shown.MA Chunhui LI Shenggang SHI Yanwei 2010Wuhan University Journal of Natural Sciences2010,15,1:3
13An E-Commerce Recommender System Based on Click and Purchase Data to Items and Considered of Interest Shifting of Customers显示文摘A well-performed recommender system for an e-commerce web site can help customers easily find favorite items and then increase the turnover of merchants, hence it is important for both customers and merchants. In most of the existing recommender systems, only the purchase information is utilized data and the navigational and behavioral data are seldom concerned. In this paper, we design a novel recommender system for comprehensive online shopping sites. In the proposed recommender system, the navigational and behavioral data, such as access, click, read, and purchase information of a customer, are utilized to calculate the preference degree to each item; then items with larger preference degrees are recommended to the customer. The proposed method has several innovations and two of them are more remarkable: one is that nonexpendable items are distinguished from expendable ones and handled by a different way; another is that the interest shifting of customers are considered. Lastly, we structure an example to show the operation procedure and the performance of the proposed recommender system. The results show that the proposed recommender method with considering interest shifting is superior to Kim et al(2011) method and the method without considering interest shifting.Duo Lin Wu Zhaoxia XU Shenggang 2015China Communications2015,12,S2:3
14Universality and Specificity of Fractal Dimension of Fractured Surfaces in Materials显示文摘After calculation on the fracture angles under various conditions of specific surface energies with different symmetry operations of rotation, the complicated behavior of dependence of fractal dimension on the strudure of crystal is shown. It is found that the crack propagates along the weakest crystal plane no matter what the direction of the maximum stress is if the anisotropy is sufficiently strong; and then, the fractal dimension of the fractured surfaces might be determined by the approximate fractal Structure already existed in the material. Specificity of the fractal dimension of fractured surfaces would be easy to appear in this case. Reversely, the crack propagates along the direction of the maximum stress no matter what direction of the weakest crystal plane is if the anisotropy is sufficiently weak. Universality of the fractal dimension of fractured surfaces would be possible to appear in this case. In many real materials, universality and specificity of the materials are associated. The fractal dimension measured may more or less be influenced by the Structure of materials and it shows its universality through the specificity of materials.Chiwei LUNG and Shenggang WANG (International Centre for Materials Physics, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China) 2000Journal of Materials Science & Technology2000,16,1:2
15The space-time coupling statistical model of reverberation from moving platforms显示文摘The space-time coupling characteristic of reverberation is one of key problems in the range of reverberation suppression with space-time processing methods.Traditional methods are not based on statistical characteristics of reverberation and not suitable to analyze the space-time coupling characteristics of reverberation in dealing with problems of reverberation extensions in the actual sea environment and non-ideal arrays.The space-time coupling relationship of moving platforms is deduced and then its space-time coupling statistical model is presented.The model describes the space-time coupling law of reverberation under the conditions as complex acoustic reverberation environments and an arbitrarily specified array.The mathematical expressions of space-time coupling relationship are described when the arrays have ideal narrow beams.The space-time distribution laws of reverberation from moving platforms are shown clearly by the analytical results and computer simulations,which validates the statistical model above.The space-time distribution law of reverberation from an uniform linear array(ULA),which is a non-ideal array,is also calculated by numerical methods.It is shown that the space-time distribution law of reverberation from any actual array can be acquired with the statistical model,and to support theoretically for reverberation suppression algorithms and systems design based on space-time processing.LIU Jianguo ZHU Lingxiao YAN Shenggang 2019Chinese Journal of Acoustics2019,38,3:2
16A weighting orthogonal method for constant beamwidth beamforming matrices显示文摘weighting 为经常的 beamwidth beamforming 矩阵的直角的方法被建议。这个方法乘 weighting 因素到相应于不同频率箱的每个直角的 beamforming 矩阵。建议的方法不引起波形错误,并且当来源有一致光谱时,不引起数组 signal-to-noise 比率的另外的损失。波形错误和数组 signal-to-noise 比率的另外的损失不能被平常的直角的方法同时避免。我们能因此由 weighting 方法同时得到好察觉和评价表演。模拟结果和水坦克实验被介绍证实结论在上面。DU Jinxiang YAN Shenggang LI Zhishun 2007Chinese Journal of Acoustics2007,26,3:2
17Grain Yield, Quality and 2-Acetyl-1-Pyrroline of Fragrant Rice in Response to Different Planting Seasons in South China显示文摘Climate conditions is an important factor affected the fragrant rice growth and development.In order to study the effects of different planting seasons on fragrant rice performance in South China,present study was conducted with three planting seasons(early season(April to July),middle season(June to September)and late season(August to November))and three fragrant rice cultivars,‘Basmati-385’,‘Meixiangzhan-2’and‘Xiangyaxiangzhan’.The results showed that the highest grain yield and grain 2-acetyl-1-pyrroline(2-AP,key component of fragrant rice aroma)content were both recorded in late season treatment while the fragrant rice in middle season treatment produced the lowest grain yield,grain filling percentage,1000-grain weight and gain 2-AP content.The highest contents of precursors(proline,pyrroline-5-carboxylic acid and 1-pyrro-line)which related to 2-AP biosynthesis were recorded in late season treatment compared with early season treatment and middle season treatment.The highest activities of enzymes(proline dehydrogenase,pyrroline-5-carboxylic acid synthetase and ornithine transaminase)which involved in 2-AP biosynthesis were also observed in late season treatment.Moreover,the fragrant rice cultivars in late season possessed the lowest chalk rice rate,chalkiness as well as the highest brown rice rate,head rice and protein content.Thus,the optimal season for fragrant rice production in South China is the late season.Leilei Kong Haowen Luo Zhaowen Mo Shenggang Pan Zhixia Liu Qiang Zhang Song Bai Xiangru Tang 2020Phyton-International Journal of Experimental Botany2020,89,3:2
18Optical storage: an emerging option in long-term digital preservation显示文摘长期的数字保藏是在数据存储区域的一个重要问题。多年,磁性的媒介基于解决方案,例如磁带,硬盘开车(HDD ) 基于档案系统,垄断由于他们的高能力和低费用转存市场的数据。然而,在数据的大数据,很快增加的体积,速度,和变化的时代设定把众多的挑战带到档案在各种各样的方面的系统例如能力,花费了,性能,可靠性,电源消费等等。在最近的年里,高能力光媒介例如 bluray 磁盘(BD ) 和 holographic 磁盘,与光存储的苏醒出现。由于光媒介的自然简单构造,档案系统基于那些光媒介,例如, BD 图书馆,表明吸引人的性质,例如费用每位,可靠性,电源消费等等,因此在长期的数字保藏成为可行选择。在这份报纸,我们考察了并且比较两个磁性、光的媒介为长期的数字保藏基于答案,在技术上由一篇摘要列在后面改进光媒介基于的档案系统。Shenggang WAN Qiang CAO Changsheng XIE 2014Frontiers of Optoelectronics2014,7,4:2
19Influence of endogenous ciliary neurotrophic factor on neural differentiation of adult rat hippocampal progenitors显示文摘Ciliary neurotrophic factor is the only known neurotrophic factor that can promote differentiation of hippocampal neural progenitor cells to glial cells and neurons in adult rats.This process is similar to spontaneous differentiation.Therefore,ciliary neurotrophic factor may be involved in spontaneous differentiation of neural stem cells.To verify this hypothesis,the present study isolated neural progenitor cells from adult male rats and cultured them in vitro.Results showed that when neural progenitor cells were cultured in the absence of mitogen fibroblast growth factor-2 or epidermal growth factor,they underwent spontaneous differentiation into neurons and glial cells.Western blot and immunocytochemical staining showed that exogenous ciliary neurotrophic factor strongly induced adult hippocampal progenitor cells to differentiate into neurons and glial cells.Moreover,passage 4 adult hippocampal progenitor cells expressed high levels of endogenous ciliary neurotrophic factor,and a neutralizing antibody against ciliary neurotrophic factor prevented the spontaneous neuronal and glial differentiation of adult hippocampal progenitor cells.These results suggest that the spontaneous differentiation of adult hippocampal progenitor cells is mediated partially by endogenous ciliary neurotrophic factor.Jun Ding Zhili He Juan Ruan Ying Liu Chengxin Gong Shenggang Sun Honghui Chen 2013Neural Regeneration Research2013,8,4:2
20Editor's note显示文摘During the past decade,prosperous development and fruitful achievements have been accomplished in the field of Terahertz(THz)science and technology,including THz sources,THz detection,THz transmission and the functional components.THz science and technology can be employed in wideLIU ShengGang University of Electronic Science and Technology of China,Chengdu XIE WeiXin Shenzhen University,Shenzhen 2012Science China(Information Sciences)2012,55,1:2
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