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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | Activation characteristics of candidate structural materials for a near-term Indian fusion reactor and the impact of their impurities on design considerations显示文摘Activation analyses play a vital role in nuclear reactor design.Activation analyses,along with nuclear analyses,provide important information for nuclear safety and maintenance strategies.Activation analyses also help in the selection of materials for a nuclear reactor,by providing the radioactivity and dose rate levels after irradiation.This information is important to help define maintenance activity for different parts of the reactor,and to plan decommissioning and radioactive waste disposal strategies.The study of activation analyses of candidate structural materials for near-term fusion reactors or ITER is equally essential,due to the presence of a highenergy neutron environment which makes decisive demands on material selection.This study comprises two parts; in the first part the activation characteristics,in a fusion radiation environment,of several elements which are widely present in structural materials,are studied.It reveals that the presence of a few specific elements in a material can diminish its feasibility for use in the nuclear environment.The second part of the study concentrates on activation analyses of candidate structural materials for near-term fusion reactors and their comparison in fusion radiation conditions.The structural materials selected for this study,i.e.India-specific Reduced Activation Ferritic-Martensitic steel(IN-RAFMS),P91-grade steel,stainless steel 316 LN ITER-grade(SS-316 LN-IG),stainless steel 316 L and stainless steel 304,are candidates for use in ITER either in vessel components or test blanket systems.Tungsten is also included in this study because of its use for ITER plasma-facing components.The study is carried out using the reference parameters of the ITER fusion reactor.The activation characteristics of the materials are assessed considering the irradiation at an ITER equatorial port.The presence of elements like Nb,Mo,Co and Ta in a structural material enhance the activity level as well as the dose level,which has an impact on design considerations.IN-RAFMS was shown to be a more effective low-activation material than SS-316 LN-IG. | H L SWAMI C DANANI A K SHAW | 2018 | Plasma Science and Technology2018，20，6： | 2 |
| 3 | Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial显示文摘 | A David Mendelow Barbara A Gregson Helen M Fernandes Gordon D Murray Graham M Teasdale D Terence Hope Abbas Karimi M Donald M Shaw David H Barer | 2005 | 2005 (9457)2005，，9457： | 2 |
| 4 | Recent progress in short-range ultraviolet communication显示文摘 | SHAW A G SIEGEL M A MODEL J | 2005 | Proc SPIE2005，5796，： | 1 |
| 5 | Recent Progress in Short-Range Ultraviolet Communication显示文摘 | Gary A Shaw Andrew M Siegel Joshua Model | 2005 | Proceedings of SPIE2005，5796，： | 1 |
| 6 | Widely spread butyrylcholinesterase can hydrolyze acetylcholine in the normal and Alzheimer brain显示文摘 | MESULAM MM GUILLOZET A SHAW p | 2002 | Neurobiol Dis2002，9，： | 1 |
| 7 | Role of seed bank substrates in the revegetation of fly ash and gypsum in the Uuited Kingdom显示文摘 | SHAW P J A | 1996 | Restoration Ecology1996，，4： | 1 |
| 8 | Natural variation in balsam fir folia components of dietary importance to spruce budworm显示文摘 | SHAW G G LITTLE C H A | 1974 | Can J For Res1974，7，： | 1 |
| 9 | Local inhomogeneity in asymmetric simple exclusion processes with extended objects 显示文摘 | SHAW L B KOLOMEISKY A B LEE K H | 2004 | J Phys A2004，37，： | 1 |
| 10 | Activation of the JAK/STAT pathway in vascular smooth muscle by serotonin 显示文摘 | Banes AK Shaw SM Tawfik A | 2005 | Am J Physiol Cell Physiol2005，288，4： | 1 |
| 11 | Immunosuppressive drugs prevent a rapid dephos?phorylation of transcription factor NF A Tl in stimulated immune cells显示文摘 | SHAW K T Y HO A M RAGHAVAN A | 1995 | Proc Natl Acad Sci USA1995，92，11： | 1 |
| 12 | A multiloeus estimator of mating system parameters in plant populations显示文摘 | Shaw D Kahler A Allard R | 1981 | Proceedings of the National Academy of Sciences1981，78，2： | 1 |
| 13 | Seed storage oil mobi lization is important but not essential for germination or seedling establishment in Arabidopsis显示文摘 | Kelly A A Quettier A L Shaw E | 2011 | Plant Physiology2011，157，2： | 1 |
| 14 | Natural in situ relationships suggest coral reef calcium carbonate production will decline with ocean acidification显示文摘 | SHAW E C PHINN S R TILBROOK B STEVEN A | 2015 | Linmology and Oceanography2015，60，3： | 1 |
| 15 | Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma显示文摘 | Berry M Morgan A Shaw D E | 2007 | Thorax2007，62，12： | 1 |
| 16 | Endogenous on cogenic K-ras (G12D) stimulates proliferation and widespread neoplastic and developmental defects 显示文摘 | Tuveson D A Shaw A T Willis N A | 2004 | Cancer Cell2004，5，4： | 1 |
| 17 | Fundamental cryobiology of mammalian oocytes and ovarian tissue 显示文摘 | Shaw JM Oranrathachai A Trouson AO | 2000 | Theriogenology2000，53，： | 1 |
| 18 | Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation显示文摘 | Shaw A S Allen P M | 1998 | Science1998，281，5376： | 1 |
| 19 | Carcinoma associated with myelomeningocele显示文摘 | BUCHAN A C SHAW J F | 1980 | Dev Med Child Neurol1980，22，4： | 1 |
| 20 | Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not显示文摘 | Gecz J Shaw M A Bellon J R | 2003 | Gene2003，320，： | 1 |
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