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| 1 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 2 | Developmental Tendency of Dry Land Farming Technologies显示文摘The developmental tendency of dry land farming technologies in the semiarid area of China were reviewed based on the overview of recent progress in dry land farming researches from China and oversea. It was emphasized that conservation tillage, limited irrigation, genetic modification and chemical control are the important aspects for the dry land farming research and development of the future. In addition, some considerations and suggestions on above-mentioned aspects were proposed in this paper. | SHAN Lun(Institute of Soil and Water Conservation, Chinese Academy of Sciences and Ministry of Water Resources, Northwest Sci-Tech University of Agriculture and Forestry, Yangling 712100, P. R . China ) | 2002 | Agricultural Sciences in China2002，1，8： | 10 |
| 3 | High corrosion resistance of electroless composite plating coatings on AZ91D magnesium alloys 显示文摘 | SONG Y W SHAN D Y CHEN R S HAN E H | 2008 | Electrochimica Acta2008，53，： | 1 |
| 4 | Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle:implications on decreased myocardial protection in diabetic cardiomyopathy显示文摘 | Shan Y X Yang T L Mestril R | 2003 | J Biol Chem2003，278，45： | 1 |
| 5 | Quantitative assessment of strain and strain rate by velocity vector imaging during dobutamine stress echocardiography to predict outcome in patients with left bundle branch Block显示文摘 | Shan Y Villarraga H R Pislaru C | 2009 | Journal of the American Society of Echocardiography2009，22，11： | 1 |
| 6 | Synthesis ot tibrous β-Si3N4 structured porous ceramics using carbothermal nitridation of silica显示文摘 | Yang J F Shan S Y Janssen R | 2005 | Acta Mater2005，53，10： | 1 |
| 7 | Genetic analysis of a novel dominant rice dwarf mutant 986083D显示文摘 | Qin R Z Qiu Y Cheng Z J Shan X Y Guo X P Zhai H Q Wan J M | 2008 | Euphytica2008，160，： | 1 |
| 8 | High corrosion resistance of electroless composite plating coatings on AZ91D magnesium alloys显示文摘 | SONG Y W SHAN D Y CHENG R S | 2008 | Electrochimica Acta2008，53，5： | 1 |
| 9 | Positive solutions for second-order m-point boundary value problems显示文摘 | Guo Y P Shan W R Ge W G | 2003 | J Comput ApplMath2003，151，2： | 1 |
| 10 | Chitin-based tubes for tissue engineering in the nervous system显示文摘 | Freier T Montenegro R Shan Koh H | 2005 | Biomaterials2005，26，22： | 1 |
| 11 | Effect of dietary phytate on growth andselenium status of chicks fed selenite or selenomethionine 显示文摘 | Shan Davis A S R H | 1994 | British Poultry Science1994，35，： | 1 |
| 12 | Specific deletion of TRAF3 in B lymphocytes leads to B - lymphoma development in mice 显示文摘 | Moore C R Liu Y Shan C | 2012 | Leuke- mia2012，26，5： | 1 |
| 13 | Residual Performance of FRP-Retrofitted RC Columns After Being Subjected to Cyclic Loading Damage显示文摘 | Shan B Xiao Y Guo Y R | 2006 | Journal of Composite for Construction ASCE2006，，10： | 1 |
| 14 | Manifold–manifold distance and its application to face recognition with image sets显示文摘 | Wang R Shan S Chen X | 2012 | Image Processing IEEE Transactions on2012，21，10： | 1 |
| 15 | Oxidative desulfurization of thiophene catalyzed by (C4H9 )4NBr·2C6HII NO coordinated ionic liquid显示文摘 | ZHAO D S SUN Z M LI FT LIU R SHAN H D | 2008 | Energy Fuels2008，22，5： | 1 |
| 16 | Self-oriented regular arrays of carbon nanotubes and their field emission properties 显示文摘 | Michael G Chapline Nathan R Franhlin | 1999 | Science1999，283，22： | 1 |
| 17 | Dehydroepiandrost erone inhibits human vascular smooth muscle cell proliferation independent of ARs and ERs 显示文摘 | MARO R I WILLIAMS SHAN Hong-ling | 2002 | J Clin Endocrinol Metab2002，87，1： | 1 |
| 18 | Blood banking in China 显示文摘 | Shan H Wang J X Ren F R | 2002 | Lancet2002，360，9347： | 1 |
| 19 | Production environmental impact and mechanical properties of glubam 显示文摘 | Xiao Y Yang R Z Shan B | 2013 | Journal of Construction and Building Materials2013，44，11： | 1 |
| 20 | Detection of rinderpest virus using N-protein monoclonal antibodies 显示文摘 | Shan R A Joseph M C Butchaiah G | 2004 | Tropical Animal Health and Production2004，36，1： | 1 |
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