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| 1 | Increased prevalence of symptoms of gastroesophageal reflux diseases in type 2 diabetics with neuropathy显示文摘AIM:To analyze the prevalence of gastroesophageal reflux disease (GERD) related symptoms in patients with diabetes mellitus (DM) and to find out the relationship between diabetic neuropathy and the prevalence of GERD symptoms. METHODS:In this prospective questionnaire study, 150 consecutive type 2 diabetic patients attending the endocrine clinic were enrolled. A junior physician helped the patients to understand the questions. Patients were asked about the presence of five most frequent symptoms of GERD that included heartburn (at least 1/wk), regurgitation, chest pain, hoarseness of voice and chronic cough. Patients with past medical history of angina, COPD, asthma, cough due to ACEI or preexisting GERD prior to onset of diabetes and apparent psychiatric disorders were excluded from the survey. We further divided the patients into two groups based on presence or absence of peripheral neuropathy. Out of 150 patients, 46 had neuropathy, whereas 104 patients did not have neuropathy. Data are expressed as mean ± SD, and number of patients in each category and percentage of total patients in that group. Normal distributions between groups were compared with Student t test and the prevalence rates between groups were compared with Chi-square tests for significance. RESULTS:The average duration of diabetes were 12 ± 9.2 years and the average HbA1c level of this group was 7.7% ± 2.0%. The mean weight and BMI were 198 ± 54 lbs. and 32 ± 7.2 kg/m2. Forty percent (61/150) patients reported having at least one of the symptoms of GERD and thirty percent (45/150) reported having heartburn at least once a week. The prevalence of GERD symptoms is higher in patients with neuropathy than patients without neuropathy (58.7% vs 32.7%, P < 0.01). The prevalence of heartburn, chest pain and chronic cough are also higher in patients with neuropathy than in patients without neuropathy (43.5% vs 24%;10.9% vs 4.8% and 17.8% vs 6.7% respectively, P < 0.05).CONCLUSION:The prevalence of GERD symptoms in type 2 DM is higher than in the general population. Our data suggest that DM neuropathy may be an important associated factor for developing GERD symptoms. | Xiangbing Wang CS Pitchumoni Khushbu Chandrarana Neha Shah | 2008 | World Journal of Gastroenterology2008，14，5： | 13 |
| 2 | Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer显示文摘 | Diefenbach CS Shah Z Iasonos A | 2007 | Gynecol Oncol2007，104，2： | 1 |
| 3 | Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer 显示文摘 | Difenbach CS Shah Z Iasonos A | 2007 | Gynecol Oncol2007，104，： | 1 |
| 4 | Ectopic thyroid cancer显示文摘 | Shah BC Ravichand CS Juluri S | 2007 | Ann Thorac Cardiovasc Surg2007，13，2： | 1 |
| 5 | In vitro assess- ment of photocatalytic titanium oxide surface modified stainless steel orthodontic brackets for antiadherent and antibacterial properties against Lactobacillus acidophilus显示文摘 | Shah AG Shetty PC Ramachandra CS | 2011 | Angle Orthod2011，81，6： | 1 |
| 6 | Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer 显示文摘 | Diefenbach CS Shah Z Iasonos A | 2007 | Gynecol Oncol2007，104，2： | 1 |
| 7 | Punctate inner choroidopathy:a survey analysis of 77 persons显示文摘 | Gerstenblith AT Thorne JE Sobrin L Do DV Shah SM Foster CS | 2007 | Ophthalmology2007，114，6： | 1 |
| 8 | Lymphadenectomy and ovarian preservation in low-grade endometrial stromal sarcoma 显示文摘 | Shah JP Bryant CS Kumar S | 2008 | Obstet Gynecol2008，112，5： | 1 |
| 9 | Essential oil composition of some Himalayan Artemisia species 显示文摘 | Mathela CS Kharkwal H Shah GC | 1994 | J Essent Oil Res1994，6，4： | 1 |
| 10 | A multicenter pooled,patient-level data analysis of diffusionweighted MRI in TIA patients显示文摘 | Shah SH Saver JL Kidwell CS | 2007 | Stroke2007，38，： | 1 |
| 11 | Preoperative serum ykl-40 is a marker for detection and prognosis of endometrial cancer显示文摘 | Diefenbach CS Shah Z Iasonos A | 2007 | Gynecol 0ncol2007，104，2： | 1 |
| 12 | Splenic tuberculosis and HIV-1 infection显示文摘 | Pramesh CS Tamhankar AP Rege SA Shah SR | 2002 | Lancet2002，359，9303： | 1 |
| 13 | Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer 显示文摘 | Diefenbach CS Shah Z Iasonos A | 2007 | Gynecol Oncol2007，104，2： | 1 |
| 14 | The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary显示文摘 | Kuman S Shah JP Bryant CS | 2008 | Gynecol Oncol2008，110，12： | 1 |
| 15 | Lymphadenectomy and ovarian preservation in low grade endometrial stromal sarcoma 显示文摘 | Shah JP Bryant CS Kumar S | 2008 | Obstet Gynecot2008，112，5： | 1 |
| 16 | Assessment of denitrif- ying bacterial composition in activated sludge显示文摘 | Srinandan CS Shah M Patel B | 2011 | Bioresour Technol2011，102，20： | 1 |
| 17 | Ectopic thyroid cancer 显示文摘 | Shah BC Ravichand CS Juluri S | 2007 | Ann Thorac Cardiovasc Surg2007，13，2： | 1 |
| 18 | A multicenter pooledpatient-level data analysis of diffusion-weighted MRI in TIA patient显示文摘 | Shah SH Saver JL Kidwell CS | 2007 | Stroke2007，38，： | 1 |
| 19 | Neuroprotection with an erythropoietin mimetic peptide (pHBSP) in a model of mild traumatic brain injury complicated by hemorrhagic shock显示文摘 | Robertson CS Cherian L Shah M | | 0，，： | 1 |
| 20 | Ectopic thyroid cancer 显示文摘 | Shah BC Ravichand CS Juluri S | 2007 | Ann Thorac Cardiovasc Surg2007，13，2： | 1 |
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