|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ileocecal valve dysfunction in small intestinal bacterial overgrowth: A pilot study显示文摘AIM: To explore whether patients with a defective ileocecal valve (ICV)/cecal distension reflex have small intestinal bacterial overgrowth. METHODS: Using a colonoscope, under conscious sedation, the ICV was intubated and the colonoscope was placed within the terminal ileum (TI). A manometry catheter with 4 pressure channels, spaced 1 cm apart, was passed through the biopsy channel of the colonoscope into the TI. The colonoscope was slowly withdrawn from the TI while the manometry catheter was advanced. The catheter was placed across the ICV so that at least one pressure port was within the TI, ICV and the cecum respectively. Pressures were continuously measured during air insufflation into the cecum, under direct endoscopic visualization, in 19 volunteers. Air was insufflated to a maximum of 40 mmHg to prevent barotrauma. All subjects underwent lactulose breath testing one month after the colonoscopy. The results of the breath tests were compared with the results of the pressures within the ICV during air insufflation. RESULTS: Nineteen subjects underwent colonoscopy with measurements of the ICV pressures after intubation of the ICV with a colonoscope. Initial baseline readings showed no statistical difference in the pressures of the TI and ICV, between subjects with positive lactulose breath tests and normal lactulose breath tests. The average peak ICV pressure during air insufflation into the cecum in subjects with normal lactu-lose breath tests was significantly higher than cecal pressures during air insufflation (49.33 ± 7.99 mmHg vs 16.40 ± 2.14 mmHg, P = 0.0011). The average percentage difference of the area under the pressure curve of the ICV from the cecum during air insufflations in subjects with normal lactulose breath tests was significantly higher (280.72% ± 43.29% vs 100% ± 0%, P = 0.0006). The average peak ICV pressure during air insufflation into the cecum in subjects with positive lactulose breath tests was not significantly different than cecal pressures during air insufflation 21.23 ± 3.52 mmHg vs 16.10 ± 3.39 mmHg. The average percentage difference of the area under the pressure curve of the ICV from the cecum during air insufflation was not significantly different 101.08% ± 7.96% vs 100% ± 0%. The total symptom score for subjects with normal lactulose breath tests and subjects with positive lactu-lose breath tests was not statistically different (13.30 ± 4.09 vs 24.14 ± 6.58). The ICV peak pressures during air insufflations were significantly higher in subjects with normal lactulose breath tests than in subjects with positive lactulose breath tests (P = 0.005). The average percent difference of the area under the pressure curve in the ICV from cecum was significantly higher in subjects with normal lactulose breath tests than in subjects with positive lactulose breath tests (P = 0.0012). Individuals with positive lactulose breath tests demonstrated symptom scores which were significantly higher for the following symptoms: not able to finish normal sized meal, feeling excessively full after meals, loss of appetite and bloating. CONCLUSION: Compared to normal, subjects with a positive lactulose breath test have a defective ICV cecal distension reflex. These subjects also more commonly have higher symptom scores. | Larry S Miller Anil K Vegesna Aiswerya Madanam Sampath Shital Prabhu Sesha Krishna Kotapati Kian Makipour | 2012 | World Journal of Gastroenterology2012，18，46： | 3 |
| 2 | First indium trichloride catalyzed self-addition of indoles: One pot synthesis of indolylindolines显示文摘 | Bikash Pal Venkatachalam Sesha Giri Parasuraman Jaisankar | 2005 | Catalysis Communications2005，，11： | 1 |
| 3 | Hydrogen storage behavior of ZrNi 70/30 and ZrNi 30/70 composites显示文摘 | Diego Escobar Sesha Srinivasan Yogi Goswami | 2008 | J Alloys Compo2008，458，12： | 1 |
| 4 | Textural Analysis of IRS-ID Panchromatic Data for Land Cover Classification 显示文摘 | Narasimha R P V Sesha S M V R Sreenivas K | 2002 | International Journal of Remote Sensing2002，23，17： | 1 |
| 5 | Thermal behaviour of poly(acyloyloxybenzoic acid)/nylon 6 blends显示文摘 | Sesha Sainath A V Inooue T Yonetake L | 2001 | Polymer2001，43，： | 1 |
| 6 | Textural Analysis of IRS - 1 D Panchromatic Data for Land Cover Classification 显示文摘 | Narasimha R P V Sesha S M V R Sreenivas K | 2002 | International Journal of Remote Sensing2002，23，17： | 1 |
| 7 | Interpretable deep learning for guided microstructure-property explorations in photovoltaics显示文摘The microstructure determines the photovoltaic performance of a thin film organic semiconductor film.The relationship between microstructure and performance is usually highly non-linear and expensive to evaluate,thus making microstructure optimization challenging.Here,we show a data-driven approach for mapping the microstructure to photovoltaic performance using deep convolutional neural networks.We characterize this approach in terms of two critical metrics,its generalizability(has it learnt a reasonable map?),and its intepretability(can it produce meaningful microstructure characteristics that influence its prediction?).A surrogate model that exhibits these two features of generalizability and intepretability is particularly useful for subsequent design exploration.We illustrate this by using the surrogate model for both manual exploration(that verifies known domain insight)as well as automated microstructure optimization.We envision such approaches to be widely applicable to a wide variety of microstructure-sensitive design problems. | Balaji Sesha Sarath Pokuri Sambuddha Ghosal Apurva Kokate Soumik Sarkar Baskar Ganapathysubramanian | 2019 | npj Computational Materials2019，，1： | 1 |
| 8 | 显示文摘 | Sesha S Srinivasan Hendrik W Brinks Bjorn C Hauback | 2004 | J Alloys Compd2004，377，： | 1 |
| 9 | Spatiotemporal analysis of meteorological drought variability in the Indian region using standardized precipitation index显示文摘 | Naresh Kumar M Murthy C S Sesha Sai M V R | 2012 | Meteorological Applications2012，19，2： | 1 |
| 10 | Textural Analysis of IRS-1D Panchromatic Data for Land Cover Classiflcation 显示文摘 | NARASIMHA R P V SESHA S M V R | 2002 | International Journal of Remote Sensing2002，23，17： | 1 |
| 11 | Macrophage-targeted single walled carbon nanotubes stimulate phagocytosis via pH-dependent drug release显示文摘Atherosclerotic cardiovascular disease is the leading cause of mortality in the world.A driving feature of atherosclerotic plaque formation is dysfunctional efferocytosis.Because the“don’t eat me”molecule CD47 is upregulated in atherosclerotic plaque cores,CD47-blocking strategies can stimulate the efferocytic clearance of apoptotic cells and thereby help prevent the progression of plaque buildup.However,these therapies are generally costly and,in clinical and murine trials,they have resulted in side effects including anemia and reticulocytosis.Here,we developed and characterized an intracellular phagocytosis-stimulating treatment in the CD47-SIRPαpathway.We loaded a novel monocyte/macrophage-selective nanoparticle carrier system with a small molecule enzymatic inhibitor that is released in a pH-dependent manner to stimulate macrophage efferocytosis of apoptotic cell debris via the CD47-SIRPαsignaling pathway.We demonstrated that single-walled carbon nanotubes(SWNTs)can selectively deliver tyrosine phosphatase inhibitor 1(TPI)intracellularly to macrophages,which potently stimulates efferocytosis,and chemically characterized the nanocarrier.Thus,SWNT-delivered TPI can stimulate macrophage efferocytosis,with the potential to reduce or prevent atherosclerotic disease. | Yapei Zhang Jianqin Ye Niloufar Hosseini-Nassab Alyssa Flores Irina Kalashnikova Sesha Lakshmi Paluri Mozhgan Lotfi Nicholas J.Leeper Bryan Ronain Smith | 2021 | Nano Research2021，14，3： | 1 |
| 12 | Textural analysis of IRS-1D panchromatic data for land cover classification 显示文摘 | Narasimha Rao P V Sesha Ssi M V R Sreenivas K | 2002 | International Journal of Remote Sensing2002，23，17： | 1 |
| 13 | The estimation ofsurface temperature over an agricultural area in the state ofHaryana and Panjab,India, and its relationship with the NormalizedDifference Vegetation Index (NDVI), using NOAA-AVHRR data显示文摘 | Gupta R K Prasad S Sesha Sai M V R | 1997 | International Journal of Remote Sensing1997，18，： | 1 |
| 14 | Saber-C An interpreter-based programming environment for the C Language 显示文摘 | Russell Lopez Sesha Pratap | | Summer Usenix0，88，： | 1 |
| 15 | Nano-Ni Doped Li-Mn- B-H System as a New Hydrogen Storage Candidate 显示文摘 | Pabitra C Sesha S Venkat R B | 2009 | Int J Hydrogen Energy2009，34，15： | 1 |
| 16 | Long Term Cycling Behavior of Titanium Doped NaAlH4 Prepared through Solvent Mediated Milling of NaH and Al with Titanium Dopant Precursors显示文摘 | SESHA S SRINIVASAN HENDRIK W Brinks Bjorn C Hauback | 2004 | Alloys Compd2004，377，12： | 1 |
| 17 | Surface soil moisture changes during 2007 summer monsoon season derived from AMSR-E Land 3 product显示文摘 | Chandrasekar K Sesha Sai M V R Dwivedi R S | 2008 | Current Science2008，95，12： | 1 |
| 18 | Programmable Function Generators- Ⅰ:Base Five-Bar Mechanism 显示文摘 | Bhartendu Seth Sesha Sai Vaddi | 2003 | Mechanism and Machine Theory2003，，38： | 1 |
| 19 | Pmgrmm-nable Function Generators- Ⅱ :Seven-bar Translatory-output Mechantsm显示文摘 | Sesha Sai Vaddi Bhartendu Seth | 2003 | Mechanism and Machine Theory2003，，38： | 1 |
| 20 | 显示文摘 | Sun Dalin Srinivasan Sesha S | 2004 | J Alloys Comp2004，373，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员