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| 1 | A double-blind,randomized,placebo-and positive-controlled phase III trial of 1% benvitimod cream in mild-to-moderate plaque psoriasis显示文摘Background:Benvitimod cream,a novel synthetic small molecule,was effective in treating mild-to-moderate plaque psoriasis.We conducted a phase III clinical trial to assess the efficacy and safety of benvitimod cream in patients with mild-to-moderate plaque psoriasis.Methods:We randomly assigned 686 patients(2:1:1)to receive 1%benvitimod cream,0.005%calcipotriol ointment or placebo twice a day for 12 weeks.The primary efficacy end points were the percentage of patients with a 75%or greater reduction from baseline in the psoriasis area and severity index(PASI 75)score and with a score of 0 or 1 in static physician’s global assessment(sPGA)at week 12.Results:The results showed that 50.4%of patients in the benvitimod group achieved PASI 75,which was significantly higher than that in the calcipotriol(38.5%,P<0.05)and placebo(13.9%,P<0.05)groups.The proportion of patients achieving an sPGA score 0 or 1 was 66.3%in the benvitimod group and 63.9%in the calcipotriol group,which were both significantly higher than that in the placebo group(34%,P<0.05).In the long-term follow-up study,50.8%of patients experienced recurrence.After retreatment with 1%benvitimod,73.3%of patients achieved an sPGA score of 0 or 1 again at week 52.Adverse events included application site irritation,follicular papules,and contact dermatitis.No systemic adverse reactions were reported.Conclusion:During this 12-week study,benvitimod cream was demonstrated with high effectiveness and safety in patients with mild-to-moderate plaque psoriasis. | Lin Cai Gen-Hui Chen Qian-Jin Lu Min Zheng Yu-Zhen Li Jin Chen Jie Zheng Fu-Ren Zhang Jian-Bin Yu Sen Yang Fu-Qiu Li Sheng-Xiang Xiao Qiu-Ning Sun Jin-Hua Xu Xing-Hua Gao Hong Fang Tian-Wen Gao Fei Hao Quan-Zhong Liu Ya-Ting Tu Ruo-Yu Li Bao-Xi Wang Dan-Qi Deng Qing-Shan Zheng Hong-Xia Liu Jian-Zhong Zhang | 2020 | Chinese Medical Journal2020，，24： | 11 |
| 2 | Increased Chondrocyte Apoptosis in Kashin-Beck Disease and Rats Induced by T-2 Toxin and Selenium Deficiency显示文摘Objective To investigate chondrocyte apoptosis and the expression of biochemical markers associated with apoptosis in Kashin-Beck disease(KBD) and in an established T-2 toxin-and selenium(Se) deficiency-induced rat model. Methods Cartilages were collected from the hand phalanges of five patients with KBD and five healthy children. Sprague-Dawley rats were administered a selenium-deficient diet for 4 weeks prior to T-2 toxin exposure. The apoptotic chondrocytes were observed by terminal deoxynucleotidyl transferase d UTP nick end labeling staining. Caspase-3, p53, Bcl-2, and Bax proteins in the cartilages were visualized by immunohistochemistry, their protein levels were determined by Western blotting, and m RNA levels were determined by real-time reverse transcription polymerase chain reaction. Results Increased chondrocyte apoptosis was observed in the cartilages of children with KBD. Increased apoptotic and caspase-3-stained cells were observed in the cartilages of rats fed with normal and Se-deficient diets plus T-2 toxin exposure compared to those in rats fed with normal and Se-deficient diets. Caspase-3, p53, and Bax proteins and m RNA levels were higher, whereas Bcl-2 levels were lower in rats fed with normal or Se-deficiency diets supplemented with T-2 toxin than the corresponding levels in rats fed with normal diet. Conclusion T-2 toxin under a selenium-deficient nutritional status induces chondrocyte death, which emphasizes the role of chondrocyte apoptosis in cartilage damage and progression of KBD. | YANG Hao Jie ZHANG Ying WANG Zhi Lun XUE Sen Hai LI Si Yuan ZHOU Xiao Rong ZHANG Meng FANG Qian WANG Wen Jun CHEN Chen DENG Xiang Hua CHEN Jing Hong | 2017 | Biomedical and Environmental Sciences2017，30，5： | 7 |
| 3 | Impulse feature extraction method for machinery fault detection using fusion sparse coding and online dictionary learning显示文摘Impulse components in vibration signals are important fault features of complex machines. Sparse coding(SC) algorithm has been introduced as an impulse feature extraction method, but it could not guarantee a satisfactory performance in processing vibration signals with heavy background noises. In this paper, a method based on fusion sparse coding(FSC) and online dictionary learning is proposed to extract impulses efficiently. Firstly, fusion scheme of different sparse coding algorithms is presented to ensure higher reconstruction accuracy. Then, an improved online dictionary learning method using FSC scheme is established to obtain redundant dictionary and it can capture specific features of training samples and reconstruct the sparse approximation of vibration signals. Simulation shows that this method has a good performance in solving sparse coefficients and training redundant dictionary compared with other methods. Lastly, the proposed method is further applied to processing aircraft engine rotor vibration signals. Compared with other feature extraction approaches, our method can extract impulse features accurately and efficiently from heavy noisy vibration signal, which has significant supports for machinery fault detection and diagnosis. | Deng Sen Jing Bo Sheng Sheng Huang Yifeng Zhou Hongliang | 2015 | Chinese Journal of Aeronautics2015，28，2： | 6 |
| 4 | A field-effect approach to directly profiling the localized states in monolayer MoS2显示文摘A fundamental understanding of the charge transport mechanism in two-dimensional semiconductors(e.g., MoS2) is crucial for fully exploring their potential in electronic and optoelectronic devices. By using monolayer graphene as the barrier-free contact to MoS2, we show that the field-modulated conductivity can be used to probe the electronic structure of the localized states. A series of regularly distributed plateaus were observed in the gate-dependent transfer curves. Calculations based on the variable-range hopping theory indicate that such plateaus can be attributed to the discrete localized states near mobility edge. This method provides an effective approach to directly profiling the localized states in conduction channel with an ultrahigh resolution up to 1 meV. | Hao Wu Yuan Liu Zeyu Deng Hung-Chieh Cheng Dehui Li Jian Guo Qiyuan He Sen Yang Mengning Ding Yun-Chiao Huang Chen Wang Yu Huang Xiangfeng Duan | 2019 | Science Bulletin2019，64，15： | 2 |
| 5 | The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation显示文摘The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic spectra.In general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific research.With the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly achievable.In this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE. | Nan‑Shun Huang Zi‑Peng Liu Bang‑Jie Deng Zi‑Han Zhu Shao‑Hua Li Tao Liu Zheng Qi Jia‑Wei Yan Wei Zhang Sheng‑Wang Xiang Yang‑Yang Lei Ya Zhu Yong‑Zhou He Qi‑Bing Yuan Fei Gao Rong‑Bing Deng Sen Sun Zhi‑Di Lei Zhi‑Qiang Jiang Meng‑Qi Duan Yuan Zhuan Xue‑Fang Huang Peng‑Cheng Dong Zhong‑Liang Li Shang‑Yu Si Lian Xue Si Chen Yong‑Fang Liu Ya‑Jun Tong Hai‑Xiao Deng Zhen‑Tang Zhao | 2023 | Nuclear Science and Techniques2023，34，1： | 2 |
| 6 | Influence of channel/back-barrier thickness on the breakdown of AlGaN/GaN MIS-HEMTs显示文摘The leakage current and breakdown voltage of Al Ga N/Ga N/Al Ga N high electron mobility transistors on silicon with different Ga N channel thicknesses were investigated.The results showed that a thin Ga N channel was beneficial for obtaining a high breakdown voltage,based on the leakage current path and the acceptor traps in the Al Ga N back-barrier.The breakdown voltage of the device with an 800 nm-thick Ga N channel was 926 V@1 m A/mm,and the leakage current increased slowly between 300 and 800 V.Besides,the raising conduction band edge of the Ga N channel by the Al Ga N back-barrier lead to little degradation for sheet 2-D electron gas density,especially,in the thin Ga N channel.The transfer and output characteristics were not obviously deteriorated for the samples with different Ga N channel thickness.Through optimizing the Ga N channel thickness and designing the Al GaN back-barrier,the lower leakage current and higher breakdown voltage would be possible. | Jie Zhao Yanhui Xing Kai Fu Peipei Zhang Liang Song Fu Chen Taotao Yang Xuguang Deng Sen Zhang Baoshun Zhang | 2018 | Journal of Semiconductors2018，39，9： | 2 |
| 7 | Synthesis and Catalytic Performance of a New V-doped CeO_(2)-supported Alkali-activated-steel-slag-based Photocatalyst显示文摘A novel V-doped CeO_(2)-supported alkali-activated-steel-slag-based catalyst(V-CeO_(2)/AC)for photocatalytic decomposition of water to hydrogen was prepared via co-impregnation method.The chemical composition,mineral phase,morphology,and optical performances of the synthesized catalyst samples were characterized by XRF,XRD,SEM,UV-Vis DRS,and so on.XRD and SEM results show that calcium silicate hydrate(Ca1.5SiO3.5·xH2O)mineral phase is formed in the carrier sample,and the prepared catalyst specimens are made up of approximately 50 nm particles.After 6 hours of xenon lamp irradiation,the catalyst supported on V-doped 8wt%CeO_(2) exhibits the highest photocatalytic hydrogen production activity(8292μmol/g),which is attributed to the interaction between the V-doped CeO_(2) active components and FeO existed in catalyst carrier.A possible photocatalytic decomposition of water for hydrogen production mechanism over the V-8CeO_(2)/AC catalyst was proposed. | 康乐 DU Huiling DENG Jun JING Xinrui ZHANG Sen ZNANG Yaojun | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，2： | 2 |
| 8 | New Algorithm Rules Out Acute-on-chronic Liver Failure Development within 28 Days from Acute Decompensation of Cirrhosis显示文摘Background and Aims:Approximately 10%of patients with acute decompensated(AD)cirrhosis develop acute-on-chronic liver failure(ACLF)within 28 days.Such cases have high mortality and are difficult to predict.Therefore,we aimed to establish and validate an algorithm to identify these patients on hospitalization.Methods:Hospitalized patients with AD who developed ACLF within 28 days were considered pre-ACLF.Organ dysfunction was defined accord-ing to the chronic liver failure-sequential organ failure as-sessment(CLIF-SOFA)criteria,and proven bacterial infec-tion was taken to indicate immune system dysfunction.A retrospective multicenter cohort and prospective one were used to derive and to validate the potential algorithm,re-spectively.A miss rate of<5%was acceptable for the calcu-lating algorithm to rule out pre-ACLF.Results:In the deri-vation cohort(n=673),46 patients developed ACLF within 28 days.Serum total bilirubin,creatinine,international normalized ratio,and present proven bacterial infection at admission were associated with the development of ACLF.AD patients with≥2 organ dysfunctions had a higher risk for pre-ACLF patients[odds ratio=16.58195%confidence interval:(4.271-64.363),p<0.001].In the derivation co-hort,67.5%of patients(454/673)had≤1 organ dysfunction and two patients(0.4%)were pre-ACLF,with a miss rate of 4.3%(missed/total,2/46).In the validation cohort,65.9%of patients(914/1388)had≤1 organ dysfunction,and four(0.3%)of them were pre-ACLF,with a miss rate of 3.4%(missed/total,4/117).Conclusions:AD patients with≤1 organ dysfunction had a significantly lower risk of developing ACLF within 28 days of admission and could be safely ruled out with a pre-ACLF miss rate of<5%. | Xiaoting Tang Hai Li Guohong Deng Xin Zheng Xianbo Wang Yan Huang Yanhang Gao Zhongji Meng Zhiping Qian Feng Liu Xiaobo Lu Yu Shi Beiling Li Wenyi Gu Xiaomei Xiang Yan Xiong Yixin Hou Jun Chen Na Gao Sen Luo Liujuan Ji Jing Li Rongjiong Zheng Haotang Ren Jinjun Chen | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
| 9 | Cu-Si Nano- cable Arrays as High-rate Anode Materials for Lithium-ion Batteries显示文摘 | Cao Fei-Fei Deng Jun-Wen Xin Sen | 2011 | Advanced Materials2011，23，38： | 1 |
| 10 | Effect of surface modifica- tion on the electrochemical performances of LaNi5 hydrogen stor- age alloy in Ni/MH batteries 显示文摘 | Deng Chao Shi Pengfei Zhang Sen | 2006 | Materials Chemistry and Phys- ics2006，98，23： | 1 |
| 11 | A sensitive and specific liquid chromatography mass spectrometry method for simultaneous determination of berberine, palmatine, coptisine, epiberberine and jatrorrhizine from Coptidis Rhizoma in rat plasma显示文摘 | Sen Y Pang X Y Deng Y X | 2007 | Inter J Mass Spect2007，268，1： | 1 |
| 12 | A novel piezoelectric immunosensor for detection of carcinoembryonic antigen 显示文摘 | Sen G Y Wang H Deng T | 2005 | Talanta2005，67，15： | 1 |
| 13 | SIMULATION RESEARCH OF ACTIVE VIBRATION CONTROL FOR ELASTIC MISSILE WITH SWING NOZZLE THRUST VECTOR CONTROL显示文摘Aiming at the deficiencies of notch filters on the aspect of vibration suppression for elastic missile with swing nozzle thrust vector control(SNTVC),an active vibration controller(AVC)is proposed.It is composed of an optimal state feedback controller(OSFC)and an optimal minimal order state observer(OMOSO),which can be respectively designed based on the separation principle.The design rules of these two elements are successively given.Computer simulation results present that AVC can realize strong vibration suppression and good convergence property after disturbing.Moreover,it has simple design and then it is easily implemented in engineering.In addition,the AVC scheme can also resolve the poor system stability to a great extent,which is resulted from the bad static stability of missile body. | XIAODONG LIU YUNJIE WU YONG DENG SEN WANG JIAYUN SONG | 2013 | International Journal of Modeling, Simulation, and Scientific Computing2013，4，4： | 1 |
| 14 | Transient analysis of alkaline anion exchange membrane fuel cell anode显示文摘 | Hao Deng Sen Huo Yafei Chang Yibo Zhou Kui Jiao | 2013 | International Journal of Hydrogen Energy2013，，15： | 1 |
| 15 | Water management in alkaline anion exchange membrane fuel cell anode显示文摘 | Sen Huo Hao Deng Yafei Chang Kui Jiao | 2012 | International Journal of Hydrogen Energy2012，，23： | 1 |
| 16 | A sensitive and specific liquid chromato graphy mass spectrometry method for simultaneous determination of berberine,palmatine,coptisine,epiberberine and jatrorrhizine from Coptidis Rhizoma in rat plasma显示文摘 | Yu Sen Pang Xiaoyan Deng Yuanxiong | 2007 | Mass Spectrom2007，268，： | 1 |
| 17 | UNCERTAINTY AND SENSITIVITY ANALYSES OF SEDIMENT TRANSPORT FORMULAS显示文摘UNCERTAINTYANDSENSITIVITYANALYSESOFSEDIMENTTRANSPORTFORMULASKehChiaYEH1andSenLongDENG2ABSTRACTInviewoftherandomcharacterist... | Keh Chia YEH 1 and Sen Long DENG 2 | 1998 | International Journal of Sediment Research1998，13，1： | 1 |
| 18 | 显示文摘 | Chao Deng Shi Pengfei Zhang Sen | 2006 | J Materials Chemistry and Physics2006，98，： | 1 |
| 19 | PA-E18G substitution in influenza A virus confers resistance to ZX-7101,a cap-dependent endonuclease inhibitor显示文摘Cap-dependent endonuclease(CEN)in the polymerase acidic protein(PA)of influenza A virus(IAV)represents a promising drug target due to its critical role in viral gene transcription.The CEN inhibitor,baloxavir marboxil(BXM),was approved in Japan and the US in 2018 and several other countries subsequently.Along with the clinical use of BXM,the emergence and spread of IAV variants with reduced susceptibility to BXM have aroused serious concern.Herein,we comprehensively characterized the in vitro and in vivo antiviral activities of ZX-7101A,an analogue of BXM.The active form of prodrug ZX-7101 showed broad-spectrum antiviral potency against various IAV subtypes,including pH1N1,H3N2,H7N9 and H9N2,in MDCK cells,and the 50%effective concentration(EC_(50))was calculated to nanomole level and comparable to that of baloxavir acid(BXA),the active form of BXM.Furthermore,in vivo assays showed that administration of ZX-7101A conferred significant protection against lethal pH1N1 challenge in mice,with reduced viral RNA loads and alleviated pulmonary damage.Importantly,serial passaging of H1N1 virus in MDCK cells under selection pressure of ZX-7101 led to a resistant variant at the 15th passage.Reverse genetic and sequencing analysis demonstrated that a single E18G substitution in the PA subunit contributed to the reduced susceptibility to both ZX-7101 and BXA.Taken together,our results not only characterized a new CEN inhibitor of IAV but also identified a novel amino acid substitution responsible for CEN inhibitor resistance,which provides critical clues for future drug development and drug resistance surveillance. | Dan Luo Qing Ye Rui-Ting Li Hang-Yu Zhou Jing-Jing Guo Suo-Qun Zhao Sen Zhang Tao Jiang Yong-Qiang Deng Cheng-Feng Qin | 2023 | Virologica Sinica2023，38，4： | 1 |
| 20 | Effect of surface modification on the electrochemical performances of LaNi5 hydrogen storage alloy in Ni/MH batteries 显示文摘 | Deng Chao Shi Pengfei Zhang Sen | 2006 | Materials Chemistry and Physics2006，98，23： | 1 |
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