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| 1 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 2 | Unique chromatin remodeling and transcriptional regulation in spermatogenesis 显示文摘 | SASSONE - CORSI P | 2002 | Science2002，296，5576： | 1 |
| 3 | Genetic control of spermiogenesis : insights from the CREM gene and implications for human infertility 显示文摘 | KRAUSZ C SASSONE - CORSI P | 2005 | Rep rod Biomed Online2005，10，1： | 1 |
| 4 | Regulation of gene expression in post - meiotic male germ cells: CREM - signalling pathways and male fertility 显示文摘 | HOGEVEEN K N SASSONE - CORSI P | 2006 | Hum Fertil ( Camb)2006，9，2： | 1 |
| 5 | Microtubule - independent and protein kinase A - mediated function of kinesin KIF17b controls the intracellular transport of activator of CREM in testis (ACT) 显示文摘 | KOTAJA N MACHO B SASSONE -CORSI P | 2005 | J Biol Chem2005，280，31： | 1 |
| 6 | Association of neighborhood char- acteristics with bystander-initiated CPR 显示文摘 | Sasson C Magid D J Chan P | 2012 | N Engl J Med2012，367，17： | 1 |
| 7 | CBP - independent activation of CREM and CREB by the LIM - only protein ACT 显示文摘 | FIMIA G M DE CESARE D SASSONE CORSI P | 1999 | Nature1999，398，6723： | 1 |
| 8 | A family of LIM- only transcriptional coactlvators: tissue - specific expression and selective activation of CREB and CREM 显示文摘 | FIMIA G M DE CESARE D SASSONE CORSI P | 2000 | Mol Cell Biol2000，20，22： | 1 |
| 9 | Infection of CD127+ (interleukin-7 receptor + ) CD4+ ceils and overexpression of CTLA-4 are linked to loss of antigen- specific CD4 T cells during primary human immunodeficiency virus type 1 infection 显示文摘 | Zaunders JJ Ip S Munier ML Kaufmann DE Suzuki K Brereton C Sasson SC Seddiki N Koelsch K Landay A Grey P Finlayson R Kaldor J Rosenberg ES Walker BD Fazekas de St Groth B Cooper DA Kelleher AD | 2006 | J Virol2006，80，10： | 1 |
| 10 | An ultrametastatic model of human coIon cancer in nude mice显示文摘 | Sun TX Sasson AR Jiang P | 1999 | Clin Exp Metastasis1999，17，1： | 1 |
| 11 | Differential regulation of glucose transport and transporters by glucose in vascular endothe- lial and smooth muscle cells显示文摘 | Kaiser N Sasson S Feener E P | 1993 | Diabetes1993，42，1： | 1 |
| 12 | Evaluation of ureaform activity in soil显示文摘 | Sasson P | 1979 | Soil Science1979，，128： | 1 |
| 13 | Metabolism and cancer : the circadian clock connection显示文摘 | Sahar S Sassone -Corsi P | 2009 | Nat Rev Cancer2009，9，12： | 1 |
| 14 | Competing business models, value creation and appropriation in English foot- ball 显示文摘 | McNamara P Peck S Sasson A | 2013 | Long Range Planning2013，46，6： | 1 |
| 15 | Association of neighborhood characteristics with bystander - initiated CPR 显示文摘 | Sasson C Magid DJ Chan P | 2012 | N Engl J Med2012，367，17： | 1 |
| 16 | Signal transduction and gene regulationthe nuclear response to cAMP 显示文摘 | Lalli E Sassone - Corsi P Rivero - Lezcano O | 1994 | J Biol Chem1994，269，26： | 1 |
| 17 | An ultra-metastatic model of human colon cancer in nude mice 显示文摘 | Sun FX Sasson AR Jiang P | 1999 | Clin Exp Metastasis1999，17，1： | 1 |
| 18 | Chromatin remoding and epigenetic features of germ cells显示文摘 | Kimmins S Sassone Corsi P | 2005 | Nature2005，434，7033： | 1 |
| 19 | Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells显示文摘 | SASSON S FEENER E P | 1993 | Diabetes1993，42，1： | 1 |
| 20 | CREM, amaster switch of the transcript ional cascade in male germcells 显示文摘 | De Cesaxe D Fimia GM Sassone Corsi P | 2000 | J En docrinol Invest2000，23，9： | 1 |
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