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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Single vs dual(en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience显示文摘AIM: To compare outcomes between single and dual en bloc(EB) kidney transplants(KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached tothe inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted. Post-transplant management strategies were standardized in all patients.RESULTS: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. Mean age of donors(17 mo vs 38 mo, P < 0.001), mean weight(11.0 kg vs 17.4 kg, P = 0.046) and male donors(50% vs 84%, P = 0.01) were lower in the dual EB compared to the single KT group, respectively. Mean cold ischemia time(21 h), kidney donor profile index(KDPI; 73% vs 62%) and levels of serum creatinine(SCr, 0.37 mg/d L vs 0.49 mg/d L, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence(12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay(mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection(6% vs 16%), operative complications(3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively(all P = NS). Mean 12 mo SCr and abbreviated MDRD levels were 1.17 mg/d L vs 1.35 mg/d L and 72.5 m L/min per 1.73 m^2 vs 60.5 m L/min per 1.73 m^2(both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can effectively expand the limited donor pool and achieve excellent medium-term outcomes. | Yousef Al-Shraideh Umar Farooq Hany El-Hennawy Alan C Farney Amudha Palanisamy Jeffrey Rogers Giuseppe Orlando Muhammad Khan Amber Reeves-Daniel William Doares Scott Kaczmorski Michael D Gautreaux Samy S Iskandar Gloria Hairston Elizabeth Brim Margaret Mangus Robert J Stratta | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 3 | Stability of aflatoxins B1 and ochrotoxin A in brewing显示文摘 | CHU F S CHANG C C SAMY H | 1975 | Applied Microbiology1975，19，3： | 1 |
| 4 | An improved model for predicting the dynamic behavior of adsorption systems显示文摘 | Sami S M Tribes C | 1996 | Applied Thermal Engineering1996，16，2： | 1 |
| 5 | Numerical prediction of capillary tube behavior with pure and binary alternation refrigerants显示文摘 | TRIBES C | 1998 | Applied Thermal Engineering1998，18，6： | 1 |
| 6 | The investment opportunity set, director ownership, and corporate policies: evidence from an emerging market 显示文摘 | Simon S M Ho Kevin C K Heibatollah Sami | 2004 | Journal of Corporate Finance2004，，10： | 1 |
| 7 | Immunamodulatory activily of shikimic acid and quereitin in comparison with oseltamivir (Tamiflu)in an in vitro model 显示文摘 | Bertelli AA Mannari C Sami S | 2008 | J Med Virol2008，80，4： | 1 |
| 8 | Adaptive control of a stewart platfor-based manipulator显示文摘 | Sami S Antrazi Zhou Zhen-lei | 1993 | J of Robotic Systems1993，10，5： | 1 |
| 9 | Numerical prediction of capillary tube behaviour and binary alternative refrigerants 显示文摘 | Sami S M Tribes C | 1998 | Applied Thermal Engineering1998，18，6： | 1 |
| 10 | Adaptive control of a Stewart platform-based manipulator显示文摘 | Charles C N Sami S A Zhen Leizhou | 1993 | Journal of Robotic Systems1993，10，5： | 1 |
| 11 | Imaging the cerebrovascu-lartree in the cadaver head for planning surgical st rategy显示文摘 | Zhao JC Chen C Sami S | | 0，，5： | 1 |
| 12 | The Investment Opportunity Set, Director Ownership, and Corporate Policies, Evidence from an Emerging Market 显示文摘 | Simon S M Ho Kevin C K Lam Heibatollah Sami | 2004 | Journal of Corporate Finance2004，，10： | 1 |
| 13 | Effect of feeding intensity and time on intramuscular fatty acid composition of Simmental bulls显示文摘 | Sami A S Augustini C Schwarz F J | 2004 | Journal of Animal Physiology and Animal Nutrition2004，88，56： | 1 |
| 14 | Stability of aflatoxins B1 and ochrotoxin A in brewing 显示文摘 | Chu F S Chang C C Samy H | 1975 | Applied Microbiology1975，19，3： | 1 |
| 15 | Decreased 5alpha-dihydrotestosterone catabolism suppresses T lymphocyte function in males after traumahemorrhage显示文摘 | ZHENG R SAMY T S SCHNEIDER C P | 2002 | Am J Physiol2002，282，： | 1 |
| 16 | The investment opportunity set, director ownership, and corporate policies: evidence from an emerging market 显示文摘 | Simon S M Ho Kevin C K Lam Heibatollah Sami | 2004 | Journal of Corporate Finance2004，，10： | 1 |
| 17 | Complex pulmonary as- pergillornatreated with single stage cavemostmny and myophsty 显示文摘 | Gebitekin C Sami BA Akin S | 2005 | Eur J ediothorac2005，27，5： | 1 |
| 18 | Complex pulmonary aspergilloma treated with single stage eavemostomy and myoplasty显示文摘 | Gebitekin C Sami BA Akin S | 2005 | EurJ Cardiothorac2005，27，5： | 1 |
| 19 | Numerical prediction of capillary tube behavior with pure and binary alternative refrigerants 显示文摘 | Sami S M Tribes C | 1998 | Applied Thermal Engineering1998，18，6： | 1 |
| 20 | The investment oppor- tunity set, director ownership, and corporate policies : evi- dence from an emerging market 显示文摘 | Ho S S M Lam K C K Sami H | 2004 | Journal of Corporate Finance2004，10，3： | 1 |
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