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| 1 | Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria显示文摘AIM: To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS: In vitro immunomodulation was assessed by measuring interleukin (IL)-12p70, IL-10, tumor necrosis factor alpha (TNFa) and interferon g (IFNg) release by human peripheral blood mononuclear cells (PBMCs) after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS: A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IL-12 cytokine ratio could not significantly attenuate colitis symptoms. CONCLUSION: These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested inmurine models for their anti-inflammatory potential. | Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin Denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot | 2007 | World Journal of Gastroenterology2007，13，2： | 22 |
| 2 | Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing. | Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann | 2022 | Bone Research2022，10，3： | 2 |
| 3 | Hydrothermal Alteration Mapping at Bode,California,Using AVRIS Hyper Spectral Data显示文摘 | Sabin E C Taranik J V | 1998 | Remote Sensing Environ1998，65，： | 1 |
| 4 | The associationsbetween age and the development of laboratory abnor-malities and treatment discontinuation for reasons otherthan virological failure in the first year of highly activeantiretroviral therapy 显示文摘 | Sabin CA Smith CJ Delpech V | 2009 | HIV Med2009，10，1： | 1 |
| 5 | Changes in respiration of fresh-cut butlerhead lettuce under controlled atmospheres using low and superatmospheric oxygen conditions with different carbon dioxide levels显示文摘 | ESCALONA V H BERT E V SABINE G | 2006 | Postharvest Biology and Technology2006，39，1： | 1 |
| 6 | Dynamics of rural landscapes and their main driving factors: A case study in the Seine Valley, Normandy, France 显示文摘 | Isabelle P Sabine V R | 1997 | Larutscape and Urban Planning1997，，： | 1 |
| 7 | Quality control oroots of eleutherococcus senticosus by HPLC 显示文摘 | Sandra A Tania N Sabine V M | 2005 | Phytochem Ana2005，16，1： | 1 |
| 8 | Influence of combined exercise training on indices of obesity,diabetes and cardiovascular risk in type 2 diabetes patients显示文摘 | Sabine L Christophe V Kristien V | | 0，，： | 1 |
| 9 | Analysis of real-time variables affecting children's exposure to diesel-related pollutants during school bus commutes in los angeles 显示文摘 | SABIN L D KOZAWA K BEHRENTZ E WINER A M FITZ D R PANKRATZ D V FRUIN S A | 2005 | Atmospheric Environment2005，39，29： | 1 |
| 10 | Long-term patterns of hepatitis C virus RNA concentrations in a cohort of HIV seronegarive men with bleeding disorders显示文摘 | Sabin CA Emery V Devereux HL | 2002 | J Med Virol2002，68，1： | 1 |
| 11 | Hydrothermalalteration mapping at Bodie, California, usingAVIRIS hyperspectral data 显示文摘 | Crosta A P Sabine C Tamnik J V | 1998 | Remote SensingEnvrionment1998，65，3： | 1 |
| 12 | Level choice in truncated total least squares显示文摘 | Diana M S Sabine V H | 2007 | Computational Statistics and Data Analysis2007，52，： | 1 |
| 13 | Changes in respiration of fresh-cut butter-head lettuce under controlled atmospheres using low and super-atmospheric oxygen conditions with different carbon dioxide levels 显示文摘 | Vctor H E Bert E V Sabine G | 2006 | Postharvest Biology and Technology2006，，1： | 1 |
| 14 | Level choice in truncated to- tal least squares显示文摘 | Diana M S Sabine V H | 2007 | Computational Statistics and Da- ta Analysis2007，，52： | 1 |
| 15 | Hydrothermal alteration mapping at Bodie,California, using AVIRIS hyper- spectral data显示文摘 | CROSTA A P SABINE C TARANIK J V | 1998 | Remote Sensing of Environment1998，65，3： | 1 |
| 16 | Virological and immunological effects of treatment interruptions in HIV infected patients with treatment failure显示文摘 | Miller V Sabin S Hertogs K | 2000 | AIDS2000，14，： | 1 |
| 17 | Long-term patterns of hepatitis C virus RNA concentrations in a cohort of HIV seronegative men with bleeding disorders显示文摘 | Sabin CA Emery V Devereux HL | 2002 | J Med Virol2002，68，1： | 1 |
| 18 | Long - term patterns of hepatitis C virus RNA concentrations in a cohort of HIV seronegative men with bleeding disorders显示文摘 | Sabin CA Emery V Devereux HL | 2002 | J Med Virol2002，68，： | 1 |
| 19 | Nonmyeloablative Stem Cell Therapy Enhances Microcirculation and Tissue Regeneration in Murine Inflammatory Bowel Disease显示文摘 | Philipe N. Khalil Véronique Weiler Peter J. Nelson Maurice N. Khalil Sabine Moosmann Wolf E. Mutschler Matthias Siebeck Ralf Huss | 2007 | Gastroenterology2007，，3： | 1 |
| 20 | Impact of admission blood glucose on outcomes of nondiabetic patients with acute ST-elevation myocardial infarction from the German Acute Coronary Syndromes Registry)显示文摘 | Naber C K Mehta R H Junger C Zeymer U Wienbergen H Sabin G V | 2009 | Am J Cardiol2009，103，： | 1 |
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