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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes显示文摘AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.METHODS: Associations between DEFA1/DEFA3 gene copy number polymorphism and diabetes as well as between the promoter polymorphisms of DEFB1 and diabetes were studied. The copy number variation of the DEFA1/DEFA3 genes was determined in 257 diabetic patients(117 patients with type 1 and 140 with type 2 diabetes). The control group consisted of 221 age- and gender-matched healthy blood donors. The cumulative copy numbers of the DEFA1/DEFA3 genes were detected by using quantitative PCR analysis. To evaluate the HNP 1-3(human neutrophil peptide 1-3 or α-defensin) levels in the circulation, plasma HNP 1-3 concentrations were measured by ELISA. The expression of DEFA1/A3 in peripheral leukocytes of the diabetic patients was measured by quantitative RT PCR analysis. Three SNPs of the human DEFB1(human defensin β-1) gene: DEFB1 G-20A(rs11362), DEFB1 C-44G(rs1800972) and DEFB1 G-52A(rs1799946) were genotyped by Custom TaqMan? Real Time PCR assay.RESULTS: Significant differences were observed in HNP1-3 levels between the healthy subjects and both groups of diabetic patients. The mean ± SE was 28.78 ± 4.2 ng/mL in type 1 diabetes, and 29.82 ± 5.36 ng/mL in type 2 diabetes, vs 11.94 ± 2.96 ng/mL in controls; P < 0.01 respectively. There was no significant difference between patients with type 1 and type 2 diabetes in the high plasma concentrations of HNP1-3. The highest concentrations of α-defensin were found in diabetic patients with nephropathy(49.4 ± 4.8 ng/mL), neuropathy(38.7 ± 4.8 ng/mL) or cardiovascular complications(45.6 ± 1.45 ng/L). There was no significant difference in the cumulative copy numbers of DEFA1/DEFA3 genes between controls and patients, or between patients with the two types of diabetes. Comparisons of HNP 1-3 plasma level and DEFA1/A3 copy number of the same patient did not reveal significant relationship between defensin-α levels and the gene copy numbers(r2 = 0.01). Similarly, no positive correlation was observed between the copy numbers and the mRNA expression levels of DEFA1/A3. Regarding the C-44G polymorphism of DEFB1, the GG 'protective' genotype was much less frequent(1%-2%) among both groups of patients than among controls(9%).CONCLUSION: Elevated HNP1-3 levels in diabetes are independent of DEFA1/DEFA3 copy numbers, but GG genotype of C-44G SNP in DEFB1 gene may result in decreased defensin β-1 production. | Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi | 2014 | World Journal of Gastroenterology2014，20，27： | 4 |
| 3 | Disturbed regulation of cholesterol synthesis in monocytes of obese patients with hypercholesterolemia显示文摘 | Balogh Z Szabolcs M | 2003 | Metabolism2003，52，： | 1 |
| 4 | Neovascularization of ischemic myocardium by human bone marrow derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function显示文摘 | Kocher A A Schuster M D Szabolcs M J Takuma S Burkhoff D Wang J | 2001 | Nat Med2001，7，： | 1 |
| 5 | Notch, Myc and breast cancer显示文摘 | Efstratiadis A Szabolcs M Klinakis A | 2007 | Cell Cycle2007，6，4： | 1 |
| 6 | Neovaseularization of ischemic myocardium by human bone marrow derived angioblasts prevents eardiomyocyte apoptosis, reduces remodeling and improves cardiac function显示文摘 | Kocher AA Schusitc 'r MD Szabolcs M J | 2001 | Nat Med2001，7，4： | 1 |
| 7 | Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function显示文摘 | Kocher A Schuster M Szabolcs M | 2001 | Nat Med2001，7，： | 1 |
| 8 | Igf1r as a therapeutic target in a mouse model of basal-like breast cancer显示文摘 | Klinakis A Szabolcs M Chen G | | 0，，： | 1 |
| 9 | Neovascularization of ischemic myocardium by human bone-marrow-derived amgioblasts prevents cardiomyocyte apoptosis,reduces remodeling and umproves cardiac function显示文摘 | Kocher A A Schuster M D Szabolcs M J | 2001 | Nat Med2001，7，4： | 1 |
| 10 | The transcription factor ATF 5 is widely expressed in carcinomas and interference with its func- tion selectively kills neoplastic, but notnontransformed, breast cell lines 显示文摘 | Monaco SE Angelastro JM Szabolcs M | 2007 | Cancer2007，120，9： | 1 |
| 11 | Proliferative activity of benign and neoplastic endocervical epithelium and correlation with HPV DNA detection显示文摘 | Isacson C Szabolcs M J | 2002 | Int J Gynecol Pathol2002，21，1： | 1 |
| 12 | Dysrcgulation of cellular pro- liferation and apoptosis mediates human autosomal dominant polycystic kidney disease ( ADPKD ) 显示文摘 | Lanoix J D'Agati V Szabolcs M | 1996 | Oncogene1996，13，6： | 1 |
| 13 | Neovascularization of ischcmic myocardium by human bonemarrow-derived angioblasts prevents cardiomyocyte apoptosis,reduces remodeling and improves cardiac function显示文摘 | Kocher A A Schuster M D Szabolcs M J | 2001 | Nat Med2001，7，4： | 1 |
| 14 | Neovascularization of ischemie myocardium by human bone - marrow - derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function显示文摘 | Kocher AA Schuster MD Szabolcs M J | 2001 | Nat Med2001，7，4： | 1 |
| 15 | Neovasculariza- tion of ischemic myocardium by human bone-marrow-derived an- gioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function显示文摘 | Kocher A A Schuster M D Szabolcs M J et ak | 2010 | Nat Med2010，7，： | 1 |
| 16 | Neovascular-ization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis,reduces remodeling and improves cardiac function显示文摘 | Kocher AA Schuster MD Szabolcs M J | 2001 | Nat Med2001，7，4： | 1 |
| 17 | Myc is a Notch1transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice显示文摘 | Klinakis A Szabolcs M Politi K | 2006 | PNAS2006，103，24： | 1 |
| 18 | Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis,reduces remodeling and improves cardiac function显示文摘 | Kocher A Schuster M Szabolcs M | 2001 | Nat Med2001，7，4： | 1 |
| 19 | The transcription factor ATF5 is widely expressed in carcinomas, and interferenee with its ruction selectively kills neoplastic, but not nontransfonned, breast cell lines 显示文摘 | Monaco SE Angelastro JM Szabolcs M | 2007 | lnt J Cancer2007，120，9： | 1 |
| 20 | Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis,reduces remodeling and improves cardiac function显示文摘 | KOCHER A A SCHUSTER M D SZABOLCS M J | 2001 | Nat Med2001，7，4： | 1 |
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