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| 1 | Stage and size using magnetic resonance imaging and endosonography in neoadjuvantly-treated rectal cancer显示文摘AIM: To assess the stage and size of rectal tumours using 1.5 Tesla (1.5T) magnetic resonance imaging (MRI) and three-dimensional (3D) endosonography (ERUS). METHODS: In this study, patients were recruited in a phaseⅠ/Ⅱ trial of neoadjuvant chemotherapy for biopsy-proven rectal cancer planned for surgical resection with or without preoperative radiotherapy. The feasibility and accuracy of 1.5T MRI and 3D ERUS were compared with the histopathology of the fixed surgical specimen (pathology) to determine the stage and size of the rectal cancer before and after neoadjuvant chemotherapy. A Philips Intera 1.5T with a cardiac 5-channel synergy surface coil was used for the MRI, and a B-K Medical Falcon 2101 EXL 3D-Probe was used at 13 MHz for the ERUS. Our hypothesis was that the staging accuracy would be the same when using MRI, ERUS and a combination of MRI and ERUS. For the combination, MRI was chosen for the assessment of the lymph nodes, and ERUS was chosen for the assessment of perirectal tissue penetration. The stage was dichotomised into stageⅠ and stage Ⅱ or greater. The size was measured as the supero-inferior length and the maximal transaxial area of the tumour. RESULTS: The staging feasibility was 37 of 37 for the MRI and 29 of 36 for the ERUS, with stenosis as a limiting factor. Complete sets of investigations were available in 18 patients for size and 23 patients for stage. The stage accuracy by MRI, ERUS and the combination of MRI and ERUS was 0.65, 0.70 and 0.74, respectively, before chemotherapy and 0.65, 0.78 and 0.83, respectively, after chemotherapy. The improvement of the post-chemotherapy staging using the combination of MRI and ERUS compared with the staging using MRI alone was significant (P = 0.046). The post-chemotherapy understaging frequency by MRI, ERUS and the combination of MRI and ERUS was 0.18, 0.14 and 0.045, respectively, and these differences were non-significant. The measurements of the supero-inferior length by ERUS compared with MRI were within 1.96 standard deviations of the difference between the methods (18 mm) for tumours smaller than 50 mm. The agreement with pathology was within 1.96 standard deviations of the difference between imaging and pathology for all tumours with MRI (15 mm) and for tumours that did not exceed 50 mm with ERUS (22 mm). Tumours exceeding 50 mm in length could not be reliably measured by ERUS due to the limit in the length of each recording. CONCLUSION: MRI is preferable to use when assessing the size of large or stenotic rectal tumours. However, staging accuracy is improved by combining MRI with ERUS. | Torbjrn Swartling Peter Klebo Kristoffer Derwinger Bengt Gustavsson Gran Kurlberg | 2013 | World Journal of Gastroenterology2013，19，21： | 9 |
| 2 | Membrane- associated echinocandin B deacylase of Actinoplanes utahensis: purification, characterization, heterologous cloning and enzymatic deacylation reaction显示文摘 | Kreuzman A J Hodges R L Swartling J R | 2000 | J Ind Microbiol Biotechnol2000，41，3： | 1 |
| 3 | Potent cortlcosteroid cream ( mometasone furoate) significantly reduces acute radiation dermatitis:results from a double-blind, randomized study显示文摘 | Bostrm A Lindman H Swartling C | 2001 | Radiother Oncol2001，59，3： | 1 |
| 4 | Botulinum toxin type A and B improve quality of life in patients with axillary and palmar hyper- hidrosis显示文摘 | RoseU K Hymnelius K Swartling C | 2013 | Acta Derm Venereol2013，93，3： | 1 |
| 5 | Potent corticosteroid cream (mometasone furoate)significantly reduces acute radiation dermatitis:Results from a double -blind,randomized study显示文摘 | Lindman H Swartling C | 2001 | Radionther Oncol2001，59，： | 1 |
| 6 | Signals that regulate the oneogenie fate of neural stem cells and progenitors 显示文摘 | Swartling FJ Bolin S Phillips JJ | 2014 | Exp Neurol2014，260，： | 1 |
| 7 | Pleiotropic role for MYCN in medulloblastoma 显示文摘 | Swartling F J Grimmer MR Hackett CS | 2010 | Genes Dev2010，24，10： | 1 |
| 8 | Accelerated Monte Carlo models to simulate fluorescence spectra from layered tissues显示文摘 | Swartling J Pifferi A Enejder A M K | 2003 | JOSA A2003，20，4： | 1 |
| 9 | Source localization for mul tiple speech sources using low complexity non parametric source separation and clustering显示文摘 | Swartling M Sallberg B Grbic N | 2011 | Signal Processing2011，91，8： | 1 |
| 10 | Potent cor-ticosteroid cream(mometasone furoate)significantly re-duces acute radiation dermatitis:results from a double-blind,randomized study显示文摘 | Bostr?m A Lindman H Swartling C | | 0，，03： | 1 |
| 11 | Prolonged out- break of adenovirus A31 in allogeneic stem cell transplant reeipi- ents显示文摘 | SWARTLING L ALLARD A TORLEN J | 2015 | Transpl Infect Dis2015，17，6： | 1 |
| 12 | Potent corticosteroid cream significantly reduces acute radiation dermatitis:results from a doubleblind,randomized study显示文摘 | Bostrom A Lindman H Swartling C | | 0，，03： | 1 |
| 13 | Membrane- associated echinocandin B deacylase of Actinoplanes utahen- sis: purification, characterization, heterologous cloning and en- zymatic deacylation reaction显示文摘 | Kreuzman A J Hodges R L Swartling J R | 2000 | J Ind Microbiol Biotechnol2000，24，3： | 1 |
| 14 | Treatment of pachyonychia congenita with plantar injections of botulinum toxin 显示文摘 | Swartling C Vahlquist A | 2006 | Br J Dermatol2006，154，4： | 1 |
| 15 | miRNA-21 is devel-opmentally regulated in mouse brain and is co-expressed with SOX2 in glioma显示文摘 | P(o)lajeva J Swartling FJ Jiang Y | | 0，，01： | 1 |
| 16 | Pro-inflammatory cytokine release in rectal surgery:comparison between laparoscopic and open surgical techniques显示文摘 | Kvarnstrm A Swartling T Kurlberg G | 2013 | Arch Immunol Ther Exp(Warsz)2013，61，5： | 1 |
| 17 | Cyclic GMP-dependent protein kinase lI inhibits cell prolifera- tion, Sox9 expression and Akt phosphorylation in human glioma cell lines 显示文摘 | Swartling FJ Ferletta M Kastemar M | 2009 | Oncogene2009，28，35： | 1 |
| 18 | The Bacillus subtilis pnbA gene encoding p-nitrobenzyl esterase : cloning, sequence and high- level expression in Escheriehia coli 显示文摘 | Zock J Cantwell C Swartling J | 1994 | Gene ( Amsterdam )1994，151，： | 1 |
| 19 | Potent corticosteroid cream (mometasone furoate )significantly reduces acute radiation dermatitis : results from a double-blind, randomized study显示文摘 | BostrSm A Lindman H Swartling C | 2001 | Ra- diother Oncol2001，59，3： | 1 |
| 20 | Optical monitoring of volcanic sulphur dioxide emissions-comparison between four different remote-sensing spectroscopy techniques显示文摘 | WEIBRING P SWARTLING J EDNER H | 2002 | Optics and Lasers in Engineering2002，37，2： | 1 |
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